R D Brinton

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. pmc Allopregnanolone-induced rise in intracellular calcium in embryonic hippocampal neurons parallels their proliferative potential
    Jun Ming Wang
    Department of Pharmacology and Pharmaceutical Sciences and Program in Neuroscience, University of Southern California, Los Angeles, CA 90089, USA
    BMC Neurosci 9:S11. 2008
  2. ncbi request reprint The estrogen replacement therapy of the Women's Health Initiative promotes the cellular mechanisms of memory and neuronal survival in neurons vulnerable to Alzheimer's disease
    R D Brinton
    Department of Molecular Pharmacology and Toxicology and the Program in Neuroscience, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90033, USA
    Maturitas 34:S35-52. 2000
  3. pmc Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signaling
    Jon Nilsen
    Department of Molecular Pharmacology and Toxicology and Program in Neuroscience, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 100:10506-11. 2003
  4. ncbi request reprint Investigative models for determining hormone therapy-induced outcomes in brain: evidence in support of a healthy cell bias of estrogen action
    Roberta Diaz Brinton
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, 1985 Zonal Ave, Los Angeles, CA 90089 9121, USA
    Ann N Y Acad Sci 1052:57-74. 2005
  5. ncbi request reprint Preclinical analyses of the therapeutic potential of allopregnanolone to promote neurogenesis in vitro and in vivo in transgenic mouse model of Alzheimer's disease
    Roberta Diaz Brinton
    Department of Molecular Pharmacology and Toxicology and Program in Neuroscience, Pharmaceutical Science Center, 1985 Zonal Avenue, University of Southern California, Los Angeles, CA 90033, USA
    Curr Alzheimer Res 3:11-7. 2006
  6. ncbi request reprint Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate
    Jon Nilsen
    Department of Molecular Pharmacology and Toxicology, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90033, USA
    Endocrinology 143:205-12. 2002
  7. ncbi request reprint Cellular and molecular mechanisms of estrogen regulation of memory function and neuroprotection against Alzheimer's disease: recent insights and remaining challenges
    R D Brinton
    Department of Molecular Pharmacology and Toxicology and the Program in Neuroscience, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, California 90033, USA
    Learn Mem 8:121-33. 2001
  8. ncbi request reprint Spatial, cellular and temporal basis of vasopressin potentiation of norepinephrine-induced cAMP formation
    R D Brinton
    Department of Molecular Pharmacology and Toxicology, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, CA 90089, USA
    Eur J Pharmacol 405:73-88. 2000
  9. ncbi request reprint Therapeutic potential of neurogenesis for prevention and recovery from Alzheimer's disease: allopregnanolone as a proof of concept neurogenic agent
    Roberta Diaz Brinton
    Department of Molecular Pharmacology and Toxicology and Program in Neuroscience, Pharmaceutical Science Center, 1985 Zonal Avenue, University of Southern California, Los Angeles, CA 90033, USA
    Curr Alzheimer Res 3:185-90. 2006
  10. ncbi request reprint The women's health initiative estrogen replacement therapy is neurotrophic and neuroprotective
    R Diaz Brinton
    Department of Molecular Pharmacology and Toxicology and the Program in Neuroscience, University of Southern California, Pharmaceutical Sciences Center, 1985 Zonal Avenue, Los Angeles, CA 90033, USA
    Neurobiol Aging 21:475-96. 2000

Collaborators

Detail Information

Publications50

  1. pmc Allopregnanolone-induced rise in intracellular calcium in embryonic hippocampal neurons parallels their proliferative potential
    Jun Ming Wang
    Department of Pharmacology and Pharmaceutical Sciences and Program in Neuroscience, University of Southern California, Los Angeles, CA 90089, USA
    BMC Neurosci 9:S11. 2008
    ..We also found that APalpha-induced proliferation of neural progenitors is abolished by a calcium channel blocker, nifedipine, indicating a calcium dependent mechanism for the proliferation...
