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| M Alan BrookhartSummaryAffiliation: University of North Carolina Country: USA Publications
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Publications
The effect of altitude change on anemia treatment response in hemodialysis patientsM Alan Brookhart
Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC 27599 7435, USA
Am J Epidemiol 173:768-77. 2011..These results support the hypothesis that altitude-induced hypoxia reduces erythropoietin requirements in hemodialysis patients with treatment-refractory anemia...
Confounding control in healthcare database research: challenges and potential approachesM Alan Brookhart
Department of Medicine, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Med Care 48:S114-20. 2010..Such reporting allows the reader to assess the sensitivity of the results to model assumptions that are often not supported by strong subject-matter knowledge...- Instrumental variable methods in comparative safety and effectiveness researchM Alan Brookhart
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 27599 7435, USA
Pharmacoepidemiol Drug Saf 19:537-54. 2010..We anticipate that IV methods will be often underpowered for drug safety studies of very rare outcomes, but may be potentially useful in studies of intended effects where uncontrolled confounding may be substantial... 
Gaps in treatment among users of osteoporosis medications: the dynamics of noncomplianceM Alan Brookhart
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, Mass 02120, USA
Am J Med 120:251-6. 2007..We sought to estimate the percentage of patients who restart osteoporosis therapy after a prolonged lapse in medication use and to identify the factors associated with a return to compliance...- Relative effectiveness of osteoporosis drugs for preventing nonvertebral fractureSuzanne M Cadarette
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, and Boston University, Boston, Massachusetts 02120, USA
Ann Intern Med 148:637-46. 2008..Little information is available on the comparative effectiveness of osteoporosis pharmacotherapies... - Increasing levels of restriction in pharmacoepidemiologic database studies of elderly and comparison with randomized trial resultsSebastian Schneeweiss
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Med Care 45:S131-42. 2007..The goal of restricting study populations is to make patients more homogeneous regarding potential confounding factors and treatment effects and thereby achieve less biased effect estimates... - Patient, physician, and payment predictors of statin adherenceDavid C Chan
Department of Medicine, Division of General Internal Medicine, Brigham and Women s Hospital, Boston, MA, USA
Med Care 48:196-202. 2010..Although many patient, physician, and payment predictors of adherence have been described, knowledge of their relative strength and overall ability to explain adherence is limited... - Instrumental variable analysis for estimation of treatment effects with dichotomous outcomesJeremy A Rassen
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, MA 02120, USA
Am J Epidemiol 169:273-84. 2009..Generalized method of moments estimation produced substantially the same results as the 2-stage logistic method. Few substantive differences among the methods were observed, despite their reliance on distinct assumptions... - State generic substitution laws can lower drug outlays under MedicaidWilliam H Shrank
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Health Aff (Millwood) 29:1383-90. 2010..Although these consent requirements are probably intended to increase patient autonomy, policy makers should consider the sizable opportunity costs... - Variation in antipsychotic treatment choice across US nursing homesKrista F Huybrechts
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
J Clin Psychopharmacol 32:11-7. 2012..The objective of this study was to quantify the variation in antipsychotic treatment choice across US nursing homes, and to characterize its correlates... - Evaluating the validity of an instrumental variable study of neuroleptics: can between-physician differences in prescribing patterns be used to estimate treatment effects?M Alan Brookhart
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts, USA
Med Care 45:S116-22. 2007..We sought to explore the validity of physician-level IV in a comparative study of short-term mortality risk among elderly users of conventional versus atypical antipsychotic medications (APM)... - Can improved prescription medication labeling influence adherence to chronic medications? An evaluation of the Target pharmacy labelWilliam H Shrank
Department of Medicine, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street Suite 3030, Boston, MA 02120, USA
J Gen Intern Med 24:570-8. 2009..A new prescription medication labeling system was implemented by Target pharmacies in May 2005 and aimed to improve readability and understanding... - High-risk patients' readiness to undergo BMD testing for osteoporosis diagnosis in PennsylvaniaJennifer M Polinski
