EDWARD BRODKIN

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Social approach-avoidance behavior of inbred mouse strains towards DBA/2 mice
    Edward S Brodkin
    Department of Psychiatry, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Room 111, Philadelphia, PA 19104 6140, USA
    Brain Res 1002:151-7. 2004
  2. ncbi request reprint BALB/c mice: low sociability and other phenotypes that may be relevant to autism
    Edward S Brodkin
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Translational Research Laboratory, Philadelphia, PA 19104 3403, USA
    Behav Brain Res 176:53-65. 2007
  3. pmc Association between polymorphisms in the metallophosphoesterase (MPPE1) gene and bipolar disorder
    Falk W Lohoff
    Translational Research Laboratory, Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, 125 South 31st Street, Room 2213, Philadelphia, PA 19104, USA
    Am J Med Genet B Neuropsychiatr Genet 153:830-6. 2010
  4. doi request reprint Social behavior phenotypes in fragile X syndrome, autism, and the Fmr1 knockout mouse: theoretical comment on McNaughton et al. (2008)
    Edward S Brodkin
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, School of Medicine, Philadelphia 19104 3403, USA
    Behav Neurosci 122:483-9. 2008
  5. pmc Serotonin transporter genotype modulates amygdala activity during mood regulation
    Seth J Gillihan
    Center for Cognitive Neuroscience, Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Soc Cogn Affect Neurosci 5:1-10. 2010
  6. ncbi request reprint Genetic variation in serotonin transporter alters resting brain function in healthy individuals
    Hengyi Rao
    Center for Functional Neuroimaging, Department of Neurology and Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Biol Psychiatry 62:600-6. 2007
  7. ncbi request reprint A mouse model system for genetic analysis of sociability: C57BL/6J versus BALB/cJ inbred mouse strains
    Geena Mary V Sankoorikal
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6140, USA
    Biol Psychiatry 59:415-23. 2006
  8. pmc Low sociability is associated with reduced size of the corpus callosum in the BALB/cJ inbred mouse strain
    Andrew H Fairless
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Translational Research Laboratory, 125 South 31st Street, Room 2220, Philadelphia, PA 19104 3403, USA
    Brain Res 1230:211-7. 2008
  9. ncbi request reprint Pharmacogenomic evaluation of the antidepressant citalopram in the mouse tail suspension test
    James J Crowley
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 31:2433-42. 2006
  10. pmc Neuregulin 1 transgenic mice display reduced mismatch negativity, contextual fear conditioning and social interactions
    Richard S Ehrlichman
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Brain Res 1294:116-27. 2009

