L S Brinen

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease
    L S Brinen
    Department of Pathology, University of California, San Francisco 94143, USA
    Structure 8:831-40. 2000
  2. ncbi Two approaches to discovering and developing new drugs for Chagas disease
    J H McKerrow
    Sandler Center at Mission Bay, University of California, San Francisco, CA 94158 2330, USA
    Mem Inst Oswaldo Cruz 104:263-9. 2009
  3. ncbi Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense
    C R Caffrey
    Tropical Disease Research Unit, Department of Pathology, University of California San Francisco, VAMC, 4150 Clement Street-113B, San Francisco, CA 94121, USA
    Mol Biochem Parasitol 118:61-73. 2001
  4. ncbi Two approaches to discovering and developing new drugs for Chagas disease
    Jh McKerrow
    Sandler Center at Mission Bay, University of California, San Francisco, CA, USA, 94158 2330
    Mem Inst Oswaldo Cruz 104:263-9. 2009

Collaborators

Detail Information

Publications4

  1. ncbi A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease
    L S Brinen
    Department of Pathology, University of California, San Francisco 94143, USA
    Structure 8:831-40. 2000
    ..Cruzain is the major cysteine protease of T cruzi and has been the target of extensive structure-based drug design...
  2. ncbi Two approaches to discovering and developing new drugs for Chagas disease
    J H McKerrow
    Sandler Center at Mission Bay, University of California, San Francisco, CA 94158 2330, USA
    Mem Inst Oswaldo Cruz 104:263-9. 2009
    ..It is optimized for robotic liquid handling and has been validated through a screen of a library of FDA-approved drugs identifying 65 hits...
  3. ncbi Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense
    C R Caffrey
    Tropical Disease Research Unit, Department of Pathology, University of California San Francisco, VAMC, 4150 Clement Street-113B, San Francisco, CA 94121, USA
    Mol Biochem Parasitol 118:61-73. 2001
    ..S2 subsite mapping of rhodesain and cruzain with fluorogenic peptidyl substrates demonstrates that the presence of alanine rather than glutamate at S2 prevents rhodesain from cleaving substrates in which P2 is arginine...
  4. ncbi Two approaches to discovering and developing new drugs for Chagas disease
    Jh McKerrow
    Sandler Center at Mission Bay, University of California, San Francisco, CA, USA, 94158 2330
    Mem Inst Oswaldo Cruz 104:263-9. 2009
    ..It is optimized for robotic liquid handling and has been validated through a screen of a library of FDA-approved drugs identifying 65 hits...