Barbara Brooks-Worrell

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Is latent autoimmune diabetes in adults distinct from type 1 diabetes or just type 1 diabetes at an older age?
    Jerry P Palmer
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, USA
    Diabetes 54:S62-7. 2005
  2. pmc Islet-specific T-cell responses and proinflammatory monocytes define subtypes of autoantibody-negative ketosis-prone diabetes
    Barbara M Brooks-Worrell
    Corresponding authors Barbara M Brooks Worrell
    Diabetes Care 36:4098-103. 2013
  3. doi request reprint Islet autoimmunity in phenotypic type 2 diabetes patients
    B Brooks-Worrell
    Department of Medicine, University of Washington, Seattle, WA, USA
    Diabetes Obes Metab 15:137-40. 2013
  4. doi request reprint Prevention versus intervention of type 1 diabetes
    Barbara Brooks-Worrell
    Department of Medicine, University of Washington, Seattle, WA 98108, USA Department of Medicine, VA Puget Sound Health Care System, Seattle, WA 98108, USA Electronic address
    Clin Immunol 149:332-8. 2013
  5. pmc Attenuation of islet-specific T cell responses is associated with C-peptide improvement in autoimmune type 2 diabetes patients
    B M Brooks-Worrell
    Department of Medicine, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Clin Exp Immunol 171:164-70. 2013
  6. doi request reprint Biomarkers and immune-modulating therapies for type 2 diabetes
    Barbara Brooks-Worrell
    Department of Medicine, University of Washington, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Trends Immunol 33:546-53. 2012
  7. pmc Immunology in the Clinic Review Series; focus on metabolic diseases: development of islet autoimmune disease in type 2 diabetes patients: potential sequelae of chronic inflammation
    B Brooks-Worrell
    Department of Medicine, University of Washington, Seattle, WA, USA
    Clin Exp Immunol 167:40-6. 2012
  8. doi request reprint Comparison of cryopreservation methods on T-cell responses to islet and control antigens from type 1 diabetic patients and controls
    B Brooks-Worrell
    University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Diabetes Metab Res Rev 27:737-45. 2011
  9. doi request reprint Is diabetes mellitus a continuous spectrum?
    Barbara Brooks-Worrell
    Department of Medicine, DVA Puget Sound Health Care System, Seattle, WA 98108, USA
    Clin Chem 57:158-61. 2011
  10. pmc Identification of autoantibody-negative autoimmune type 2 diabetic patients
    Barbara M Brooks-Worrell
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes Care 34:168-73. 2011