Brigham and Women s Hospital, Boston, Massachusetts, USA
Int Q Community Health Educ 29:223-40. 2008..We found several correlates of readiness to undergo BMD screening that may be used to design effective interventions... - Seizure outcomes following the use of generic versus brand-name antiepileptic drugs: a systematic review and meta-analysisAaron S Kesselheim
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
Drugs 70:605-21. 2010..In the absence of better data, physicians may want to consider more intensive monitoring of high-risk patients taking AEDs when any switch occurs... - High-dimensional propensity score adjustment in studies of treatment effects using health care claims dataSebastian Schneeweiss
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Epidemiology 20:512-22. 2009..Here, we develop and test an algorithm that empirically identifies candidate covariates, prioritizes covariates, and integrates them into a propensity-score-based confounder adjustment model... - Comparative mortality risk of anemia management practices in incident hemodialysis patientsM Alan Brookhart
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, USA
JAMA 303:857-64. 2010..Controversy exists about optimal management of anemia in end-stage renal disease... - The association between statin use and outcomes potentially attributable to an unhealthy lifestyle in older adultsAmanda R Patrick
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Value Health 14:513-20. 2011.... - Risk of death and hospital admission for major medical events after initiation of psychotropic medications in older adults admitted to nursing homesKrista F Huybrechts
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
CMAJ 183:E411-9. 2011..We assessed the comparative safety of different classes of psychotropic medications used in nursing home residents... - Percutaneous vertebroplasty among low income Medicare beneficiariesDaniel H Solomon
Divisions of Pharmacoepidemiology, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
Spine (Phila Pa 1976) 32:2910-4. 2007..Cohort... - The implications of propensity score variable selection strategies in pharmacoepidemiology: an empirical illustrationAmanda R Patrick
Division of Pharmacoepidemiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Pharmacoepidemiol Drug Saf 20:551-9. 2011.... - The complex relation between bisphosphonate adherence and fracture reductionAmanda R Patrick
Divisions of Pharmacoepidemiology and Pharmacoeconomics Department of Medicine, Brigham and Women s Hospital, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
J Clin Endocrinol Metab 95:3251-9. 2010.... - The relationship between focal erosions and generalized osteoporosis in postmenopausal women with rheumatoid arthritisDaniel H Solomon
Brigham and Women s Hospital, Division of Rheumatology, Boston, Massachusetts 02115, USA
Arthritis Rheum 60:1624-31. 2009..The aim of this study was to determine whether lower BMD is associated with higher erosion scores among patients with RA... - Instrumental variables II: instrumental variable application-in 25 variations, the physician prescribing preference generally was strong and reduced covariate imbalanceJeremy A Rassen
Brigham and Women s Hospital, Boston, MA 02120, USA
J Clin Epidemiol 62:1233-41. 2009..As reduction in covariate imbalance may suggest increased IV validity, we sought to examine the covariate balance and instrument strength in 25 formulations of the PPP IV in two cohort studies... - Osteoporosis improvement: a large-scale randomized controlled trial of patient and primary care physician educationDaniel H Solomon
Division of Pharmacoepidemiology, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
J Bone Miner Res 22:1808-15. 2007..04; 95% ci, 0.85-1.26)... - Compliance with osteoporosis medicationsDaniel H Solomon
Divisions of Pharmacoepidemiology, Brigham and Women s Hospital, Boston, MA 02120, USA
Arch Intern Med 165:2414-9. 2005..This study was undertaken to assess the level and determinants of compliance with drugs prescribed for osteoporosis... - The effect of altitude on dosing and response to erythropoietin in ESRDM Alan Brookhart
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
J Am Soc Nephrol 19:1389-95. 2008..Furthermore, resistance to EPO decreased with elevation. Our results suggest that ESRD patients living at high altitude either increase endogenous EPO production or respond better to endogenous and exogenous EPO... - The epidemiology of prescriptions abandoned at the pharmacyWilliam H Shrank
Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
Ann Intern Med 153:633-40. 2010..Understanding the epidemiology and correlates of prescription abandonment may have an important effect on health care quality... - Adherence to lipid-lowering therapy and the use of preventive health services: an investigation of the healthy user effectM Alan Brookhart
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02120, USA
