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Genomes and Genes | J M BronsteinSummaryAffiliation: University of California Country: USA Publications
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Publications
Disrupted compaction of CNS myelin in an OSP/Claudin-11 and PLP/DM20 double knockout mouseE Chow
Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
Mol Cell Neurosci 29:405-13. 2005..These data demonstrate that OSP/claudin-11 and PLP have essential structural functions in maintaining normal compact myelin and there is redundancy in their functions...
Deep brain stimulation for Parkinson disease: an expert consensus and review of key issuesJeff M Bronstein
University of California, Los Angeles, School of Medicine, Department of Neurology, 710 Westwood Plaza, Los Angeles, CA 90095, USA
Arch Neurol 68:165. 2011..To provide recommendations to patients, physicians, and other health care providers on several issues involving deep brain stimulation (DBS) for Parkinson disease (PD)...- Function of tetraspan proteins in the myelin sheathJ M Bronstein
UCLA School of Medicine, Department of Neurology, Reed Neurological Research Center, 710 Westwood Plaza, Los Angeles, CA 90095, USA
Curr Opin Neurobiol 10:552-7. 2000..In addition, several new myelin tetraspans have been identified that are involved in adhesion, molecular trafficking, growth regulation, and migration of oligodendrocytes and Schwann cells... - Involvement of OSP/claudin-11 in oligodendrocyte membrane interactions: role in biology and diseaseJ M Bronstein
Departments of Neurology and the Brain Research Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA
J Neurosci Res 59:706-11. 2000..Furthermore, evidence is presented implicating OSP/claudin-11 as an autoantigen in the development of autoimmune demyelinating disease... - Stereotactic pallidotomy in the treatment of Parkinson disease: an expert opinionJ M Bronstein
Department of Neurology, University of California, Los Angeles, School of Medicine, 90024, USA
Arch Neurol 56:1064-9. 1999..Benefits of pallidotomy appear to be long lasting. (5) Each institution's complication rate should be discussed before surgery... - A humoral response to oligodendrocyte-specific protein in MS: a potential molecular mimicJ M Bronstein
Department of Neurology and the Brain Research Institute, UCLA School of Medicine, Los Angeles, CA 90024, USA
Neurology 53:154-61. 1999..To determine the antibody response to oligodendrocyte-specific protein (OSP) in patients with MS... - Oligodendrocyte-specific protein (OSP) is a major component of CNS myelinJ M Bronstein
Department of Neurology, University of California, Los Angeles School of Medicine, 90024, USA
J Neurosci Res 50:713-20. 1997..No binding was found to several agglutinins or a HNK1-specific antibody suggesting that OSP is not a glycoprotein... 
OSP/claudin-11 forms a complex with a novel member of the tetraspanin super family and beta1 integrin and regulates proliferation and migration of oligodendrocytesS K Tiwari-Woodruff
Department of Neurology, University of California at Los Angeles School of Medicine, Los Angeles, California 90095, USA
J Cell Biol 153:295-305. 2001..These data suggest a role for OSP/claudin-11, OAP-1, and beta1 integrin complex in regulating proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair...- Developmental expression of OSP/claudin-11J M Bronstein
Department of Neurology, UCLA School of Medicine, Los Angeles, California 90024, USA
J Neurosci Res 60:284-90. 2000..These data demonstrate that OSP/claudin-11 expression is highly regulated during development and, therefore, may play an important role in growth and differentiation of oligodendrocytes and other cells outside the CNS... - Cerebrospinal fluid immunoglobulin G promotes oligodendrocyte progenitor cell migrationS K Tiwari-Woodruff
Department of Neurology and the Brain Research Institute, UCLA School of Medicine, Los Angeles, California 90095, USA
J Neurosci Res 77:363-6. 2004..These data demonstrate that CSF IgG promotes OPC migration. Identification of the specific IgG fraction responsible for this effect could lead to novel therapies to promote recovery in MS... - Motor, cognitive, and behavioral performance following unilateral ventroposterior pallidotomy for Parkinson diseaseD Masterman
Department of Neurology, University of California, Los Angeles School of Medicine, USA
