Karen Briski


Affiliation: University of Louisiana at Monroe
Country: USA


  1. Ali M, Napit P, Mahmood A, Bheemanapally K, Alhamami H, Uddin M, et al. Hindbrain estrogen receptor regulation of ventromedial hypothalamic glycogen metabolism and glucoregulatory transmitter expression in the hypoglycemic male rat. Neuroscience. 2019;: pubmed publisher
    ..Sex differences in hypoglycemic VMN NE accumulation, glycogen metabolism, and transmitter signaling may involve, in part, discrepant regulatory involvement or differential magnitude of impact of these hindbrain ERs. ..
  2. Ibrahim M, Alhamami H, Briski K. Norepinephrine regulation of ventromedial hypothalamic nucleus metabolic transmitter biomarker and astrocyte enzyme and receptor expression: Impact of 5' AMP-activated protein kinase. Brain Res. 2019;1711:48-57 pubmed publisher
  3. Hasan Mahmood A, Mandal S, Bheemanapally K, Ibrahim M, Briski K. Norepinephrine control of ventromedial hypothalamic nucleus glucoregulatory neurotransmitter expression in the female rat: Role of monocarboxylate transporter function. Mol Cell Neurosci. 2019;95:51-58 pubmed publisher
  4. Mandal S, Briski K. Hindbrain dorsal vagal complex AMPK controls hypothalamic gluco-regulatory transmitter and counter-regulatory hormone responses to hypoglycemia. Brain Res Bull. 2019;144:171-179 pubmed publisher
  5. Hasan Mahmood A, Uddin M, Ibrahim M, Mandal S, Alhamami H, Briski K. Sex differences in forebrain estrogen receptor regulation of hypoglycemic patterns of counter-regulatory hormone secretion and ventromedial hypothalamic nucleus glucoregulatory neurotransmitter and astrocyte glycogen metabolic enzyme expression. Neuropeptides. 2018;72:65-74 pubmed publisher
  6. Mandal S, Shrestha P, Alenazi F, Shakya M, Alhamami H, Briski K. Effects of estradiol on lactoprivic signaling of the hindbrain upon the contraregulatory hormonal response and metabolic neuropeptide synthesis in hypoglycemic female rats. Neuropeptides. 2018;70:37-46 pubmed publisher
    ..Outcomes emphasize a need for insight on systems-level organization, interaction, and involvement of E signal strength-sensitive neuropeptides in counter-regulatory functions. ..
  7. Shakya M, Shrestha P, Briski K. Hindbrain 5'-Adenosine Monophosphate-activated Protein Kinase Mediates Short-term Food Deprivation Inhibition of the Gonadotropin-releasing Hormone-Luteinizing Hormone Axis: Role of Nitric Oxide. Neuroscience. 2018;383:46-59 pubmed publisher
    ..Results indicate that neural networks linking this sensor to GnRH neurons likely involve NO signaling, which may function upstream of one or more neurotransmitters identified here by SIN-1-reversible inhibitory responses to FD. ..
  8. Tamrakar P, Shrestha P, Briski K. Sex-specific basal and hypoglycemic patterns of in vivo caudal dorsal vagal complex astrocyte glycogen metabolic enzyme protein expression. Brain Res. 2014;1586:90-8 pubmed publisher
    ..Current data demonstrating sex-dependent basal and hypoglycemic patterns of hindbrain astrocyte glycogen metabolic enzyme expression imply that glycogen volume and turnover during glucose sufficiency and shortage may vary accordingly. ..
  9. Ibrahim B, Briski K. Role of dorsal vagal complex A2 noradrenergic neurons in hindbrain glucoprivic inhibition of the luteinizing hormone surge in the steroid-primed ovariectomized female rat: effects of 5-thioglucose on A2 functional biomarker and AMPK activity. Neuroscience. 2014;269:199-214 pubmed publisher
    ..Further studies are needed to determine if decreased AMPK activation in these cell populations reflect compensatory gain in positive energy balance and/or direct effects of estrogen on AMPK. ..

