JOSEPH PAUL BRODERICK

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. pmc Endovascular therapy after intravenous t-PA versus t-PA alone for stroke
    Joseph P Broderick
    Department of Neurology, University of Cincinnati Neuroscience Institute, University of Cincinnati Academic Health Center, Cincinnati, OH 45267 0525, USA
    N Engl J Med 368:893-903. 2013
  2. pmc The use of standardized patients for mock oral board exams in neurology: a pilot study
    Brett Kissela
    Department of Neurology, University of Cincinnati, Cincinnati, OH 45267 0525, USA
    BMC Med Educ 6:22. 2006
  3. ncbi request reprint Apolipoprotein E phenotype and the efficacy of intravenous tissue plasminogen activator in acute ischemic stroke
    J Broderick
    Department of Neurology, University of Cincinnati, OH 45267 0525, USA
    Ann Neurol 49:736-44. 2001
  4. ncbi request reprint Overview of stroke care in the United States and beyond
    Joseph P Broderick
    Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0525, USA
    Am J Prev Med 31:S189-91. 2006
  5. doi request reprint Endovascular therapy for acute ischemic stroke
    Joseph P Broderick
    Department of Neurology, 260 Stetson St, Suite 2300, University of Cincinnati Medical Center, PO Box, Cincinnati, OH, USA
    Stroke 40:S103-6. 2009
  6. ncbi request reprint The STICH trial: what does it tell us and where do we go from here?
    Joseph P Broderick
    Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Stroke 36:1619-20. 2005
  7. pmc The Familial Intracranial Aneurysm (FIA) study protocol
    Joseph P Broderick
    Department of Neurology, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267 0525, USA
    BMC Med Genet 6:17. 2005
  8. pmc Greater rupture risk for familial as compared to sporadic unruptured intracranial aneurysms
    Joseph P Broderick
    Department of Neurology, Center for Stroke and Cerebrovascular Disease, University of Cincinnati Neuroscience Institute, UC College of Medicine, 260 Stetson Street, Cincinnati, OH 45267 0525, USA
    Stroke 40:1952-7. 2009
  9. ncbi request reprint Gross underfunding of stroke research
    Joseph Broderick
    Department of Neurology, University of Cincinnati, OH, USA
    Lancet Neurol 3:705-6. 2004
  10. ncbi request reprint Treatment of acute ischemic stroke: Part I: recanalization strategies
    Joseph P Broderick
    Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Circulation 106:1563-9. 2002

Research Grants

  1. Familial Intracranial Aneurysm Study II (FIA II)
    JOSEPH PAUL BRODERICK; Fiscal Year: 2010
  2. Interventional Management of Stroke III Planning Grant
    Joseph Broderick; Fiscal Year: 2004
  3. HEMORRHAGIC AND ISCHEMIC STROKE AMONG BLACKS AND WHITES
    Joseph Broderick; Fiscal Year: 2003
  4. HEMORRHAGIC AND ISCHEMIC STROKE AMONG BLACKS AND WHITES
    Joseph Broderick; Fiscal Year: 2005
  5. Familial Intracranial Aneurysm Study
    Joseph Broderick; Fiscal Year: 2006
  6. Familiar Intracranial Aneurysm Study II (FIA II)
    Joseph Broderick; Fiscal Year: 2009
  7. Cerebrovascular Fellowship Training Program
    Joseph Broderick; Fiscal Year: 2007
  8. Genetic&Environment Risk Factors for Hemorrhagic Stroke
    Joseph Broderick; Fiscal Year: 2006
  9. Interventional Management of Stroke Study
    Joseph Broderick; Fiscal Year: 2007
  10. Recanalization Therapies and Markers of Stroke Outcome
    Joseph Broderick; Fiscal Year: 2006

Detail Information

Publications43

  1. pmc Endovascular therapy after intravenous t-PA versus t-PA alone for stroke
    Joseph P Broderick
    Department of Neurology, University of Cincinnati Neuroscience Institute, University of Cincinnati Academic Health Center, Cincinnati, OH 45267 0525, USA
    N Engl J Med 368:893-903. 2013
    ....
  2. pmc The use of standardized patients for mock oral board exams in neurology: a pilot study
    Brett Kissela
    Department of Neurology, University of Cincinnati, Cincinnati, OH 45267 0525, USA
    BMC Med Educ 6:22. 2006
    ..We sought to create a standardized patient mock oral board exam that would allow comparison of residents' clinical performance...
