Jennifer Brodbelt

Summary

Affiliation: University of Texas
Country: USA

Publications

  1. pmc Screening of threading bis-intercalators binding to duplex DNA by electrospray ionization tandem mass spectrometry
    Carolyn L Mazzitelli
    Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas 78712 0165, USA
    J Am Soc Mass Spectrom 18:311-21. 2007
  2. doi request reprint Evaluation of DNA/Ligand interactions by electrospray ionization mass spectrometry
    Jennifer S Brodbelt
    Department of Chemistry and Biochemistry, University of Texas, Austin, 78712, USA
    Annu Rev Anal Chem (Palo Alto Calif) 3:67-87. 2010
  3. doi request reprint Shedding light on the frontier of photodissociation
    Jennifer S Brodbelt
    Department of Chemistry and Biochemistry, University of Texas, Austin, TX 78712, USA
    J Am Soc Mass Spectrom 22:197-206. 2011
  4. doi request reprint Infrared multiphoton dissociation in quadrupole ion traps
    Jennifer S Brodbelt
    Department of Chemistry and Biochemistry, University of Texas, Austin, TX 78712, USA
    Mass Spectrom Rev 28:390-424. 2009
  5. ncbi request reprint Novel guanosine-cytidine dinucleoside that self-assembles into a trimeric supramolecule
    Jonathan L Sessler
    Department of Chemistry and Biochemistry and Institute of Cellular and Molecular Biology, 1 University Station A5300, The University of Texas at Austin, 78712 0165, USA
    Org Lett 5:2627-30. 2003
  6. ncbi request reprint Enhancing Hoogsteen interactions: a pyrrole-containing purine nucleoside that competes with guanosine self-assembly
    Jonathan L Sessler
    Department of Chemistry and Biochemistry and Institute for Cellular and Molecular Biology, 1 University Station A5300, The University of Texas at Austin, Austin, TX 78712 0165, USA
    J Am Chem Soc 126:11460-1. 2004
  7. ncbi request reprint Duplex and quadruplex DNA binding and photocleavage by trioxatriangulenium ion
    Arti Pothukuchy
    Division of Medicinal Chemistry and Institute for Cellular and Molecular Biology, The University of Texas, Austin, Texas 78712, USA
    Biochemistry 44:2163-72. 2005
  8. pmc Probing ligand binding to duplex DNA using KMnO4 reactions and electrospray ionization tandem mass spectrometry
    Carolyn L Mazzitelli
    Department of Chemistry and Biochemistry, 1 University Station A5300, University of Texas at Austin, Austin, Texas 78712, USA
    Anal Chem 79:4636-47. 2007
  9. ncbi request reprint Investigation of quadruplex oligonucleotide-drug interactions by electrospray ionization mass spectrometry
    Wendi M David
    Department of Chemistry and Biochemistry, College of Pharmacy, University of Texas at Austin, 78712, USA
    Anal Chem 74:2029-33. 2002
  10. pmc ESI-MS characterization of a novel pyrrole-inosine nucleoside that interacts with guanine bases
    Sarah E Pierce
    Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, TX 78712 1167, United States
    Anal Chim Acta 627:129-35. 2008

Research Grants

  1. Design and Characterization of DNA Interactive Agents
    Jennifer S Brodbelt; Fiscal Year: 2010
  2. Design and Characterization of DNA Interactive Agents
    Jennifer Brodbelt; Fiscal Year: 2005
  3. Analysis of Phenolic Phytochemical by ESI-MS
    Jennifer Brodbelt; Fiscal Year: 2003
  4. Design and Characterization of DNA Interactive Agents
    Jennifer S Brodbelt; Fiscal Year: 2011

