Research Topics
Genomes and Genes | Kim A BrogdenSummaryAffiliation: University of Iowa Country: USA Publications
| Collaborators
|
Detail Information
Publications
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?Kim A Brogden
Department of Periodontics and Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, Iowa 52242, USA
Nat Rev Microbiol 3:238-50. 2005..In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented...
The emerging role of peptides and lipids as antimicrobial epidermal barriers and modulators of local inflammationN K Brogden
Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky, USA
Skin Pharmacol Physiol 25:167-81. 2012....- The nervous system and innate immunity: the neuropeptide connectionKim A Brogden
Department of Periodontics and Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, Iowa 52252, USA
Nat Immunol 6:558-64. 2005..As examples, we have chosen five well described, locally produced neuropeptides that may serve a previously unrecognized, direct antimicrobial, innate immune function in four anatomical sites... - Human polymicrobial infectionsKim A Brogden
Department of Periodontics and Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City, IA 52242, USA
Lancet 365:253-5. 2005.... - Antimicrobial activity of cathelicidins BMAP28, SMAP28, SMAP29, and PMAP23 against Pasteurella multocida is more broad-spectrum than host species specificKim A Brogden
Department of Periodontics, Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
Vet Microbiol 119:76-81. 2007..7 microM); and PMAP23 (MICs and MBCs, 4.3 to > or = 6.8 microM). Overall, the results of this study suggest that synthesized cathelicidins from cattle, sheep, and pigs had broad-spectrum antimicrobial activity against all P. multocida... - Defensins attenuate cytokine responses yet enhance antibody responses to Porphyromonas gingivalis adhesins in miceKarl G Kohlgraf
Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
Future Microbiol 5:115-25. 2010.... 
Human beta-defensin 3 binds to hemagglutinin B (rHagB), a non-fimbrial adhesin from Porphyromonas gingivalis, and attenuates a pro-inflammatory cytokine responseLindsey C Pingel
Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
Immunol Cell Biol 86:643-9. 2008..Thus, HBD3 binds rHagB and this interaction may be an important initial step to attenuate a pro-inflammatory cytokine response and an ERK 1/2 response...- Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birthDavid A Stoltz
Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Sci Transl Med 2:29ra31. 2010.... - Quantitation of SPLUNC1 in saliva with an xMAP particle-based antibody capture and detection immunoassayKarl G Kohlgraf
Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
Arch Oral Biol 57:197-204. 2012..This immunoassay may prove to be useful in determining the concentration of SPLUNC1 in saliva for assessing its role in the pathogenesis of oral infections, oral inflammatory disorders, or oral malignancies... - Targeted antimicrobial activity of a specific IgG-SMAP28 conjugate against Porphyromonas gingivalis in a mixed cultureMichael R Franzman
Department of Periodontics, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
Int J Antimicrob Agents 33:14-20. 2009..gingivalis. This is an initial step to develop a selective antimicrobial agent that can eliminate a specific periodontal pathogen, such as P. gingivalis, from patients with periodontal disease without harming the normal commensal flora... - Antibacterial activity of sphingoid bases and fatty acids against Gram-positive and Gram-negative bacteriaCarol L Fischer
Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City, Iowa, USA
Antimicrob Agents Chemother 56:1157-61. 2012..5 h for some lipids but took as long as 24 h for others. Hence, sphingoid bases and fatty acids have different antibacterial activities and may have potential for prophylactic or therapeutic intervention in infection... - Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigsChristopher S Rogers
Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Science 321:1837-41. 2008..The pig model may provide opportunities to address persistent questions about CF pathogenesis and accelerate discovery of strategies for prevention and treatment... - Human β-defensin-3 alters, but does not inhibit, the binding of Porphyromonas gingivalis haemagglutinin B to the surface of human dendritic cellsJonathan R Van Hemert
Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
Int J Antimicrob Agents 40:75-9. 2012..Overall, these results suggest that HBD3 binding to rHagB alters, but does not inhibit, the binding of rHagB to human myeloid dendritic cells... - Antimicrobial activity of Substance P and Neuropeptide Y against laboratory strains of bacteria and oral microorganismsChristopher J Hansen
Department of Periodontics and Dows Institute for Dental Research, The University of Iowa College of Dentistry, Iowa City, IA 52252, USA
J Neuroimmunol 177:215-8. 2006..However, this remains to be determined... - Defensins as anti-inflammatory compounds and mucosal adjuvantsKarl G Kohlgraf
Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
Future Microbiol 5:99-113. 2010.... - Thematic review series: skin lipids. Antimicrobial lipids at the skin surfaceDavid R Drake
Dows Institute, University of Iowa, Iowa City, IA 52242, USA
J Lipid Res 49:4-11. 2008..In fact, this combination was far more effective than mupirocin with or without ethanol. Mupirocin is a "gold standard" for activity against MRSA... - Presence of wax esters and squalene in human salivaAndrew J Brasser
Dows Institute for Dental Research, University of Iowa, Iowa City, IA 52242, USA
Arch Oral Biol 56:588-91. 2011..The purpose of this study was to determine the presence and relative composition of neutral lipids in human saliva... - Influence of smoking on gingival crevicular fluid cytokines in severe chronic periodontitisKeelen D Tymkiw
Department of Periodontics, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
J Clin Periodontol 38:219-28. 2011..The aim of this study was to compare the expression of 22 chemokines and cytokines in gingival crevicular fluid (GCF) from smokers and non-smokers with periodontitis and periodontally healthy control subjects... - Defensin DEFB103 bidirectionally regulates chemokine and cytokine responses to a pro-inflammatory stimulusLauren E Harvey
Dows Institute for Dental Research or Department of Periodontics, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
Sci Rep 3:1232. 2013.... - Carbamoylcholine chloride induces a rapid increase in IL6 in the nasal cavity of C57BL/6 miceXiaoying Lu
Department of Periodontics, College of Public Health, The University of Iowa, Iowa City, IA, USA
Comp Med 57:349-54. 2007..In summary, carbamoylcholine chloride induces a rapid, elevated IL6 response in the nasal cavity and respiratory tract of mice but does not alter the levels of other Th1, Th2, or proinflammatory cytokines... - Effects of polymicrobial communities on host immunity and responseXiaoying Lu
Department of Periodontics and Dows Institute for Dental Research, N401, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
FEMS Microbiol Lett 265:141-50. 2006..Such an activity may be a mechanism that the host uses to sense what is on its mucosal surfaces, as well as to differentiate among commensals and pathogens... - Lentivirus vector can be readministered to nasal epithelia without blocking immune responsesPatrick L Sinn
Department of Pediatrics, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
J Virol 82:10684-92. 2008..Prolonged gene expression has been observed in vivo following a single dose of virus vector; however, depending on the application, repeated administration of vector may be necessary to achieve stable, therapeutic gene expression... - Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals?Nicole K Brogden
Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40536, USA
Int J Antimicrob Agents 38:217-25. 2011..These groups of new peptides have creative medical and industrial application potentials to treat antibiotic-resistant bacterial infections and septic shock, to preserve food or to sanitise surfaces both in vitro and in vivo... - Human alpha- and beta-defensins bind to immobilized adhesins from Porphyromonas gingivalisDeborah E Dietrich
Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, Iowa 52242, USA
Infect Immun 76:5714-20. 2008..Binding of defensins to adhesins may serve to prevent microbial adherence to tissues, attenuate proinflammatory cytokine responses, and facilitate delivery of bound antigen to antigen-presenting cells with defensin receptors... - The porcine lung as a potential model for cystic fibrosisChristopher S Rogers
Department of Internal Medicine, Roy J Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
