Research Topics
Species | Robert D BrookSummaryAffiliation: University of Michigan Country: USA Publications
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Publications
Reduced metabolic insulin sensitivity following sub-acute exposures to low levels of ambient fine particulate matter air pollutionRobert D Brook
Division of Cardiovascular Medicine, University of Michigan, United States
Sci Total Environ 448:66-71. 2013..5 exposures. Our findings suggest that ambient PM2.5, even at low levels, may reduce metabolic insulin sensitivity supporting the plausibility that air pollution could potentiate the development of DM...
Can personal exposures to higher nighttime and early-morning temperatures increase blood pressure?Robert D Brook
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48106, USA
J Clin Hypertens (Greenwich) 13:881-8. 2011..The authors provide the first evidence that personal exposure to warmer nighttime and early-morning environmental temperatures might lead to an increase in BP during the ensuing day...- "Environmental hypertensionology" the effects of environmental factors on blood pressure in clinical practice and researchRobert D Brook
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48188, USA
J Clin Hypertens (Greenwich) 13:836-42. 2011..The authors propose using the term environmental hypertensionology to refer to the study of the effects of environmental factors on BP in clinical and research settings... 
A negative carotid plaque area test is superior to other noninvasive atherosclerosis studies for reducing the likelihood of having underlying significant coronary artery diseaseRobert D Brook
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA
Arterioscler Thromb Vasc Biol 26:656-62. 2006..Although each test may enhance risk stratification, their comparative abilities to screen for underlying coronary stenoses in individual patients is less established...- You are what you breathe: evidence linking air pollution and blood pressureRobert D Brook
Division of Cardiovascular Medicine, University of Michigan, 24 Frank Lloyd Wright Drive, PO Box 322, Ann Arbor, MI 48106 0739, USA
Curr Hypertens Rep 7:427-34. 2005..However, even the small elevations in blood pressure observed following certain exposures to PM have tremendous public health implications, due to the ubiquitous nature of air pollution... - Differences in blood pressure and vascular responses associated with ambient fine particulate matter exposures measured at the personal versus community levelRobert D Brook
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA
Occup Environ Med 68:224-30. 2011..Higher ambient fine particulate matter (PM₂.₅) levels can be associated with increased blood pressure and vascular dysfunction... - Usefulness of low-density lipoprotein particle size measurement in cardiovascular disease preventionRobert D Brook
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA
Clin Cardiol 28:534-7. 2005.... - Obesity, weight loss, and vascular functionRobert D Brook
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA
Endocrine 29:21-5. 2006..Nevertheless, lifestyle changes that lead to weight reduction are able to improve vascular function in overweight adults... - Particulate matter air pollution and atherosclerosisRobert D Brook
Division of Cardiovascular Medicine, University of Michigan, 24 Frank Lloyd Wright Dr, PO Box 322, Ann Arbor, MI 48106, USA
Curr Atheroscler Rep 12:291-300. 2010..Due to the billions of people continually exposed to PM(2.5), the long-term pro-atherosclerotic effects of this ubiquitous air pollutant are likely to be of enormous and growing global public health importance... - Why physicians who treat hypertension should know more about air pollutionRobert D Brook
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109 0739, USA
J Clin Hypertens (Greenwich) 9:629-35. 2007..Because air pollution exposure is ubiquitous throughout the world, however, all health care providers and especially those who treat hypertension should be aware of this emerging and important biologic relationship... - Cardiovascular effects of air pollutionRobert D Brook
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48106 0739, USA
Clin Sci (Lond) 115:175-87. 2008..800,000 annual deaths)... - Is air pollution a cause of cardiovascular disease? Updated review and controversiesRobert D Brook
Division of Cardiovascular Medicine, University of Michigan, USA
