Roberta Diaz Brinton

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. doi request reprint Neurosteroids as regenerative agents in the brain: therapeutic implications
    Roberta D Brinton
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA
    Nat Rev Endocrinol 9:241-50. 2013
  2. pmc Minireview: translational animal models of human menopause: challenges and emerging opportunities
    Roberta Diaz Brinton
    Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, PSC 502, Los Angeles, California 90033, USA
    Endocrinology 153:3571-8. 2012
  3. pmc Progesterone receptors: form and function in brain
    Roberta Diaz Brinton
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
    Front Neuroendocrinol 29:313-39. 2008
  4. doi request reprint The healthy cell bias of estrogen action: mitochondrial bioenergetics and neurological implications
    Roberta Diaz Brinton
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy Pharmaceutical Sciences Center, Los Angeles, CA 90033, USA
    Trends Neurosci 31:529-37. 2008
  5. ncbi request reprint Impact of estrogen therapy on Alzheimer's disease: a fork in the road?
    Roberta D Brinton
    Department of Molecular Pharmacology and Toxicology and the Program in Neuroscience, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, California, USA
    CNS Drugs 18:405-22. 2004
  6. pmc Estrogen regulation of glucose metabolism and mitochondrial function: therapeutic implications for prevention of Alzheimer's disease
    Roberta Diaz Brinton
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy Pharmaceutical Sciences Center, Los Angeles, California 90033, USA
    Adv Drug Deliv Rev 60:1504-11. 2008
  7. ncbi request reprint Building a neuroscience legacy
    Roberta Diaz Brinton
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90033, USA
    J Neurosci 27:11163-6. 2007
  8. ncbi request reprint Requirements of a brain selective estrogen: advances and remaining challenges for developing a NeuroSERM
    Roberta Diaz Brinton
    Department of Molecular Pharmacology and Toxicology and the Program in Neuroscience, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, CA 90089, USA
    J Alzheimers Dis 6:S27-35. 2004
  9. pmc Estrogen-induced plasticity from cells to circuits: predictions for cognitive function
    Roberta Diaz Brinton
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy Pharmaceutical Sciences Center, Los Angeles, CA 90033, USA
    Trends Pharmacol Sci 30:212-22. 2009
  10. ncbi request reprint Estrogenic agonist activity of ICI 182,780 (Faslodex) in hippocampal neurons: implications for basic science understanding of estrogen signaling and development of estrogen modulators with a dual therapeutic profile
    Liqin Zhao
    Molecular Pharmacology and Toxicology, Neuroscience, and Biomedical Engineering, University of Southern California, 1985 Zonal Avenue, PSC 503, Los Angeles, CA 90089, USA
    J Pharmacol Exp Ther 319:1124-32. 2006

Research Grants

Collaborators

Detail Information

Publications69

  1. doi request reprint Neurosteroids as regenerative agents in the brain: therapeutic implications
    Roberta D Brinton
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA
    Nat Rev Endocrinol 9:241-50. 2013
    ..Allopregnanolone serves as proof of concept for therapeutics that target endogenous regeneration, windows of therapeutic opportunity for regeneration, and critical system biology factors that will determine the efficacy of regeneration...
  2. pmc Minireview: translational animal models of human menopause: challenges and emerging opportunities
    Roberta Diaz Brinton
    Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, PSC 502, Los Angeles, California 90033, USA
    Endocrinology 153:3571-8. 2012
    ..With focus on predictive validity and strategic use of advances in genetic and epigenetic science, new animal models of human menopause have the opportunity to set new directions for menopausal clinical care for women worldwide...
  3. pmc Progesterone receptors: form and function in brain
    Roberta Diaz Brinton
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
    Front Neuroendocrinol 29:313-39. 2008
    ....
  4. doi request reprint The healthy cell bias of estrogen action: mitochondrial bioenergetics and neurological implications
    Roberta Diaz Brinton
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy Pharmaceutical Sciences Center, Los Angeles, CA 90033, USA
    Trends Neurosci 31:529-37. 2008
    ....
  5. ncbi request reprint Impact of estrogen therapy on Alzheimer's disease: a fork in the road?
