D Broide

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial Siglec-F ligands which are up-regulated by IL-4 and IL-13
    Jae Youn Cho
    Department of Medicine, University of California San Diego, USA
    Respir Res 11:154. 2010
  2. pmc Chronic allergen challenge induces bronchial mast cell accumulation in BALB/c but not C57BL/6 mice and is independent of IL-9
    Suzan Pae
    Department of Medicine, University of California San Diego, San Diego, CA, USA
    Immunogenetics 62:499-506. 2010
  3. pmc TNFA deletion alters apoptosis as well as caspase 3 and 4 expression during otitis media
    Joerg Ebmeyer
    Department of Otorhinolaryngology, Head and Neck Surgery Klinikum Bielefeld, Academic Teaching Hospital University of Münster, Bielefeld, Germany
    BMC Immunol 12:12. 2011
  4. doi Allergic rhinitis: Pathophysiology
    David H Broide
    Department of Medicine, University of California San Diego, 92093 0635, USA
    Allergy Asthma Proc 31:370-4. 2010
  5. pmc Immunomodulation of allergic disease
    David H Broide
    Department of Medicine, University of California San Diego, La Jolla, California 92093, USA
    Annu Rev Med 60:279-91. 2009
  6. doi New perspectives on mechanisms underlying chronic allergic inflammation and asthma in 2007
    David Broide
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0635, USA
    J Allergy Clin Immunol 122:475-80. 2008
  7. pmc Immunologic and inflammatory mechanisms that drive asthma progression to remodeling
    David H Broide
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0635, USA
    J Allergy Clin Immunol 121:560-70; quiz 571-2. 2008
  8. ncbi The pathophysiology of allergic rhinoconjunctivitis
    David H Broide
    Department of Medicine, University of California San Diego, San Diego, California, USA
    Allergy Asthma Proc 28:398-403. 2007
  9. pmc Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium
    David H Broide
    Department of Medicine, Laboratory of Gene Regulation and Signal Transduction, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 102:17723-8. 2005
  10. ncbi Immunostimulatory sequences of DNA and conjugates in the treatment of allergic rhinitis
    David H Broide
    Department of Medicine, University of California San Diego, 9500 Gilman Drive, MC 0635, La Jolla, CA 92093, USA
    Curr Allergy Asthma Rep 5:182-5. 2005

Research Grants

  1. Eosinophil Trafficking
    David Broide; Fiscal Year: 2003
  2. RSV AND ASTHMA
    David Broide; Fiscal Year: 2003
  3. Biomarkers in sputum in COPD
    David Broide; Fiscal Year: 2003
  4. Eosinophil Trafficking
    David Broide; Fiscal Year: 2004
  5. Biomarkers in sputum in COPD
    David Broide; Fiscal Year: 2004
  6. Eosinophil Trafficking
    David Broide; Fiscal Year: 2005
  7. Biomarkers in sputum in COPD
    David Broide; Fiscal Year: 2005
  8. Airway Inflammation and Airway Remodeling
    David Broide; Fiscal Year: 2006
  9. Eosinophil trafficking and chronic tissue damage induced by allergic inflammation
    David Broide; Fiscal Year: 2007
  10. TRAINING IN MOLECULAR AND CELL BIOLOGY OF ALLERGY
    David Broide; Fiscal Year: 2007

Collaborators

Detail Information

Publications56

  1. pmc Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial Siglec-F ligands which are up-regulated by IL-4 and IL-13
    Jae Youn Cho
    Department of Medicine, University of California San Diego, USA
    Respir Res 11:154. 2010
    ....
  2. pmc Chronic allergen challenge induces bronchial mast cell accumulation in BALB/c but not C57BL/6 mice and is independent of IL-9
    Suzan Pae
    Department of Medicine, University of California San Diego, San Diego, CA, USA
    Immunogenetics 62:499-506. 2010
    ....
