F M Brodsky

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc T cell receptor engagement leads to phosphorylation of clathrin heavy chain during receptor internalization
    Victoria L Crotzer
    The GW Hooper Foundation, Department of Microbiology, University of California San Francisco, 94143, USA
    J Exp Med 199:981-91. 2004
  2. ncbi request reprint Biological basket weaving: formation and function of clathrin-coated vesicles
    F M Brodsky
    Department of Biopharmaceutical Sciences, University of California, San Francisco, California, USA
    Annu Rev Cell Dev Biol 17:517-68. 2001
  3. ncbi request reprint Human pathogen subversion of antigen presentation
    F M Brodsky
    G W Hooper Foundation, Department of Microbiology and Immunology, University of California, San Francisco 94143 0552, USA
    Immunol Rev 168:199-215. 1999
  4. pmc Clathrin hub expression affects early endosome distribution with minimal impact on receptor sorting and recycling
    E M Bennett
    Department of Microbiology and Immunology, The G. W. Hooper Foundation, University of California, San Francisco, CA 94143-0552, USA
    Mol Biol Cell 12:2790-9. 2001
  5. pmc A novel clathrin homolog that co-distributes with cytoskeletal components functions in the trans-Golgi network
    S H Liu
    The G.W.Hooper Foundation, Department of Microbiology, University of California, San Francisco, CA 94143-0552, USA
    EMBO J 20:272-84. 2001
  6. ncbi request reprint Molecular structures of proteins involved in vesicle coat formation
    D E Wakeham
    G W Hooper Foundation, Box 0552, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Traffic 1:393-8. 2000
  7. ncbi request reprint Clathrin self-assembly is mediated by a tandemly repeated superhelix
    J A Ybe
    The G W Hooper Foundation, Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
    Nature 399:371-5. 1999
  8. ncbi request reprint Clathrin hub expression dissociates the actin-binding protein Hip1R from coated pits and disrupts their alignment with the actin cytoskeleton
    E M Bennett
    The G. W. Hooper Foundation, Department of Microbiology and Immunology, University of California, San Francisco 94143-0552, USA
    Traffic 2:851-8. 2001
  9. ncbi request reprint Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4
    X Lu
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco, 94143 0703, USA
    Immunity 8:647-56. 1998
  10. ncbi request reprint Enhanced interaction of HLA-DM with HLA-DR in enlarged vacuoles of hereditary and infectious lysosomal diseases
    L Lem
    The G W Hooper Foundation, Department of Microbiology and Immunology, University of California, San Francisco 94143, USA
    J Immunol 162:523-32. 1999