More Information


  1. Alenazi F, Ibrahim B, Briski K. Re-purposing of histological tissue sections for corroborative western blot analysis of hypothalamic metabolic neuropeptide expression following delineation of transactivated structures by Fos immuno-mapping. Neuropeptides. 2015;50:29-33 pubmed publisher
  2. Shrestha P, Briski K. Hindbrain lactate regulates preoptic gonadotropin-releasing hormone (GnRH) neuron GnRH-I protein but not AMPK responses to hypoglycemia in the steroid-primed ovariectomized female rat. Neuroscience. 2015;298:467-74 pubmed publisher
    ..Lack of effect of lactate on hypoglycemic patterns of GnRH AMPK activity suggests that this sensor is uninvolved in metabolic-inhibition of positive-feedback-stimulated hypophysiotropic signaling to pituitary gonadotropes. ..
  3. Tamrakar P, Shrestha P, Briski K. Dorsomedial hindbrain catecholamine regulation of hypothalamic astrocyte glycogen metabolic enzyme protein expression: Impact of estradiol. Neuroscience. 2015;292:34-45 pubmed publisher
  4. Ibrahim B, Alenazi F, Briski K. Energy status determines hindbrain signal transduction pathway transcriptional reactivity to AMPK in the estradiol-treated ovariectomized female rat. Neuroscience. 2015;284:888-99 pubmed publisher
  5. Alhamami H, Uddin M, Mahmood A, Briski K. Lateral but not Medial Hypothalamic AMPK Activation Occurs at the Hypoglycemic Nadir in Insulin-injected Male Rats: Impact of Caudal Dorsomedial Hindbrain Catecholamine Signaling. Neuroscience. 2018;379:103-114 pubmed publisher
  6. Tamrakar P, Briski K. Estradiol regulation of hypothalamic astrocyte adenosine 5'-monophosphate-activated protein kinase activity: role of hindbrain catecholamine signaling. Brain Res Bull. 2015;110:47-53 pubmed publisher
    ..Further research is needed to determine the role of astrocyte AMPK in reactivity of these glia to metabolic imbalance and contribution to restoration of neuro-metabolic stability. ..
  7. Alenazi F, Ibrahim B, Briski K. Estradiol Regulates Dorsal Vagal Complex Signal Transduction Pathway Transcriptional Reactivity to the AMPK Activator 5-Aminoimidazole-4-Carboxamide-Riboside (AICAR). J Mol Neurosci. 2015;56:907-16 pubmed publisher
  8. Alenazi F, Ibrahim B, Al Hamami H, Shakiya M, Briski K. Role of estradiol in intrinsic hindbrain AMPK regulation of hypothalamic AMPK, metabolic neuropeptide, and norepinephrine activity and food intake in the female rat. Neuroscience. 2016;314:35-46 pubmed publisher
    ..Divergent changes in NE content of hypothalamic loci in O/Cc uniquely demonstrate sensor-induced bimodal catecholamine signaling to those sites. ..
  9. Briski K, Shrestha P. Hindbrain estrogen receptor-beta antagonism normalizes reproductive and counter-regulatory hormone secretion in hypoglycemic steroid-primed ovariectomized female rats. Neuroscience. 2016;331:62-71 pubmed publisher
    ..Data also show that caudal hindbrain ER? exerts site-specific control of NE activity in forebrain projection sites during hypoglycemia, including the ARH where prepro-kisspeptin may be a target of that signaling. ..
  10. Shakya M, Briski K. Rebound Feeding in the Wake of Short-Term Suspension of Food Intake Differs in the Presence of Estrous Cycle Peak versus Nadir Levels of Estradiol. Endocrinol Metab (Seoul). 2017;32:475-484 pubmed publisher
  11. request reprint
    Tamrakar P, Briski K. Impact of recurrent hypoglycemic stress on hindbrain A2 nerve cell energy metabolism and catecholamine biosynthesis: modulation by estradiol. Acta Neurobiol Exp (Wars). 2017;77:31-44 pubmed
    ..Augmentation of negative energy balance during this recurring metabolic stress in the absence of E is a likely impetus for augmented vs. decreased A2 signaling of energy imbalance by D?H in O vs. E rats during RIIH. ..
  12. Briski K, Alhamami H, Alshamrani A, Mandal S, Shakya M, Ibrahim M. Sex Differences and Role of Estradiol in Hypoglycemia-Associated Counter-Regulation. Adv Exp Med Biol. 2017;1043:359-383 pubmed publisher
  13. Alhamami H, Alshamrani A, Briski K. Inhibition of glycogen phosphorylase stimulates ventromedial hypothalamic nucleus AMP-activated protein kinase: Activity and neuronal nitric oxide synthase protein expression in male rats. Physiol Rep. 2017;5: pubmed publisher
    ..DAB/I upregulation of GAD alongside prevention of hypercorticosteronemia suggests that indicators of metabolic sufficiency may occur secondary to local compensatory adaptations to severe restriction of glucose-derived energy. ..
  14. Mandal S, Shrestha P, Alenazi F, Shakya M, Alhamami H, Briski K. Role of hindbrain adenosine 5'-monophosphate-activated protein kinase (AMPK) in hypothalamic AMPK and metabolic neuropeptide adaptation to recurring insulin-induced hypoglycemia in the male rat. Neuropeptides. 2017;66:25-35 pubmed publisher
  15. Briski K, Parihar M. Effects of orchidectomy on adaptation of arcuate neuropeptide Y, proopiomelanocortin, and cocaine- and amphetamine-related transcript gene profiles to recurring insulin-induced hypoglycemia in the male rat. Neuropeptides. 2008;42:585-91 pubmed publisher
    ..Collectively, these results demonstrate that in the male rat, testes-dependent mechanisms underlie patterns of acclimated or unvarying reactivity to RIIH of the specific ARH metabolic neuropeptide genes evaluated here. ..
  16. Briski K, Cherian A, Genabai N, Vavaiya K. In situ coexpression of glucose and monocarboxylate transporter mRNAs in metabolic-sensitive caudal dorsal vagal complex catecholaminergic neurons: transcriptional reactivity to insulin-induced hypoglycemia and caudal hindbrain glucose or lactate rep. Neuroscience. 2009;164:1152-60 pubmed publisher