Am J Epidemiol 166:348-54. 2007..Further work is needed to identify study design and analysis methods that can be used to minimize the healthy user bias in studies of preventive therapies... - Trends in the incidence, demographics, and outcomes of end-stage renal disease due to lupus nephritis in the US from 1995 to 2006Karen H Costenbader
Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Arthritis Rheum 63:1681-8. 2011.... - A comparison of statistical approaches for physician-randomized trials with survival outcomesMargaret R Stedman
Orthopedics and Arthritis Center for Outcomes Research, Department of Orthopedics, Brigham and Women s Hospital, Boston, MA 02115, USA
Contemp Clin Trials 33:104-15. 2012..The marginal proportional hazards method performed well even when model assumptions were violated. Nonlinear mixed models were only advantageous when the distribution was correctly specified... - Primary medication non-adherence: analysis of 195,930 electronic prescriptionsMichael A Fischer
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, MA 02120, USA
J Gen Intern Med 25:284-90. 2010..Little is known about the frequency with which patients fail to fill prescriptions when new medications are started ("primary non-adherence") or predictors of failure to fill... - Simultaneous assessment of short-term gastrointestinal benefits and cardiovascular risks of selective cyclooxygenase 2 inhibitors and nonselective nonsteroidal antiinflammatory drugs: an instrumental variable analysisSebastian Schneeweiss
Harvard Medical School, Division of Pharmacoepidemiology and Pharmacoeconomics, Boston, MA 021205, USA
Arthritis Rheum 54:3390-8. 2006.... - Doubly robust estimation of causal effectsMichele Jonsson Funk
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Am J Epidemiol 173:761-7. 2011..Cary, North Carolina) for doubly robust estimation, available for download at http://www.unc.edu/~mfunk/dr/... - Trends in the use and outcomes of implantable cardioverter-defibrillators in patients undergoing dialysis in the United StatesDavid M Charytan
Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Am J Kidney Dis 58:409-17. 2011..Sudden cardiac death constitutes the leading cause of death in patients receiving dialysis. Little is known about the trends in implantable cardioverter-defibrillator (ICD) use and the outcomes of such device placement... - The medical license number accurately identifies the prescribing physician in a large pharmacy claims databaseM Alan Brookhart
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
Med Care 45:907-10. 2007..We studied the accuracy of the medical license number in data from a state-run drug benefit plan by assessing its consistency with 2 external sources of data... - Physician follow-up and provider continuity are associated with long-term medication adherence: a study of the dynamics of statin useM Alan Brookhart
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
Arch Intern Med 167:847-52. 2007.... - Altitude and the risk of cardiovascular events in incident US dialysis patientsWolfgang C Winkelmayer
Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA
Nephrol Dial Transplant 27:2411-7. 2012..We hypothesized that higher altitude would be associated with lower rates of cardiovascular events due to an altered physiological response of dialysis patients to altitude induced hypoxia... - Medicare part D's impact on antipsychotic drug use and costs among elderly patients without prior drug insuranceJennifer M Polinski
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, MA 02120, USA
J Clin Psychopharmacol 32:3-10. 2012..Part D implementation was associated with increased use and affordability of APMs for the elderly without prior drug insurance... - Osteoporosis telephonic intervention to improve medication regimen adherence: a large, pragmatic, randomized controlled trialDaniel H Solomon
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
Arch Intern Med 172:477-83. 2012..We examined the effectiveness of a telephone-based counseling program rooted in motivational interviewing to improve adherence to a medication regimen for osteoporosis... - Covariate selection in high-dimensional propensity score analyses of treatment effects in small samplesJeremy A Rassen
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
Am J Epidemiol 173:1404-13. 2011..hd-PS is a flexible analytical tool for nonrandomized research across a range of study sizes and event frequencies... - Physician effectiveness in interventions to improve cardiovascular medication adherence: a systematic reviewSarah L Cutrona
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, MA 02120, USA
J Gen Intern Med 25:1090-6. 2010..Medications for the prevention and treatment of cardiovascular disease save lives but adherence is often inadequate. The optimal role for physicians in improving adherence remains unclear... - Evaluating short-term drug effects using a physician-specific prescribing preference as an instrumental variableM Alan Brookhart
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02120, USA