  3. pmc TNFA deletion alters apoptosis as well as caspase 3 and 4 expression during otitis media
    Joerg Ebmeyer
    Department of Otorhinolaryngology, Head and Neck Surgery Klinikum Bielefeld, Academic Teaching Hospital University of Münster, Bielefeld, Germany
    BMC Immunol 12:12. 2011
    ....
  4. doi Allergic rhinitis: Pathophysiology
    David H Broide
    Department of Medicine, University of California San Diego, 92093 0635, USA
    Allergy Asthma Proc 31:370-4. 2010
    ..In addition, regulatory T cells may play an important role in mediating active tolerance to allergens. An improved understanding of the pathophysiology of allergic rhinitis may provide important insight into novel therapeutic targets...
  5. pmc Immunomodulation of allergic disease
    David H Broide
    Department of Medicine, University of California San Diego, La Jolla, California 92093, USA
    Annu Rev Med 60:279-91. 2009
    ..Anti-IL-5 is effective as a corticosteroid-sparing agent in the hypereosinophilic syndrome. It has not shown benefit in moderate asthmatics with persistent symptoms but may reduce aspects of airway remodeling in asthma...
  6. doi New perspectives on mechanisms underlying chronic allergic inflammation and asthma in 2007
    David Broide
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0635, USA
    J Allergy Clin Immunol 122:475-80. 2008
    ....
  7. pmc Immunologic and inflammatory mechanisms that drive asthma progression to remodeling
    David H Broide
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0635, USA
    J Allergy Clin Immunol 121:560-70; quiz 571-2. 2008
    ....
  8. ncbi The pathophysiology of allergic rhinoconjunctivitis
    David H Broide
    Department of Medicine, University of California San Diego, San Diego, California, USA
    Allergy Asthma Proc 28:398-403. 2007
    ....
  9. pmc Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium
    David H Broide
    Department of Medicine, Laboratory of Gene Regulation and Signal Transduction, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 102:17723-8. 2005
    ..Overall, these studies show an important role for NF-kappaB regulated genes in airway epithelium in allergen-induced airway remodeling, including peribronchial fibrosis and mucus production...
  10. ncbi Immunostimulatory sequences of DNA and conjugates in the treatment of allergic rhinitis
    David H Broide
    Department of Medicine, University of California San Diego, 9500 Gilman Drive, MC 0635, La Jolla, CA 92093, USA
    Curr Allergy Asthma Rep 5:182-5. 2005
    ..These ongoing clinical trials will help to determine whether any of these ISS DNA-based therapies are safe and effective to use in subjects with allergic rhinitis and asthma...
  11. ncbi Inhibition of pulmonary eosinophilia in P-selectin- and ICAM-1-deficient mice
    D H Broide
    Department of Medicine, University of California at San Diego, 92093 0635, USA
    Am J Respir Cell Mol Biol 18:218-25. 1998
    ..These studies suggest an important role for ICAM-1 and P-selectin in eosinophil recruitment to the lung after allergen challenge...
  12. ncbi Fast flowing eosinophils: signals for stopping and stepping out of blood vessels
    David Broide
    Department of Medicine, University of California San Diego, La Jolla 92093 0635, USA
    Am J Respir Cell Mol Biol 26:637-40. 2002
  13. ncbi Core 2 oligosaccharides mediate eosinophil and neutrophil peritoneal but not lung recruitment
    David H Broide
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Am J Physiol Lung Cell Mol Physiol 282:L259-66. 2002
    ....
  14. ncbi DNA-Based immunization for asthma
    D Broide
    University of California San Diego, Department of Medicine, La Jolla, CA, USA
    Int Arch Allergy Immunol 118:453-6. 1999
    ..Immunostimulatory DNA sequences (ISS) containing a CpG motif are able to inhibit Th2-mediated airway eosinophilia and bronchial hyperresponsiveness in a mouse model of asthma...