Arch Neurol 55:1201-8. 1998..To evaluate the effects of ventroposterior pallidotomy on motor disability and on behavior and cognition in patients with medically intractable idiopathic Parkinson disease... - Staged bilateral pallidotomy for treatment of Parkinson diseaseP M Intemann
Department of Neurology, University of California at Los Angeles School of Medicine, 90024, USA
J Neurosurg 94:437-44. 2001..CONCLUSIONS: Bilateral pallidotomy results in modest benefits but is associated with an increased risk of complications... - T-cell responses to oligodendrocyte-specific protein in multiple sclerosisT Vu
Department of Neurology and the Brain Research Institute, UCLA School of Medicine, Los Angeles, California 90095, USA
J Neurosci Res 66:506-9. 2001..Given the lack of specificity to MS, OSP-reactive T-cells are unlikely to be solely responsible for the disease process... - Isolation and characterization of a novel oligodendrocyte-specific proteinJ M Bronstein
UCLA School of Medicine, Department of Neurology 90024, USA
Neurology 47:772-8. 1996..Since OSP is localized to oligodendrocytes and myelin, has a similar structure with PMP-22, and has a developmental pattern of expression like other myelin proteins, it probably has an important role in CNS myelinogenesis... - Treatment of a patient by vaccination with autologous dendritic cells pulsed with allogeneic major histocompatibility complex class I-matched tumor peptides. Case ReportL M Liau
Division of Neurosurgery, Department of Neurology, University of California at Los Angeles School of Medicine, Los Angeles, California 90095 6901, USA
Neurosurg Focus 9:e8. 2000..Phase I trials for malignant glioma are currently underway... - Identification of a human glioma-associated growth factor gene, granulin, using differential immuno-absorptionL M Liau
Division of Neurosurgery, Jonsson Comprehensive Cancer Center, University of California at Los Angeles School of Medicine, 90095 6901, USA
Cancer Res 60:1353-60. 2000.... - Treatment of intracranial gliomas with bone marrow-derived dendritic cells pulsed with tumor antigensL M Liau
Department of Neurology, Jonsson Comprehensive Cancer Center, University of California at Los Angeles School of Medicine, 90095, USA
J Neurosurg 90:1115-24. 1999..The authors investigated the ability of "professional" antigen-presenting cells (dendritic cells) to enhance host antitumor immune responses when injected as a vaccine into tumor-bearing animals... - Prenatal ontogeny of the epidermal growth factor receptor and its ligand, transforming growth factor alpha, in the rat brainH I Kornblum
Department of Molecular and Medical Pharmacology, UCLA School of Medicine 90095, USA
J Comp Neurol 380:243-61. 1997..These data indicate that TGF alpha and EGF-R are positioned to have a role in the genesis, differentiation, migration, or survival of numerous cell populations in the embryonic brain... - TRPM-2 expression and tunel staining in neurodegenerative diseases: studies in wobbler and rd miceP Popper
Department of Neurobiology, University of California, Los Angeles, California, 90095, USA
Exp Neurol 143:246-54. 1997..In the wobbler spinal cords dying motoneurons were not labeled. These data suggest that the process of neurodegenerative motoneuron cell death in wobbler mice is different from the apoptotic process of rd photoreceptors... - Deep brain stimulation in intraoperative MRI environment - comparison of imaging techniques and electrode fixation methodsM W Y Lee
Division of Neurosurgery, University of California Los Angeles School of Medicine, Los Angeles, USA
Minim Invasive Neurosurg 48:1-6. 2005..Satisfactory microelectrode recording was feasible in low-field 0.2 T and high-field 1.5 T MRI environments. Further studies on performing DBS in real-time intraoperative MRI are warranted... - Chromosomal localization of murine and human oligodendrocyte-specific protein genesJ M Bronstein
Department of Neurology, UCLA School of Medicine, Los Angeles, California, 90024, USA
Genomics 34:255-7. 1996..Fine mapping with fluorescence in situ hybridization placed the OSP gene at human chromosome 3q26.2-q26.3. To date, there are no known inherited neurological disorders that localize to these regions... - CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null miceA Gow
Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
Cell 99:649-59. 1999..These novel results provide direct evidence of the pivotal role of the claudin family in generating the paracellular physical barrier of tight junctions necessary for spermatogenesis and normal CNS function...