Research Topics
Genomes and GenesSpecies | Arthur BrodySummaryAffiliation: University of California Country: USA Publications
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Publications
FDG-PET predictors of response to behavioral therapy and pharmacotherapy in obsessive compulsive disorderA L Brody
UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA, USA
Psychiatry Res 84:1-6. 1998..35, P = 0.04), but worse outcome (tau = -0.57, P = 0.03) in the fluoxetine-treated group. These results suggest that subjects with differing patterns of metabolism preferentially respond to BT vs. medication...
Effect of secondhand smoke on occupancy of nicotinic acetylcholine receptors in brainArthur L Brody
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, USA
Arch Gen Psychiatry 68:953-60. 2011..Despite progress in tobacco control, secondhand smoke (SHS) exposure remains prevalent worldwide and is implicated in the initiation and maintenance of cigarette smoking...- Gene variants of brain dopamine pathways and smoking-induced dopamine release in the ventral caudate/nucleus accumbensArthur L Brody
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
Arch Gen Psychiatry 63:808-16. 2006..Preclinical studies demonstrate that nicotine administration leads to dopamine release in the ventral striatum. However, human studies reveal considerable interindividual variability in the extent of smoking-induced dopamine release... - Cigarette smoking saturates brain alpha 4 beta 2 nicotinic acetylcholine receptorsArthur L Brody
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
Arch Gen Psychiatry 63:907-15. 2006.... - Neural substrates of resisting craving during cigarette cue exposureArthur L Brody
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 300 UCLA Medical Plaza, Los Angeles, CA 90095, USA
Biol Psychiatry 62:642-51. 2007..We sought to determine changes in brain activity in response to cigarette cues when smokers actively resist craving... - Ventral striatal dopamine release in response to smoking a regular vs a denicotinized cigaretteArthur L Brody
UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90095, USA
Neuropsychopharmacology 34:282-9. 2009..Thus, nicotine delivered through cigarette smoking appears to be important for ventral striatal DA release. Study findings also suggest that mood improvement from smoking is specifically related to ventral striatal DA release... - Brain nicotinic acetylcholine receptor occupancy: effect of smoking a denicotinized cigaretteArthur L Brody
UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90095, USA
Int J Neuropsychopharmacol 12:305-16. 2009..Furthermore, smoking a denicotinized cigarette resulted in substantial nAChR occupancy... - Effect of a history of major depressive disorder on smoking-induced dopamine releaseArthur L Brody
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095, USA
Biol Psychiatry 66:898-901. 2009..We sought to determine if cigarette smokers with a history of MDD and current mild depressive symptoms have abnormal smoking-induced DA release (measured indirectly as change in (11)C-raclopride binding potential [BP(ND)])... - Effects of treatment for tobacco dependence on resting cerebral glucose metabolismMatthew R Costello
Greater Los Angeles Veterans Administration Healthcare System, Los Angeles, CA 90095, USA
Neuropsychopharmacology 35:605-12. 2010..Thus, this study supports the theory that active treatments for tobacco dependence move the brain into a more goal-oriented state... - Smoking-induced change in intrasynaptic dopamine concentration: effect of treatment for Tobacco DependenceArthur L Brody
Department of Psychiatry, UCLA, Los Angeles, CA 90095, USA
Psychiatry Res 183:218-24. 2010..These data indicate that smoking-induced DA release is dose-dependent, and is not significantly affected by reductions in daily smoking levels or treatment type... - Functional brain imaging of tobacco use and dependenceArthur L Brody
Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, 300 UCLA Medical Plaza, Suite 2200, Los Angeles, CA 90095, United States
J Psychiatr Res 40:404-18. 2006..Activation of this circuitry may be responsible for the effects of smoking seen in tobacco dependent subjects, such as improvements in attentional performance, mood, anxiety, and irritability... - Smoking-induced ventral striatum dopamine releaseArthur L Brody
Veterans Affairs Greater Los Angeles Healthcare, 300 UCLA Medical Plaza, Suite 2200, Los Angeles, CA 90095, USA
Am J Psychiatry 161:1211-8. 2004..The authors used [(11)C]raclopride bolus-plus-continuous-infusion positron emission tomography (PET) to determine smoking-induced ventral striatum dopamine release in humans... - Personality changes in adult subjects with major depressive disorder or obsessive-compulsive disorder treated with paroxetineA L Brody