Epidemiology 17:268-75. 2006..Instrumental variable methods have been proposed as a potential approach to control confounding by indication in nonexperimental studies of treatment effects; however, good instruments are hard to find... - Risk of death in elderly users of conventional vs. atypical antipsychotic medicationsPhilip S Wang
Department of Psychiatry, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
N Engl J Med 353:2335-41. 2005..However, the advisory did not apply to conventional antipsychotic medications; the risk of death with these older agents is not known... - Effects of noncardiovascular comorbidities on antihypertensive use in elderly hypertensivesPhilip S Wang
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Hypertension 46:273-9. 2005..Highly prevalent, noncardiovascular conditions appear to deter use of antihypertensives in elderly with hypertension... - Design of cluster-randomized trials of quality improvement interventions aimed at medical care providersRobert J Glynn
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
Med Care 45:S38-43. 2007..Such trials are frequently embedded in health care systems with available automated records, which can be used to enhance the design of the trial... - Altitude and all-cause mortality in incident dialysis patientsWolfgang C Winkelmayer
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont St, Ste 3 030, Boston, MA 02120, USA
JAMA 301:508-12. 2009..Increased iron availability caused by activation of hypoxia-induced factors at higher altitude may explain this finding. Hypoxia-induced factors are also involved in other pathways that may affect morbidity and mortality... - Instrumental variables I: instrumental variables exploit natural variation in nonexperimental data to estimate causal relationshipsJeremy A Rassen
Brigham and Women s Hospital, Boston, MA 02120, USA
J Clin Epidemiol 62:1226-32. 2009..It gives examples of instruments used in clinical epidemiology and concludes with an outline on estimation of effects... - Instrumental variable analysis of secondary pharmacoepidemiologic dataM Alan Brookhart
Division of Pharmacoepidemiology, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02120, USA
Epidemiology 17:373-4. 2006 - Correlations of nursing home characteristics with prescription of osteoporosis medicationsSeema Parikh
Harvard Medical School, Boston, MA, USA
Bone 48:1164-8. 2011..NH characteristics have been associated with prescription of some medications. We examined associations of NH-level characteristics with osteoporosis treatment in elderly patients admitted to a NH after a fracture... - Variable selection for propensity score modelsM Alan Brookhart
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
Am J Epidemiol 163:1149-56. 2006..These simulation studies and other analytical results suggest that standard model-building tools designed to create good predictive models of the exposure will not always lead to optimal PS models, particularly in small studies... - Trends in drug prescribing for osteoporosis after hip fracture, 1995-2004Suzanne M Cadarette
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
J Rheumatol 35:319-26. 2008..To examine trends in osteoporosis drug prescribing after hip fracture from 1995 to 2004... - Influenza vaccine effectiveness in patients on hemodialysis: an analysis of a natural experimentLeah J McGrath
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
Arch Intern Med 172:548-54. 2012..Observational studies of vaccine effectiveness (VE) are challenging because vaccinated subjects may be healthier than unvaccinated subjects... - Healthy user and related biases in observational studies of preventive interventions: a primer for physiciansWilliam H Shrank
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
J Gen Intern Med 26:546-50. 2011..More careful consideration of these sources of bias and study designs by providers can enhance evidence-based decision-making... - Measuring concurrent adherence to multiple related medicationsNiteesh K Choudhry
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, MA 02120, USA
Am J Manag Care 15:457-64. 2009..To propose standardized methods for measuring concurrent adherence to multiple related medications and to apply these definitions to a cohort of patients with diabetes mellitus... - Assessing health state utilities in elderly patients at cardiovascular riskWolfgang C Winkelmayer
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
Med Decis Making 26:247-54. 2006..Health state preferences can be a crucial component of cost-effectiveness analyses, but off-the-shelf health state utilities specifically for older people are not available... - Evaluating uses of data mining techniques in propensity score estimation: a simulation studySoko Setoguchi
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02130, USA
Pharmacoepidemiol Drug Saf 17:546-55. 2008.... - Explained variation in a model of therapeutic decision making is partitioned across patient, physician, and clinic factorsM Alan Brookhart
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
