Mark Brodie

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. pmc Reversal of dopamine D2 agonist-induced inhibition of ventral tegmental area neurons by Gq-linked neurotransmitters is dependent on protein kinase C, G protein-coupled receptor kinase, and dynamin
    Sudarat Nimitvilai
    Department of Physiology and Biophysics, University of Illinois at Chicago, 835 S Wolcott, Chicago, IL 60612 7342, USA
    J Pharmacol Exp Ther 344:253-63. 2013
  2. pmc Reversal of quinpirole inhibition of ventral tegmental area neurons is linked to the phosphatidylinositol system and is induced by agonists linked to G(q)
    Sudarat Nimitvilai
    Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612 7342, USA
    J Neurophysiol 108:263-74. 2012
  3. ncbi request reprint Ethanol directly excites dopaminergic ventral tegmental area reward neurons
    M S Brodie
    Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine, 60612 7342, USA
    Alcohol Clin Exp Res 23:1848-52. 1999
  4. ncbi request reprint Dopaminergic neurons in the ventral tegmental area of C57BL/6J and DBA/2J mice differ in sensitivity to ethanol excitation
    M S Brodie
    Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine, 60612 7342, USA
    Alcohol Clin Exp Res 24:1120-4. 2000
  5. ncbi request reprint Increased ethanol excitation of dopaminergic neurons of the ventral tegmental area after chronic ethanol treatment
    Mark S Brodie
    Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine, Chicago, Illinois 60612 7342, USA
    Alcohol Clin Exp Res 26:1024-30. 2002
  6. ncbi request reprint Electrophysiological effects of cocaethylene, cocaine, and ethanol on dopaminergic neurons of the ventral tegmental area
    E B Bunney
    Department of Emergency Medicine, University of Illinois, College of Medicine, Chicago, Illinois 60612-7354, USA
    J Pharmacol Exp Ther 297:696-703. 2001
  7. ncbi request reprint The effects of clomipramine on the excitatory action of ethanol on dopaminergic neurons of the ventral tegmental area in vitro
    R D Trifunović
    Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine, USA
    J Pharmacol Exp Ther 276:34-40. 1996
  8. ncbi request reprint Cocaine potentiates ethanol-induced excitation of dopaminergic reward neurons in the ventral tegmental area
    E B Bunney
    Department of Emergency Medicine, University of Illinois at Chicago, College of Medicine, Chicago, Illinois 60612 7342, USA
    J Pharmacol Exp Ther 293:383-9. 2000
  9. ncbi request reprint Ethanol excitation of dopaminergic ventral tegmental area neurons is blocked by quinidine
    Sarah B Appel
    Department of Physiology and Biophysics M C 901, University of Illinois at Chicago, 835 S Wolcott Ave, Chicago, IL 60612 7342, USA
    J Pharmacol Exp Ther 306:437-46. 2003
  10. pmc Dissociation of rewarding and dopamine transporter-mediated properties of amphetamine
    Evgeny A Budygin
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Proc Natl Acad Sci U S A 101:7781-6. 2004