Rev Environ Health 22:115-37. 2007..Although long-term air pollution exposure has been shown to promote the development of atherosclerosis, the clinical significance of this relation requires more investigation... - The relationship between diabetes mellitus and traffic-related air pollutionRobert D Brook
Division of Cardiovascular Medicine, University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA
J Occup Environ Med 50:32-8. 2008..Many of the biological pathways involved could also promote diabetes mellitus (DM). We therefore investigated the association between DM prevalence and exposure to traffic-related air pollution (nitrogen dioxide [NO 2])... - Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adultsRobert D Brook
University of Michigan, Ann Arbor, USA
Circulation 105:1534-6. 2002..Fine particulate air pollution and ozone are associated with increased cardiovascular events. To help explain the mechanism behind these observations, we investigated the effect of air pollution exposure on vascular function... - Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humansRobert D Brook
University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA
Hypertension 54:659-67. 2009..Our findings demonstrate credible mechanisms whereby fine particulate matter could trigger acute cardiovascular events and that aspects of exposure location may be an important determinant of the health consequences... - Exploration of the rapid effects of personal fine particulate matter exposure on arterial hemodynamics and vascular function during the same dayRobert D Brook
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA
Environ Health Perspect 119:688-94. 2011..5 μm in aerodynamic diameter (PM(2.5))] are associated with alterations in arterial hemodynamics and vascular function. However, the characteristics of the same-day exposure-response relationships remain unclear... - Air pollution: the "Heart" of the problemRobert D Brook
University of Michigan, 3918 Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
Curr Hypertens Rep 5:32-9. 2003..Many questions, however, remain unanswered and future studies will be required to clarify the relevant biologic mechanisms and to identify the specific constituents responsible for mediating the adverse health impacts... - Effect of short-term weight loss on the metabolic syndrome and conduit vascular endothelial function in overweight adultsRobert D Brook
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA
Am J Cardiol 93:1012-6. 2004..18 +/- 5.89 vs 18.87 +/- 7.11%, p = 0.13) of the brachial artery. A moderate degree of weight reduction over 3 months improved the metabolic syndrome profile but not the vascular dysfunction associated with uncomplicated obesity... - Risk factors associated with metabolic syndrome in bipolar and schizophrenia subjects treated with antipsychotics: the role of folate pharmacogeneticsVicki L Ellingrod
Department of Clinical Social and Administrative Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA
J Clin Psychopharmacol 32:261-5. 2012..Use of this information clinically may help to reduce the risk for AAP metabolic complications in those whose clinical care necessitates the use of AAPs... - Lipoprotein (a): perspectives from a lipid-referral programMelvyn Rubenfire
Division of Cardiovascular Medicine, University of Michigan, 24 Frank Lloyd Wright Drive, PO Box 322, Ann Arbor, MI 48188, USA
J Clin Lipidol 6:66-73. 2012..Lipoprotein (a) [Lp(a)] has a strong association with coronary disease (CHD). We evaluated the implications of implementing a niacin strategy in persons above low risk by the Framingham risk score (FRS)... - Effects of concentrated fine ambient particles on rat plasma levels of asymmetric dimethylarginineJ Timothy Dvonch
Department of Environmental Health Sciences, University of Michigan, Ann Arbor, 48109-2029, USA
Inhal Toxicol 16:473-80. 2004..5) at high concentrations may trigger an acute increase in circulating ADMA level. This finding has implications for the regulation of vasomotor tone by particulate pollutants and the propensity for adverse cardiovascular events... - Hypertension and triglyceride catabolism: implications for the hemodynamic model of the metabolic syndromeRobert D Brook
Division of Hypertension, University of Michigan, 3918 Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI 48104, USA