Collaborators

  • Jonathan Sessler
  • S M Kerwin
  • Andrew Ellington
  • B B Hasinoff
  • M H Gelb
  • Miguel Salazar
  • Junmei Wang
  • Myles W Gardner
  • James A Madsen
  • Carolyn L Mazzitelli
  • Jeffrey J Wilson
  • Suncerae I Smith
  • Michael Pikulski
  • Karin M Keller
  • Junmei Zhang
  • Matthew C Crowe
  • Sarah E Pierce
  • Frank S Guziec
  • Lisa A Vasicek
  • Mireya Rodriguez
  • Leon Oehlers
  • Joseph E Chipuk
  • Lisa Vasicek
  • Aaron R Ledvina
  • George C Stafford
  • Joshua J Coon
  • Jae C Schwartz
  • Lynn J Guziec
  • Eric V Anslyn
  • Arti Pothukuchy
  • Sheldon M Williams
  • Barry D Davis
  • Wendi M David
  • Na Li
  • Daniel R Boutz
  • Lynn Guziec
  • Shagufta Shabbir
  • Candace M Lawrence
  • Gregory J Kirkovits
  • Courtney L Sherman
  • Janarthanan Jayawickramarajah
  • Yongjun Chu
  • Brent L Iverson
  • Apolonio Aguilar
  • Shagufta H Shabbir
  • Amanda Hargrove
  • Joseph J Reczek
  • Jonathan T Kern
  • Megan M Breeden
  • Mireya L Rodriguez
  • Bodin Tuesuwan
  • Paul Hergenrother
  • Pei Wang Thomas
  • Brian J Goolsby