  2. ncbi request reprint The estrogen replacement therapy of the Women's Health Initiative promotes the cellular mechanisms of memory and neuronal survival in neurons vulnerable to Alzheimer's disease
    R D Brinton
    Department of Molecular Pharmacology and Toxicology and the Program in Neuroscience, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90033, USA
    Maturitas 34:S35-52. 2000
    ....
  3. pmc Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signaling
    Jon Nilsen
    Department of Molecular Pharmacology and Toxicology and Program in Neuroscience, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 100:10506-11. 2003
    ..The recent results from the Women's Health Initiative trial, which used MPA as the progestinal agent, indicate that differences between progestin formulations are crucial to health outcomes in women...
  4. ncbi request reprint Investigative models for determining hormone therapy-induced outcomes in brain: evidence in support of a healthy cell bias of estrogen action
    Roberta Diaz Brinton
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, 1985 Zonal Ave, Los Angeles, CA 90089 9121, USA
    Ann N Y Acad Sci 1052:57-74. 2005
    ....
  5. ncbi request reprint Preclinical analyses of the therapeutic potential of allopregnanolone to promote neurogenesis in vitro and in vivo in transgenic mouse model of Alzheimer's disease
    Roberta Diaz Brinton
    Department of Molecular Pharmacology and Toxicology and Program in Neuroscience, Pharmaceutical Science Center, 1985 Zonal Avenue, University of Southern California, Los Angeles, CA 90033, USA
    Curr Alzheimer Res 3:11-7. 2006
    ....
  6. ncbi request reprint Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate
    Jon Nilsen
    Department of Molecular Pharmacology and Toxicology, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90033, USA
    Endocrinology 143:205-12. 2002
    ....
  7. ncbi request reprint Cellular and molecular mechanisms of estrogen regulation of memory function and neuroprotection against Alzheimer's disease: recent insights and remaining challenges
    R D Brinton
    Department of Molecular Pharmacology and Toxicology and the Program in Neuroscience, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, California 90033, USA
    Learn Mem 8:121-33. 2001
    ....
  8. ncbi request reprint Spatial, cellular and temporal basis of vasopressin potentiation of norepinephrine-induced cAMP formation
    R D Brinton
    Department of Molecular Pharmacology and Toxicology, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, CA 90089, USA
    Eur J Pharmacol 405:73-88. 2000
    ....
  9. ncbi request reprint Therapeutic potential of neurogenesis for prevention and recovery from Alzheimer's disease: allopregnanolone as a proof of concept neurogenic agent
    Roberta Diaz Brinton
    Department of Molecular Pharmacology and Toxicology and Program in Neuroscience, Pharmaceutical Science Center, 1985 Zonal Avenue, University of Southern California, Los Angeles, CA 90033, USA
    Curr Alzheimer Res 3:185-90. 2006
    ..Also included is a review of our current research into the neurogenic potential of the small molecule, blood brain barrier penetrating, neurosteroid allopregnanolone (APalpha)...
  10. ncbi request reprint The women's health initiative estrogen replacement therapy is neurotrophic and neuroprotective
    R Diaz Brinton
    Department of Molecular Pharmacology and Toxicology and the Program in Neuroscience, University of Southern California, Pharmaceutical Sciences Center, 1985 Zonal Avenue, Los Angeles, CA 90033, USA
    Neurobiol Aging 21:475-96. 2000
    ....
  11. ncbi request reprint Vasopressin-induction of the immediate early gene, NGFI-A, in cultured hippocampal glial cells
    R D Brinton
    Department of Molecular Pharmacology and Toxicology, University of Southern California, 1985 Zonal Ave, Los Angeles, CA 90033, USA
    Brain Res Mol Brain Res 57:73-85. 1998
    ..To our knowledge, these data are the first report of a vasopressin mediated response in hippocampal glial cells. The potential functional significance of these findings is discussed...