Detail Information

Publications19

  1. ncbi request reprint Is latent autoimmune diabetes in adults distinct from type 1 diabetes or just type 1 diabetes at an older age?
    Jerry P Palmer
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, USA
    Diabetes 54:S62-7. 2005
    ..These patients appear to be similar to type 1.5 patients in having decreased stimulated C-peptide values. These immunological differences between type 1 and type 1.5 diabetes suggest at least partially distinct disease processes...
  2. pmc Islet-specific T-cell responses and proinflammatory monocytes define subtypes of autoantibody-negative ketosis-prone diabetes
    Barbara M Brooks-Worrell
    Corresponding authors Barbara M Brooks Worrell
    Diabetes Care 36:4098-103. 2013
    ..These three A- KPD subtypes are characterized by absence of humoral islet autoimmune markers, but a role for cellular islet autoimmunity is unknown...
  3. doi request reprint Islet autoimmunity in phenotypic type 2 diabetes patients
    B Brooks-Worrell
    Department of Medicine, University of Washington, Seattle, WA, USA
    Diabetes Obes Metab 15:137-40. 2013
    ..In this manuscript, the involvement of cell-mediated islet autoimmune disease in the progression of T2D disease and the similarities in islet-specific T-cell reactivity between type 1 diabetes (T1D) and T2D are discussed. ..
  4. doi request reprint Prevention versus intervention of type 1 diabetes
    Barbara Brooks-Worrell
    Department of Medicine, University of Washington, Seattle, WA 98108, USA Department of Medicine, VA Puget Sound Health Care System, Seattle, WA 98108, USA Electronic address
    Clin Immunol 149:332-8. 2013
    ..We will also discuss potential caveats for why prevention and intervention trials in T1D may not have experienced the same success as prediction trials. ..
  5. pmc Attenuation of islet-specific T cell responses is associated with C-peptide improvement in autoimmune type 2 diabetes patients
    B M Brooks-Worrell
    Department of Medicine, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Clin Exp Immunol 171:164-70. 2013
    ..Our results suggest that down-regulation of islet-specific T cell autoimmunity through anti-inflammatory therapy may help to improve beta cell function in autoimmune phenotypic T2DM patients...
  6. doi request reprint Biomarkers and immune-modulating therapies for type 2 diabetes
    Barbara Brooks-Worrell
    Department of Medicine, University of Washington, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Trends Immunol 33:546-53. 2012
    ....
  7. pmc Immunology in the Clinic Review Series; focus on metabolic diseases: development of islet autoimmune disease in type 2 diabetes patients: potential sequelae of chronic inflammation
    B Brooks-Worrell
    Department of Medicine, University of Washington, Seattle, WA, USA
    Clin Exp Immunol 167:40-6. 2012
    ....
  8. doi request reprint Comparison of cryopreservation methods on T-cell responses to islet and control antigens from type 1 diabetic patients and controls
    B Brooks-Worrell
    University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Diabetes Metab Res Rev 27:737-45. 2011
    ..The use of cryopreserved cells is preferable to the use of freshly isolated cells to monitor clinical trials to decrease assay and laboratory variability...
  9. doi request reprint Is diabetes mellitus a continuous spectrum?
    Barbara Brooks-Worrell
    Department of Medicine, DVA Puget Sound Health Care System, Seattle, WA 98108, USA
    Clin Chem 57:158-61. 2011
    ..Diabetes mellitus has been historically divided into type 1 and type 2 diabetes, with type 1 being an autoimmune disease and type 2 being primarily a metabolic disease...
  10. pmc Identification of autoantibody-negative autoimmune type 2 diabetic patients
    Barbara M Brooks-Worrell
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes Care 34:168-73. 2011
    ..In this study, we investigated whether islet reactive T cells might also be present in type 2 diabetic patients and how islet reactive T cells correlate with β-cell function...
  11. ncbi request reprint Cellular immune responses to human islet proteins in antibody-positive type 2 diabetic patients
    B M Brooks-Worrell
    Department of Medicine, Department of Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Diabetes 48:983-8. 1999
    ..Some subjects demonstrate PBMC responses similar to those of "classic" type 1 diabetic patients, whereas others have PBMC responses potentially distinct from type 1 diabetic patients...
  12. doi request reprint Improved T cell assay for identification of type 1 diabetes patients
    Barbara Brooks-Worrell
    Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    J Immunol Methods 344:79-83. 2009
    ..This improved T cell assay, which directly measures islet reactive T cell responses in autoimmune diabetes patients with excellent sensitivity and specificity, will likely improve patient follow-up during intervention studies...
  13. ncbi request reprint Autoimmunity to islet proteins in children diagnosed with new-onset diabetes
    Barbara M Brooks-Worrell
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Clin Endocrinol Metab 89:2222-7. 2004
    ..Moreover, the presence of obesity or acanthosis nigracans does not reliably distinguish children with or without islet cell autoimmunity...
  14. ncbi request reprint Intermolecular antigen spreading occurs during the preclinical period of human type 1 diabetes
    B Brooks-Worrell
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Immunol 166:5265-70. 2001
    ..Our data strongly support the conclusion that intermolecular spreading of T cell and Ab responses to islet proteins occurs during the preclinical period of type 1 diabetes...
  15. ncbi request reprint Equivalent insulin resistance in latent autoimmune diabetes in adults (LADA) and type 2 diabetic patients
    Harvey K Chiu
    Veterans Affairs Puget Sound Health Care System, Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington Seattle, WA, United States
    Diabetes Res Clin Pract 77:237-44. 2007
    ..As complications and treatment regimens specific to LADA are realized, improved means of identification of LADA will become increasingly important...
  16. ncbi request reprint T-cell responses to islet antigens improves detection of autoimmune diabetes and identifies patients with more severe beta-cell lesions in phenotypic type 2 diabetes
    Amit Goel
    Veterans Affairs Puget Sound Health Care System, Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, WA 98108, USA
    Diabetes 56:2110-5. 2007
    ....
  17. pmc Parenteral insulin suppresses T cell proliferation to islet antigens
    Carla J Greenbaum
    Benaroya Research Institute, Seattle, WA, USA
    Pediatr Diabetes 12:150-5. 2011
    ..Further study is needed to determine whether a therapy that results in sustained suppression of T cell proliferation could yield a measurable clinical benefit...
  18. ncbi request reprint Precursor frequencies of T-cells reactive to insulin in recent onset type 1 diabetes mellitus
    Ramachandra G Naik
    Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition, University of Washington and Department of Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
    J Autoimmun 23:55-61. 2004
    ..Consequently the precursor frequency of insulin autoreactive cells in patients and their siblings is probably much higher than calculated...
  19. ncbi request reprint Autoimmunity and clinical course in children with type 1, type 2, and type 1.5 diabetes
    Lisa K Gilliam
    Department of Medicine, University of Washington, 1959 N E Pacific St, Box 357710, Seattle, 98195, USA
    J Autoimmun 25:244-50. 2005
    ..We examined the relationship between diabetes autoantibodies (DAA), human leukocyte antigen (HLA), and clinical course in subjects grouped by clinical diabetes type...