  3. ncbi request reprint Apolipoprotein E phenotype and the efficacy of intravenous tissue plasminogen activator in acute ischemic stroke
    J Broderick
    Department of Neurology, University of Cincinnati, OH 45267 0525, USA
    Ann Neurol 49:736-44. 2001
    ..In contrast to prior studies of head injury and stroke, we could not detect a relationship between Apo E4 phenotype and clinical outcome...
  4. ncbi request reprint Overview of stroke care in the United States and beyond
    Joseph P Broderick
    Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0525, USA
    Am J Prev Med 31:S189-91. 2006
  5. doi request reprint Endovascular therapy for acute ischemic stroke
    Joseph P Broderick
    Department of Neurology, 260 Stetson St, Suite 2300, University of Cincinnati Medical Center, PO Box, Cincinnati, OH, USA
    Stroke 40:S103-6. 2009
    ..To review advances in endovascular therapy for acute ischemic stroke...
  6. ncbi request reprint The STICH trial: what does it tell us and where do we go from here?
    Joseph P Broderick
    Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Stroke 36:1619-20. 2005
  7. pmc The Familial Intracranial Aneurysm (FIA) study protocol
    Joseph P Broderick
    Department of Neurology, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267 0525, USA
    BMC Med Genet 6:17. 2005
    ..The long-term goal of the Familial Intracranial Aneurysm (FIA) Study is to identify genes that underlie the development and rupture of intracranial aneurysms (IA)...
  8. pmc Greater rupture risk for familial as compared to sporadic unruptured intracranial aneurysms
    Joseph P Broderick
    Department of Neurology, Center for Stroke and Cerebrovascular Disease, University of Cincinnati Neuroscience Institute, UC College of Medicine, 260 Stetson Street, Cincinnati, OH 45267 0525, USA
    Stroke 40:1952-7. 2009
    ..The risk of intracranial aneurysm (IA) rupture in asymptomatic members of families who have multiple affected individuals is not known...
  9. ncbi request reprint Gross underfunding of stroke research
    Joseph Broderick
    Department of Neurology, University of Cincinnati, OH, USA
    Lancet Neurol 3:705-6. 2004
  10. ncbi request reprint Treatment of acute ischemic stroke: Part I: recanalization strategies
    Joseph P Broderick
    Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Circulation 106:1563-9. 2002
  11. pmc Withdrawal of antithrombotic agents and its impact on ischemic stroke occurrence
    Joseph P Broderick
    University of Cincinnati, Department of Neurology, University of Cincinnati Neuroscience Institute, University of Cincinnati Academic Health Center MSB 0525, Cincinnati, OH 45242, USA
    Stroke 42:2509-14. 2011
    ..These medications are also stopped by patients for various reasons such as cost, side effects, or unwillingness to take medication...
  12. pmc Equipoise among recanalization strategies
    T A Tomsick
    Department of Neurology, UC Neuroscience Institute, University of Cincinnati Academic Health Center, Cincinnati, OH 45267 0525, USA
    Neurology 74:1069-76. 2010
    ..Where equipoise exists, randomizing subjects to either IV rt-PA therapy or IV therapy followed by IA intervention, while incorporating new interventions into the study design, is a rational and appropriate research approach...
  13. ncbi request reprint Major risk factors for aneurysmal subarachnoid hemorrhage in the young are modifiable
    Joseph P Broderick
    Department of Neurology, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267, USA
    Stroke 34:1375-81. 2003
    ..To identify risk factors for subarachnoid hemorrhage (SAH) and intracerebral hemorrhage, we designed a case-control study of men and women 18 to 49 years of age (the Hemorrhagic Stroke Project [HSP]). This report focuses on SAH...
  14. ncbi request reprint William M. Feinberg Lecture: stroke therapy in the year 2025: burden, breakthroughs, and barriers to progress
    Joseph P Broderick
    Division of Neurology, University of Cincinnati College of Medicine, 231 Bethesda Ave, Mail Location 525, Cincinnati, Ohio 45242, USA
    Stroke 35:205-11. 2004
    ....
  15. ncbi request reprint Association of ALOX5AP with ischemic stroke: a population-based case-control study
    Ritesh Kaushal
    Department of Environmental Health, Center for Genome Information, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0525, USA
    Hum Genet 121:601-7. 2007
    ..In conclusion, we report significant association of variants of ALOX5AP with ischemic stroke and ischemic stroke subtypes among whites. No significant association was identified among blacks...