  12. ncbi request reprint Advances and challenges in the prevention and treatment of Alzheimer's disease
    R Diaz Brinton
    Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles 90033, USA
    Pharm Res 15:386-98. 1998
    ..The final section addresses the issue of the genetic linkages of AD, the impact of transgenic and gene knockout mouse models of AD on research in the field and the potential use of gene therapy to treat AD...
  13. ncbi request reprint 17 beta-Estradiol enhances the outgrowth and survival of neocortical neurons in culture
    R D Brinton
    Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles 90033, USA
    Neurochem Res 22:1339-51. 1997
    ....
  14. ncbi request reprint 17Beta-estradiol induced Ca2+ influx via L-type calcium channels activates the Src/ERK/cyclic-AMP response element binding protein signal pathway and BCL-2 expression in rat hippocampal neurons: a potential initiation mechanism for estrogen-induced neurop
    T W Wu
    Neuroscience Program, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089 9121, USA
    Neuroscience 135:59-72. 2005
    ..Implications of these data for understanding estrogen action in brain and use of estrogen therapy for prevention of neurodegenerative disease are discussed...
  15. ncbi request reprint Equilin, a principal component of the estrogen replacement therapy premarin, increases the growth of cortical neurons via an NMDA receptor-dependent mechanism
    R D Brinton
    USC STAR Program, University of Southern California, Los Angeles 90033, USA
    Exp Neurol 147:211-20. 1997
    ....
  16. ncbi request reprint Vasopressin and oxytocin receptor mRNA expression during rat telencephalon development
    Q Chen
    Department of Molecular Pharmacology and Toxicology, Pharmaceutical Sciences Center, University of Southern California Los Angeles, Los Angeles, CA 90033, USA
    Neuropeptides 34:173-80. 2000
    ..Temporal patterns of vasopressin receptor and vasopressin peptide mRNA expression along with oxytocin receptor mRNA suggest a temporal role for vasopressin- and oxytocin-mediated actions during rat telencephalon development...
  17. ncbi request reprint 17beta-estradiol induces Ca2+ influx, dendritic and nuclear Ca2+ rise and subsequent cyclic AMP response element-binding protein activation in hippocampal neurons: a potential initiation mechanism for estrogen neurotrophism
    L Zhao
    Department of Molecular Pharmacology and Toxicology, Norris Foundation Laboratory for Neuroscience Research, University of Southern California, Pharmaceutical Sciences Center, 1985 Zonal Avenue, Los Angeles, CA 90089 9121, USA
    Neuroscience 132:299-311. 2005
    ....
  18. ncbi request reprint Localization of V1a vasopressin receptor mRNA expression in cultured neurons, astroglia, and oligodendroglia of rat cerebral cortex
    R S Yamazaki
    Department of Molecular Pharmacology and Toxicology, University of Southern California Pharmaceutical Sciences Center, Los Angeles 90033, USA
    Brain Res Mol Brain Res 45:138-40. 1997
    ..These data indicate that V1aR is broadly distributed throughout the cerebral cortex and suggest that vasopressin plays an important role in cortical functions...
  19. ncbi request reprint Regulation and mechanism of L-type calcium channel activation via V1a vasopressin receptor activation in cultured cortical neurons
    M C Son
    Department of Molecular Pharmacology and Toxicology, Pharmaceutical Sciences Center, Los Angeles, California 90089, USA
    Neurobiol Learn Mem 76:388-402. 2001
    ....
  20. ncbi request reprint 17beta-Estradiol potentiates field excitatory postsynaptic potentials within each subfield of the hippocampus with greatest potentiation of the associational/commissural afferents of CA3
    M T Kim
    Neuroscience Program, University of Southern California, Los Angeles, CA 90089 2520, USA
    Neuroscience 141:391-406. 2006
    ..The implications of 17beta-estradiol potentiation of the field potential in each of the hippocampal subfields and in particular CA3 associational/commissural fibers for memory function and clinical assessment are discussed...