J Am Coll Nutr 22:290-5. 2003..We sought to determine if hypertensive adults have a blunted triglyceride catabolic rate (TG K(2)) and if related hemodynamic and vascular alterations are determinants of TG K(2)... - Combined continuous ethinyl estradiol/norethindrone acetate does not improve forearm blood flow in postmenopausal women at risk for cardiovascular events: a pilot studyClaire S Duvernoy
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48105, USA
J Womens Health (Larchmt) 16:963-70. 2007.... - Neutral effect on markers of heart failure, inflammation, endothelial activation and function, and vagal tone after high-dose HMG-CoA reductase inhibition in non-diabetic patients with non-ischemic cardiomyopathy and average low-density lipoprotein levelBarry E Bleske
University of Michigan, College of Pharmacy, Ann Arbor, Michigan 48109 1065, USA
J Am Coll Cardiol 47:338-41. 2006.... - Cardiovascular risk, obesity, and myocardial blood flow in postmenopausal womenApurva A Motivala
Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
J Nucl Cardiol 15:510-7. 2008..Whether this is because of obesity itself or the accompanying increase in cardiovascular risk factors (CRFs) remains controversial... - Determinants of vascular function in patients with chronic goutRobert D Brook
Divisions of Rheumatology and Cardiology, Department of Internal Medicine the Michigan Institute for Clinical Research, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
J Clin Hypertens (Greenwich) 13:178-88. 2011..These results do not support the notion that gout is an independent risk factor for premature CVD... - Does "hidden undercuffing" occur among obese patients? Effect of arm sizes and other predictors of the difference between wrist and upper arm blood pressuresHardik Doshi
Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48106, USA
J Clin Hypertens (Greenwich) 12:82-8. 2010.... - Potential effects on clinical management of treatment algorithms on the basis of apolipoprotein-B/A-1 and total/high-density lipoprotein-cholesterol ratiosDeepthi Vodnala
Division of Cardiovascular Medicine, University of Michigan, 24 Frank Lloyd Wright Drive, PO Box 322, Ann Arbor, MI 48106, USA
J Clin Lipidol 5:159-65. 2011.... - Plasminogen activator inhibitor-1 is associated with impaired endothelial function in women with systemic lupus erythematosusEmily C Somers
Division of Rheumatology, University of Michigan Health System, 1150 W Medical Center Dr, 5520 MSRB 1, Ann Arbor, MI 48109 0680, USA
Ann N Y Acad Sci 1051:271-80. 2005..Given the high incidence of cardiovascular disease in SLE, further investigation of the role of subclinical markers of CVD is needed... - Interactive effects of the ACE DD polymorphism with the NOS III homozygous G849T (Glu298-->Asp) variant in determining endothelial function in coronary artery diseaseMichael A Schmidt
Section of Vascular Medicine, Division of Cardiology, University of Michigan School of Medicine, Ann Arbor, MI 48109 0273, USA
Vasc Med 8:177-83. 2003.... - Utility of C-reactive protein measurement in risk stratification during primary cardiovascular disease preventionRobert L Bard
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA
Am J Cardiol 95:1378-9. 2005..Because hs-CRP evaluation significantly altered the cardiovascular risk strata of most intermediate-risk patients, it may therefore be a useful test during primary cardiovascular disease prevention... - Patient awareness of the risks for heart disease posed by air pollutionMatthew R Nowka
University of Michigan, Ann Arbor, MI 48106, USA
Prog Cardiovasc Dis 53:379-84. 2011..The purpose of this study was to assess patient awareness of the coronary heart disease (CHD) risks posed by air pollution... - Endothelial cell apoptosis in systemic lupus erythematosus: a common pathway for abnormal vascular function and thrombosis propensitySanjay Rajagopalan
Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109-0680, USA
Blood 103:3677-83. 2004..Heightened endothelial apoptosis may represent an important mechanism for development of atherothrombosis in SLE... - Potential effect of an apoprotein B-based algorithm on management of new patients with hypertriglyceridemia referred to a specialty lipid clinicRobert D Brook
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA
Clin Cardiol 32:251-5. 2009..In patients with hypertriglyceridemia, non-high density lipoprotein cholesterol (nonHDL-C) is a targeted goal. However, apoprotein B100 (apoB) may be superior in predicting cardiovascular risk so we assessed the utility of an apoB-based... - Effect of carotid atherosclerosis screening on risk stratification during primary cardiovascular disease preventionRobert L Bard