  16. pmc Intravenous recombinant tissue plasminogen activator improves arterial recanalization rates and reduces infarct volumes in patients with hyperdense artery sign on baseline computed tomography
    Christopher Nichols
    University of Cincinnati College of Medicine, Cincinnati, Ohio 45267
    J Stroke Cerebrovasc Dis 17:64-8. 2008
    ....
  17. ncbi request reprint Safety and feasibility of recombinant factor VIIa for acute intracerebral hemorrhage
    Stephan A Mayer
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Stroke 36:74-9. 2005
    ..Activated recombinant factor VII (rFVIIa) promotes hemostasis at sites of vascular injury and may minimize hematoma growth after ICH...
  18. ncbi request reprint Recombinant activated factor VII for acute intracerebral hemorrhage
    Stephan A Mayer
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA
    N Engl J Med 352:777-85. 2005
    ..We sought to determine whether recombinant activated factor VII (rFVIIa) can reduce hematoma growth after intracerebral hemorrhage...
  19. pmc Subarachnoid hemorrhage: tests of association with apolipoprotein E and elastin genes
    Ritesh Kaushal
    Department of Environmental Health, Center for Genome Information, University of Cincinnati, Cincinnati, Ohio, USA
    BMC Med Genet 8:49. 2007
    ..Associations were tested at genotype, allele, and haplotype levels. A genomic control analysis was performed to check for spurious associations resulting from population substructure...
  20. pmc Eligibility for the surgical trial in intracerebral hemorrhage II study in a population-based cohort
    Opeolu Adeoye
    Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA
    Neurocrit Care 9:237-41. 2008
    ..We sought to determine how many patients in a population-based ICH cohort would have been eligible for surgery using the Surgical Trial in Intracerebral Hemorrhage II (STICH II) criteria...
  21. doi request reprint Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage
    Stephan A Mayer
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA
    N Engl J Med 358:2127-37. 2008
    ..We performed this phase 3 trial to confirm a previous study in which recombinant activated factor VII (rFVIIa) reduced growth of the hematoma and improved survival and functional outcomes...
  22. pmc The combined approach to lysis utilizing eptifibatide and rt-PA in acute ischemic stroke: the CLEAR stroke trial
    Arthur M Pancioli
    Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0769, USA
    Stroke 39:3268-76. 2008
    ....
  23. pmc Surgical management and case-fatality rates of intracerebral hemorrhage in 1988 and 2005
    Opeolu Adeoye
    Department of Emergency Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0525, USA
    Neurosurgery 63:1113-7; discussion 1117-8. 2008
    ..To compare surgical management and case-fatality rates of intracerebral hemorrhage (ICH) in 1988 and 2005...
  24. pmc Clinical prediction of functional outcome after ischemic stroke: the surprising importance of periventricular white matter disease and race
    Brett Kissela
    Department of Neurology, University of Cincinnati, Ohio, USA
    Stroke 40:530-6. 2009
    ....
  25. pmc Emergency medical services use by stroke patients: a population-based study
    Opeolu Adeoye
    Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA
    Am J Emerg Med 27:141-5. 2009
    ..In an epidemiological study, we determined the proportion of stroke patients who used EMS, hypothesizing that demographics, stroke severity, stroke type, and location at stroke onset would be associated with EMS use...
  26. pmc The effects of study participation in the Familial Intracranial Aneurysm Study on cigarette smoking
    Laura R Sauerbeck
    Department of Neurology, University of Cincinnati, Ohio 45267 0525, USA
    J Stroke Cerebrovasc Dis 17:370-2. 2008
    ..Cigarette smoking is the most modifiable risk factor for the formation and rupture of intracranial aneurysm (IA). This study examined the impact of participation in the Familial IA study on smoking behavior...
  27. ncbi request reprint Association of Phosphodiesterase 4D with ischemic stroke: a population-based case-control study
    Daniel Woo
    Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0525, USA
    Stroke 37:371-6. 2006
    ..None of the reports included significant proportions of blacks. We tested for genotype and haplotype association of polymorphisms of the PDE4D gene with ischemic stroke in a population-based, biracial, case-control study...
  28. ncbi request reprint Ischemic stroke subtypes: a population-based study of incidence rates among blacks and whites
    Alexander T Schneider
    Department of Neurology and the Neuroscience Institute, 231 Albert Sabin Way, University of Cincinnati, ML 0525, Cincinnati, Ohio 45267, USA
    Stroke 35:1552-6. 2004
    ..The objective of this study is to compare the incidence rates of ischemic stroke subtypes between blacks and whites within a large, representative, biracial population...