  21. pmc Selective oestrogen receptor modulators differentially potentiate brain mitochondrial function
    R W Irwin
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, CA 90089, USA
    J Neuroendocrinol 24:236-48. 2012
    ..As active components in hormone therapy, synthetically designed oestrogens as well as natural phyto-oestrogen cocktails can be tailored to improve brain mitochondrial endpoints...
  22. ncbi request reprint Impact of the selective estrogen receptor modulator, raloxifene, on neuronal survival and outgrowth following toxic insults associated with aging and Alzheimer's disease
    Kathleen O'Neill
    Department of Molecular Pharmacology and Toxicology, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90033, USA
    Exp Neurol 185:63-80. 2004
    ..Results of this study indicate that raloxifene exerted partial estrogen agonist action in the absence of 17 beta-estradiol whereas in the presence of 17 beta-estradiol, raloxifene exerted a mixed estrogen agonist-antagonist effect...
  23. ncbi request reprint Estrogen receptor protein interaction with phosphatidylinositol 3-kinase leads to activation of phosphorylated Akt and extracellular signal-regulated kinase 1/2 in the same population of cortical neurons: a unified mechanism of estrogen action
    Paolo Mannella
    Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles, California 90033, USA
    J Neurosci 26:9439-47. 2006
    ..Implications of these results for understanding estrogen mechanism of action in neurons and therapeutic development are considered...
  24. pmc Activation of estrogen receptor alpha increases and estrogen receptor beta decreases apolipoprotein E expression in hippocampus in vitro and in vivo
    Jun Ming Wang
    Department of Pharmacology and Pharmaceutical Science, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 103:16983-8. 2006
    ..These data suggest that use of ER-selective ligands could provide therapeutic benefit to reduce the risk of AD by increasing ApoE expression in ApoE2/3 allele carriers and decreasing ApoE expression in ApoE4 allele carriers...
  25. ncbi request reprint Neuronal network morphology and electrophysiologyof hippocampal neurons cultured on surface-treated multielectrode arrays
    Walid V Soussou
    Neuroscience Program, University of Southern California, Los Angeles, CA 90089 2520, USA
    IEEE Trans Biomed Eng 54:1309-20. 2007
    ..These data indicate that factors, which influence adherence of neurons to surfaces, can profoundly impact both neuronal network morphology and electrophysiological activity in vitro...
  26. ncbi request reprint Estrogen receptor alpha and beta differentially regulate intracellular Ca(2+) dynamics leading to ERK phosphorylation and estrogen neuroprotection in hippocampal neurons
    Liqin Zhao
    Department of Pharmacology and Pharmaceutical Sciences, Norris Foundation Laboratory for Neuroscience Research, University of Southern California, Los Angeles, CA 90089, USA
    Brain Res 1172:48-59. 2007
    ..Further, the present analyses suggest that separate from a classical nuclear ER-mediated response, estrogen promotes neuronal survival likely through a non-nuclear cytoplasm or membrane-associated ER-mediated rapid signaling cascade...
  27. ncbi request reprint Regenerative potential of allopregnanolone
    Jun Ming Wang
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, CA 90089 9121, USA
    Brain Res Rev 57:398-409. 2008
    ..This review summarizes current APalpha research in different animal models, neural progenitor regeneration within a degenerative milieu and the challenge for developing neuroregenerative therapeutics...
  28. ncbi request reprint Building a neuroscience legacy
    Roberta Diaz Brinton
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90033, USA
    J Neurosci 27:11163-6. 2007
  29. pmc Estradiol-17beta-induced human neural progenitor cell proliferation is mediated by an estrogen receptor beta-phosphorylated extracellularly regulated kinase pathway
    Jun Ming Wang
    Department of Pharmacology and Pharmacological Science, University of Southern California, 1985 Zonal Avenue, Los Angeles, California 90089 9121, USA
    Endocrinology 149:208-18. 2008
    ..Therapeutic implications of these findings relevant to hormone therapy and prevention of neurodegenerative disease are discussed...