Detail Information

Publications49

  1. pmc Screening of threading bis-intercalators binding to duplex DNA by electrospray ionization tandem mass spectrometry
    Carolyn L Mazzitelli
    Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas 78712 0165, USA
    J Am Soc Mass Spectrom 18:311-21. 2007
    ....
  2. doi request reprint Evaluation of DNA/Ligand interactions by electrospray ionization mass spectrometry
    Jennifer S Brodbelt
    Department of Chemistry and Biochemistry, University of Texas, Austin, 78712, USA
    Annu Rev Anal Chem (Palo Alto Calif) 3:67-87. 2010
    ..Chemical probe methods applied to DNA/ligand complexes with ESI-MS detection afford information about ligand-binding sites and conformational changes of DNA that occur upon ligand binding...
  3. doi request reprint Shedding light on the frontier of photodissociation
    Jennifer S Brodbelt
    Department of Chemistry and Biochemistry, University of Texas, Austin, TX 78712, USA
    J Am Soc Mass Spectrom 22:197-206. 2011
    ..Moreover, the discussion will emphasize photodissociation in quadrupole ion traps, because that platform has been used for one of the greatest arrays of new applications over the past decade...
  4. doi request reprint Infrared multiphoton dissociation in quadrupole ion traps
    Jennifer S Brodbelt
    Department of Chemistry and Biochemistry, University of Texas, Austin, TX 78712, USA
    Mass Spectrom Rev 28:390-424. 2009
    ..Numerous applications of IRMPD are discussed as well, including ones related to the analysis of drugs, peptides, nucleic acids, and oligosaccharides...
  5. ncbi request reprint Novel guanosine-cytidine dinucleoside that self-assembles into a trimeric supramolecule
    Jonathan L Sessler
    Department of Chemistry and Biochemistry and Institute of Cellular and Molecular Biology, 1 University Station A5300, The University of Texas at Austin, 78712 0165, USA
    Org Lett 5:2627-30. 2003
    ..Dinucleoside 1 was obtained by utilizing two consecutive palladium-catalyzed cross-coupling reactions. Ensemble I was analyzed by ESI-MS, NMR spectroscopies, size exclusion chromatography (SEC), and vapor pressure osmometry (VPO)...
  6. ncbi request reprint Enhancing Hoogsteen interactions: a pyrrole-containing purine nucleoside that competes with guanosine self-assembly
    Jonathan L Sessler
    Department of Chemistry and Biochemistry and Institute for Cellular and Molecular Biology, 1 University Station A5300, The University of Texas at Austin, Austin, TX 78712 0165, USA
    J Am Chem Soc 126:11460-1. 2004
    ..Nucleoside 1 is shown to bind guanosine 10 (a classic ADD motif) to form ensemble I. This interaction competes effectively with guanosine self-assembly and, as such, is capable of disrupting guanosine quadruplex formation...
  7. ncbi request reprint Duplex and quadruplex DNA binding and photocleavage by trioxatriangulenium ion
    Arti Pothukuchy
    Division of Medicinal Chemistry and Institute for Cellular and Molecular Biology, The University of Texas, Austin, Texas 78712, USA
    Biochemistry 44:2163-72. 2005
    ..Analysis by denaturing polyacrylamide gel electrophoresis reveals significantly less TOTA photocleavage of these quadruplex telomeric repeats when compared to the duplex repeats...
  8. pmc Probing ligand binding to duplex DNA using KMnO4 reactions and electrospray ionization tandem mass spectrometry
    Carolyn L Mazzitelli
    Department of Chemistry and Biochemistry, 1 University Station A5300, University of Texas at Austin, Austin, Texas 78712, USA
    Anal Chem 79:4636-47. 2007
    ..Collisional activated dissociation (CAD) and infrared multiphoton dissociation (IRMPD) experiments were used to determine the site of oxidation based on oligonucleotide fragmentation patterns...
  9. ncbi request reprint Investigation of quadruplex oligonucleotide-drug interactions by electrospray ionization mass spectrometry
    Wendi M David
    Department of Chemistry and Biochemistry, College of Pharmacy, University of Texas at Austin, 78712, USA
    Anal Chem 74:2029-33. 2002
    ..These ESI-MS results are applicable to both the identification and characterization of G-quadruplex interactive agents and may also be useful in probing unusual DNA structures...
  10. pmc ESI-MS characterization of a novel pyrrole-inosine nucleoside that interacts with guanine bases
    Sarah E Pierce
    Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, TX 78712 1167, United States
    Anal Chim Acta 627:129-35. 2008
    ..The specific binding of 1 to guanine-rich DNA emphasizes the necessity of careful ligand design for specific sequence recognition...
  11. pmc Infrared multiphoton dissociation of duplex DNA/drug complexes in a quadrupole ion trap
    Jeffrey J Wilson
    Department of Chemistry and Biochemistry, 1 University Station A5300, University of Texas at Austin, Austin, Texas 78712, USA
    Anal Chem 79:2067-77. 2007
    ....
  12. doi request reprint Top-down protein fragmentation by infrared multiphoton dissociation in a dual pressure linear ion trap
    James A Madsen
    Department of Chemistry and Biochemistry, The University of Texas at Austin, 1 University Station A5300, Austin, Texas 78712, USA
    Anal Chem 81:8677-86. 2009
    ....
  13. ncbi request reprint Evaluation of binding of perylene diimide and benzannulated perylene diimide ligands to DNA by electrospray ionization mass spectrometry