Division of Cardiovascular Medicine, Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
Am J Cardiol 93:1030-2. 2004..These tests adjust the risk strata of >/=63% of patients deemed as having intermediate risk by Framingham scores... - Attenuation of haemodynamic, metabolic and energy expenditure responses to isoproterenol in patients with hypertensionMariaconsuelo Valentini
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
J Hypertens 22:1999-2006. 2004.... - Valsartan Improves Insulin Sensitivity without Altering Vascular Function in Healthy Overweight Adults without the Metabolic SyndromeRobert D Brook
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI
Metab Syndr Relat Disord 5:255-61. 2007..However, it is possible that obese patients with central adiposity may improve FMD with RAS blockade, and future investigation is warranted in this subgroup... - Is acute high-dose secondhand smoke exposure always harmful to microvascular function in healthy adults?Robert L Bard
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA
Prev Cardiol 13:175-9. 2010..4 ± 5.6 mm Hg. Our brief SHS exposure did not impair microvascular endothelial function or arterial compliance in healthy nonsmoking adults, but brachial diastolic BP increased... - Blood pressure and vascular effects of leptin in humansRobert D Brook
Cardiovascular Medicine Division, University of Michigan, Ann Arbor, MI
Metab Syndr Relat Disord 5:270-4. 2007..These combined findings do not support a direct role for leptin in linking obesity to hypertension, however more studies are required to corroborate these observations... - Acute effects of ambient particulate matter on blood pressure: differential effects across urban communitiesJ Timothy Dvonch
Department of Environmental Health Sciences, University of Michigan, 109 South Observatory, Ann Arbor, MI 48109 2029, USA
Hypertension 53:853-9. 2009..Short-term increases in exposure to ambient PM(2.5) are associated with acute increases in BP in adults, especially within communities with elevated levels of exposure... - Secondary causes of dyslipidemiaDeepthi Vodnala
Michigan State University, East Lansing, MI, USA
Am J Cardiol 110:823-5. 2012..Numerous disorders were identified, with diabetes mellitus and excessive alcohol being the most common... - Air-Pollution and Cardiometabolic Diseases (AIRCMD): a prospective study investigating the impact of air pollution exposure and propensity for type II diabetesZhichao Sun
Department of Biostatistics, The University of Michigan, Ann Arbor, MI, USA
Sci Total Environ 448:72-8. 2013..We believe that AIRCMD will allow for unprecedented new investigations into the association between environmental risk factors and CM disorders... - Medical management of the patient with intermittent claudicationDeepthi Vodnala
Michigan State University, East Lansing, MI, USA
Cardiol Clin 29:363-79. 2011..Management of IC requires a comprehensive approach toward symptomatic relief of pain with strategies that prolong life and prevent limb loss... - Low-sodium dietary approaches to stop hypertension diet reduces blood pressure, arterial stiffness, and oxidative stress in hypertensive heart failure with preserved ejection fractionScott L Hummel
Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, 1500 East Medical Center Dr, CVC Room 2383, SPC 5853, Ann Arbor, MI 48109, USA
Hypertension 60:1200-6. 2012..Further dietary modification studies could provide insights into the development and progression of hypertensive HFPEF... - Treating mixed hyperlipidemia and the atherogenic lipid phenotype for prevention of cardiovascular eventsMelvyn Rubenfire
Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Mich 48106, USA
Am J Med 123:892-8. 2010.... - HDL cholesterol and cardiovascular outcomes: what is the evidence?Melvyn Rubenfire
Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
Curr Cardiol Rep 15:349. 2013..Until those results are available, the clinician is left with only weak evidence to support whether or not to target treatment of HDL-C with pharmacological therapy... - Management of intermittent claudicationRobert D Brook
Division of Cardiology and Vascular Medicine Program, University of Michigan, 3918 Taubman Medical Center, Ann Arbor, MI 48109, USA
