Research Topics
Species | ROBERTA BRINTONSummaryAffiliation: University of Southern California Country: USA Publications
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Publications
Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and functionJon Nilsen
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90033, USA
BMC Neurosci 7:74. 2006..Although all underlying molecular mechanisms of amyloid beta neurotoxicity remain undetermined, mitochondrial dysfunction, including altered calcium homeostasis and Bcl-2 expression, are involved in neurodegenerative vulnerability...- Select estrogens within the complex formulation of conjugated equine estrogens (Premarin) are protective against neurodegenerative insults: implications for a composition of estrogen therapy to promote neuronal function and prevent Alzheimer's diseaseLiqin Zhao
Department of Molecular Pharmacology and Toxicology, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, CA 90089, USA
BMC Neurosci 7:24. 2006..Further, we sought, through computer-aided modeling analyses, to investigate the potential correlation of the molecular mechanisms that conferred estrogen neuroprotection with estrogen interactions with the estrogen receptor (ER)... - Progesterone receptors: form and function in brainRoberta Diaz Brinton
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
Front Neuroendocrinol 29:313-39. 2008.... - Building a neuroscience legacyRoberta Diaz Brinton
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90033, USA
J Neurosci 27:11163-6. 2007 - Estrogen regulation of glucose metabolism and mitochondrial function: therapeutic implications for prevention of Alzheimer's diseaseRoberta Diaz Brinton
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy Pharmaceutical Sciences Center, Los Angeles, California 90033, USA
Adv Drug Deliv Rev 60:1504-11. 2008..The enhanced aerobic glycolysis in the aging brain would be predicted to prevent conversion of the brain to using alternative sources of fuel such as the ketone body pathway characteristic of Alzheimer's... - The healthy cell bias of estrogen action: mitochondrial bioenergetics and neurological implicationsRoberta Diaz Brinton
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy Pharmaceutical Sciences Center, Los Angeles, CA 90033, USA
Trends Neurosci 31:529-37. 2008.... - Requirements of a brain selective estrogen: advances and remaining challenges for developing a NeuroSERMRoberta Diaz Brinton
Department of Molecular Pharmacology and Toxicology and the Program in Neuroscience, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, CA 90089, USA
J Alzheimers Dis 6:S27-35. 2004.... - Estrogen-induced plasticity from cells to circuits: predictions for cognitive functionRoberta Diaz Brinton
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy Pharmaceutical Sciences Center, Los Angeles, CA 90033, USA
Trends Pharmacol Sci 30:212-22. 2009.... - Impact of estrogen therapy on Alzheimer's disease: a fork in the road?Roberta D Brinton
Department of Molecular Pharmacology and Toxicology and the Program in Neuroscience, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, California, USA
CNS Drugs 18:405-22. 2004..An estrogen advantage hypothesis is put forth that provides a unifying mechanism of estrogen action with implications for both the benefits and risks of estrogen therapy... - Targeting mitochondrial bioenergetics for Alzheimer's prevention and treatmentJia Yao
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, 90033, USA
Curr Pharm Des 17:3474-9. 2011.... - Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neuronsLiqin Zhao
Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Pharmaceutical Sciences Center, 1985 Zonal Avenue, Los Angeles, CA 90089 9121, USA
Brain Res 1010:22-34. 2004.... - Impact of progestins on estradiol potentiation of the glutamate calcium responseJon Nilsen
Department of Molecular Pharmacology and Toxicology and the Program in Neuroscience, University of Southern California, Pharmaceutical Sciences Center, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
Neuroreport 13:825-30. 2002..These results may have important implications for effective use of HRT to maintain cognitive function during menopause and aging... - Estrogenic agonist activity of ICI 182,780 (Faslodex) in hippocampal neurons: implications for basic science understanding of estrogen signaling and development of estrogen modulators with a dual therapeutic profileLiqin Zhao
Molecular Pharmacology and Toxicology, Neuroscience, and Biomedical Engineering, University of Southern California, 1985 Zonal Avenue, PSC 503, Los Angeles, CA 90089, USA