Collaborators

Detail Information

Publications14

  1. pmc T cell receptor engagement leads to phosphorylation of clathrin heavy chain during receptor internalization
    Victoria L Crotzer
    The GW Hooper Foundation, Department of Microbiology, University of California San Francisco, 94143, USA
    J Exp Med 199:981-91. 2004
    ..Thus, we propose that CHC phosphorylation and dephosphorylation are involved in TCR internalization and that this is a regulatory mechanism linking TCR signaling to endocytosis...
  2. ncbi request reprint Biological basket weaving: formation and function of clathrin-coated vesicles
    F M Brodsky
    Department of Biopharmaceutical Sciences, University of California, San Francisco, California, USA
    Annu Rev Cell Dev Biol 17:517-68. 2001
    ..Tissue-specific functions of CCVs require even more-specialized regulation and defects in these pathways can now be correlated with human diseases...
  3. ncbi request reprint Human pathogen subversion of antigen presentation
    F M Brodsky
    G W Hooper Foundation, Department of Microbiology and Immunology, University of California, San Francisco 94143 0552, USA
    Immunol Rev 168:199-215. 1999
    ..Pathogen-host co-evolution is evident in these subversion tactics for which the pathogen crime seems tailored to fit the immune system punishment...
  4. pmc Clathrin hub expression affects early endosome distribution with minimal impact on receptor sorting and recycling
    E M Bennett
    Department of Microbiology and Immunology, The G. W. Hooper Foundation, University of California, San Francisco, CA 94143-0552, USA
    Mol Biol Cell 12:2790-9. 2001
    ..Thus, clathrin's role on endosomal membranes is to influence organelle localization and is distinct from its role in trafficking pathways at the plasma membrane and trans-Golgi network...
  5. pmc A novel clathrin homolog that co-distributes with cytoskeletal components functions in the trans-Golgi network
    S H Liu
    The G.W.Hooper Foundation, Department of Microbiology, University of California, San Francisco, CA 94143-0552, USA
    EMBO J 20:272-84. 2001
    ..Overexpression of a subdomain of CHC22 induces altered distribution of TGN markers. Together these results implicate CHC22 in TGN membrane traffic involving the cytoskeleton...
  6. ncbi request reprint Molecular structures of proteins involved in vesicle coat formation
    D E Wakeham
    G W Hooper Foundation, Box 0552, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Traffic 1:393-8. 2000
    ..This review includes 16 structures of vesicle coat components and accessory proteins and a description of their roles in vesicle budding or coat disassembly...
  7. ncbi request reprint Clathrin self-assembly is mediated by a tandemly repeated superhelix
    J A Ybe
    The G W Hooper Foundation, Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
    Nature 399:371-5. 1999
    ..The resulting model provides a three-dimensional framework for understanding clathrin heavy-chain self-assembly, light-chain binding and trimerization...
  8. ncbi request reprint Clathrin hub expression dissociates the actin-binding protein Hip1R from coated pits and disrupts their alignment with the actin cytoskeleton
    E M Bennett
    The G. W. Hooper Foundation, Department of Microbiology and Immunology, University of California, San Francisco 94143-0552, USA
    Traffic 2:851-8. 2001
    ..These findings indicate that proper function of clathrin is required for coated pit alignment with the actin cytoskeleton and suggest that the clathrin-Hip1R interaction is involved in the cytoskeletal organization of coated pits...
  9. ncbi request reprint Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4
    X Lu
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco, 94143 0703, USA
    Immunity 8:647-56. 1998
    ..Direct interactions between Nef and NBP1 were correlated with the ability of Nef to internalize CD4. The expression of the antisense NBP1 abrogated these effects. We conclude that NBP1 helps to connect Nef with the endocytic pathway...
  10. ncbi request reprint Enhanced interaction of HLA-DM with HLA-DR in enlarged vacuoles of hereditary and infectious lysosomal diseases
    L Lem
    The G W Hooper Foundation, Department of Microbiology and Immunology, University of California, San Francisco 94143, USA
    J Immunol 162:523-32. 1999
    ..These findings suggest a mechanism for perturbation of Ag presentation by class II molecules and consequent immune deficiencies in both diseases...
  11. ncbi request reprint Cutting edge: adenovirus E19 has two mechanisms for affecting class I MHC expression
    E M Bennett
    The G W Hooper Foundation, Department of Microbiology and Immunology, University of California, San Francisco 94143, USA
    J Immunol 162:5049-52. 1999
    ....
  12. ncbi request reprint Regulation of clathrin assembly and trimerization defined using recombinant triskelion hubs
    S H Liu
    Department of Pharmacy, School of Pharmacy, University of California, San Francisco 94143 0552, USA
    Cell 83:257-67. 1995
    ..These studies define molecular interactions controlling clathrin self-assembly and establish a recombinant system for future analysis...
  13. ncbi request reprint Neuron-specific expression of high-molecular-weight clathrin light chain
    D H Wong
    Department of Pharmacy, School of Pharmacy, University of California, San Francisco
    J Neurosci 10:3025-31. 1990
    ..These results indicate that the high-molecular-weight forms of clathrin light chains are restricted in expression and found in neuronal cells...
  14. pmc Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells
    Dun Yang
    G W Hooper Foundation and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0552, USA
    Proc Natl Acad Sci U S A 99:9942-7. 2002
    ..esiRNA works by eliciting the destruction of its cognate mRNA. Because of its simplicity and potency, this approach is useful for analysis of mammalian gene functions...