Arthur Brody

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Treatment for tobacco dependence: effect on brain nicotinic acetylcholine receptor density
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    Neuropsychopharmacology 38:1548-56. 2013
  2. pmc Up-regulation of nicotinic acetylcholine receptors in menthol cigarette smokers
    Arthur L Brody
    Department of Psychiatry, University of California at Los Angeles, Los Angeles, USA
    Int J Neuropsychopharmacol 16:957-66. 2013
  3. ncbi request reprint FDG-PET predictors of response to behavioral therapy and pharmacotherapy in obsessive compulsive disorder
    A L Brody
    UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA, USA
    Psychiatry Res 84:1-6. 1998
  4. pmc Functional brain imaging of tobacco use and dependence
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, 300 UCLA Medical Plaza, Suite 2200, Los Angeles, CA 90095, United States
    J Psychiatr Res 40:404-18. 2006
  5. pmc Gene variants of brain dopamine pathways and smoking-induced dopamine release in the ventral caudate/nucleus accumbens
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 63:808-16. 2006
  6. pmc Effects of treatment for tobacco dependence on resting cerebral glucose metabolism
    Matthew R Costello
    Greater Los Angeles Veterans Administration Healthcare System, Los Angeles, CA 90095, USA
    Neuropsychopharmacology 35:605-12. 2010
  7. pmc Effect of a history of major depressive disorder on smoking-induced dopamine release
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095, USA
    Biol Psychiatry 66:898-901. 2009
  8. pmc Brain nicotinic acetylcholine receptor occupancy: effect of smoking a denicotinized cigarette
    Arthur L Brody
    UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90095, USA
    Int J Neuropsychopharmacol 12:305-16. 2009
  9. pmc Ventral striatal dopamine release in response to smoking a regular vs a denicotinized cigarette
    Arthur L Brody
    UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90095, USA
    Neuropsychopharmacology 34:282-9. 2009
  10. pmc Cigarette smoking saturates brain alpha 4 beta 2 nicotinic acetylcholine receptors
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 63:907-15. 2006