  30. ncbi request reprint WHI and WHIMS follow-up and human studies of soy isoflavones on cognition
    Liqin Zhao
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Expert Rev Neurother 7:1549-64. 2007
    ..Development of an effective phytoestrogen formulation would benefit both women and men to prevent or treat hormone-dependent conditions and, most of all, to improve neurological health and reduce the risk of Alzheimer's disease...
  31. pmc Regeneration in a degenerating brain: potential of allopregnanolone as a neuroregenerative agent
    Jun Ming Wang
    Department of Pharmacology and Pharmaceutical Sciences and Program in Neuroscience, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
    Curr Alzheimer Res 4:510-7. 2007
    ..Together the data indicate that APalpha may maintain the regenerative ability of the brain and modify progression of AD related pathology. Challenges for efficacy of regenerative agents within a degenerative milieu are discussed...
  32. pmc Progesterone and estrogen regulate oxidative metabolism in brain mitochondria
    Ronald W Irwin
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Pharmaceutical Sciences Center, 1985 Zonal Avenue, Los Angeles, California 90089, USA
    Endocrinology 149:3167-75. 2008
    ..As such, ovarian hormone replacement induces mitochondrial alterations in the central nervous system supporting efficient and balanced bioenergetics reducing oxidative stress and attenuating endogenous oxidative damage...
  33. pmc Progesterone receptors: form and function in brain
    Roberta Diaz Brinton
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
    Front Neuroendocrinol 29:313-39. 2008
    ....
  34. ncbi request reprint Estrogenic agonist activity of ICI 182,780 (Faslodex) in hippocampal neurons: implications for basic science understanding of estrogen signaling and development of estrogen modulators with a dual therapeutic profile
    Liqin Zhao
    Molecular Pharmacology and Toxicology, Neuroscience, and Biomedical Engineering, University of Southern California, 1985 Zonal Avenue, PSC 503, Los Angeles, CA 90089, USA
    J Pharmacol Exp Ther 319:1124-32. 2006
    ....
  35. ncbi request reprint Dose and temporal pattern of estrogen exposure determines neuroprotective outcome in hippocampal neurons: therapeutic implications
    Shuhua Chen
    Department of Molecular Pharmacology and Toxicology, University of Southern California, 1985 Zonal Avenue, Los Angeles, California 90089 9121, USA
    Endocrinology 147:5303-13. 2006
    ..treat Alzheimer's disease. Furthermore, these data are consistent with a healthy cell bias of estrogen benefit...
  36. ncbi request reprint Effects of estrogen plus progestin on risk of dementia
    Roberta Diaz Brinton
    JAMA 290:1706; author reply 1707-8. 2003
  37. ncbi request reprint Mitochondria as therapeutic targets of estrogen action in the central nervous system
    Jon Nilsen
    Department of Molecular Pharmacology and Toxicology, University of Southern California, Pharmaceutical Sciences Center, Los Angeles 90033, USA
    Curr Drug Targets CNS Neurol Disord 3:297-313. 2004
    ....
  38. ncbi request reprint Requirements of a brain selective estrogen: advances and remaining challenges for developing a NeuroSERM
    Roberta Diaz Brinton
    Department of Molecular Pharmacology and Toxicology and the Program in Neuroscience, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, CA 90089, USA
    J Alzheimers Dis 6:S27-35. 2004
    ....
  39. ncbi request reprint Vasopressin-induced cytoplasmic and nuclear calcium signaling in embryonic cortical astrocytes: dynamics of calcium and calcium-dependent kinase translocation
    Lixia Zhao
    Department of Molecular Pharmacology and Toxicology, Program in Neuroscience, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, California 90089 9121, USA
    J Neurosci 23:4228-39. 2003
    ..Implications for development and regeneration induced by V1aR activation of CREB-regulated gene expression in cortical astrocytes are discussed...
