Kim A Brogden

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi request reprint Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
    Kim A Brogden
    Department of Periodontics and Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, Iowa 52242, USA
    Nat Rev Microbiol 3:238-50. 2005
  2. pmc Defensin DEFB103 bidirectionally regulates chemokine and cytokine responses to a pro-inflammatory stimulus
    Lauren E Harvey
    Dows Institute for Dental Research or Department of Periodontics, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
    Sci Rep 3:1232. 2013
  3. pmc Histatin 5 binds to Porphyromonas gingivalis hemagglutinin B (HagB) and alters HagB-induced chemokine responses
    Derek S Borgwardt
    Department of Periodontics, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
    Sci Rep 4:3904. 2014
  4. pmc The emerging role of peptides and lipids as antimicrobial epidermal barriers and modulators of local inflammation
    N K Brogden
    Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky, USA
    Skin Pharmacol Physiol 25:167-81. 2012
  5. ncbi request reprint The nervous system and innate immunity: the neuropeptide connection
    Kim A Brogden
    Department of Periodontics and Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, Iowa 52252, USA
    Nat Immunol 6:558-64. 2005
  6. ncbi request reprint Antimicrobial activity of cathelicidins BMAP28, SMAP28, SMAP29, and PMAP23 against Pasteurella multocida is more broad-spectrum than host species specific
    Kim A Brogden
    Department of Periodontics, Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
    Vet Microbiol 119:76-81. 2007
  7. ncbi request reprint Human polymicrobial infections
    Kim A Brogden
    Department of Periodontics and Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City, IA 52242, USA
    Lancet 365:253-5. 2005
  8. pmc Defensins attenuate cytokine responses yet enhance antibody responses to Porphyromonas gingivalis adhesins in mice
    Karl G Kohlgraf
    Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
    Future Microbiol 5:115-25. 2010
  9. doi request reprint Human beta-defensin 3 binds to hemagglutinin B (rHagB), a non-fimbrial adhesin from Porphyromonas gingivalis, and attenuates a pro-inflammatory cytokine response
    Lindsey C Pingel
    Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
    Immunol Cell Biol 86:643-9. 2008
  10. pmc Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth
    David A Stoltz
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Sci Transl Med 2:29ra31. 2010

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
    Kim A Brogden
    Department of Periodontics and Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, Iowa 52242, USA
    Nat Rev Microbiol 3:238-50. 2005
    ..In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented...
  2. pmc Defensin DEFB103 bidirectionally regulates chemokine and cytokine responses to a pro-inflammatory stimulus
    Lauren E Harvey
    Dows Institute for Dental Research or Department of Periodontics, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
    Sci Rep 3:1232. 2013
    ....
  3. pmc Histatin 5 binds to Porphyromonas gingivalis hemagglutinin B (HagB) and alters HagB-induced chemokine responses
    Derek S Borgwardt
    Department of Periodontics, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
    Sci Rep 4:3904. 2014
    ..0 μM histatin 5 attenuated (p < 0.05) 0.02 μM HagB-induced CCL3/MIP-1α, CCL4/MIP-1β, and TNFα responses. Thus histatin 5 is capable of attenuating chemokine responses, which may help control oral inflammation...
  4. pmc The emerging role of peptides and lipids as antimicrobial epidermal barriers and modulators of local inflammation
    N K Brogden
    Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky, USA
    Skin Pharmacol Physiol 25:167-81. 2012
    ....
  5. ncbi request reprint The nervous system and innate immunity: the neuropeptide connection
    Kim A Brogden
    Department of Periodontics and Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, Iowa 52252, USA
    Nat Immunol 6:558-64. 2005
    ..As examples, we have chosen five well described, locally produced neuropeptides that may serve a previously unrecognized, direct antimicrobial, innate immune function in four anatomical sites...
  6. ncbi request reprint Antimicrobial activity of cathelicidins BMAP28, SMAP28, SMAP29, and PMAP23 against Pasteurella multocida is more broad-spectrum than host species specific
    Kim A Brogden
    Department of Periodontics, Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
    Vet Microbiol 119:76-81. 2007
    ..7 microM); and PMAP23 (MICs and MBCs, 4.3 to > or = 6.8 microM). Overall, the results of this study suggest that synthesized cathelicidins from cattle, sheep, and pigs had broad-spectrum antimicrobial activity against all P. multocida...