J Pharmacol Exp Ther 319:1124-32. 2006.... - Impact of the selective estrogen receptor modulator, raloxifene, on neuronal survival and outgrowth following toxic insults associated with aging and Alzheimer's diseaseShuhua Chen
Department of Molecular Pharmacology and Toxicology, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90033, USA
Exp Neurol 185:63-80. 2004..Results of this study indicate that raloxifene exerted partial estrogen agonist action in the absence of 17 beta-estradiol whereas in the presence of 17 beta-estradiol, raloxifene exerted a mixed estrogen agonist-antagonist effect... - Estrogen receptor alpha and beta differentially regulate intracellular Ca(2+) dynamics leading to ERK phosphorylation and estrogen neuroprotection in hippocampal neuronsLiqin Zhao
Department of Pharmacology and Pharmaceutical Sciences, Norris Foundation Laboratory for Neuroscience Research, University of Southern California, Los Angeles, CA 90089, USA
Brain Res 1172:48-59. 2007..Further, the present analyses suggest that separate from a classical nuclear ER-mediated response, estrogen promotes neuronal survival likely through a non-nuclear cytoplasm or membrane-associated ER-mediated rapid signaling cascade... - Dose and temporal pattern of estrogen exposure determines neuroprotective outcome in hippocampal neurons: therapeutic implicationsShuhua Chen
Department of Molecular Pharmacology and Toxicology, University of Southern California, 1985 Zonal Avenue, Los Angeles, California 90089-9121, USA
Endocrinology 147:5303-13. 2006..treat Alzheimer's disease. Furthermore, these data are consistent with a healthy cell bias of estrogen benefit... - The neurosteroid allopregnanolone promotes proliferation of rodent and human neural progenitor cells and regulates cell-cycle gene and protein expressionJun Ming Wang
Department of Molecular Pharmacology and Toxicology and Program in Neuroscience, Pharmaceutical Science Center, University of Southern California, Los Angeles, California 90033, USA
J Neurosci 25:4706-18. 2005..The therapeutic potential of allopregnanolone as a neurogenic molecule is discussed... - Estrogen receptor protein interaction with phosphatidylinositol 3-kinase leads to activation of phosphorylated Akt and extracellular signal-regulated kinase 1/2 in the same population of cortical neurons: a unified mechanism of estrogen actionPaolo Mannella
Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles, California 90033, USA
J Neurosci 26:9439-47. 2006..Implications of these results for understanding estrogen mechanism of action in neurons and therapeutic development are considered... - Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's diseaseJun Ming Wang
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern corrected California, Los Angeles, CA 90089, USA
Proc Natl Acad Sci U S A 107:6498-503. 2010.... - Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescenceJia Yao
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA
Biochim Biophys Acta 1800:1121-6. 2010..Herein, we sought to determine the impact of reproductive senescence on mitochondrial function in the normal non-transgenic (nonTg) and 3xTgAD female mouse model of AD... - Estradiol-17beta-induced human neural progenitor cell proliferation is mediated by an estrogen receptor beta-phosphorylated extracellularly regulated kinase pathwayJun Ming Wang
Department of Pharmacology and Pharmacological Science, University of Southern California, 1985 Zonal Avenue, Los Angeles, California 90089 9121, USA
Endocrinology 149:208-18. 2008..Therapeutic implications of these findings relevant to hormone therapy and prevention of neurodegenerative disease are discussed... - Vasopressin-induced cytoplasmic and nuclear calcium signaling in embryonic cortical astrocytes: dynamics of calcium and calcium-dependent kinase translocationLixia Zhao
Department of Molecular Pharmacology and Toxicology, Program in Neuroscience, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, California 90089-9121, USA
J Neurosci 23:4228-39. 2003..Implications for development and regeneration induced by V1aR activation of CREB-regulated gene expression in cortical astrocytes are discussed... - Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's diseaseJia Yao
Department of Pharmacology and Pharmaceutical Sciences and Program in Neuroscience, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90033, USA
Proc Natl Acad Sci U S A 106:14670-5. 2009..Mitochondrial dysfunction provides a plausible mechanistic rationale for the hypometabolism in brain that precedes AD diagnosis and suggests therapeutic targets for prevention of AD... - Allopregnanolone-induced rise in intracellular calcium in embryonic hippocampal neurons parallels their proliferative potentialJun Ming Wang