    Carolyn L Mazzitelli
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 58712 0165, USA
    J Am Soc Mass Spectrom 17:593-604. 2006
    ..Our results indicate that Tel01, Tel12, and Tel34 are the most selective for G-quadruplex DNA...
  14. ncbi request reprint Differentiation of phosphorylated and unphosphorylated peptides by high-performance liquid chromatography-electrospray ionization-infrared multiphoton dissociation in a quadrupole ion trap
    Matthew C Crowe
    Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas 78712, USA
    Anal Chem 77:5726-34. 2005
    ..The ability of this technique to differentiate peptides based on phosphorylation state is unaffected by whether the peptides are protonated or sodium-cationized...
  15. pmc Infrared multiphoton dissociation of peptide cations in a dual pressure linear ion trap mass spectrometer
    Myles W Gardner
    Department of Chemistry and Biochemistry, The University of Texas at Austin, 1 University Station A5300, Austin, Texas 78751, USA
    Anal Chem 81:8109-18. 2009
    ..Highly charged primary product ions also underwent efficient photodissociation to yield singly charged secondary product ions, thus simplifying the IRMPD product ion mass spectra...
  16. pmc Interactions of sulfur-containing acridine ligands with DNA by ESI-MS
    Suncerae I Smith
    Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, TX 78712, USA
    Analyst 134:2058-66. 2009
    ..At higher irradiation times, a variety of sequence ions were observed, some retaining the AS4/AN1 ligand, which was indicative of covalent binding...
  17. ncbi request reprint Impact of proline and aspartic acid residues on the dissociation of intermolecularly crosslinked peptides
    Myles W Gardner
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA
    J Am Soc Mass Spectrom 19:344-57. 2008
    ....
  18. pmc Photodissociation of non-covalent peptide-crown ether complexes
    Jeffrey J Wilson
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA
    J Am Soc Mass Spectrom 19:257-60. 2008
    ....
  19. ncbi request reprint Sequencing and characterization of oligosaccharides using infrared multiphoton dissociation and boronic acid derivatization in a quadrupole ion trap
    Michael Pikulski
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712 0165, USA
    J Am Soc Mass Spectrom 18:2094-106. 2007
    ..We demonstrate this approach for two series of oligosaccharides, the lacto-N-fucopentaoses (LNFPs) and the lacto-N-difucohexaoses (LNDFHs)...
  20. ncbi request reprint MS/MS simplification by 355 nm ultraviolet photodissociation of chromophore-derivatized peptides in a quadrupole ion trap
    Jeffrey J Wilson
    Department of Chemistry and Biochemistry, University of Texas at Austin, 1 University Station A5300, Austin, Texas 78712, USA
    Anal Chem 79:7883-92. 2007
    ..The abundances of chromophore-containing a/b fragment ions follow a quadratic trend due to the extensive secondary fragmentation at higher laser energies or multiple pulses...
  21. pmc Evaluation of metal-mediated DNA binding of benzoxazole ligands by electrospray ionization mass spectrometry
    Carolyn L Mazzitelli
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA
    J Am Soc Mass Spectrom 19:209-18. 2008
    ..Metal ions also enhanced the DNA binding of the ligands with the long side chains, especially for 9, which also exhibited the highest level of cytotoxicity of the long side-chain compounds...
  22. pmc Asymmetric charge partitioning upon dissociation of DNA duplexes
    James A Madsen
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712 0165, USA
    J Am Soc Mass Spectrom 21:1144-50. 2010
    ..Comparisons were made with the dissociation behavior previously studied for protein noncovalent complexes and past studies of the gas-phase conformations and dissociation of DNA complexes...
  23. ncbi request reprint Electrospray ionization of nucleic acid aptamer/small molecule complexes for screening aptamer selectivity
    Karin M Keller
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin TX 78712, USA
    J Mass Spectrom 40:1327-37. 2005
    ..These results indicate that in at least some cases, mass spectrometric data on aptamer/ligand binding affinities should be used in conjunction with complementary techniques to fully assess aptamer molecular recognition properties...
  24. ncbi request reprint Influence of initial charge state on fragmentation patterns for noncovalent drug/DNA duplex complexes
    Karin M Keller
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin TX 78712, USA
    J Mass Spectrom 40:1362-71. 2005
    ..The dissociation pathways for the lower charge state complexes are probably more reflective of specific drug-DNA interactions because Coulombic and/or conformational effects are less marked for these precursors...
  25. pmc Infrared multiphoton dissociation of small-interfering RNA anions and cations
    Myles W Gardner
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712 0165, USA
    J Am Soc Mass Spectrom 21:580-91. 2010
    ..With longer irradiation times, however, the individual single-strands underwent secondary dissociation to yield informative sequence ions not obtained by CID...
  26. ncbi request reprint Collisionally activated dissociation and infrared multiphoton dissociation of oligonucleotides in a quadrupole ion trap
    Karin M Keller
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX 78712, USA