J Clin Epidemiol 59:18-25. 2006..A statistical method is presented for attributing explained variation in patient care to different levels of aggregation in a multilevel model with the aim of prioritizing and targeting quality improvement interventions... - Assessing residual confounding of the association between antipsychotic medications and risk of death using survey dataSebastian Schneeweiss
Division of Pharmacoepidemiology and Pharmacoeconomics, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
CNS Drugs 23:171-80. 2009..Nonrandomised studies on the causal effects of psychotropic medications may be biased by patient characteristics that are not fully adjusted... - An evaluation of statistical approaches for analyzing physician-randomized quality improvement interventionsMargaret R Stedman
Boston University School of Public Health, Department of Biostatistics, Boston, MA, USA
Contemp Clin Trials 29:687-95. 2008..PQL yielded biased results. The permutation test preserved Type I error rates, but had less power than the other methods considered... - Use of disease-modifying medications for rheumatoid arthritis by race and ethnicity in the National Ambulatory Medical Care SurveyDaniel H Solomon
Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Arthritis Care Res (Hoboken) 64:184-9. 2012..We investigated the use of DMARDs in patients with RA in a nationally representative sample of visits to US physicians in the National Ambulatory Care Medical Survey (NAMCS)... - A SAS macro for a clustered logrank testMargaret R Stedman
Harvard Medical School, Boston, MA, United States
Comput Methods Programs Biomed 104:266-70. 2011..We discuss the theory and applications behind this test as well as details of the SAS code... - Analytic strategies to adjust confounding using exposure propensity scores and disease risk scores: nonsteroidal antiinflammatory drugs and short-term mortality in the elderlyTIL STURMER
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
Am J Epidemiol 161:891-8. 2005..26, 1.68). In this setting, analytic strategies using EPS or disease risk scores were not generally superior to "conventional" models. Various ways to use EPS and disease risk scores behaved differently with smaller study size... - Kidney function and use of recommended medications after myocardial infarction in elderly patientsWolfgang C Winkelmayer
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
Clin J Am Soc Nephrol 1:796-801. 2006..Differences in other characteristics such as age, rather than kidney function, may be responsible for much or all the reported reduction in use of preventive medications after MI seen in patients with chronic kidney disease... - An evaluation of the relationship between the implementation of a newly designed prescription drug label at Target pharmacies and health outcomesWilliam H Shrank
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
Med Care 47:1031-5. 2009..A new prescription medication labeling system was implemented by Target pharmacies in May 2005 and aimed to improve health outcomes... - Simple estimators of the intensity of seasonal occurrenceM Alan Brookhart
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School Boston, MA, USA
BMC Med Res Methodol 8:67. 2008..From this fitted curve, estimates of the seasonal intensity of occurrence (i.e., peak-to-low ratio of the fitted curve) can be generated... - Impact of statin use on outcomes after coronary artery bypass graft surgeryAlexander Kulik
Brigham and Women s Hospital, 1620 Tremont St, Suite 3030, Boston, MA 02120, USA
Circulation 118:1785-92. 2008.... - Psychotropic medication use for behavioral symptoms of dementiaPhilip S Wang
Department of Psychiatry, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
Curr Neurol Neurosci Rep 6:490-5. 2006..Also, although various psychotropic medications used for behavioral disturbances in dementia patients may be somewhat effective, they have been increasingly associated with important safety risks... - Clinical equivalence of generic and brand-name drugs used in cardiovascular disease: a systematic review and meta-analysisAaron S Kesselheim
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
JAMA 300:2514-26. 2008..Use of generic drugs, which are bioequivalent to brand-name drugs, can help contain prescription drug spending. However, there is concern among patients and physicians that brand-name drugs may be clinically superior to generic drugs... - Impact of reimbursement changes on statin use among patients with diabetes in AustriaWolfgang C Winkelmayer
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Wien Klin Wochenschr 122:89-94. 2010..These have used various instruments to steer appropriate use of such treatment. It was the purpose of this study to examine the effect of two reimbursement policy changes of statin therapy in patients with diabetes in Austria... - Osteoporosis action: design of the healthy bones project trialDaniel H Solomon
Division of Pharmacoepidemiology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA, USA
Contemp Clin Trials 26:78-94. 2005..All outcomes will be analyzed using random effects models accounting for clustering of subjects within physicians' practices...