  15. pmc Genes that regulate eosinophilic inflammation
    D H Broide
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0635, USA
    Am J Hum Genet 65:302-7. 1999
  16. ncbi Inhibition of eosinophilic inflammation in allergen-challenged, IL-1 receptor type 1-deficient mice is associated with reduced eosinophil rolling and adhesion on vascular endothelium
    D H Broide
    Department of Medicine, University of California, San Diego, La Jolla 92093 0635, USA
    Blood 95:263-9. 2000
    ..Blood. 2000;95:263-269)..
  17. ncbi Inhibition of eosinophilic inflammation in allergen-challenged TNF receptor p55/p75--and TNF receptor p55-deficient mice
    D H Broide
    Department of Medicine, University of California, San Diego, La Jolla, 92093 0635, USA
    Am J Respir Cell Mol Biol 24:304-11. 2001
    ..Overall, these studies demonstrate that TNF, released after allergen challenge, is important in the induction of endothelial cell adhesiveness, a prerequisite for recruitment of circulating eosinophils...
  18. ncbi Eosinophil trafficking to sites of allergic inflammation
    D Broide
    Department of Medicine, University of California San Diego, La Jolla 92093 0635, USA
    Immunol Rev 179:163-72. 2001
    ..Immunostimulatory DNA sequences do not induce eosinophil apoptosis, but function at the level of the bone marrow to inhibit the IL-5-induced bone marrow generation and release of eosinophils...
  19. ncbi Systemic administration of immunostimulatory DNA sequences mediates reversible inhibition of Th2 responses in a mouse model of asthma
    D H Broide
    Department of Medicine, University of California, San Diego, La Jolla 92093, USA
    J Clin Immunol 21:175-82. 2001
    ..However, ISS did not inhibit a Th2 response to the second inhalation of ova 8 weeks later. The reversible inhibition of Th2 responses at 8 weeks suggests the need for repeated ISS administration at monthly intervals...
  20. ncbi Inhibition of allergic inflammation in the lung by plasmid DNA allergen immunization
    H L Spiegelberg
    Department of Pediatrics, University of California San Diego, School of Medicine, La Jolla 92093 0833, USA
    Pediatr Pulmonol Suppl 18:118-21. 1999
    ....
  21. ncbi DNA-based immunotherapeutics for the treatment of allergic disease
    A A Horner
    Department of Medicine and The Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, La Jolla 92093-0663, USA
    Immunol Rev 179:102-18. 2001
    ..This review will focus on our present understanding of the biological activities of DNA-based immunotherapeutics and their application to the treatment of allergic diseases...
  22. ncbi Immunostimulatory DNA is a potent mucosal adjuvant
    A A Horner
    Department of Medicine, and The Sam and Rose Stein Institute for Aging, University of California at San Diego, 9500 Gilman Drive, La Jolla, California, 92093 0663, USA
    Cell Immunol 190:77-82. 1998
    ..This immunization approach deserves consideration in the development of vaccines against mucosal pathogens...
  23. pmc Advances in mechanisms of asthma, allergy, and immunology in 2008
    Joshua A Boyce
    Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, and Harvard Medical School, Boston, Mass, USA
    J Allergy Clin Immunol 123:569-74. 2009
    ..Articles from other journals have been included to supplement the topics presented...
  24. ncbi Cytokines and growth factors in airway remodeling in asthma
    Taylor Doherty
    Department of Medicine, University of California, San Diego, La Jolla, CA, USA
    Curr Opin Immunol 19:676-80. 2007
    ....
  25. ncbi Induction and inhibition of the Th2 phenotype spread: implications for childhood asthma
    Tomoko Hayashi
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    J Immunol 174:5864-73. 2005
    ..These findings provide a mechanistic insight into Th2 phenotype spread and offer an animal model for testing relevant immunomodulatory interventions...
  26. pmc Potent inhibitors of pro-inflammatory cytokine production produced by a marine-derived bacterium
    Wendy K Strangman
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    J Med Chem 52:2317-27. 2009
    ..This study provides the foundation for the optimization of these potent anti-inflammatory compounds for development in the treatment of asthma...