  7. ncbi request reprint Human polymicrobial infections
    Kim A Brogden
    Department of Periodontics and Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City, IA 52242, USA
    Lancet 365:253-5. 2005
    ....
  8. pmc Defensins attenuate cytokine responses yet enhance antibody responses to Porphyromonas gingivalis adhesins in mice
    Karl G Kohlgraf
    Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
    Future Microbiol 5:115-25. 2010
    ....
  9. doi request reprint Human beta-defensin 3 binds to hemagglutinin B (rHagB), a non-fimbrial adhesin from Porphyromonas gingivalis, and attenuates a pro-inflammatory cytokine response
    Lindsey C Pingel
    Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
    Immunol Cell Biol 86:643-9. 2008
    ..Thus, HBD3 binds rHagB and this interaction may be an important initial step to attenuate a pro-inflammatory cytokine response and an ERK 1/2 response...
  10. pmc Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth
    David A Stoltz
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Sci Transl Med 2:29ra31. 2010
    ....
  11. pmc Oral mucosal lipids are antibacterial against Porphyromonas gingivalis, induce ultrastructural damage, and alter bacterial lipid and protein compositions
    Carol L Fischer
    Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, USA
    Int J Oral Sci 5:130-40. 2013
    ..Prophylactic or therapeutic lipid treatments may be beneficial for intervention of infection by supplementing the natural immune function of endogenous lipids on mucosal surfaces. ..
  12. pmc Quantitation of SPLUNC1 in saliva with an xMAP particle-based antibody capture and detection immunoassay
    Karl G Kohlgraf
    Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
    Arch Oral Biol 57:197-204. 2012
    ..This immunoassay may prove to be useful in determining the concentration of SPLUNC1 in saliva for assessing its role in the pathogenesis of oral infections, oral inflammatory disorders, or oral malignancies...
  13. pmc Antibacterial activity of sphingoid bases and fatty acids against Gram-positive and Gram-negative bacteria
    Carol L Fischer
    Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City, Iowa, USA
    Antimicrob Agents Chemother 56:1157-61. 2012
    ..5 h for some lipids but took as long as 24 h for others. Hence, sphingoid bases and fatty acids have different antibacterial activities and may have potential for prophylactic or therapeutic intervention in infection...
  14. pmc The roles of cutaneous lipids in host defense
    Carol L Fischer
    Dows Institute, University of Iowa, Iowa City, IA, USA
    Biochim Biophys Acta 1841:319-22. 2014
    ..This article is part of a Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the Formation and Maintenance of the Cutaneous Barrier. Guest Editors: Kenneth R. Feingold and Peter Elias. ..
  15. ncbi request reprint Oral inflammation, a role for antimicrobial peptide modulation of cytokine and chemokine responses
    Kim A Brogden
    Dows Institute for Dental Research, College of Dentistry, University of Iowa, N423 DSB, 801 Newton Road, Iowa City, IA 52242, USA
    Expert Rev Anti Infect Ther 11:1097-113. 2013
    ....
  16. pmc Targeted antimicrobial activity of a specific IgG-SMAP28 conjugate against Porphyromonas gingivalis in a mixed culture
    Michael R Franzman
    Department of Periodontics, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
    Int J Antimicrob Agents 33:14-20. 2009
    ..gingivalis. This is an initial step to develop a selective antimicrobial agent that can eliminate a specific periodontal pathogen, such as P. gingivalis, from patients with periodontal disease without harming the normal commensal flora...
  17. pmc Human β-defensin-3 alters, but does not inhibit, the binding of Porphyromonas gingivalis haemagglutinin B to the surface of human dendritic cells
    Jonathan R Van Hemert
    Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
    Int J Antimicrob Agents 40:75-9. 2012
    ..Overall, these results suggest that HBD3 binding to rHagB alters, but does not inhibit, the binding of rHagB to human myeloid dendritic cells...
  18. pmc Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs
    Christopher S Rogers
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Science 321:1837-41. 2008
    ..The pig model may provide opportunities to address persistent questions about CF pathogenesis and accelerate discovery of strategies for prevention and treatment...
  19. pmc Influence of smoking on gingival crevicular fluid cytokines in severe chronic periodontitis
    Keelen D Tymkiw
    Department of Periodontics, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
    J Clin Periodontol 38:219-28. 2011
    ..The aim of this study was to compare the expression of 22 chemokines and cytokines in gingival crevicular fluid (GCF) from smokers and non-smokers with periodontitis and periodontally healthy control subjects...