  29. ncbi request reprint Stroke in a biracial population: the excess burden of stroke among blacks
    Brett Kissela
    Department of Neurology, Neuroscience Institute, University of Cincinnati, OH 45267 0525, USA
    Stroke 35:426-31. 2004
    ..31 million people, which is representative of the US white and black populations with regard to many demographic and socioeconomic characteristics...
  30. ncbi request reprint Association of apolipoprotein E4 and haplotypes of the apolipoprotein E gene with lobar intracerebral hemorrhage
    Daniel Woo
    University of Cincinnati, Cincinnati, OH, USA
    Stroke 36:1874-9. 2005
    ..We genotyped 12 single-nucleotide polymorphisms in the 5' upstream regulatory, exonic, and intronic regions of the apo E gene and performed genotype and haplotype association analyses...
  31. ncbi request reprint Subarachnoid hemorrhage: a preventable disease with a heritable component
    Brett M Kissela
    Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0525, USA
    Stroke 33:1321-6. 2002
    ..Prevention of SAH is therefore of paramount importance. We present a preliminary analysis of risk factors for SAH from our population-based, case-control study...
  32. ncbi request reprint Lack of evidence for an association between hemodynamic variables and hematoma growth in spontaneous intracerebral hemorrhage
    Edward C Jauch
    Department of Emergency Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0769, USA
    Stroke 37:2061-5. 2006
    ..We hypothesized that hemodynamic parameters are associated with the increase in hematoma volume owing to their relationship to blood vessel wall stresses...
  33. ncbi request reprint The unchanging incidence and case-fatality of stroke in the 1990s: a population-based study
    Dawn Kleindorfer
    University of Cincinnati, 231 Albert Sabin Way ML 0525, Cincinnati, OH 45267 0525, USA
    Stroke 37:2473-8. 2006
    ..The objective of this study was to examine temporal trends in stroke incidence and case-fatality within a large, biracial population during the 1990s...
  34. ncbi request reprint Association of serial biochemical markers with acute ischemic stroke: the National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator Stroke Study
    Edward C Jauch
    Department of Emergency Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267 0769, USA
    Stroke 37:2508-13. 2006
    ..These biochemical markers, myelin basic protein (MBP), neuron-specific enolase (NSE), S100beta, and soluble thrombomodulin, were studied for an association with initial stroke severity, infarct volume, and functional outcome...
  35. ncbi request reprint Impact of socioeconomic status on stroke incidence: a population-based study
    Dawn O Kleindorfer
    Department of Neurology, University of Cincinnati, Cincinnati, OH, USA
    Ann Neurol 60:480-4. 2006
  36. ncbi request reprint Impact of recombinant activated factor VII on health-related quality of life after intracerebral hemorrhage
    Michael N Diringer
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cerebrovasc Dis 24:219-25. 2007
    ..29%) and poor outcome (modified Rankin Scale, mRS, 4-6, 53 vs. 69%). This analysis was performed to determine the impact of rFVIIa on health-related quality of life (HRQoL) in those patients...
  37. ncbi request reprint Effect of untreated hypertension on hemorrhagic stroke
    Daniel Woo
    University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0525, Cincinnati, OH 45267 0525, USA
    Stroke 35:1703-8. 2004
    ..Hypertension is an important risk factor for these subtypes of stroke. We sought to determine whether untreated hypertension carries a different risk from treated hypertension for hemorrhagic stroke...
  38. ncbi request reprint Recombinant activated factor VII for acute intracerebral hemorrhage: US phase IIA trial
    Stephan A Mayer
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neurocrit Care 4:206-14. 2006
    ..We conducted this trial to evaluate the safety of activated recombinant factor VII (rFVIIa; NovoSeven) for preventing early hematoma growth in acute ICH...
  39. doi request reprint Screening for brain aneurysm in the Familial Intracranial Aneurysm study: frequency and predictors of lesion detection
    Robert D Brown
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    J Neurosurg 108:1132-8. 2008
    ..A better understanding of predictors of aneurysm detection in familial IA may allow more targeted aneurysm screening strategies...
  40. ncbi request reprint Guidelines for the management of spontaneous intracerebral hemorrhage in adults: 2007 update: a guideline from the American Heart Association/American Stroke Association Stroke Council, High Blood Pressure Research Council, and the Quality of Care and Out
    Joseph Broderick
    University of Cincinnati, USA
    Circulation 116:e391-413. 2007
    ..The aim of this statement is to present current and comprehensive recommendations for the diagnosis and treatment of acute spontaneous intracerebral hemorrhage...