  27. pmc Adiponectin-deficient mice are protected against tobacco-induced inflammation and increased emphysema
    Marina Miller
    Department of Medicine, Univ of California, San Diego, La Jolla, 92093 0635, USA
    Am J Physiol Lung Cell Mol Physiol 299:L834-42. 2010
    ..These studies suggest that adiponectin plays an important proinflammatory role in tobacco smoke-induced COPD-E...
  28. pmc Persistent airway inflammation and emphysema progression on CT scan in ex-smokers observed for 4 years
    Marina Miller
    Department of Medicine, University of California, San Diego, CA, USA
    Chest 139:1380-7. 2011
    ....
  29. ncbi Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis
    Peter S Creticos
    Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, USA
    N Engl J Med 355:1445-55. 2006
    ..Conjugating immunostimulatory sequences of DNA to specific allergens offers a new approach to allergen immunotherapy that reduces acute allergic responses...
  30. pmc IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis
    Christoph J Binder
    Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla 92093 0682, USA
    J Clin Invest 114:427-37. 2004
    ..Thus, IL-5 links adaptive and natural immunity specific to epitopes of OxLDL and protects from atherosclerosis, in part by stimulating the expansion of atheroprotective natural IgM specific for OxLDL...
  31. ncbi Down-regulation of caveolin-1, an inhibitor of transforming growth factor-beta signaling, in acute allergen-induced airway remodeling
    Claude Jourdan Le Saux
    Department of Cell and Molecular Biology, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, USA
    J Biol Chem 283:5760-8. 2008
    ..This study demonstrates a previously unknown modulation of TGF-beta signaling by IL-4, via cav1, suggesting novel therapeutic targets for controlling the effects of TGF-beta and thereby ameliorating pathological airway remodeling...
  32. ncbi Immunostimulatory DNA inhibits transforming growth factor-beta expression and airway remodeling
    Jae Youn Cho
    Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA 92093 0635, USA
    Am J Respir Cell Mol Biol 30:651-61. 2004
    ..These studies demonstrate that ISS prevents not only Th2-mediated airway inflammation in response to acute allergen challenge, but also airway remodeling associated with chronic allergen challenge...
  33. ncbi Airway fibrosis and angiogenesis due to eosinophil trafficking in chronic asthma
    Seema S Aceves
    Department of Medicine, University of California San Diego, Biomedical Sciences Building, Room 5090, 9500 Gilman Drive, La Jolla, CA 92093 0635, USA
    Curr Mol Med 8:350-8. 2008
    ..Further studies in both humans and animal models will help to increase our knowledge of the contribution of the eosinophil to remodeling in asthma as well as EE...
  34. ncbi Accumulation of peribronchial mast cells in a mouse model of ovalbumin allergen induced chronic airway inflammation: modulation by immunostimulatory DNA sequences
    Reid K Ikeda
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    J Immunol 171:4860-7. 2003
    ....
  35. ncbi Resolution of airway inflammation following ovalbumin inhalation: comparison of ISS DNA and corticosteroids
    Reid K Ikeda
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0635, USA
    Am J Respir Cell Mol Biol 28:655-63. 2003
    ..The combination of the shared and distinct anti-inflammatory pathways may account for the additive effect of ISS and corticosteroids on inhibiting AHR...
  36. ncbi Computed tomographic scan-diagnosed chronic obstructive pulmonary disease-emphysema: eotaxin-1 is associated with bronchodilator response and extent of emphysema
    Marina Miller
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0635, USA
    J Allergy Clin Immunol 120:1118-25. 2007
    ..We evaluated subjects with COPD and computed tomographic (CT) scan evidence of emphysema to determine the biomarker profile associated with a bronchodilator response...
  37. pmc Inhibition of experimental asthma by indoleamine 2,3-dioxygenase
    Tomoko Hayashi
    University of California, San Diego, Department of Medicine, La Jolla 92093 0663, USA
    J Clin Invest 114:270-9. 2004
    ..Our results provide a mechanistic insight into the various formulations of the hygiene hypothesis and underscore the notion that activation of innate immunity can inhibit adaptive Th cell responses...