Research Grants

Detail Information

Publications41

  1. pmc Treatment for tobacco dependence: effect on brain nicotinic acetylcholine receptor density
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    Neuropsychopharmacology 38:1548-56. 2013
    ..Study findings could prove useful in the treatment of smokers by providing encouragement with the knowledge that decreased smoking leads to normalization of specific brain receptors...
  2. pmc Up-regulation of nicotinic acetylcholine receptors in menthol cigarette smokers
    Arthur L Brody
    Department of Psychiatry, University of California at Los Angeles, Los Angeles, USA
    Int J Neuropsychopharmacol 16:957-66. 2013
    ..These results provide additional information about the severity of menthol cigarette use and may help explain why these smokers have more trouble quitting in standard treatment programmes...
  3. ncbi request reprint FDG-PET predictors of response to behavioral therapy and pharmacotherapy in obsessive compulsive disorder
    A L Brody
    UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA, USA
    Psychiatry Res 84:1-6. 1998
    ..35, P = 0.04), but worse outcome (tau = -0.57, P = 0.03) in the fluoxetine-treated group. These results suggest that subjects with differing patterns of metabolism preferentially respond to BT vs. medication...
  4. pmc Functional brain imaging of tobacco use and dependence
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, 300 UCLA Medical Plaza, Suite 2200, Los Angeles, CA 90095, United States
    J Psychiatr Res 40:404-18. 2006
    ..Activation of this circuitry may be responsible for the effects of smoking seen in tobacco dependent subjects, such as improvements in attentional performance, mood, anxiety, and irritability...
  5. pmc Gene variants of brain dopamine pathways and smoking-induced dopamine release in the ventral caudate/nucleus accumbens
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 63:808-16. 2006
    ..Preclinical studies demonstrate that nicotine administration leads to dopamine release in the ventral striatum. However, human studies reveal considerable interindividual variability in the extent of smoking-induced dopamine release...
  6. pmc Effects of treatment for tobacco dependence on resting cerebral glucose metabolism
    Matthew R Costello
    Greater Los Angeles Veterans Administration Healthcare System, Los Angeles, CA 90095, USA
    Neuropsychopharmacology 35:605-12. 2010
    ..Thus, this study supports the theory that active treatments for tobacco dependence move the brain into a more goal-oriented state...
  7. pmc Effect of a history of major depressive disorder on smoking-induced dopamine release
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095, USA
    Biol Psychiatry 66:898-901. 2009
    ..We sought to determine if cigarette smokers with a history of MDD and current mild depressive symptoms have abnormal smoking-induced DA release (measured indirectly as change in (11)C-raclopride binding potential [BP(ND)])...
  8. pmc Brain nicotinic acetylcholine receptor occupancy: effect of smoking a denicotinized cigarette
    Arthur L Brody
    UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90095, USA
    Int J Neuropsychopharmacol 12:305-16. 2009
    ..Furthermore, smoking a denicotinized cigarette resulted in substantial nAChR occupancy...
  9. pmc Ventral striatal dopamine release in response to smoking a regular vs a denicotinized cigarette
    Arthur L Brody
    UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90095, USA
    Neuropsychopharmacology 34:282-9. 2009
    ..Thus, nicotine delivered through cigarette smoking appears to be important for ventral striatal DA release. Study findings also suggest that mood improvement from smoking is specifically related to ventral striatal DA release...
  10. pmc Cigarette smoking saturates brain alpha 4 beta 2 nicotinic acetylcholine receptors
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 63:907-15. 2006
    ....
  11. pmc Neural substrates of resisting craving during cigarette cue exposure
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 300 UCLA Medical Plaza, Los Angeles, CA 90095, USA
    Biol Psychiatry 62:642-51. 2007
    ..We sought to determine changes in brain activity in response to cigarette cues when smokers actively resist craving...
  12. ncbi request reprint Smoking-induced ventral striatum dopamine release
    Arthur L Brody
    Veterans Affairs Greater Los Angeles Healthcare, 300 UCLA Medical Plaza, Suite 2200, Los Angeles, CA 90095, USA
    Am J Psychiatry 161:1211-8. 2004
    ..The authors used [(11)C]raclopride bolus-plus-continuous-infusion positron emission tomography (PET) to determine smoking-induced ventral striatum dopamine release in humans...
  13. pmc Smoking-induced change in intrasynaptic dopamine concentration: effect of treatment for Tobacco Dependence
    Arthur L Brody
    Department of Psychiatry, UCLA, Los Angeles, CA 90095, USA
    Psychiatry Res 183:218-24. 2010
    ..These data indicate that smoking-induced DA release is dose-dependent, and is not significantly affected by reductions in daily smoking levels or treatment type...
  14. ncbi request reprint Brain metabolic changes in major depressive disorder from pre- to post-treatment with paroxetine
    A L Brody
    UCLA Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute and Hospital, Los Angeles, CA 90024, USA