  20. pmc Defensins as anti-inflammatory compounds and mucosal adjuvants
    Karl G Kohlgraf
    Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
    Future Microbiol 5:99-113. 2010
    ....
  21. ncbi request reprint Antimicrobial activity of Substance P and Neuropeptide Y against laboratory strains of bacteria and oral microorganisms
    Christopher J Hansen
    Department of Periodontics and Dows Institute for Dental Research, The University of Iowa College of Dentistry, Iowa City, IA 52252, USA
    J Neuroimmunol 177:215-8. 2006
    ..However, this remains to be determined...
  22. ncbi request reprint Effects of polymicrobial communities on host immunity and response
    Xiaoying Lu
    Department of Periodontics and Dows Institute for Dental Research, N401, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
    FEMS Microbiol Lett 265:141-50. 2006
    ..Such an activity may be a mechanism that the host uses to sense what is on its mucosal surfaces, as well as to differentiate among commensals and pathogens...
  23. ncbi request reprint Thematic review series: skin lipids. Antimicrobial lipids at the skin surface
    David R Drake
    Dows Institute, University of Iowa, Iowa City, IA 52242, USA
    J Lipid Res 49:4-11. 2008
    ..In fact, this combination was far more effective than mupirocin with or without ethanol. Mupirocin is a "gold standard" for activity against MRSA...
  24. pmc Presence of wax esters and squalene in human saliva
    Andrew J Brasser
    Dows Institute for Dental Research, University of Iowa, Iowa City, IA 52242, USA
    Arch Oral Biol 56:588-91. 2011
    ..The purpose of this study was to determine the presence and relative composition of neutral lipids in human saliva...
  25. pmc Human alpha- and beta-defensins bind to immobilized adhesins from Porphyromonas gingivalis
    Deborah E Dietrich
    Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, Iowa 52242, USA
    Infect Immun 76:5714-20. 2008
    ..Binding of defensins to adhesins may serve to prevent microbial adherence to tissues, attenuate proinflammatory cytokine responses, and facilitate delivery of bound antigen to antigen-presenting cells with defensin receptors...
  26. ncbi request reprint Carbamoylcholine chloride induces a rapid increase in IL6 in the nasal cavity of C57BL/6 mice
    Xiaoying Lu
    Department of Periodontics, College of Public Health, The University of Iowa, Iowa City, IA, USA
    Comp Med 57:349-54. 2007
    ..In summary, carbamoylcholine chloride induces a rapid, elevated IL6 response in the nasal cavity and respiratory tract of mice but does not alter the levels of other Th1, Th2, or proinflammatory cytokines...
  27. pmc Human β-defensin HBD3 binds to immobilized Bla g2 from the German cockroach (Blattella germanica)
    Deborah E Dietrich
    Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
    Peptides 53:265-9. 2014
    ..Thus, HBD3, found in mucosal secretions has the ability to bind to allergens like Bla g2 possibly by electrostatic interaction, and may alter the ability of Bla g2 to induce localized allergic and/or inflammatory mucosal responses. ..
  28. pmc Lentivirus vector can be readministered to nasal epithelia without blocking immune responses
    Patrick L Sinn
    Department of Pediatrics, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    J Virol 82:10684-92. 2008
    ..Prolonged gene expression has been observed in vivo following a single dose of virus vector; however, depending on the application, repeated administration of vector may be necessary to achieve stable, therapeutic gene expression...
  29. pmc Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals?
    Nicole K Brogden
    Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40536, USA
    Int J Antimicrob Agents 38:217-25. 2011
    ..These groups of new peptides have creative medical and industrial application potentials to treat antibiotic-resistant bacterial infections and septic shock, to preserve food or to sanitise surfaces both in vitro and in vivo...
  30. pmc The porcine lung as a potential model for cystic fibrosis
    Christopher S Rogers
    Department of Internal Medicine, Roy J Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Lung Cell Mol Physiol 295:L240-63. 2008
    ..Thus pigs with a targeted CFTR gene might provide a good model for CF. Here, we review aspects of porcine airways and lung that are relevant to CF...