  38. pmc A murine model to study leukocyte rolling and intravascular trafficking in lung microvessels
    Lyudmila Sikora
    Division of Vascular Biology, La Jolla Institute for Molecular Medicine, San Diego 92121, USA
    Am J Pathol 162:2019-28. 2003
    ....
  39. ncbi Fine structure mapping of CIAS1: identification of an ancestral haplotype and a common FCAS mutation, L353P
    Hal M Hoffman
    Division of Rheumatology, Allergy, and Immunology, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093 0635, USA
    Hum Genet 112:209-16. 2003
    ..We also report a comprehensive list of intragenic single nucleotide polymorphisms. The data provided here will assist others researching the 1q44 region and will aid clinicians in the diagnosis of FCAS...
  40. ncbi Constitutive overexpression of IL-5 induces extramedullary hematopoiesis in the spleen
    Sophia Khaldoyanidi
    Division of Vascular Biology, La Jolla Institute for Molecular Medicine, San Diego, CA 92121, USA
    Blood 101:863-8. 2003
    ..Overall, our results suggest that constitutive overexpression of IL-5 can potentially induce colonization of spleen with MSP cells, which provides the necessary microenvironment for establishment of hematopoiesis in extramedullary sites...
  41. ncbi Plasmid DNA encoding the respiratory syncytial virus G protein protects against RSV-induced airway hyperresponsiveness
    Marina Miller
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0635, USA
    Vaccine 20:3023-33. 2002
    ..The DNA-G vaccine we constructed significantly inhibited RSV viral replication, mucus expression, and importantly was associated with inhibition of RSV induced airway responsiveness...
  42. pmc 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis
    Tomoko Hayashi
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0663, USA
    Proc Natl Acad Sci U S A 104:18619-24. 2007
    ..Thus, HAA is a natural inhibitor that restrains T cell expansion and activation...
  43. pmc Inhibition of airway remodeling in IL-5-deficient mice
    Jae Youn Cho
    Department of Medicine, University of California San Diego, La Jolla, California 92093 0635, USA
    J Clin Invest 113:551-60. 2004
    ..Increased airway epithelial expression of alphaVbeta6 integrin may contribute to the increased activation of latent TGF-beta. These results suggest an important role for IL-5, eosinophils, alphaVbeta6, and TGF-beta in airway remodeling...
  44. ncbi Combination of corticosteroid therapy and allergen avoidance reverses allergen-induced airway remodeling in mice
    Jae Youn Cho
    Department of Medicine, University of California San Diego, USA
    J Allergy Clin Immunol 116:1116-22. 2005
    ..Allergen avoidance and anti-inflammatory therapy are standard therapeutic approaches guidelines advocate to control asthma symptoms. Currently, it is not known whether such strategies reduce airway remodeling...
  45. ncbi Immunostimulatory DNA reverses established allergen-induced airway remodeling
    Cho Jae Youn
    Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    J Immunol 173:7556-64. 2004
    ....
  46. ncbi Corticosteroids prevent myofibroblast accumulation and airway remodeling in mice
    Marina Miller
    Department of Medicine, University of California San Diego, CA 92093 0635, USA
    Am J Physiol Lung Cell Mol Physiol 290:L162-9. 2006
    ....
  47. ncbi Indoleamine-2,3-dioxygenase modulation of allergic immune responses
    Annie V Le
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0635, La Jolla, CA 92093, USA
    Curr Allergy Asthma Rep 6:27-31. 2006
    ....
  48. ncbi Immunostimulatory DNA inhibits allergen-induced peribronchial angiogenesis in mice
    Sook Young Lee
    Department of Medicine, University of California San Diego, La Jolla 92093 0635, USA, and Kangnam St Mary s Hospital, Seoul, Korea
    J Allergy Clin Immunol 117:597-603. 2006
    ..Airway remodeling in asthma is associated with angiogenesis...