    Anal Biochem 326:200-10. 2004
    ..For this reason IRMPD can sometimes facilitate analysis of sequences containing modified bases...
  27. doi request reprint Reduction of chemical noise in electrospray ionization mass spectrometry by supplemental IR activation
    Myles W Gardner
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712 0165, USA
    J Am Soc Mass Spectrom 20:2206-10. 2009
    ..Collision activation was not as effective for desolvating the ions present in the chemical noise...
  28. ncbi request reprint Characterization of erythromycin analogs by collisional activated dissociation and infrared multiphoton dissociation in a quadrupole ion trap
    Matthew C Crowe
    Department of Chemistry and Biochemistry, University of Texas at Austin 78712 1167, USA
    J Am Soc Mass Spectrom 13:630-49. 2002
    ..Multi-step IRMPD allows mapping of the fragmentation genealogies in greater detail and supports the proposed structures of the fragment ions...
  29. pmc Ultrafast ultraviolet photodissociation at 193 nm and its applicability to proteomic workflows
    James A Madsen
    Department of Chemistry and Biochemistry, The University of Texas at Austin, 1 University Station A5300, Austin, Texas 78712, USA
    J Proteome Res 9:4205-14. 2010
    ....
  30. doi request reprint Preferential cleavage of N-N hydrazone bonds for sequencing bis-arylhydrazone conjugated peptides by electron transfer dissociation
    Myles W Gardner
    Department of Chemistry and Biochemistry, The University of Texas at Austin, 1 University Station A5300, Austin, Texas 78712, USA
    Anal Chem 82:5751-9. 2010
    ....
  31. pmc Rapid and selective screening for sulfhydryl analytes in plasma and urine using surface-enhanced transmission mode desorption electrospray ionization mass spectrometry
    Joseph E Chipuk
    Department of Chemistry and Biochemistry, University of Texas at Austin, University Station A5300, Austin, Texas 78712, USA
    Anal Chem 82:4130-9. 2010
    ..Integration of the chemoselective capture materials with ambient ionization and tandem mass spectrometry results in a powerful combination of speed and selectivity for targeted analyte screening...
  32. ncbi request reprint Differentiation of flavonoid glycoside isomers by using metal complexation and electrospray ionization mass spectrometry
    Michael Pikulski
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712 0165, USA
    J Am Soc Mass Spectrom 14:1437-53. 2003
    ..Using this technique, three groups of flavonoid glycoside isomers are differentiated, including glycosides of apigenin, quercetin, and luteolin...
  33. pmc Characterization of aziridinylbenzoquinone DNA cross-links by liquid chromatography-infrared multiphoton dissociation-mass spectrometry
    Sarah E Pierce
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA
    Chem Res Toxicol 23:1097-104. 2010
    ....
  34. doi request reprint Ultraviolet photodissociation mass spectrometry of bis-aryl hydrazone conjugated peptides
    Myles W Gardner
    Department of Chemistry and Biochemistry, The University of Texas at Austin, 1 University Station A5300, Austin, Texas 78712 1167, USA
    Anal Chem 81:4864-72. 2009
    ..Ultraviolet photodissociation of BAH-cross-linked peptides also yielded more diagnostic sequence ions than CID to unambiguously locate the site of conjugation...
  35. doi request reprint Simplifying fragmentation patterns of multiply charged peptides by N-terminal derivatization and electron transfer collision activated dissociation
    James A Madsen
    Department of Chemistry and Biochemistry, The University of Texas at Austin, 1 University Station A5300, Austin, Texas 78712, USA
    Anal Chem 81:3645-53. 2009
    ..This improved LC-MS(n) strategy was demonstrated for a variety of multiply charged model peptides and a tryptic digest of myoglobin...
  36. ncbi request reprint Gas-phase hydrogen/deuterium exchange and conformations of deprotonated flavonoids and gas-phase acidities of flavonoids
    Junmei Zhang
    Department of Chemistry and Biochemistry, University of Texas, Austin, Texas 78712, USA
    J Am Chem Soc 126:5906-19. 2004
    ....
  37. ncbi request reprint MS(n) characterization of protonated cyclic peptides and metal complexes
    Sheldon M Williams
    Department of Chemistry and Biochemistry, The University of Texas at Austin, 78712, USA
    J Am Soc Mass Spectrom 15:1039-54. 2004
    ..For cyclic lipopeptides, complexes with silver, nickel and strontium ions provided enhanced abundances of key fragment ions...
  38. ncbi request reprint Infrared multiphoton dissociation for enhanced de novo sequence interpretation of N-terminal sulfonated peptides in a quadrupole ion trap
    Jeffrey J Wilson
    Department of Chemistry and Biochemistry, 1 University Station A5300, University of Texas at Austin, Austin, Texas 78712, USA
    Anal Chem 78:6855-62. 2006
    ..Energy-variable CAD studies confirmed a 30-40% reduction in the critical energies of the N-terminal sulfonated peptides relative to unmodified peptides. This reduction in dissociation energy facilitates IRMPD in a quadrupole ion trap...
  39. ncbi request reprint Threshold dissociation and molecular modeling of transition metal complexes of flavonoids
    Junmei Zhang
    Department of Chemistry and Biochemistry, University of Texas, Austin, Texas 78712 0165, USA
    J Am Soc Mass Spectrom 16:139-51. 2005
