David Briles

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Intranasal immunization of mice with a mixture of the pneumococcal proteins PsaA and PspA is highly protective against nasopharyngeal carriage of Streptococcus pneumoniae
    D E Briles
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Infect Immun 68:796-800. 2000
  2. ncbi request reprint The potential to use PspA and other pneumococcal proteins to elicit protection against pneumococcal infection
    D E Briles
    Department of Microbiology, University of Alabama at Birmingham, 658 BBLB, 845 19th Street South, Birmingham, AL 35294, USA
    Vaccine 18:1707-11. 2000
  3. ncbi request reprint Immunization of humans with recombinant pneumococcal surface protein A (rPspA) elicits antibodies that passively protect mice from fatal infection with Streptococcus pneumoniae bearing heterologous PspA
    D E Briles
    Departments of Microbiology and Pediatrics, University of Alabama at Birmingham, AL 35294, USA
    J Infect Dis 182:1694-701. 2000
  4. ncbi request reprint The potential for using protein vaccines to protect against otitis media caused by Streptococcus pneumoniae
    D E Briles
    Department of Microbiology, University of Alabama at Birmingham UAB, Birmingham, AL 35294 2170, USA
    Vaccine 19:S87-95. 2000
  5. ncbi request reprint Protection of the elderly from pneumococcal pneumonia with a protein-based vaccine?
    David E Briles
    Department of Microbiology, University of Alabama at Birmingham, Suite 258 11, Bevill Biomedical Research Building, 1530 3rd Avenue South, Birmingham, AL 35294 2170, USA
    Mech Ageing Dev 125:129-31. 2004
  6. ncbi request reprint Immunizations with pneumococcal surface protein A and pneumolysin are protective against pneumonia in a murine model of pulmonary infection with Streptococcus pneumoniae
    David E Briles
    Department of Microbiology, University of Alabama at Birmingham, USA
    J Infect Dis 188:339-48. 2003
  7. doi request reprint Elicitation of mucosal immunity by proteins of Streptococcus pneumoniae
    David E Briles
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    Adv Otorhinolaryngol 72:25-7. 2011
  8. pmc Nasal colonization with Streptococcus pneumoniae includes subpopulations of surface and invasive pneumococci
    David E Briles
    Department of Microbiology, University of Alabama at Birmingham, USA
    Infect Immun 73:6945-51. 2005
  9. pmc Role of pneumococcal surface protein C in nasopharyngeal carriage and pneumonia and its ability to elicit protection against carriage of Streptococcus pneumoniae
    Priya Balachandran
    Department of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Infect Immun 70:2526-34. 2002
  10. pmc Regions of PspA/EF3296 best able to elicit protection against Streptococcus pneumoniae in a murine infection model
    Hazeline Roche
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Infect Immun 71:1033-41. 2003

Research Grants

  1. IMMUNITY TO PNEUMOCOCCAL SURFACE PROTEIN A AND C
    David Briles; Fiscal Year: 2002
  2. Mechanism of Action of Antibody to PspA
    David Briles; Fiscal Year: 2003
  3. Mechanism of Action of Antibody to PspA
    David Briles; Fiscal Year: 2006
  4. Mechanism of Action of Antibody to PspA
    David Briles; Fiscal Year: 2007
  5. MOLECULAR AND CELLULAR BACTERIAL PATHOGENESIS
    David Briles; Fiscal Year: 2007
  6. PspA: A Potential Pneumococcal Vaccine Component
    David Briles; Fiscal Year: 2009
  7. PspA: A Potential Pneumococcal Vaccine Component
    David E Briles; Fiscal Year: 2010
  8. PROTECTIVE IMMUNITY TO PNEUMOCOCCAL SURFACE PROTEIN A
    David Briles; Fiscal Year: 1993
  9. PROTECTIVE IMMUNITY TO PNEUMOCOCCAL SURFACE PROTEINS
    David Briles; Fiscal Year: 1991
  10. PspA: A Potential Pneumococcal Vaccine Component
    David Briles; Fiscal Year: 2009