University of California at Los Angeles, Department of Psychiatry and Biobehavioral Sciences, USA
J Clin Psychiatry 61:349-55. 2000..We also sought to determine whether or not these personality changes were associated with disease state (MDD vs. OCD) or treatment response (responders vs. nonresponders)... - Prefrontal-subcortical and limbic circuit mediation of major depressive disorderA L Brody
UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA, USA
Semin Clin Neuropsychiatry 6:102-12. 2001.... - Regional brain metabolic changes in patients with major depression treated with either paroxetine or interpersonal therapy: preliminary findingsA L Brody
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, CA, USA
Arch Gen Psychiatry 58:631-40. 2001..We also performed a preliminary comparison of regional changes with 2 distinct forms of treatment (paroxetine and interpersonal psychotherapy)... - Brain metabolic changes in major depressive disorder from pre- to post-treatment with paroxetineA L Brody
UCLA Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute and Hospital, Los Angeles, CA 90024, USA
Psychiatry Res 91:127-39. 1999..These findings implicate ventral prefrontal-subcortical brain circuitry in the mediation of response to serotonin reuptake inhibitors in MDD... - Brain metabolic changes during cigarette cravingArthur L Brody
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 300 UCLA Medical Plaza, Suite 2200, Los Angeles, CA 90095, USA
Arch Gen Psychiatry 59:1162-72. 2002..The objective of this study was to determine changes in regional cerebral glucose metabolism and correlations between craving and regional metabolism in heavy cigarette smokers exposed to cigarette-related cues... - Attenuation of cue-induced cigarette craving and anterior cingulate cortex activation in bupropion-treated smokers: a preliminary studyArthur L Brody
Department of Psychiatry and Biobehavioral Sciences, David Geffen Schol of Medicine, University of Californai at Los Angeles, and Positron Emission Tomography Center, Greater Los Angeles Veterans Affairs Healthcare System, USA
Psychiatry Res 130:269-81. 2004..These results are consistent with the known effects of bupropion HCl, including its enhancement of catecholaminergic neurotransmission... - Brain activity in cigarette smokers performing a working memory task: effect of smoking abstinenceJiansong Xu
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
Biol Psychiatry 58:143-50. 2005..CONCLUSIONS: We conclude that neural processing related to working memory in the left DLPFC is less efficient during acute abstinence from smoking than at smoking satiety... - Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivityBuyean Lee
Department of Psychiatry, Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90024, USA
J Neurosci 29:14734-40. 2009..12 corrected). The findings suggest that low striatal D(2)/D(3) receptor availability may mediate impulsive temperament and thereby influence addiction... - Effects of acute smoking on brain activity vary with abstinence in smokers performing the N-Back task: a preliminary studyJiansong Xu
Department of Psychiatry, University of California Los Angeles, Los Angeles, CA 90024, USA
Psychiatry Res 148:103-9. 2006..This interaction merits further examination in larger studies specifically designed to consider this issue... - Working memory in cigarette smokers: comparison to non-smokers and effects of abstinenceAdrianna Mendrek
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA
Addict Behav 31:833-44. 2006..These findings provide further evidence for a deficit in working memory associated with acute abstinence from smoking, which may contribute to the difficulty of smoking cessation... - Differences between smokers and nonsmokers in regional gray matter volumes and densitiesArthur L Brody
Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90095, USA
Biol Psychiatry 55:77-84. 2004..These findings might reflect effects of chronic smoking, predisposing traits that lead to smoking, or some combination of these factors... - Effect of cigarette smoking on prefrontal cortical function in nondeprived smokers performing the Stroop TaskJiansong Xu
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
Neuropsychopharmacology 32:1421-8. 2007..Even after brief abstinence from smoking, therefore, smokers exhibit compromised functional efficiency in the right FEF and adjacent precentral sulcus in a test of selective attention; and smoking ameliorates this condition... - Gender effects on mood and cigarette craving during early abstinence and resumption of smokingJiansong Xu
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angles, Los Angeles, CA, USA
Nicotine Tob Res 10:1653-61. 2008..These differences may contribute to the greater likelihood of relapse when women try to quit smoking... - Differential brain metabolic predictors of response to paroxetine in obsessive-compulsive disorder versus major depressionSanjaya Saxena