    ..The conformations were combined with the point charges and helium accessible surface areas to explain qualitatively the differences in threshold energies for isomeric flavonoids...
  40. ncbi request reprint Tunable transition metal-ligand complexation for enhanced elucidation of flavonoid diglycosides by electrospray ionization mass spectrometry
    Michael Pikulski
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712 0165, USA
    J Am Soc Mass Spectrom 18:422-31. 2007
    ..Upon collisionally activated dissociation, the complexes yield fragmentation patterns in which the abundances of key diagnostic ions are enhanced, thus facilitating isomer differentiation...
  41. ncbi request reprint Evaluation of complexes of DNA duplexes and novel benzoxazoles or benzimidazoles by electrospray ionization mass spectrometry
    Leon Oehlers
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712 0165, USA
    J Am Soc Mass Spectrom 15:1593-603. 2004
    ..Complexation between DNA and the biologically inactive analog 1 was not observed, either in the absence or presence of metal cations...
  42. ncbi request reprint Evaluation of relative DNA binding affinities of anthrapyrazoles by electrospray ionization mass spectrometry
    Suncerae I Smith
    Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, TX 78712, USA
    J Mass Spectrom 42:681-8. 2007
    ..However, for complexes containing AP2 or mitoxantrone, strand separation with the ligand remaining on one of the single strands was observed, indicative of a different binding mode or stronger binding...
  43. ncbi request reprint Infrared multiphoton dissociation (IRMPD) and collisionally activated dissociation of peptides in a quadrupole ion trap with selective IRMPD of phosphopeptides
    Matthew C Crowe
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712 0165, USA
    J Am Soc Mass Spectrom 15:1581-92. 2004
    ..Finally, the selectivity of the IRMPD technique for phosphorylated species in complex mixtures is confirmed with the analysis of a mock peptide mixture and a tryptic digest of alpha-casein...
  44. ncbi request reprint Determination of the glycosylation site of flavonoid monoglucosides by metal complexation and tandem mass spectrometry
    Barry D Davis
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712 0165, USA
    J Am Soc Mass Spectrom 15:1287-99. 2004
    ....
  45. doi request reprint Chromogenic cross-linker for the characterization of protein structure by infrared multiphoton dissociation mass spectrometry
    Myles W Gardner
    Department of Chemistry and Biochemistry, The University of Texas at Austin, 1 University Station A5300, Austin, Texas, USA 78712, USA
    Anal Chem 80:4807-19. 2008
    ....
  46. pmc Gas-phase stability of G-quadruplex DNA determined by electrospray ionization tandem mass spectrometry and molecular dynamics simulations
    Carolyn L Mazzitelli
    Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas 78712, USA
    J Am Soc Mass Spectrom 18:1760-73. 2007
    ..This discrepancy is attributed to differences in the fragmentation pathway of the quadruplex...
  47. doi request reprint Improved infrared multiphoton dissociation of peptides through N-terminal phosphonite derivatization
    Lisa A Vasicek
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA
    J Am Soc Mass Spectrom 20:377-84. 2009
    ..We compare the effectiveness of this derivatization/IRMPD approach to that of a common N-terminal sulfonation reaction that utilizes 4-sulfophenylisothiocyanate (SPITC) in conjunction with CID and IRMPD...
  48. doi request reprint Comparison of infrared multiphoton dissociation and collision-induced dissociation of supercharged peptides in ion traps
    James A Madsen
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712 0165, USA
    J Am Soc Mass Spectrom 20:349-58. 2009
    ..The enhanced sequence coverage afforded by IRMPD of supercharged ions was demonstrated for a variety of model peptides, as well as for a tryptic digest of cytochrome c...
  49. doi request reprint Enhanced electron transfer dissociation through fixed charge derivatization of cysteines
    Lisa Vasicek
    Department of Chemistry and Biochemistry, The University of Texas at Austin, 1 University Station A5300, Austin, Texas 78712, USA
    Anal Chem 81:7876-84. 2009
    ..In addition, the formation of product ions in multiple charge states upon ETD is minimized for the APTA-modified peptides...

Research Grants12

  1. Design and Characterization of DNA Interactive Agents
    Jennifer S Brodbelt; Fiscal Year: 2010
    ..This research enables the design of new anticancer aziridinylbenzoquinones and advances the analysis of DNA-drug adducts by innovative mass spectrometric strategies. ..
  2. Design and Characterization of DNA Interactive Agents
    Jennifer Brodbelt; Fiscal Year: 2005
    ..The anticancer and antibacterial effects of UK-1 and A-62176 analogs will be examined in a range of human cancer cell lines and Gram negative and Gram positive bacteria. ..
  3. Analysis of Phenolic Phytochemical by ESI-MS
    Jennifer Brodbelt; Fiscal Year: 2003
    ....
  4. Design and Characterization of DNA Interactive Agents
    Jennifer S Brodbelt; Fiscal Year: 2011
    ..This research enables the design of new anticancer aziridinylbenzoquinones and advances the analysis of DNA-drug adducts by innovative mass spectrometric strategies. ..