  49. ncbi Remodeling associated expression of matrix metalloproteinase 9 but not tissue inhibitor of metalloproteinase 1 in airway epithelium: modulation by immunostimulatory DNA
    Jae Youn Cho
    Department of Medicine, University of California San Diego, La Jolla 92093 0635, USA
    J Allergy Clin Immunol 117:618-25. 2006
    ..Matrix metalloproteinase 9 (MMP-9) and its tissue inhibitor of metalloproteinase 1 (TIMP-1) are hypothesized to play a role in the pathogenesis of airway remodeling in asthma...
  50. ncbi Reduced peribronchial fibrosis in allergen-challenged MMP-9-deficient mice
    Dae Hyun Lim
    Department of Medicine, University of California San Diego, La Jolla, 92093, USA
    Am J Physiol Lung Cell Mol Physiol 291:L265-71. 2006
    ..e., modest reduction in levels of peribronchial fibrosis) but does not play a significant role in mucus expression, smooth muscle thickness, or airway responsiveness...
  51. pmc Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils
    Mai Zhang
    Glycobiology Research and Training Center, Departments of Medicine and Cellular and Molecular Medicine, and Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, CA 92093 0687, USA
    Blood 109:4280-7. 2007
    ....
  52. ncbi Coexposure to environmental tobacco smoke increases levels of allergen-induced airway remodeling in mice
    Myung Goo Min
    Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    J Immunol 178:5321-8. 2007
    ....
  53. ncbi Inhibition of allergen-induced airway remodeling in Smad 3-deficient mice
    Annie V Le
    Division of Allergy and Immunology, Scripps Clinic and Research Institute, La Jolla, CA 92037, USA
    J Immunol 178:7310-6. 2007
    ..However, Smad 3 signaling does not contribute significantly to airway responsiveness...
  54. ncbi Cutting edge: activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma
    Vanessa Redecke
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Immunol 172:2739-43. 2004
    ....
  55. ncbi Esophageal remodeling in pediatric eosinophilic esophagitis
    Seema S Aceves
    Division of Allergy, Immunology, Children s Hospital, San Diego, and the University of California, San Diego, CA 92123, USA
    J Allergy Clin Immunol 119:206-12. 2007
    ..Eosinophils are associated with airway remodeling in asthma, but studies have not yet determined whether eosinophilic esophagitis (EE) is associated with esophageal remodeling...
  56. ncbi DNA vaccines: an evolving approach to the treatment of allergic disorders
    David H Broide
    Department of Medicine, University of California San Diego, 9500 Gilman Drive, MC 0635, La Jolla, CA 92093, USA
    Allergy Asthma Proc 26:195-8. 2005
    ..Furthermore, ongoing large-scale phase III clinical trials will be able to determine whether any of these DNA-based therapies are safe and effective to use in subjects with allergic rhinitis and asthma...

Research Grants37

  1. Eosinophil Trafficking
    David Broide; Fiscal Year: 2003
    ..Overall, these studies should improve our understanding of the molecular mechanism of eosinophil recruitment in vivo and its effect on airway structure and function. ..
  2. RSV AND ASTHMA
    David Broide; Fiscal Year: 2003
    ..Overall these studies will contribute to our understanding of the mechanism of eosinophilic inflammation during RSV infection and suggest candidate vaccine strategies to inhibit RSV infection and airway inflammation. ..
  3. Biomarkers in sputum in COPD
    David Broide; Fiscal Year: 2003
    ..abstract_text> ..
  4. Eosinophil Trafficking
    David Broide; Fiscal Year: 2004
    ..Overall, these studies should improve our understanding of the molecular mechanism of eosinophil recruitment in vivo and its effect on airway structure and function. ..
  5. Biomarkers in sputum in COPD
    David Broide; Fiscal Year: 2004
    ..abstract_text> ..
  6. Eosinophil Trafficking
    David Broide; Fiscal Year: 2005
    ..Overall, these studies should improve our understanding of the molecular mechanism of eosinophil recruitment in vivo and its effect on airway structure and function. ..
  7. Biomarkers in sputum in COPD
    David Broide; Fiscal Year: 2005
    ..abstract_text> ..