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Am J Psychiatry 160:522-32. 2003.... - Cerebral glucose metabolism in obsessive-compulsive hoardingSanjaya Saxena
UCLA Neuropsychiatric Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Am J Psychiatry 161:1038-48. 2004..The authors sought to identify cerebral metabolic patterns specifically associated with the compulsive hoarding syndrome using positron emission tomography (PET)... - Differential cerebral metabolic changes with paroxetine treatment of obsessive-compulsive disorder vs major depressionSanjaya Saxena
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 300 UCLA Medical Plaza, Room 2229, Los Angeles, CA 90095, USA
Arch Gen Psychiatry 59:250-61. 2002.... - Severity of nicotine dependence moderates performance on perceptual-motor tests of attentionAllen Azizian
Department of Psychiatry and Biobehavioral Sciences, Laboratory of Molecular Neuroimaging, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024, USA
Nicotine Tob Res 10:599-606. 2008..The findings suggest that severity of nicotine dependence and slowness in perceptual-motor tasks of attention share an underlying basis... - Cerebral metabolic dysfunction and impaired vigilance in recently abstinent methamphetamine abusersEdythe D London
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90024 1759, USA
Biol Psychiatry 58:770-8. 2005..The links between cognitive impairment and these cerebral abnormalities are not established... - Methamphetamine craving induced in an online virtual reality environmentChristopher Culbertson
Department of Psychiatry, UCLA, Los Angeles, CA, USA
Pharmacol Biochem Behav 96:454-60. 2010.... - Differences in regional brain metabolism associated with marijuana abuse in methamphetamine abusersBradley Voytek
Department of Psychiatry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90024, USA
Synapse 57:113-5. 2005 - Effects of cigarette smoking and abstinence on Stroop task performanceCatherine P Domier
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, Los Angeles, CA, USA
Psychopharmacology (Berl) 195:1-9. 2007..Selective attention may be important in this regard, but earlier literature presents inconsistent findings on how smoking abstinence and resumption of smoking influence this cognitive function... - Smoking reduces conflict-related anterior cingulate activity in abstinent cigarette smokers performing a Stroop taskAllen Azizian
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
Neuropsychopharmacology 35:775-82. 2010..Resumption of smoking may enhance cognitive control in smokers, involving a reduction in ACC response conflict activity together with improvement in conflict resolution involving the dorsolateral prefrontal cortex... - Short-term naturalistic treatment outcomes in cigarette smokers with substance abuse and/or mental illnessRisa B Gershon Grand
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 90095, USA
J Clin Psychiatry 68:892-8; quiz 980-1. 2007..We sought to examine the effect of specific substance abuse/mental illness diagnoses compared to one another on treatment outcomes... - Common substrates of dysphoria in stimulant drug abuse and primary depression: therapeutic targetsKate Baicy
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles California 90024, USA
Int Rev Neurobiol 65:117-45. 2005 - Effect of bupropion treatment on brain activation induced by cigarette-related cues in smokersChristopher S Culbertson
Department of Psychiatry, University of California, Los Angeles, CA, USA
Arch Gen Psychiatry 68:505-15. 2011..Bupropion hydrochloride treatment reduces cue-induced craving in cigarette smokers; however, the mechanism by which bupropion exerts this effect has not yet been described... - Whole-body radiation dosimetry of 2-[18F]Fluoro-A-85380 in human PET imaging studiesSebastian L Obrzut
Department of Radiology, Division of Nuclear Medicine, University of California San Diego, La Jolla, CA 92093, USA
Nucl Med Biol 32:869-74. 2005..184 rad/mCi) and the kidneys (0.0470 mGy/MBq, 0.174 rad/mCi). The mean effective dose equivalent is estimated to be 0.0278 mSv/MBq (0.103 rem/mCi), indicating that radiation dosimetry associated with 2-[18F]FA is within acceptable limits... - Paroxetine treatment of compulsive hoardingSanjaya Saxena
UCSD Department of Psychiatry, VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
J Psychiatr Res 41:481-7. 2007..We sought to determine whether compulsive hoarders would respond as well as non-hoarding OCD patients to the SRI, paroxetine...
Research Grants
- Treatments for Nicotine Dependence: Brain MechanismsArthur Brody; Fiscal Year: 2005..abstract_text> ..
- Nicotine Receptor Density & Dopamine System FunctionArthur Brody; Fiscal Year: 2009..abstract_text> ..