Department of Pharmacology and Pharmaceutical Sciences and Program in Neuroscience, University of Southern California, Los Angeles, CA 90089, USA
BMC Neurosci 9:S11. 2008..We also found that APalpha-induced proliferation of neural progenitors is abolished by a calcium channel blocker, nifedipine, indicating a calcium dependent mechanism for the proliferation... - Regeneration in a degenerating brain: potential of allopregnanolone as a neuroregenerative agentJun Ming Wang
Department of Pharmacology and Pharmaceutical Sciences and Program in Neuroscience, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
Curr Alzheimer Res 4:510-7. 2007..Together the data indicate that APalpha may maintain the regenerative ability of the brain and modify progression of AD related pathology. Challenges for efficacy of regenerative agents within a degenerative milieu are discussed... - Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signalingJon Nilsen
Department of Molecular Pharmacology and Toxicology and Program in Neuroscience, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90089, USA
Proc Natl Acad Sci U S A 100:10506-11. 2003..The recent results from the Women's Health Initiative trial, which used MPA as the progestinal agent, indicate that differences between progestin formulations are crucial to health outcomes in women... - Progesterone and estrogen regulate oxidative metabolism in brain mitochondriaRonald W Irwin
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Pharmaceutical Sciences Center, 1985 Zonal Avenue, Los Angeles, California 90089, USA
Endocrinology 149:3167-75. 2008..As such, ovarian hormone replacement induces mitochondrial alterations in the central nervous system supporting efficient and balanced bioenergetics reducing oxidative stress and attenuating endogenous oxidative damage... - WHI and WHIMS follow-up and human studies of soy isoflavones on cognitionLiqin Zhao
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
Expert Rev Neurother 7:1549-64. 2007..Development of an effective phytoestrogen formulation would benefit both women and men to prevent or treat hormone-dependent conditions and, most of all, to improve neurological health and reduce the risk of Alzheimer's disease... - A select combination of clinically relevant phytoestrogens enhances estrogen receptor beta-binding selectivity and neuroprotective activities in vitro and in vivoLiqin Zhao
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
Endocrinology 150:770-83. 2009.... - Therapeutic potential of neurogenesis for prevention and recovery from Alzheimer's disease: allopregnanolone as a proof of concept neurogenic agentRoberta Diaz Brinton
Department of Molecular Pharmacology and Toxicology and Program in Neuroscience, Pharmaceutical Science Center, 1985 Zonal Avenue, University of Southern California, Los Angeles, CA 90033, USA
Curr Alzheimer Res 3:185-90. 2006..Also included is a review of our current research into the neurogenic potential of the small molecule, blood brain barrier penetrating, neurosteroid allopregnanolone (APalpha)... - Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetateJon Nilsen
Department of Molecular Pharmacology and Toxicology, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90033, USA
Endocrinology 143:205-12. 2002.... - Dual action of estrogen on glutamate-induced calcium signaling: mechanisms requiring interaction between estrogen receptors and src/mitogen activated protein kinase pathwayJon Nilsen
Department of Molecular Pharmacology and Toxicology, Pharmaceutical Sciences Center, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
Brain Res 930:216-34. 2002..These data provide potential mechanisms to explain the cognitive enhancing and neuroprotective effects exerted by ERT... - Mitochondria as therapeutic targets of estrogen action in the central nervous systemJon Nilsen
Department of Molecular Pharmacology and Toxicology, University of Southern California, Pharmaceutical Sciences Center, Los Angeles 90033, USA
Curr Drug Targets CNS Neurol Disord 3:297-313. 2004.... - Investigative models for determining hormone therapy-induced outcomes in brain: evidence in support of a healthy cell bias of estrogen actionRoberta Diaz Brinton
Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, 1985 Zonal Ave, Los Angeles, CA 90089 9121, USA
Ann N Y Acad Sci 1052:57-74. 2005.... - Turning students into science starsJoseph D Cocozza
Biomimetic MicroElectornic Systems Engineering Research Center, USA
IEEE Eng Med Biol Mag 24:82-91. 2005 - Impact of clinically relevant progestins on the neural effects of estradiol and the signaling pathways involvedJon Nilsen