    Roberta D Brinton
    Department of Molecular Pharmacology and Toxicology and the Program in Neuroscience, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, California, USA
    CNS Drugs 18:405-22. 2004
    ..An estrogen advantage hypothesis is put forth that provides a unifying mechanism of estrogen action with implications for both the benefits and risks of estrogen therapy...
  6. pmc Estrogen regulation of glucose metabolism and mitochondrial function: therapeutic implications for prevention of Alzheimer's disease
    Roberta Diaz Brinton
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy Pharmaceutical Sciences Center, Los Angeles, California 90033, USA
    Adv Drug Deliv Rev 60:1504-11. 2008
    ..The enhanced aerobic glycolysis in the aging brain would be predicted to prevent conversion of the brain to using alternative sources of fuel such as the ketone body pathway characteristic of Alzheimer's...
  7. ncbi request reprint Building a neuroscience legacy
    Roberta Diaz Brinton
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90033, USA
    J Neurosci 27:11163-6. 2007
  8. ncbi request reprint Requirements of a brain selective estrogen: advances and remaining challenges for developing a NeuroSERM
    Roberta Diaz Brinton
    Department of Molecular Pharmacology and Toxicology and the Program in Neuroscience, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, CA 90089, USA
    J Alzheimers Dis 6:S27-35. 2004
    ....
  9. pmc Estrogen-induced plasticity from cells to circuits: predictions for cognitive function
    Roberta Diaz Brinton
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy Pharmaceutical Sciences Center, Los Angeles, CA 90033, USA
    Trends Pharmacol Sci 30:212-22. 2009
    ....
  10. ncbi request reprint Estrogenic agonist activity of ICI 182,780 (Faslodex) in hippocampal neurons: implications for basic science understanding of estrogen signaling and development of estrogen modulators with a dual therapeutic profile
    Liqin Zhao
    Molecular Pharmacology and Toxicology, Neuroscience, and Biomedical Engineering, University of Southern California, 1985 Zonal Avenue, PSC 503, Los Angeles, CA 90089, USA
    J Pharmacol Exp Ther 319:1124-32. 2006
    ....
  11. pmc Allopregnanolone restores hippocampal-dependent learning and memory and neural progenitor survival in aging 3xTgAD and nonTg mice
    Chanpreet Singh
    Neuroscience Program, University of Southern California, Los Angeles, CA 90089 9121, USA
    Neurobiol Aging 33:1493-506. 2012
    ..Results provide preclinical evidence that APα promoted survival of newly generated cells and restored cognitive performance in the preplaque phase of AD pathology and in late-stage normal aging...
  12. pmc Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
    Jia Yao
    Department of Pharmacology and Pharmaceutical Sciences and Program in Neuroscience, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 106:14670-5. 2009
    ..Mitochondrial dysfunction provides a plausible mechanistic rationale for the hypometabolism in brain that precedes AD diagnosis and suggests therapeutic targets for prevention of AD...
  13. pmc Ovariectomy induces a shift in fuel availability and metabolism in the hippocampus of the female transgenic model of familial Alzheimer's
    Fan Ding
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 8:e59825. 2013
    ..These findings also indicate that estrogen plays a critical role in sustaining brain bioenergetic capacity through preservation of glucose metabolism...
  14. pmc Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function
    Jon Nilsen
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90033, USA
    BMC Neurosci 7:74. 2006
    ..Although all underlying molecular mechanisms of amyloid beta neurotoxicity remain undetermined, mitochondrial dysfunction, including altered calcium homeostasis and Bcl-2 expression, are involved in neurodegenerative vulnerability...
  15. pmc Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease
    Jun Ming Wang
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern corrected California, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 107:6498-503. 2010
    ....
  16. ncbi request reprint Estrogen receptor alpha and beta differentially regulate intracellular Ca(2+) dynamics leading to ERK phosphorylation and estrogen neuroprotection in hippocampal neurons
    Liqin Zhao
    Department of Pharmacology and Pharmaceutical Sciences, Norris Foundation Laboratory for Neuroscience Research, University of Southern California, Los Angeles, CA 90089, USA
    Brain Res 1172:48-59. 2007
    ..Further, the present analyses suggest that separate from a classical nuclear ER-mediated response, estrogen promotes neuronal survival likely through a non-nuclear cytoplasm or membrane-associated ER-mediated rapid signaling cascade...