    Psychiatry Res 91:127-39. 1999
    ..These findings implicate ventral prefrontal-subcortical brain circuitry in the mediation of response to serotonin reuptake inhibitors in MDD...
  15. ncbi request reprint Personality changes in adult subjects with major depressive disorder or obsessive-compulsive disorder treated with paroxetine
    A L Brody
    University of California at Los Angeles, Department of Psychiatry and Biobehavioral Sciences, USA
    J Clin Psychiatry 61:349-55. 2000
    ..We also sought to determine whether or not these personality changes were associated with disease state (MDD vs. OCD) or treatment response (responders vs. nonresponders)...
  16. ncbi request reprint Prefrontal-subcortical and limbic circuit mediation of major depressive disorder
    A L Brody
    UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA, USA
    Semin Clin Neuropsychiatry 6:102-12. 2001
    ....
  17. ncbi request reprint Regional brain metabolic changes in patients with major depression treated with either paroxetine or interpersonal therapy: preliminary findings
    A L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, CA, USA
    Arch Gen Psychiatry 58:631-40. 2001
    ..We also performed a preliminary comparison of regional changes with 2 distinct forms of treatment (paroxetine and interpersonal psychotherapy)...
  18. ncbi request reprint Brain metabolic changes during cigarette craving
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 300 UCLA Medical Plaza, Suite 2200, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 59:1162-72. 2002
    ..The objective of this study was to determine changes in regional cerebral glucose metabolism and correlations between craving and regional metabolism in heavy cigarette smokers exposed to cigarette-related cues...
  19. pmc Effect of secondhand smoke on occupancy of nicotinic acetylcholine receptors in brain
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, USA
    Arch Gen Psychiatry 68:953-60. 2011
    ..Despite progress in tobacco control, secondhand smoke (SHS) exposure remains prevalent worldwide and is implicated in the initiation and maintenance of cigarette smoking...
  20. pmc Attenuation of cue-induced cigarette craving and anterior cingulate cortex activation in bupropion-treated smokers: a preliminary study
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, David Geffen Schol of Medicine, University of Californai at Los Angeles, and Positron Emission Tomography Center, Greater Los Angeles Veterans Affairs Healthcare System, USA
    Psychiatry Res 130:269-81. 2004
    ..These results are consistent with the known effects of bupropion HCl, including its enhancement of catecholaminergic neurotransmission...
  21. pmc Brain activity in cigarette smokers performing a working memory task: effect of smoking abstinence
    Jiansong Xu
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    Biol Psychiatry 58:143-50. 2005
    ..Our aim, therefore, was to identify abnormalities in the circuitry that mediates working memory in nicotine-dependent subjects after they initiate abstinence from smoking...
  22. pmc Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity
    Buyean Lee
    Department of Psychiatry, Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90024, USA
    J Neurosci 29:14734-40. 2009
    ..12 corrected). The findings suggest that low striatal D(2)/D(3) receptor availability may mediate impulsive temperament and thereby influence addiction...
  23. pmc Effects of acute smoking on brain activity vary with abstinence in smokers performing the N-Back task: a preliminary study
    Jiansong Xu
    Department of Psychiatry, University of California Los Angeles, Los Angeles, CA 90024, USA
    Psychiatry Res 148:103-9. 2006
    ..This interaction merits further examination in larger studies specifically designed to consider this issue...
  24. pmc Working memory in cigarette smokers: comparison to non-smokers and effects of abstinence
    Adrianna Mendrek
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA
    Addict Behav 31:833-44. 2006
    ..These findings provide further evidence for a deficit in working memory associated with acute abstinence from smoking, which may contribute to the difficulty of smoking cessation...
  25. pmc Effect of cigarette smoking on prefrontal cortical function in nondeprived smokers performing the Stroop Task
    Jiansong Xu
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Neuropsychopharmacology 32:1421-8. 2007
    ..Even after brief abstinence from smoking, therefore, smokers exhibit compromised functional efficiency in the right FEF and adjacent precentral sulcus in a test of selective attention; and smoking ameliorates this condition...
  26. ncbi request reprint Differences between smokers and nonsmokers in regional gray matter volumes and densities
    Arthur L Brody
    Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90095, USA
    Biol Psychiatry 55:77-84. 2004
    ..Using MRI, we examined these regions for differences in gray matter between smokers and nonsmokers...
  27. pmc Gender effects on mood and cigarette craving during early abstinence and resumption of smoking
    Jiansong Xu
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angles, Los Angeles, CA, USA
    Nicotine Tob Res 10:1653-61. 2008
    ..These differences may contribute to the greater likelihood of relapse when women try to quit smoking...