Department of Molecular Pharmacology and Toxicology, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, California 90089, USA
Drug News Perspect 18:545-53. 2005.... - Preclinical analyses of the therapeutic potential of allopregnanolone to promote neurogenesis in vitro and in vivo in transgenic mouse model of Alzheimer's diseaseRoberta Diaz Brinton
Department of Molecular Pharmacology and Toxicology and Program in Neuroscience, Pharmaceutical Science Center, 1985 Zonal Avenue, University of Southern California, Los Angeles, CA 90033, USA
Curr Alzheimer Res 3:11-7. 2006.... - Medroxyprogesterone acetate exacerbates glutamate excitotoxicityJon Nilsen
Department of Molecular Pharmacology and Toxicology, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, CA 90089, USA
Gynecol Endocrinol 22:355-61. 2006..Collectively these results predict that the progestin formulation of hormone therapy will affect the vulnerability of the central nervous system to degenerative insults... - Activation of estrogen receptor alpha increases and estrogen receptor beta decreases apolipoprotein E expression in hippocampus in vitro and in vivoJun Ming Wang
Department of Pharmacology and Pharmaceutical Science, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
Proc Natl Acad Sci U S A 103:16983-8. 2006..These data suggest that use of ER-selective ligands could provide therapeutic benefit to reduce the risk of AD by increasing ApoE expression in ApoE2/3 allele carriers and decreasing ApoE expression in ApoE4 allele carriers... - Neuronal network morphology and electrophysiologyof hippocampal neurons cultured on surface-treated multielectrode arraysWalid V Soussou
Neuroscience Program, University of Southern California, Los Angeles, CA 90089 2520, USA
IEEE Trans Biomed Eng 54:1309-20. 2007..These data indicate that factors, which influence adherence of neurons to surfaces, can profoundly impact both neuronal network morphology and electrophysiological activity in vitro... - Regenerative potential of allopregnanoloneJun Ming Wang
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, CA 90089 9121, USA
Brain Res Rev 57:398-409. 2008..This review summarizes current APalpha research in different animal models, neural progenitor regeneration within a degenerative milieu and the challenge for developing neuroregenerative therapeutics... - Progesterone increases rat neural progenitor cell cycle gene expression and proliferation via extracellularly regulated kinase and progesterone receptor membrane components 1 and 2Lifei Liu
Program in Neuroscience, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, California 90089, USA
Endocrinology 150:3186-96. 2009..Progesterone mediated NPC proliferation and concomitant regulation of mitotic cell cycle genes via a PGRMC/ERK pathway mechanism is a potential novel therapeutic target for promoting neurogenesis in the mammalian brain... - Vasopressin-induced cytoplasmic and nuclear calcium signaling in cultured cortical astrocytesLixia Zhao
Department of Molecular Pharmacology and Toxicology, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, CA 90089, USA
Brain Res 943:117-31. 2002..To our knowledge, this is the first documentation of a vasopressin receptor-induced calcium signaling cascade in cortical astrocytes and the first documentation of vasopressin receptor induction of nuclear calcium signaling... - Medroxyprogesterone acetate antagonizes estrogen up-regulation of brain mitochondrial functionRonald W Irwin
Department of Pharmacology and Pharmaceutical Sciences, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, California 90089, USA
Endocrinology 152:556-67. 2011..These preclinical findings on the basis of acute exposure to MPA raise concerns regarding neurological health after chronic use of MPA in contraceptive and hormone therapy... - Estradiol in vivo regulation of brain mitochondrial proteomeJon Nilsen
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, Pharmaceutical Sciences Center, and Program in Neuroscience, University of Southern California, Los Angeles, California 90033, USA
J Neurosci 27:14069-77. 2007.... - Effects of estrogen plus progestin on risk of dementiaRoberta Diaz Brinton
JAMA 290:1706; author reply 1707-8. 2003
Research Grants
- Estrogen-Induced Neuroprotective Mitochondrial MechanismROBERTA BRINTON; Fiscal Year: 2007....
- Estrogen-Induced Neuroprotective Mitochondrial MechanismRoberta Diaz Brinton; Fiscal Year: 2010..Our project will investigate estrogen regulation of mitochondrial function as healthy mitochondria are key to sustaining neurological function and preventing neurodegenerative diseases. ..