  17. pmc Potentiation of brain mitochondrial function by S-equol and R/S-equol estrogen receptor β-selective phytoSERM treatments
    Jia Yao
    University of Southern California, Pharmacology and Pharmaceutical Sciences, School of Pharmacy, 1985 Zonal Avenue, PSC 502, Los Angeles, CA 90033, United States
    Brain Res 1514:128-41. 2013
    ..This article is part of a Special Issue entitled Hormone Therapy...
  18. pmc Hippocampal responsiveness to 17β-estradiol and equol after long-term ovariectomy: implication for a therapeutic window of opportunity
    Ryan T Hamilton
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Brain Res 1379:11-22. 2011
    ..By extension, the data are consistent with a primary tenet of the critical window hypothesis, i.e., that the brains of post-menopausal women ultimately lose their ability to respond positively to estrogenic stimulation...
  19. pmc Estradiol-17beta-induced human neural progenitor cell proliferation is mediated by an estrogen receptor beta-phosphorylated extracellularly regulated kinase pathway
    Jun Ming Wang
    Department of Pharmacology and Pharmacological Science, University of Southern California, 1985 Zonal Avenue, Los Angeles, California 90089 9121, USA
    Endocrinology 149:208-18. 2008
    ..Therapeutic implications of these findings relevant to hormone therapy and prevention of neurodegenerative disease are discussed...
  20. pmc Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence
    Jia Yao
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA
    Biochim Biophys Acta 1800:1121-6. 2010
    ..Herein, we sought to determine the impact of reproductive senescence on mitochondrial function in the normal non-transgenic (nonTg) and 3xTgAD female mouse model of AD...
  21. pmc Clinically relevant progestins regulate neurogenic and neuroprotective responses in vitro and in vivo
    Lifei Liu
    Program in Neuroscience, University of Southern California, School of Pharmacy Pharmaceutical Sciences Center, Los Angeles, California 90033, USA
    Endocrinology 151:5782-94. 2010
    ..Progestin impact on the regenerative capacity of the brain has clinical implications for contraceptive and hormone therapy formulations prescribed for pre- and postmenopausal women...
  22. pmc Medroxyprogesterone acetate antagonizes estrogen up-regulation of brain mitochondrial function
    Ronald W Irwin
    Department of Pharmacology and Pharmaceutical Sciences, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, California 90089, USA
    Endocrinology 152:556-67. 2011
    ..These preclinical findings on the basis of acute exposure to MPA raise concerns regarding neurological health after chronic use of MPA in contraceptive and hormone therapy...
  23. ncbi request reprint Vasopressin-induced cytoplasmic and nuclear calcium signaling in embryonic cortical astrocytes: dynamics of calcium and calcium-dependent kinase translocation
    Lixia Zhao
    Department of Molecular Pharmacology and Toxicology, Program in Neuroscience, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, California 90089 9121, USA
    J Neurosci 23:4228-39. 2003
    ..Implications for development and regeneration induced by V1aR activation of CREB-regulated gene expression in cortical astrocytes are discussed...
  24. ncbi request reprint Estrogen receptor protein interaction with phosphatidylinositol 3-kinase leads to activation of phosphorylated Akt and extracellular signal-regulated kinase 1/2 in the same population of cortical neurons: a unified mechanism of estrogen action
    Paolo Mannella
    Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles, California 90033, USA
    J Neurosci 26:9439-47. 2006
    ..Implications of these results for understanding estrogen mechanism of action in neurons and therapeutic development are considered...
  25. ncbi request reprint Dose and temporal pattern of estrogen exposure determines neuroprotective outcome in hippocampal neurons: therapeutic implications
    Shuhua Chen
    Department of Molecular Pharmacology and Toxicology, University of Southern California, 1985 Zonal Avenue, Los Angeles, California 90089 9121, USA
    Endocrinology 147:5303-13. 2006
    ..treat Alzheimer's disease. Furthermore, these data are consistent with a healthy cell bias of estrogen benefit...
  26. ncbi request reprint Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons
    Liqin Zhao
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Pharmaceutical Sciences Center, 1985 Zonal Avenue, Los Angeles, CA 90089 9121, USA
    Brain Res 1010:22-34. 2004
    ....