  41. ncbi request reprint West Nile virus encephalitis in organ transplant recipients: another high-risk group for meningoencephalitis and death
    Debby DeSalvo
    Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0585, USA
    Transplantation 77:466-9. 2004
    ..Suggestions for the prevention, diagnosis, and treatment of West Nile virus infection in this patient population are described...
  42. pmc Peroxynitrite decomposition catalyst prevents matrix metalloproteinase activation and neurovascular injury after prolonged cerebral ischemia in rats
    Yalikun Suofu
    Department of Neurology, University of Cincinnati, Cincinnati, OH 45267 0532, USA
    J Neurochem 115:1266-76. 2010
    ..This strategy may be useful for future therapies targeted at preventing breakdown of the blood-brain barrier and hemorrhagic transformation...
  43. pmc Update of the stroke therapy academic industry roundtable preclinical recommendations
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Stroke 40:2244-50. 2009
    ..Although the recommendations cannot be validated until effective therapies based on them emerge from clinical trials, it is hoped that adherence to them might enhance the chances for success...

Research Grants41

  1. Familial Intracranial Aneurysm Study II (FIA II)
    JOSEPH PAUL BRODERICK; Fiscal Year: 2010
    ..Finally, we will use bioinformatics, statistical methods, and gene sequencing, to identify specific disease producing mutations and/or high risk haplotypes whose functional relevance will be subsequently explored. ..
  2. Interventional Management of Stroke III Planning Grant
    Joseph Broderick; Fiscal Year: 2004
    ..10. Explore funding of interventional angiography by CMS. 11. Continue interaction with industry, with attention to devices that might be applied to a device-augmented future IV/IA paradigm. ..
  3. HEMORRHAGIC AND ISCHEMIC STROKE AMONG BLACKS AND WHITES
    Joseph Broderick; Fiscal Year: 2003
    ....
  4. HEMORRHAGIC AND ISCHEMIC STROKE AMONG BLACKS AND WHITES
    Joseph Broderick; Fiscal Year: 2005
    ..Surveyed people who receive stroke education with the FAST mnemonic will be more likely to know stroke warning signs after thirty days than those who receive the standard current educational message used by the Brain Attack Coalition. ..
  5. Familial Intracranial Aneurysm Study
    Joseph Broderick; Fiscal Year: 2006
    ..Only a multidisciplinary, collaborative effort to identify, accrue, and genotype FIA families will be successful in identifying sufficient high-risk families to characterize the genetic basis of IA. ..
  6. Familiar Intracranial Aneurysm Study II (FIA II)
    Joseph Broderick; Fiscal Year: 2009
    ..Finally, we will use bioinformatics, statistical methods, and gene sequencing, to identify specific disease producing mutations and/or high risk haplotypes whose functional relevance will be subsequently explored. ..
  7. Cerebrovascular Fellowship Training Program
    Joseph Broderick; Fiscal Year: 2007
    ..Potential trainees must have completed a residency in neurology or emergency medicine and must demonstrate a commitment to an academic career in cerebrovascular disease. ..
  8. Genetic&Environment Risk Factors for Hemorrhagic Stroke
    Joseph Broderick; Fiscal Year: 2006
    ..abstract_text> ..
  9. Interventional Management of Stroke Study
    Joseph Broderick; Fiscal Year: 2007
    ..The trial is open-label since blinding of the intervention is not possible but the primary 3-month and secondary endpoints will be done by an investigator blinded to treatment assignment. ..
  10. Recanalization Therapies and Markers of Stroke Outcome
    Joseph Broderick; Fiscal Year: 2006
    ..We are confident that these projects will lead to better and safer therapy for patients with acute ischemic stroke...
  11. STROKE INCIDENCE AND OUTCOME AMONG BLACKS AND WHITES
    Joseph Broderick; Fiscal Year: 1993
    ..Factors likely to explain any racial, gender, or temporal differences in stroke incidence rates will be investigated. These data are crucial for developing more focused and effective public health efforts to prevent stroke...
  12. GENETIC AND ENVIRONMENTAL RISK FACTORS FOR STROKE
    Joseph Broderick; Fiscal Year: 2000
    ..Hypothesis 5: although the age- and sex-adjusted incidence rates of both ICH and SAH will be increased among African-Americans as compared to whites, race will not be an independent risk factor for either ICH or SAH. ..