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Social approach-avoidance behavior of inbred mouse strains towards DBA/2 mice
    Edward S Brodkin
    Department of Psychiatry, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Room 111, Philadelphia, PA 19104 6140, USA
    Brain Res 1002:151-7. 2004
    ..Thus, this phenotype is affected by spontaneous genetic variation in mice and can be measured in an assay useful for future neurogenetic studies...
  2. ncbi request reprint BALB/c mice: low sociability and other phenotypes that may be relevant to autism
    Edward S Brodkin
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Translational Research Laboratory, Philadelphia, PA 19104 3403, USA
    Behav Brain Res 176:53-65. 2007
    ..In conclusion, the BALB/c inbred strain may be a useful animal model for identifying genes and neurobiological pathways involved in autism-related phenotypes...
  3. pmc Association between polymorphisms in the metallophosphoesterase (MPPE1) gene and bipolar disorder
    Falk W Lohoff
    Translational Research Laboratory, Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, 125 South 31st Street, Room 2213, Philadelphia, PA 19104, USA
    Am J Med Genet B Neuropsychiatr Genet 153:830-6. 2010
    ..Our results provide evidence of an association between a polymorphism in the MPPE1 gene and BPD. Additional studies are necessary to confirm and elucidate the role of MPPE1 as a susceptibility gene for BPD on chromosome 18p...
  4. doi request reprint Social behavior phenotypes in fragile X syndrome, autism, and the Fmr1 knockout mouse: theoretical comment on McNaughton et al. (2008)
    Edward S Brodkin
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, School of Medicine, Philadelphia 19104 3403, USA
    Behav Neurosci 122:483-9. 2008
    ..Their significant refinements in measurement of social behavior phenotypes will help to advance future efforts to elucidate the genetic and neural mechanisms underlying social behavior disturbances in FXS and autism...
  5. pmc Serotonin transporter genotype modulates amygdala activity during mood regulation
    Seth J Gillihan
    Center for Cognitive Neuroscience, Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Soc Cogn Affect Neurosci 5:1-10. 2010
    ....
  6. ncbi request reprint Genetic variation in serotonin transporter alters resting brain function in healthy individuals
    Hengyi Rao
    Center for Functional Neuroimaging, Department of Neurology and Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Biol Psychiatry 62:600-6. 2007
    ..Perfusion functional magnetic resonance imaging (fMRI) was used to investigate the effect of genetic variation of the human serotonin transporter (5-HTT) gene (5-HTTLPR, SLC6A4) on resting brain function of healthy individuals...
  7. ncbi request reprint A mouse model system for genetic analysis of sociability: C57BL/6J versus BALB/cJ inbred mouse strains
    Geena Mary V Sankoorikal
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6140, USA
    Biol Psychiatry 59:415-23. 2006
    ..To progress toward developing such a model system, we tested the hypothesis that C57BL/6J inbred mice show higher levels of sociability than BALB/cJ inbred mice...
  8. pmc Low sociability is associated with reduced size of the corpus callosum in the BALB/cJ inbred mouse strain
    Andrew H Fairless
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Translational Research Laboratory, 125 South 31st Street, Room 2220, Philadelphia, PA 19104 3403, USA
    Brain Res 1230:211-7. 2008
    ..Additional studies are warranted to elucidate the relationship between brain connectivity and sociability in this model system...
  9. ncbi request reprint Pharmacogenomic evaluation of the antidepressant citalopram in the mouse tail suspension test
    James J Crowley
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 31:2433-42. 2006
    ..The present quantitative trait study suggests possible candidate genes for human pharmacogenetic studies of therapeutic responses to SSRIs such as citalopram...
  10. pmc Neuregulin 1 transgenic mice display reduced mismatch negativity, contextual fear conditioning and social interactions
    Richard S Ehrlichman
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Brain Res 1294:116-27. 2009
    ..Event-related potentials (ERPs) were recorded to assess auditory gating and novel stimulus detection...
  11. ncbi request reprint Association between serotonin transporter genotype and extraversion
    Seth J Gillihan
    Center for Cognitive Neuroscience, Department of Psychology, University of Pennsylvania, Philadelphia 19104 3403, Pennsylvania, USA
    Psychiatr Genet 17:351-4. 2007
    ..4% of the variance in extraversion. These findings provide support for the effect of the 5-HTTLPR, and for the serotonergic system more broadly, on behaviors related to extraversion...
  12. ncbi request reprint Identification of quantitative trait Loci that affect aggressive behavior in mice
    Edward S Brodkin
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Neurosci 22:1165-70. 2002
    ....

Research Grants6

  1. GENETIC DISSECTION OF AGGRESSIVE BEHAVIORS
    EDWARD BRODKIN; Fiscal Year: 2007
    ..Dr. Wade Berrettini will be the mentor, and Drs. Maja Bucan, Russell Buono, Thomas Ferraro, and Irwin Lucki will provide additional consultation in genetics and behavioral analysis. ..
  2. Neurobiology of sociability in a mouse model system relevant to autism
    EDWARD BRODKIN; Fiscal Year: 2009
    ..By testing the relationships among social behavior and brain phenotypes relevant to autism, these studies may identify promising directions for future clinical and basic research on sociability impairments in autism. ..
  3. Neurobiology of sociability in a mouse model system relevant to autism
    Edward S Brodkin; Fiscal Year: 2010
    ..By testing the relationships among social behavior and brain phenotypes relevant to autism, these studies may identify promising directions for future clinical and basic research on sociability impairments in autism. ..
  4. Neurobiology of sociability in a mouse model system relevant to autism
    EDWARD BRODKIN; Fiscal Year: 2009
    ..By testing the relationships among social behavior and brain phenotypes relevant to autism, these studies may identify promising directions for future clinical and basic research on sociability impairments in autism. ..