  27. ncbi request reprint Medroxyprogesterone acetate exacerbates glutamate excitotoxicity
    Jon Nilsen
    Department of Molecular Pharmacology and Toxicology, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, CA 90089, USA
    Gynecol Endocrinol 22:355-61. 2006
    ..Collectively these results predict that the progestin formulation of hormone therapy will affect the vulnerability of the central nervous system to degenerative insults...
  28. pmc Progesterone increases rat neural progenitor cell cycle gene expression and proliferation via extracellularly regulated kinase and progesterone receptor membrane components 1 and 2
    Lifei Liu
    Program in Neuroscience, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, California 90089, USA
    Endocrinology 150:3186-96. 2009
    ..Progesterone mediated NPC proliferation and concomitant regulation of mitotic cell cycle genes via a PGRMC/ERK pathway mechanism is a potential novel therapeutic target for promoting neurogenesis in the mammalian brain...
  29. doi request reprint A select combination of clinically relevant phytoestrogens enhances estrogen receptor beta-binding selectivity and neuroprotective activities in vitro and in vivo
    Liqin Zhao
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Endocrinology 150:770-83. 2009
    ....
  30. pmc Estrogen protection against mitochondrial toxin-induced cell death in hippocampal neurons: antagonism by progesterone
    Jia Yao
    Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA
    Brain Res 1379:2-10. 2011
    ..The data also predict that continuous combined co-administration of estrogen and progesterone common to many hormone therapy regimens is unlikely to prevent the deficits in mitochondrial function...
  31. pmc Allopregnanolone-induced rise in intracellular calcium in embryonic hippocampal neurons parallels their proliferative potential
    Jun Ming Wang
    Department of Pharmacology and Pharmaceutical Sciences and Program in Neuroscience, University of Southern California, Los Angeles, CA 90089, USA
    BMC Neurosci 9:S11. 2008
    ..We also found that APalpha-induced proliferation of neural progenitors is abolished by a calcium channel blocker, nifedipine, indicating a calcium dependent mechanism for the proliferation...
  32. ncbi request reprint Impact of the selective estrogen receptor modulator, raloxifene, on neuronal survival and outgrowth following toxic insults associated with aging and Alzheimer's disease
    Kathleen O'Neill
    Department of Molecular Pharmacology and Toxicology, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90033, USA
    Exp Neurol 185:63-80. 2004
    ..Results of this study indicate that raloxifene exerted partial estrogen agonist action in the absence of 17 beta-estradiol whereas in the presence of 17 beta-estradiol, raloxifene exerted a mixed estrogen agonist-antagonist effect...
  33. pmc Regeneration in a degenerating brain: potential of allopregnanolone as a neuroregenerative agent
    Jun Ming Wang
    Department of Pharmacology and Pharmaceutical Sciences and Program in Neuroscience, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
    Curr Alzheimer Res 4:510-7. 2007
    ..Together the data indicate that APalpha may maintain the regenerative ability of the brain and modify progression of AD related pathology. Challenges for efficacy of regenerative agents within a degenerative milieu are discussed...
  34. pmc 17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention
    Liqin Zhao
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA
    Neurobiol Aging 32:1949-63. 2011
    ....
  35. pmc Allopregnanolone promotes regeneration and reduces β-amyloid burden in a preclinical model of Alzheimer's disease
    Shuhua Chen
    Department of Pharmacology and Pharmaceutical Science, School of Pharmacy, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 6:e24293. 2011
    ....
  36. pmc 2-Deoxy-D-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease
    Jia Yao
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 6:e21788. 2011
    ..Collectively, these data provide preclinical evidence for dietary 2-DG as a disease-modifying intervention to delay progression of bioenergetic deficits in brain and associated β-amyloid burden...
  37. pmc Activation of estrogen receptor alpha increases and estrogen receptor beta decreases apolipoprotein E expression in hippocampus in vitro and in vivo
    Jun Ming Wang
    Department of Pharmacology and Pharmaceutical Science, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 103:16983-8. 2006
    ..These data suggest that use of ER-selective ligands could provide therapeutic benefit to reduce the risk of AD by increasing ApoE expression in ApoE2/3 allele carriers and decreasing ApoE expression in ApoE4 allele carriers...