Cardiol Clin 20:521-34. 2002..In the future, the availability of newer stents and therapies to prevent re-stenosis may extend the applicability of endovascular treatment to difficult-to-treat infra-inguinal lesions... - Particulate matter, air pollution, and blood pressureRobert D Brook
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA
J Am Soc Hypertens 3:332-50. 2009..Due to the ubiquitous, continuous and often involuntary nature of exposure, PM(2.5) may be an important and under-appreciated worldwide environmental risk factor for increased arterial BP... - Initial hypertension treatment: one combination fits most?Robert D Brook
J Am Soc Hypertens 5:66-75. 2011..It is our hypothesis that this streamlined approach is likely to yield an overall positive risk/benefit ratio and that it should be tested in an outcome trial versus accepted monotherapies in stage I hypertension... - Dietary, lifestyle and pharmacogenetic factors associated with arteriole endothelial-dependent vasodilatation in schizophrenia patients treated with atypical antipsychotics (AAPs)Vicki L Ellingrod
University of Michigan, College of Pharmacy, Department of Clinical Social and Administrative Sciences, 428 Church Street, Ann Arbor, Michigan 48109, USA
Schizophr Res 130:20-6. 2011..This study examined the status of endothelial function within the schizophrenia population and determined pharmacogenetic, medication, dietary, and lifestyle factors associated with this functioning... - Letter by Brook regarding article, "Residential exposure to traffic is associated with coronary atherosclerosis"Robert D Brook
Circulation 117:e16; author reply e17. 2008 - Letter by Brook et al regarding article "Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis"Robert D Brook
Circulation 113:e871; author reply e872. 2006 - Air pollution and cardiovascular eventsRobert D Brook
N Engl J Med 356:2104-5; author reply 2105-6. 2007 - Long-term air pollution exposure and acceleration of atherosclerosis and vascular inflammation in an animal modelQinghua Sun
The Zena and Michael A. Wiener Cardiovascular Institute, , Mount Sinai School of Medicine, New York, NY 10029-6574, USA
JAMA 294:3003-10. 2005..001). CONCLUSION: In an apoE-/- mouse model, long-term exposure to low concentration of PM2.5 altered vasomotor tone, induced vascular inflammation, and potentiated atherosclerosis... - Acute blood pressure responses in healthy adults during controlled air pollution exposuresBruce Urch
Gage Occupational and Environmental Health Unit, St Michael s Hospital, Toronto, Ontario, Canada
Environ Health Perspect 113:1052-5. 2005..5 carbon content. Exposure to vehicular traffic may provide a common link between our observations and previous studies in which traffic exposure was identified as a potential risk factor for cardiovascular disease... - Relative contributions of PM2.5 chemical constituents to acute arterial vasoconstriction in humansBruce Urch
Gage Occupational and Environmental Health Unit, St. Michael's Hospital, and Public Health Sciences, University of Toronto, Toronto, Ontario, Canada
Inhal Toxicol 16:345-52. 2004..An understanding of the PM constituents most responsible for adverse health outcomes is critical for efforts to develop pollution abatement strategies that maximize benefits to public health... - Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho/ROCKQinghua Sun
Division of Environmental Health Sciences, Davis Heart Lung Research Institute, Colleges of Medicine and Public Health, The Ohio State University, Columbus, OH 43210 1252, USA
Arterioscler Thromb Vasc Biol 28:1760-6. 2008..Fine particulate matter <2.5 microm (PM(2.5)) has been implicated in vasoconstriction and potentiation of hypertension in humans. We investigated the effects of short-term exposure to PM(2.5) in the angiotensin II (AII) infusion model... - Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart AssociationRobert D Brook
Circulation 109:2655-71. 2004..Practical recommendations for healthcare providers and their patients are outlined. In the final section, suggestions for future research are made to address a number of remaining scientific questions... - Letter by Rundek et al regarding article, "Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis"Tatjana Rundek
Circulation 116:e317; author reply e318. 2007 - Air pollution: what is bad for the arteries might be bad for the veinsRobert D Brook
Arch Intern Med 168:909-11. 2008