  31. pmc Loss of Bardet-Biedl syndrome proteins alters the morphology and function of motile cilia in airway epithelia
    Alok S Shah
    Departments of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 105:3380-5. 2008
    ..These results emphasize the role of BBS proteins in both the structure and function of motile cilia. They also invite additional scrutiny of motile cilia dysfunction in patients with this disease...
  32. ncbi request reprint Antimicrobial anionic peptide binds in vivo to Mannheimia (Pasteurella) haemolytica attached to ovine alveolar epithelium
    Mohammad Heidari
    Respiratory Diseases of Livestock Research Unit, US Department of Agriculture, Agricultural Research Service, National Animal Disease Center, PO Box 70, Ames, IA 50010, USA
    Int J Antimicrob Agents 20:69-72. 2002
    ..At 5-20 min, many organisms were distorted with flocculated intracellular constituents characteristic of AP cellular damage indicating that AP can bind to and presumably help inactivate organisms in vivo...
  33. ncbi request reprint Differential expression of sheep beta-defensin-1 and -2 and interleukin 8 during acute Mannheimia haemolytica pneumonia
    Mark R Ackermann
    Department of Veterinary Pathology, College of Veterinary Medicine, 2738 Veterinary Medicine, Iowa State University, Ames, IA 50011 1250, USA
    Microb Pathog 37:21-7. 2004
    ..This study suggests that SDB-1 expression occurs in epithelia and decreases during severe bacterial pneumonia, which is in contrast to the increase that occurs with PI-3 infection...
  34. pmc Enhanced surfactant protein and defensin mRNA levels and reduced viral replication during parainfluenza virus type 3 pneumonia in neonatal lambs
    Branka Grubor
    Department of Veterinary Pathology, 2740 Veterinary Medicine, Iowa State University, Ames, IA 50011 1250, USA
    Clin Diagn Lab Immunol 11:599-607. 2004
    ....
  35. ncbi request reprint Antimicrobial peptides in animals and their role in host defences
    Kim A Brogden
    Respiratory Diseases of Livestock Research Unit, US Department of Agriculture, Agricultural Research Service, National Animal Disease Center, PO Box 70, Ames, Iowa 50010, USA
    Int J Antimicrob Agents 22:465-78. 2003
    ..g. myeloid antimicrobial peptides, alpha-, beta-defensins, and protegrins) or are specific to one of these groups (e.g. porcine cecropin P1, Bac5, Bac7, PR-39 and prophenin)...
  36. ncbi request reprint Repeated intravenous doses of all-trans-retinoyl beta-D-glucuronide is not effective in the treatment of bacterial bronchopneumonia in lambs but is devoid of gross and acute toxicity
    Jack M Gallup
    Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames 50011 1250, USA
    Med Sci Monit 8:BR345-53. 2002
    ..Since the reparative effects of retinoids on epithelium are well-known, our aim was to study the effect(s) of intravenously-administered all-trans-retinoyl beta-D-glucuronide in lambs with chronic bacterial bronchopneumonia...
  37. pmc Coordinated expression of tracheal antimicrobial peptide and inflammatory-response elements in the lungs of neonatal calves with acute bacterial pneumonia
    Jessica M Caverly
    Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011 1250, USA
    Infect Immun 71:2950-5. 2003
    ..This work suggests that the coordinated expression of beta-defensin and inflammatory elements occurs during bacterial pneumonia...
  38. ncbi request reprint Effect of danofloxacin and tilmicosin on body temperatures of beef calves with pneumonia experimentally induced by inoculation with Mannheimia haemolytica
    Virginia R Fajt
    Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50010 3020, USA
    Am J Vet Res 65:610-5. 2004
    ..To examine effects of danofloxacin and tilmicosin on continuously recorded body temperature in beef calves with pneumonia experimentally induced by inoculation of Mannheimia haemolytica...
  39. ncbi request reprint Surfactant protein D expression in normal and pneumonic ovine lung
    Branka Grubor
    Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Veterinary Medicine, Ames, IA 50011 1250, USA
    Vet Immunol Immunopathol 101:235-42. 2004
    ....
  40. pmc Increased anionic peptide distribution and intensity during progression and resolution of bacterial pneumonia
    Amanda J Fales-Williams
    Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA 50011 1250, USA
    Clin Diagn Lab Immunol 9:28-32. 2002
    ..This increased production of AP by hyperplastic cells may protect the lung against further infection until new, fully differentiated epithelial cells are capable of expressing their own inducible array of antimicrobial peptides...