  38. pmc Estrogen and hippocampal plasticity in rodent models
    Michael R Foy
    Department of Psychology, Loyola Marymount University, Los Angeles, CA 90045, USA
    J Alzheimers Dis 15:589-603. 2008
    ..A better understanding of the non-reproductive functions of ovarian hormones has far-reaching implications for hormone therapy to maintain health and function within the nervous system throughout aging...
  39. pmc Ovarian hormone loss induces bioenergetic deficits and mitochondrial β-amyloid
    Jia Yao
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA
    Neurobiol Aging 33:1507-21. 2012
    ..These findings provide a plausible mechanism for increased risk of Alzheimer's disease in premenopausally oophorectomized women while also suggesting a therapeutic strategy for prevention...
  40. ncbi request reprint Investigative models for determining hormone therapy-induced outcomes in brain: evidence in support of a healthy cell bias of estrogen action
    Roberta Diaz Brinton
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, 1985 Zonal Ave, Los Angeles, CA 90089 9121, USA
    Ann N Y Acad Sci 1052:57-74. 2005
    ....
  41. pmc Select estrogens within the complex formulation of conjugated equine estrogens (Premarin) are protective against neurodegenerative insults: implications for a composition of estrogen therapy to promote neuronal function and prevent Alzheimer's disease
    Liqin Zhao
    Department of Molecular Pharmacology and Toxicology, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, CA 90089, USA
    BMC Neurosci 7:24. 2006
    ..Further, we sought, through computer-aided modeling analyses, to investigate the potential correlation of the molecular mechanisms that conferred estrogen neuroprotection with estrogen interactions with the estrogen receptor (ER)...
  42. pmc Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signaling
    Jon Nilsen
    Department of Molecular Pharmacology and Toxicology and Program in Neuroscience, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 100:10506-11. 2003
    ..The recent results from the Women's Health Initiative trial, which used MPA as the progestinal agent, indicate that differences between progestin formulations are crucial to health outcomes in women...
  43. pmc The effect of dietary soy isoflavones before and after ovariectomy on hippocampal protein markers of mitochondrial bioenergetics and antioxidant activity in female monkeys
    Jamaica R Rettberg
    Program in Neuroscience, University of Southern California, Los Angeles, CA 90089, USA
    Brain Res 1379:23-33. 2011
    ....
  44. ncbi request reprint Impact of progestins on estradiol potentiation of the glutamate calcium response
    Jon Nilsen
    Department of Molecular Pharmacology and Toxicology and the Program in Neuroscience, University of Southern California, Pharmaceutical Sciences Center, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
    Neuroreport 13:825-30. 2002
    ..These results may have important implications for effective use of HRT to maintain cognitive function during menopause and aging...
  45. ncbi request reprint Impact of the selective estrogen receptor modulator, tamoxifen, on neuronal outgrowth and survival following toxic insults associated with aging and Alzheimer's disease
    Kathleen O'Neill
    Department of Molecular Pharmacology and Toxicology, University of Southern California, Pharmaceutical Sciences Center, Los Angeles 90033, USA
    Exp Neurol 188:268-78. 2004
    ..Results of these studies predict that TMX and OHT could exert a neuroprotective function but would not promote estrogen-dependent memory function...
  46. ncbi request reprint Therapeutic potential of neurogenesis for prevention and recovery from Alzheimer's disease: allopregnanolone as a proof of concept neurogenic agent
    Roberta Diaz Brinton
    Department of Molecular Pharmacology and Toxicology and Program in Neuroscience, Pharmaceutical Science Center, 1985 Zonal Avenue, University of Southern California, Los Angeles, CA 90033, USA
    Curr Alzheimer Res 3:185-90. 2006
    ..Also included is a review of our current research into the neurogenic potential of the small molecule, blood brain barrier penetrating, neurosteroid allopregnanolone (APalpha)...
  47. pmc Shift in brain metabolism in late onset Alzheimer's disease: implications for biomarkers and therapeutic interventions
    Jia Yao
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, United States
    Mol Aspects Med 32:247-57. 2011
    ....