  40. ncbi request reprint The neurosteroid allopregnanolone promotes proliferation of rodent and human neural progenitor cells and regulates cell-cycle gene and protein expression
    Jun Ming Wang
    Department of Molecular Pharmacology and Toxicology and Program in Neuroscience, Pharmaceutical Science Center, University of Southern California, Los Angeles, California 90033, USA
    J Neurosci 25:4706-18. 2005
    ..The therapeutic potential of allopregnanolone as a neurogenic molecule is discussed...
  41. ncbi request reprint Vasopressin-induced cytoplasmic and nuclear calcium signaling in cultured cortical astrocytes
    Lixia Zhao
    Department of Molecular Pharmacology and Toxicology, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, CA 90089, USA
    Brain Res 943:117-31. 2002
    ..To our knowledge, this is the first documentation of a vasopressin receptor-induced calcium signaling cascade in cortical astrocytes and the first documentation of vasopressin receptor induction of nuclear calcium signaling...
  42. ncbi request reprint Impact of progestins on estradiol potentiation of the glutamate calcium response
    Jon Nilsen
    Department of Molecular Pharmacology and Toxicology and the Program in Neuroscience, University of Southern California, Pharmaceutical Sciences Center, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
    Neuroreport 13:825-30. 2002
    ..These results may have important implications for effective use of HRT to maintain cognitive function during menopause and aging...
  43. ncbi request reprint Turning students into science stars
    Joseph D Cocozza
    Biomimetic MicroElectornic Systems Engineering Research Center, USA
    IEEE Eng Med Biol Mag 24:82-91. 2005
  44. ncbi request reprint Impact of clinically relevant progestins on the neural effects of estradiol and the signaling pathways involved
    Jon Nilsen
    Department of Molecular Pharmacology and Toxicology, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, California 90089, USA
    Drug News Perspect 18:545-53. 2005
    ....
  45. ncbi request reprint Dual action of estrogen on glutamate-induced calcium signaling: mechanisms requiring interaction between estrogen receptors and src/mitogen activated protein kinase pathway
    Jon Nilsen
    Department of Molecular Pharmacology and Toxicology, Pharmaceutical Sciences Center, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
    Brain Res 930:216-34. 2002
    ..These data provide potential mechanisms to explain the cognitive enhancing and neuroprotective effects exerted by ERT...
  46. pmc Select estrogens within the complex formulation of conjugated equine estrogens (Premarin) are protective against neurodegenerative insults: implications for a composition of estrogen therapy to promote neuronal function and prevent Alzheimer's disease
    Liqin Zhao
    Department of Molecular Pharmacology and Toxicology, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, CA 90089, USA
    BMC Neurosci 7:24. 2006
    ..Further, we sought, through computer-aided modeling analyses, to investigate the potential correlation of the molecular mechanisms that conferred estrogen neuroprotection with estrogen interactions with the estrogen receptor (ER)...
  47. ncbi request reprint Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons
    Liqin Zhao
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Pharmaceutical Sciences Center, 1985 Zonal Avenue, Los Angeles, CA 90089 9121, USA
    Brain Res 1010:22-34. 2004
    ....
  48. ncbi request reprint Medroxyprogesterone acetate exacerbates glutamate excitotoxicity
    Jon Nilsen
    Department of Molecular Pharmacology and Toxicology, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, CA 90089, USA
    Gynecol Endocrinol 22:355-61. 2006
    ..Collectively these results predict that the progestin formulation of hormone therapy will affect the vulnerability of the central nervous system to degenerative insults...
  49. pmc Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function
    Jon Nilsen
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90033, USA
    BMC Neurosci 7:74. 2006
    ..Although all underlying molecular mechanisms of amyloid beta neurotoxicity remain undetermined, mitochondrial dysfunction, including altered calcium homeostasis and Bcl-2 expression, are involved in neurodegenerative vulnerability...
  50. ncbi request reprint Estradiol in vivo regulation of brain mitochondrial proteome
    Jon Nilsen
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, Pharmaceutical Sciences Center, and Program in Neuroscience, University of Southern California, Los Angeles, California 90033, USA
    J Neurosci 27:14069-77. 2007
    ....