Collaborators

Detail Information

Publications15

  1. pmc Reversal of dopamine D2 agonist-induced inhibition of ventral tegmental area neurons by Gq-linked neurotransmitters is dependent on protein kinase C, G protein-coupled receptor kinase, and dynamin
    Sudarat Nimitvilai
    Department of Physiology and Biophysics, University of Illinois at Chicago, 835 S Wolcott, Chicago, IL 60612 7342, USA
    J Pharmacol Exp Ther 344:253-63. 2013
    ..As drugs of abuse produce persistent increases in DA concentration in the ventral tegmental area, reduction of D2 receptor sensitivity as a result of drug abuse may be a critical factor in the processes of addiction...
  2. pmc Reversal of quinpirole inhibition of ventral tegmental area neurons is linked to the phosphatidylinositol system and is induced by agonists linked to G(q)
    Sudarat Nimitvilai
    Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612 7342, USA
    J Neurophysiol 108:263-74. 2012
    ..These results indicate that some agonists that stimulate PI turnover can facilitate desensitization of D2 receptors but that there may be other factors in addition to PI that control that interaction...
  3. ncbi request reprint Ethanol directly excites dopaminergic ventral tegmental area reward neurons
    M S Brodie
    Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine, 60612 7342, USA
    Alcohol Clin Exp Res 23:1848-52. 1999
    ....
  4. ncbi request reprint Dopaminergic neurons in the ventral tegmental area of C57BL/6J and DBA/2J mice differ in sensitivity to ethanol excitation
    M S Brodie
    Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine, 60612 7342, USA
    Alcohol Clin Exp Res 24:1120-4. 2000
    ..The present electrophysiological study examined the effect of ethanol on individual dopaminergic VTA neurons from these two inbred mouse strains...
  5. ncbi request reprint Increased ethanol excitation of dopaminergic neurons of the ventral tegmental area after chronic ethanol treatment
    Mark S Brodie
    Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine, Chicago, Illinois 60612 7342, USA
    Alcohol Clin Exp Res 26:1024-30. 2002
    ....
  6. ncbi request reprint Electrophysiological effects of cocaethylene, cocaine, and ethanol on dopaminergic neurons of the ventral tegmental area
    E B Bunney
    Department of Emergency Medicine, University of Illinois, College of Medicine, Chicago, Illinois 60612-7354, USA
    J Pharmacol Exp Ther 297:696-703. 2001
    ....
  7. ncbi request reprint The effects of clomipramine on the excitatory action of ethanol on dopaminergic neurons of the ventral tegmental area in vitro
    R D Trifunović
    Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine, USA
    J Pharmacol Exp Ther 276:34-40. 1996
    ..These results may have some implications for the development of serotonergic drugs, including serotonin uptake inhibitors, for the treatment of alcoholism...
  8. ncbi request reprint Cocaine potentiates ethanol-induced excitation of dopaminergic reward neurons in the ventral tegmental area
    E B Bunney
    Department of Emergency Medicine, University of Illinois at Chicago, College of Medicine, Chicago, Illinois 60612 7342, USA
    J Pharmacol Exp Ther 293:383-9. 2000
    ..The enhanced ethanol excitation of VTA dopaminergic neurons caused by cocaine may partially explain the high incidence of the coabuse of these two substances...
  9. ncbi request reprint Ethanol excitation of dopaminergic ventral tegmental area neurons is blocked by quinidine
    Sarah B Appel
    Department of Physiology and Biophysics M C 901, University of Illinois at Chicago, 835 S Wolcott Ave, Chicago, IL 60612 7342, USA
    J Pharmacol Exp Ther 306:437-46. 2003
    ..This effect of quinidine was concentration-dependent and reversible. These results suggest that ethanol excites DA VTA neurons by reducing a quinidine-sensitive K+ current...
  10. pmc Dissociation of rewarding and dopamine transporter-mediated properties of amphetamine
    Evgeny A Budygin
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Proc Natl Acad Sci U S A 101:7781-6. 2004
    ..The 5-HT system may be involved in the rewarding effects of AMPH in these mice...
  11. ncbi request reprint Queer currents, steady rhythms, and drunken da neurons. Focus on "hyperpolarization-activated cation current (Ih) is an ethanol target in midbrain dopamine neurons of mice"
    Carl R Lupica
    J Neurophysiol 95:585-6. 2006
  12. pmc Ethanol inhibition of m-current and ethanol-induced direct excitation of ventral tegmental area dopamine neurons
    Susumu Koyama
    Department of Physiology and Biophysics M C 901 University of Illinois at Chicago, 835 S Wolcott Avenue, Chicago, IL 60612 7342, USA
    J Neurophysiol 97:1977-85. 2007
    ....
  13. ncbi request reprint Ethanol interactions with calcium-dependent potassium channels
    Mark S Brodie
    Department of Physiology and Biophysics, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA
    Alcohol Clin Exp Res 31:1625-32. 2007
    ....
  14. ncbi request reprint Serotonin reduces the hyperpolarization-activated current (Ih) in ventral tegmental area dopamine neurons: involvement of 5-HT2 receptors and protein kinase C
    Zhaoping Liu
    Departments of Physiology and Biophysics and Emergency Medicine, University of Illinois, Chicago, Illinois 60612, USA
    J Neurophysiol 90:3201-12. 2003
    ....
  15. ncbi request reprint The effects of long chain-length n-alcohols on the firing frequency of dopaminergic neurons of the ventral tegmental area
    Sarah B Appel
    Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612 7342, USA
    J Pharmacol Exp Ther 318:1137-45. 2006
    ..This is likely to be a characteristic of the ethanol-sensitive element of DA VTA neurons and may be useful in identifying the element of the membrane that is responsible for ethanol-induced excitation...

Research Grants12

  1. INTRACELLULAR STUDY OF ETHANOL EFFECTS ON BRAIN NEURONS
    Mark Brodie; Fiscal Year: 2009
    ..abstract_text> ..
  2. ETHANOL-NEUROTRANSMITTER INTERACTIONS IN BRAIN NEURONS
    Mark Brodie; Fiscal Year: 2007
    ..Ultimately, information generated by this project may help in the development of pharmacotherapies for the amelioration of alcoholism. ..
  3. ETHANOL/NEUROTRANSMITTER INTERACTIONS IN BRAIN NEURONS
    Mark Brodie; Fiscal Year: 2000
    ..These studies should elucidate the ionic mechanisms by which serotonin alters the action of ethanol in the VTA. This knowledge could be exploited to develop drugs for the treatment of alcoholism which reduce ethanol craving. ..
  4. ETHANOL-NEUROTRANSMITTER INTERACTIONS IN BRAIN NEURONS
    Mark Brodie; Fiscal Year: 1993
    ....
  5. INTRACELLULAR STUDY OF ETHANOL EFFECTS ON BRAIN NEURONS
    Mark S Brodie; Fiscal Year: 2010
    ..abstract_text> ..