Am J Physiol Lung Cell Mol Physiol 295:L240-63. 2008..Thus pigs with a targeted CFTR gene might provide a good model for CF. Here, we review aspects of porcine airways and lung that are relevant to CF... - Loss of Bardet-Biedl syndrome proteins alters the morphology and function of motile cilia in airway epitheliaAlok S Shah
Departments of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Proc Natl Acad Sci U S A 105:3380-5. 2008..These results emphasize the role of BBS proteins in both the structure and function of motile cilia. They also invite additional scrutiny of motile cilia dysfunction in patients with this disease... - Antimicrobial anionic peptide binds in vivo to Mannheimia (Pasteurella) haemolytica attached to ovine alveolar epitheliumMohammad Heidari
Respiratory Diseases of Livestock Research Unit, US Department of Agriculture, Agricultural Research Service, National Animal Disease Center, PO Box 70, Ames, IA 50010, USA
Int J Antimicrob Agents 20:69-72. 2002..At 5-20 min, many organisms were distorted with flocculated intracellular constituents characteristic of AP cellular damage indicating that AP can bind to and presumably help inactivate organisms in vivo... - Antimicrobial peptides in animals and their role in host defencesKim A Brogden
Respiratory Diseases of Livestock Research Unit, US Department of Agriculture, Agricultural Research Service, National Animal Disease Center, PO Box 70, Ames, Iowa 50010, USA
Int J Antimicrob Agents 22:465-78. 2003..g. myeloid antimicrobial peptides, alpha-, beta-defensins, and protegrins) or are specific to one of these groups (e.g. porcine cecropin P1, Bac5, Bac7, PR-39 and prophenin)... - Enhanced surfactant protein and defensin mRNA levels and reduced viral replication during parainfluenza virus type 3 pneumonia in neonatal lambsBranka Grubor
Department of Veterinary Pathology, 2740 Veterinary Medicine, Iowa State University, Ames, IA 50011 1250, USA
Clin Diagn Lab Immunol 11:599-607. 2004.... - Differential expression of sheep beta-defensin-1 and -2 and interleukin 8 during acute Mannheimia haemolytica pneumoniaMark R Ackermann
Department of Veterinary Pathology, College of Veterinary Medicine, 2738 Veterinary Medicine, Iowa State University, Ames, IA 50011 1250, USA
Microb Pathog 37:21-7. 2004..This study suggests that SDB-1 expression occurs in epithelia and decreases during severe bacterial pneumonia, which is in contrast to the increase that occurs with PI-3 infection... - Effect of danofloxacin and tilmicosin on body temperatures of beef calves with pneumonia experimentally induced by inoculation with Mannheimia haemolyticaVirginia R Fajt
Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50010-3020, USA
Am J Vet Res 65:610-5. 2004..Normal daily variation in body temperature must be considered in the face of respiratory tract disease during clinical evaluation of feedlot cattle... - Coordinated expression of tracheal antimicrobial peptide and inflammatory-response elements in the lungs of neonatal calves with acute bacterial pneumoniaJessica M Caverly
Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011-1250, USA
Infect Immun 71:2950-5. 2003..This work suggests that the coordinated expression of beta-defensin and inflammatory elements occurs during bacterial pneumonia... - Repeated intravenous doses of all-trans-retinoyl beta-D-glucuronide is not effective in the treatment of bacterial bronchopneumonia in lambs but is devoid of gross and acute toxicityJack M Gallup
Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames 50011 1250, USA
Med Sci Monit 8:BR345-53. 2002..Since the reparative effects of retinoids on epithelium are well-known, our aim was to study the effect(s) of intravenously-administered all-trans-retinoyl beta-D-glucuronide in lambs with chronic bacterial bronchopneumonia... - Surfactant protein D expression in normal and pneumonic ovine lungBranka Grubor
Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Veterinary Medicine, Ames, IA 50011 1250, USA
Vet Immunol Immunopathol 101:235-42. 2004.... - Increased anionic peptide distribution and intensity during progression and resolution of bacterial pneumoniaAmanda J Fales-Williams
Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA 50011-1250, USA
Clin Diagn Lab Immunol 9:28-32. 2002..This increased production of AP by hyperplastic cells may protect the lung against further infection until new, fully differentiated epithelial cells are capable of expressing their own inducible array of antimicrobial peptides...