  28. ncbi request reprint Differential brain metabolic predictors of response to paroxetine in obsessive-compulsive disorder versus major depression
    Sanjaya Saxena
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Am J Psychiatry 160:522-32. 2003
    ....
  29. ncbi request reprint Cerebral glucose metabolism in obsessive-compulsive hoarding
    Sanjaya Saxena
    UCLA Neuropsychiatric Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Am J Psychiatry 161:1038-48. 2004
    ..The authors sought to identify cerebral metabolic patterns specifically associated with the compulsive hoarding syndrome using positron emission tomography (PET)...
  30. ncbi request reprint Differential cerebral metabolic changes with paroxetine treatment of obsessive-compulsive disorder vs major depression
    Sanjaya Saxena
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 300 UCLA Medical Plaza, Room 2229, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 59:250-61. 2002
    ....
  31. ncbi request reprint Differences in regional brain metabolism associated with marijuana abuse in methamphetamine abusers
    Bradley Voytek
    Department of Psychiatry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90024, USA
    Synapse 57:113-5. 2005
  32. ncbi request reprint Cerebral metabolic dysfunction and impaired vigilance in recently abstinent methamphetamine abusers
    Edythe D London
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90024 1759, USA
    Biol Psychiatry 58:770-8. 2005
    ..The links between cognitive impairment and these cerebral abnormalities are not established...
  33. pmc Severity of nicotine dependence moderates performance on perceptual-motor tests of attention
    Allen Azizian
    Department of Psychiatry and Biobehavioral Sciences, Laboratory of Molecular Neuroimaging, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024, USA
    Nicotine Tob Res 10:599-606. 2008
    ..The findings suggest that severity of nicotine dependence and slowness in perceptual-motor tasks of attention share an underlying basis...
  34. pmc Methamphetamine craving induced in an online virtual reality environment
    Christopher Culbertson
    Department of Psychiatry, UCLA, Los Angeles, CA, USA
    Pharmacol Biochem Behav 96:454-60. 2010
    ....
  35. pmc Effects of cigarette smoking and abstinence on Stroop task performance
    Catherine P Domier
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, Los Angeles, CA, USA
    Psychopharmacology (Berl) 195:1-9. 2007
    ..Selective attention may be important in this regard, but earlier literature presents inconsistent findings on how smoking abstinence and resumption of smoking influence this cognitive function...
  36. pmc Smoking reduces conflict-related anterior cingulate activity in abstinent cigarette smokers performing a Stroop task
    Allen Azizian
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    Neuropsychopharmacology 35:775-82. 2010
    ..Resumption of smoking may enhance cognitive control in smokers, involving a reduction in ACC response conflict activity together with improvement in conflict resolution involving the dorsolateral prefrontal cortex...
  37. pmc Short-term naturalistic treatment outcomes in cigarette smokers with substance abuse and/or mental illness
    Risa B Gershon Grand
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 90095, USA
    J Clin Psychiatry 68:892-8; quiz 980-1. 2007
    ..We sought to examine the effect of specific substance abuse/mental illness diagnoses compared to one another on treatment outcomes...
  38. ncbi request reprint Common substrates of dysphoria in stimulant drug abuse and primary depression: therapeutic targets
    Kate Baicy
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles California 90024, USA
    Int Rev Neurobiol 65:117-45. 2005
  39. pmc Effect of bupropion treatment on brain activation induced by cigarette-related cues in smokers
    Christopher S Culbertson
    Department of Psychiatry, University of California, Los Angeles, CA, USA
    Arch Gen Psychiatry 68:505-15. 2011
    ..Bupropion hydrochloride treatment reduces cue-induced craving in cigarette smokers; however, the mechanism by which bupropion exerts this effect has not yet been described...
  40. ncbi request reprint Whole-body radiation dosimetry of 2-[18F]Fluoro-A-85380 in human PET imaging studies
    Sebastian L Obrzut
    Department of Radiology, Division of Nuclear Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Nucl Med Biol 32:869-74. 2005
    ..184 rad/mCi) and the kidneys (0.0470 mGy/MBq, 0.174 rad/mCi). The mean effective dose equivalent is estimated to be 0.0278 mSv/MBq (0.103 rem/mCi), indicating that radiation dosimetry associated with 2-[18F]FA is within acceptable limits...
  41. pmc Paroxetine treatment of compulsive hoarding
    Sanjaya Saxena
    UCSD Department of Psychiatry, VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    J Psychiatr Res 41:481-7. 2007
    ..We sought to determine whether compulsive hoarders would respond as well as non-hoarding OCD patients to the SRI, paroxetine...

Research Grants10

  1. Treatments for Nicotine Dependence: Brain Mechanisms
    Arthur Brody; Fiscal Year: 2005
    ..abstract_text> ..
  2. Nicotine Receptor Density & Dopamine System Function
    Arthur Brody; Fiscal Year: 2009
    ..abstract_text> ..