  48. pmc 17β-estradiol and progesterone regulate expression of β-amyloid clearance factors in primary neuron cultures and female rat brain
    Anusha Jayaraman
    Neuroscience Graduate Program, University of Southern California, Los Angeles, California 90089, USA
    Endocrinology 153:5467-79. 2012
    ..These findings further define sex steroid hormone actions involved in regulation of Aβ, a relationship potentially important to therapeutic approaches aimed at reducing risk of Alzheimer's disease...
  49. pmc Progesterone and estrogen regulate oxidative metabolism in brain mitochondria
    Ronald W Irwin
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Pharmaceutical Sciences Center, 1985 Zonal Avenue, Los Angeles, California 90089, USA
    Endocrinology 149:3167-75. 2008
    ..As such, ovarian hormone replacement induces mitochondrial alterations in the central nervous system supporting efficient and balanced bioenergetics reducing oxidative stress and attenuating endogenous oxidative damage...
  50. ncbi request reprint Regenerative potential of allopregnanolone
    Jun Ming Wang
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, CA 90089 9121, USA
    Brain Res Rev 57:398-409. 2008
    ..This review summarizes current APalpha research in different animal models, neural progenitor regeneration within a degenerative milieu and the challenge for developing neuroregenerative therapeutics...
  51. doi request reprint Estrogen regulation of mitochondrial bioenergetics: implications for prevention of Alzheimer's disease
    Jia Yao
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, USA
    Adv Pharmacol 64:327-71. 2012
    ..As the continuum of neurological health progresses from healthy to unhealthy, so too do the benefits of estrogen or hormone therapy...
  52. ncbi request reprint Mitochondria as therapeutic targets of estrogen action in the central nervous system
    Jon Nilsen
    Department of Molecular Pharmacology and Toxicology, University of Southern California, Pharmaceutical Sciences Center, Los Angeles 90033, USA
    Curr Drug Targets CNS Neurol Disord 3:297-313. 2004
    ....
  53. ncbi request reprint Preclinical analyses of the therapeutic potential of allopregnanolone to promote neurogenesis in vitro and in vivo in transgenic mouse model of Alzheimer's disease
    Roberta Diaz Brinton
    Department of Molecular Pharmacology and Toxicology and Program in Neuroscience, Pharmaceutical Science Center, 1985 Zonal Avenue, University of Southern California, Los Angeles, CA 90033, USA
    Curr Alzheimer Res 3:11-7. 2006
    ....
  54. ncbi request reprint Impact of clinically relevant progestins on the neural effects of estradiol and the signaling pathways involved
    Jon Nilsen
    Department of Molecular Pharmacology and Toxicology, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, California 90089, USA
    Drug News Perspect 18:545-53. 2005
    ....
  55. ncbi request reprint Selective estrogen receptor modulators (SERMs) for the brain: current status and remaining challenges for developing NeuroSERMs
    Liqin Zhao
    Department of Molecular Pharmacology and Toxicology and the Program in Neuroscience, School of Pharmacy, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, CA 90089, USA
    Brain Res Brain Res Rev 49:472-93. 2005
    ..Results of these endeavors have yielded insights into strategies for developing novel molecules with NeuroSERM potential in order to prevent brain related climacteric symptoms and neurodegenerative diseases...
  56. pmc Mechanism of estrogen-mediated neuroprotection: regulation of mitochondrial calcium and Bcl-2 expression
    Jon Nilsen
    Department of Molecular Pharmacology and Toxicology and Program in Neuroscience, Pharmaceutical Sciences Center, 1985 Zonal Avenue, University of Southern California, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 100:2842-7. 2003
    ....
  57. pmc Early decline in glucose transport and metabolism precedes shift to ketogenic system in female aging and Alzheimer's mouse brain: implication for bioenergetic intervention
    Fan Ding
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 8:e79977. 2013
    ....
  58. ncbi request reprint The neurosteroid allopregnanolone promotes proliferation of rodent and human neural progenitor cells and regulates cell-cycle gene and protein expression
    Jun Ming Wang
    Department of Molecular Pharmacology and Toxicology and Program in Neuroscience, Pharmaceutical Science Center, University of Southern California, Los Angeles, California 90033, USA
    J Neurosci 25:4706-18. 2005
    ..The therapeutic potential of allopregnanolone as a neurogenic molecule is discussed...
