Karl Broman

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Haplotype probabilities in advanced intercross populations
    Karl W Broman
    Department of Biostatistics and Medical Informatics, University of Wisconsin Madison, Madison, Wisconsin 53706
    G3 (Bethesda) 2:199-202. 2012
  2. pmc Mapping quantitative trait loci onto a phylogenetic tree
    Karl W Broman
    Department of Biostatistics and Medical Informatics, Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 192:267-79. 2012
  3. pmc Genotype probabilities at intermediate generations in the construction of recombinant inbred lines
    Karl W Broman
    Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 190:403-12. 2012
  4. pmc Detecting single-nucleotide polymorphism by single-nucleotide polymorphism interactions in rheumatoid arthritis using a two-step approach with machine learning and a Bayesian threshold least absolute shrinkage and selection operator (LASSO) model
    Oscar González-Recio
    Department of Dairy Science, University of Wisconsin Madison, 266 Animal Science Building, 1675 Observatory Drive, Madison, Wisconsin 53706, USA
    BMC Proc 3:S63. 2009
  5. pmc Differential MHC class I expression in distinct leukocyte subsets
    Justin M Greene
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, 53706 Wisconsin, USA
    BMC Immunol 12:39. 2011
  6. pmc Characterization of killer immunoglobulin-like receptor genetics and comprehensive genotyping by pyrosequencing in rhesus macaques
    Anna J Moreland
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    BMC Genomics 12:295. 2011

Research Grants

Collaborators

  • Cecile Ane
  • Bret A Payseur
  • Saunak Sen
  • DAVID H O'CONNOR
  • Anna J Moreland
  • Justin M Greene
  • Benjamin N Bimber
  • Oscar González-Recio
  • Oriana E Hawkins
  • Kevin J Kunstman
  • William H Hildebrand
  • R Keith Reeves
  • Julie A Karl
  • Peter Parham
  • Roger W Wiseman
  • Jennifer J Lhost
  • Simon M Lank
  • Benjamin J Burwitz
  • Lisbeth A Guethlein
  • R Paul Johnson
  • Steven M Wolinsky
  • Andrés T Vega
  • Corinne D Engelman
  • Evangelina López de Maturana

Detail Information

Publications6

  1. pmc Haplotype probabilities in advanced intercross populations
    Karl W Broman
    Department of Biostatistics and Medical Informatics, University of Wisconsin Madison, Madison, Wisconsin 53706
    G3 (Bethesda) 2:199-202. 2012
    ..I further derive the map expansion in these populations, which is the frequency of recombination breakpoints on a random chromosome...
  2. pmc Mapping quantitative trait loci onto a phylogenetic tree
    Karl W Broman
    Department of Biostatistics and Medical Informatics, Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 192:267-79. 2012
    ..Finally, we explore the method's performance in computer simulations, and we illustrate its use through application to a set of four mouse intercrosses among five inbred strains, with data on HDL cholesterol...
  3. pmc Genotype probabilities at intermediate generations in the construction of recombinant inbred lines
    Karl W Broman
    Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 190:403-12. 2012
    ..In addition, I present a number of useful quantities, including single-locus genotype probabilities, two-locus haplotype probabilities, and the fixation probability and map expansion at each generation along the course to inbreeding...
  4. pmc Detecting single-nucleotide polymorphism by single-nucleotide polymorphism interactions in rheumatoid arthritis using a two-step approach with machine learning and a Bayesian threshold least absolute shrinkage and selection operator (LASSO) model
    Oscar González-Recio
    Department of Dairy Science, University of Wisconsin Madison, 266 Animal Science Building, 1675 Observatory Drive, Madison, Wisconsin 53706, USA
    BMC Proc 3:S63. 2009
    ..g., rs2395175, rs660895, rs10484560, and rs2476601). Further, some other SNPs detected in this study may be considered in candidate gene studies...
  5. pmc Differential MHC class I expression in distinct leukocyte subsets
    Justin M Greene
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, 53706 Wisconsin, USA
    BMC Immunol 12:39. 2011
    ..It is unclear how cDNA species are expressed in distinct cell subsets in humans and particularly in macaques which transcribe upwards of 20 distinct MHC class I alleles at variable levels...
  6. pmc Characterization of killer immunoglobulin-like receptor genetics and comprehensive genotyping by pyrosequencing in rhesus macaques
    Anna J Moreland
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    BMC Genomics 12:295. 2011
    ..Rhesus macaques serve as important animal models for many human diseases in which KIRs are implicated; however, the study of KIR activity in this model is hindered by incomplete characterization of KIR genetics...

Research Grants6

  1. Statistical Methods and Software for QTL Mapping
    Karl Broman; Fiscal Year: 2006
    ..abstract_text> ..
  2. Statistical Methods and Software for QTL Mapping
    Karl Broman; Fiscal Year: 2007
    ..abstract_text> ..
  3. Statistical Methods and Software for QTL Mapping
    Karl Broman; Fiscal Year: 2007
    ..abstract_text> ..
  4. Statistical Methods and Software for QTL Mapping
    Karl Broman; Fiscal Year: 2009
    ..abstract_text> ..
  5. Statistical Methods and Software for QTL Mapping
    Karl W Broman; Fiscal Year: 2010
    ....