Igor E Brodsky
Affiliation: University of Pennsylvania
Philip N, Dillon C, Snyder A, Fitzgerald P, Wynosky Dolfi M, Zwack E, et al
. Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-ÎºB and MAPK signaling. Proc Natl Acad Sci U S A. 2014;111:7385-90 pubmed publisher
Sorobetea D, Brodsky I. HVEM LIGHTs the Way for ILC3s. Cell Host Microbe. 2018;24:187-188 pubmed publisher
..2018) demonstrate that TNF-TNFR superfamily molecules LIGHT and HVEM stimulate early IFN-? production by type 3 innate lymphoid cells, which are critical for defense against Yersinia enterocolitica. ..
Zwack E, Snyder A, Wynosky Dolfi M, Ruthel G, Philip N, Marketon M, et al
. Inflammasome activation in response to the Yersinia type III secretion system requires hyperinjection of translocon proteins YopB and YopD. MBio. 2015;6:e02095-14 pubmed publisher
..Our findings indicate that hypertranslocation of pore complex proteins promotes inflammasome activation and that YopK prevents inflammasome activation by the T3SS by limiting translocation of YopD and YopB themselves. ..
Shin S, Brodsky I. The inflammasome: Learning from bacterial evasion strategies. Semin Immunol. 2015;27:102-10 pubmed publisher
..Deeper understanding of pathogen evasion of inflammasome activation has the potential to lead to development of novel classes of immunomodulatory factors that could be used in the context of human inflammatory diseases. ..
Philip N, Zwack E, Brodsky I. Activation and Evasion of Inflammasomes by Yersinia. Curr Top Microbiol Immunol. 2016;397:69-90 pubmed publisher
..Here, we describe the current state of knowledge on interactions between Yersinia and the inflammasome system, with the goal of integrating these findings within the general framework of inflammasome responses to microbial pathogens. ..
Peterson L, Philip N, Dillon C, Bertin J, Gough P, Green D, et al
. Cell-Extrinsic TNF Collaborates with TRIF Signaling To Promote Yersinia-Induced Apoptosis. J Immunol. 2016;197:4110-4117 pubmed
Zwack E, Feeley E, Burton A, Hu B, Yamamoto M, Kanneganti T, et al
. Guanylate Binding Proteins Regulate Inflammasome Activation in Response to Hyperinjected Yersinia Translocon Components. Infect Immun. 2017;85: pubmed publisher
..Our findings indicate that lysosomal damage by Yersinia translocon proteins promotes inflammasome activation and implicate GBPs as key regulators of this process. ..
Peterson L, Philip N, DeLaney A, Wynosky Dolfi M, Asklof K, Gray F, et al
. RIPK1-dependent apoptosis bypasses pathogen blockade of innate signaling to promote immune defense. J Exp Med. 2017;214:3171-3182 pubmed publisher