  59. ncbi request reprint Targeting mitochondrial bioenergetics for Alzheimer's prevention and treatment
    Jia Yao
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, 90033, USA
    Curr Pharm Des 17:3474-9. 2011
    ....
  60. ncbi request reprint Vasopressin-induced cytoplasmic and nuclear calcium signaling in cultured cortical astrocytes
    Lixia Zhao
    Department of Molecular Pharmacology and Toxicology, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, CA 90089, USA
    Brain Res 943:117-31. 2002
    ..To our knowledge, this is the first documentation of a vasopressin receptor-induced calcium signaling cascade in cortical astrocytes and the first documentation of vasopressin receptor induction of nuclear calcium signaling...
  61. ncbi request reprint Dual action of estrogen on glutamate-induced calcium signaling: mechanisms requiring interaction between estrogen receptors and src/mitogen activated protein kinase pathway
    Jon Nilsen
    Department of Molecular Pharmacology and Toxicology, Pharmaceutical Sciences Center, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
    Brain Res 930:216-34. 2002
    ..These data provide potential mechanisms to explain the cognitive enhancing and neuroprotective effects exerted by ERT...
  62. ncbi request reprint Turning students into science stars
    Joseph D Cocozza
    Biomimetic MicroElectornic Systems Engineering Research Center, USA
    IEEE Eng Med Biol Mag 24:82-91. 2005
  63. ncbi request reprint Estradiol in vivo regulation of brain mitochondrial proteome
    Jon Nilsen
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, Pharmaceutical Sciences Center, and Program in Neuroscience, University of Southern California, Los Angeles, California 90033, USA
    J Neurosci 27:14069-77. 2007
    ....
  64. ncbi request reprint WHI and WHIMS follow-up and human studies of soy isoflavones on cognition
    Liqin Zhao
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Expert Rev Neurother 7:1549-64. 2007
    ..Development of an effective phytoestrogen formulation would benefit both women and men to prevent or treat hormone-dependent conditions and, most of all, to improve neurological health and reduce the risk of Alzheimer's disease...
  65. pmc Neuroregenerative mechanisms of allopregnanolone in Alzheimer's disease
    Ronald W Irwin
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California Los Angeles, CA, USA
    Front Endocrinol (Lausanne) 2:117. 2011
    ..To our knowledge, APα is the only small molecule that both promotes neural progenitor regeneration in brain and simultaneously reduces AD pathology burden...
  66. ncbi request reprint Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate
    Jon Nilsen
    Department of Molecular Pharmacology and Toxicology, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90033, USA
    Endocrinology 143:205-12. 2002
    ....
  67. ncbi request reprint Neuronal network morphology and electrophysiologyof hippocampal neurons cultured on surface-treated multielectrode arrays
    Walid V Soussou
    Neuroscience Program, University of Southern California, Los Angeles, CA 90089 2520, USA
    IEEE Trans Biomed Eng 54:1309-20. 2007
    ..These data indicate that factors, which influence adherence of neurons to surfaces, can profoundly impact both neuronal network morphology and electrophysiological activity in vitro...
  68. ncbi request reprint Neuroprotective and neurotrophic efficacy of phytoestrogens in cultured hippocampal neurons
    Lixia Zhao
    Department of Molecular Pharmacology and Toxicology and Neuroscience Program, Pharmaceutical Sciences Center, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
    Exp Biol Med (Maywood) 227:509-19. 2002
    ....
  69. ncbi request reprint Effects of estrogen plus progestin on risk of dementia
    Roberta Diaz Brinton
    JAMA 290:1706; author reply 1707-8. 2003

Research Grants9

  1. Estrogen-Induced Neuroprotective Mitochondrial Mechanism
    ROBERTA BRINTON; Fiscal Year: 2007
    ....
  2. Estrogen-Induced Neuroprotective Mitochondrial Mechanism
    Roberta Diaz Brinton; Fiscal Year: 2010
    ..Our project will investigate estrogen regulation of mitochondrial function as healthy mitochondria are key to sustaining neurological function and preventing neurodegenerative diseases. ..