  8. Airway Inflammation and Airway Remodeling
    David Broide; Fiscal Year: 2006
    ....
  9. Eosinophil trafficking and chronic tissue damage induced by allergic inflammation
    David Broide; Fiscal Year: 2007
    ..These studies may identify potential therapeutic targets which can reduce the tissue damage and swelling at sites of ongoing allergic inflammation in human subjects with severe ongoing allergies. ..
  10. TRAINING IN MOLECULAR AND CELL BIOLOGY OF ALLERGY
    David Broide; Fiscal Year: 2007
    ..Trainees will develop a solid background in the molecular and cellular mechanisms of allergic inflammation and become qualified to embark upon their careers as independent investigators in allergy research. ..
  11. Siglec-F and Resolution of Allergic Inflammation
    David Broide; Fiscal Year: 2009
    ....
  12. Siglec-F and Resolution of Allergic Inflammation
    David H Broide; Fiscal Year: 2010
    ....
  13. Biomarkers in sputum in COPD
    David Broide; Fiscal Year: 2002
    ..abstract_text> ..
  14. RSV AND ASTHMA
    David Broide; Fiscal Year: 2002
    ..Overall these studies will contribute to our understanding of the mechanism of eosinophilic inflammation during RSV infection and suggest candidate vaccine strategies to inhibit RSV infection and airway inflammation. ..
  15. Eosinophil Trafficking
    David Broide; Fiscal Year: 2002
    ..Overall, these studies should improve our understanding of the molecular mechanism of eosinophil recruitment in vivo and its effect on airway structure and function. ..
  16. ENDOTHELIUM--SIGNALING FROM MAST CELLS TO EOSINOPHILS
    David Broide; Fiscal Year: 1999
    ....
  17. RSV AND ASTHMA
    David Broide; Fiscal Year: 1999
    ..Overall these studies will contribute to our understanding of the mechanism of eosinophilic inflammation during RSV infection and suggest candidate vaccine strategies to inhibit RSV infection and airway inflammation. ..
  18. CYTOKINES AND EOSINOPHIL ADHESION IN VITRO AND IN VIVO
    David Broide; Fiscal Year: 1999
    ..Overall, these studies should improve our understanding of the molecular mechanisms of eosinophil adhesion to endothelium in vitro and in vivo. ..
  19. ENDOTHELIUM--SIGNALING FROM MAST CELLS TO EOSINOPHILS
    David Broide; Fiscal Year: 2000
    ....
  20. RSV AND ASTHMA
    David Broide; Fiscal Year: 2000
    ..Overall these studies will contribute to our understanding of the mechanism of eosinophilic inflammation during RSV infection and suggest candidate vaccine strategies to inhibit RSV infection and airway inflammation. ..
  21. CYTOKINES AND EOSINOPHIL ADHESION IN VITRO AND IN VIVO
    David Broide; Fiscal Year: 2000
    ..Overall, these studies should improve our understanding of the molecular mechanisms of eosinophil adhesion to endothelium in vitro and in vivo. ..
  22. Eosinophil Trafficking
    David Broide; Fiscal Year: 2001
    ..Overall, these studies should improve our understanding of the molecular mechanism of eosinophil recruitment in vivo and its effect on airway structure and function. ..
  23. ENDOTHELIUM--SIGNALING FROM MAST CELLS TO EOSINOPHILS
    David Broide; Fiscal Year: 2001
    ....
  24. RSV AND ASTHMA
    David Broide; Fiscal Year: 2001
    ..Overall these studies will contribute to our understanding of the mechanism of eosinophilic inflammation during RSV infection and suggest candidate vaccine strategies to inhibit RSV infection and airway inflammation. ..
  25. ENDOTHELIUM--SIGNALING FROM MAST CELLS TO EOSINOPHILS
    David Broide; Fiscal Year: 2002
    ....
  26. Siglec-F and Resolution of Allergic Inflammation
    David H Broide; Fiscal Year: 2011
    ....