Collaborators

Detail Information

Publications53

  1. pmc Intranasal immunization of mice with a mixture of the pneumococcal proteins PsaA and PspA is highly protective against nasopharyngeal carriage of Streptococcus pneumoniae
    D E Briles
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Infect Immun 68:796-800. 2000
    ..As PspA and pneumolysin are known to elicit immunity to bacteremia and pneumonia, their inclusion in a mucosal vaccine may enable such a vaccine to prevent invasive disease as well as carriage...
  2. ncbi request reprint The potential to use PspA and other pneumococcal proteins to elicit protection against pneumococcal infection
    D E Briles
    Department of Microbiology, University of Alabama at Birmingham, 658 BBLB, 845 19th Street South, Birmingham, AL 35294, USA
    Vaccine 18:1707-11. 2000
    ..The immune human serum protected mice from infections with pneumococci expressing either of the major PspA families (1 and 2) and both of the pneumococcal capsular types tested: 3 and 6...
  3. ncbi request reprint Immunization of humans with recombinant pneumococcal surface protein A (rPspA) elicits antibodies that passively protect mice from fatal infection with Streptococcus pneumoniae bearing heterologous PspA
    D E Briles
    Departments of Microbiology and Pediatrics, University of Alabama at Birmingham, AL 35294, USA
    J Infect Dis 182:1694-701. 2000
    ..pneumoniae expressing either family 1 or 2 PspAs and with strains of all 3 capsular types tested: 3, 6A, and 6B. These studies suggest that PspA may have efficacy as a human vaccine...
  4. ncbi request reprint The potential for using protein vaccines to protect against otitis media caused by Streptococcus pneumoniae
    D E Briles
    Department of Microbiology, University of Alabama at Birmingham UAB, Birmingham, AL 35294 2170, USA
    Vaccine 19:S87-95. 2000
    ..The inclusion of a few of these proteins into the polysaccharide-protein conjugate vaccines may be able to enhance their efficacy against otitis media and might be able to constitute a successful all-protein pneumococcal vaccine...
  5. ncbi request reprint Protection of the elderly from pneumococcal pneumonia with a protein-based vaccine?
    David E Briles
    Department of Microbiology, University of Alabama at Birmingham, Suite 258 11, Bevill Biomedical Research Building, 1530 3rd Avenue South, Birmingham, AL 35294 2170, USA
    Mech Ageing Dev 125:129-31. 2004
    ..PspA has been used in human safety trials and was shown to elicit antibodies that can protect mice from otherwise fatal pneumococcal infections...
  6. ncbi request reprint Immunizations with pneumococcal surface protein A and pneumolysin are protective against pneumonia in a murine model of pulmonary infection with Streptococcus pneumoniae
    David E Briles
    Department of Microbiology, University of Alabama at Birmingham, USA
    J Infect Dis 188:339-48. 2003
    ....
  7. doi request reprint Elicitation of mucosal immunity by proteins of Streptococcus pneumoniae
    David E Briles
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    Adv Otorhinolaryngol 72:25-7. 2011
    ..3) Complement-fixing IgG antibody can protect against colonization and may act by protecting against colonization of bacteria...
  8. pmc Nasal colonization with Streptococcus pneumoniae includes subpopulations of surface and invasive pneumococci
    David E Briles
    Department of Microbiology, University of Alabama at Birmingham, USA
    Infect Immun 73:6945-51. 2005
    ..Although this speculation is unproven, the observation that there are separate populations of pneumococci during colonization may help guide future attempts to understand the biology of nasal colonization by this pathogen...
  9. pmc Role of pneumococcal surface protein C in nasopharyngeal carriage and pneumonia and its ability to elicit protection against carriage of Streptococcus pneumoniae
    Priya Balachandran
    Department of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Infect Immun 70:2526-34. 2002
    ..This latter finding strongly indicates that pneumococci are actively metabolizing and growing while in the nasopharynx...
  10. pmc Regions of PspA/EF3296 best able to elicit protection against Streptococcus pneumoniae in a murine infection model
    Hazeline Roche
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Infect Immun 71:1033-41. 2003
    ..These studies provide support for the importance of the C-terminal 104 and N-terminal 115 amino acids of the alpha-helical region of PspA in the elicitation of cross-protection...
  11. pmc Relative roles of genetic background and variation in PspA in the ability of antibodies to PspA to protect against capsular type 3 and 4 strains of Streptococcus pneumoniae
    Hazeline Roche
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Infect Immun 71:4498-505. 2003
    ..These results point out the importance of including more than one PspA in any PspA vaccines developed for human use...
  12. ncbi request reprint The virulence function of Streptococcus pneumoniae surface protein A involves inhibition of complement activation and impairment of complement receptor-mediated protection
    Bing Ren
    Department of Microbiology, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 173:7506-12. 2004
    ..Our new results suggest that complement receptors CR1/2, CR3, and CR4 all play important roles in host defense against pneumococcal infection...
  13. pmc Mn2+-dependent regulation of multiple genes in Streptococcus pneumoniae through PsaR and the resultant impact on virulence
    Jason W Johnston
    Department of Microbiology, University of Iowa, BSB 3 401, 51 Newton Road, Iowa City, IA 52242, USA
    Infect Immun 74:1171-80. 2006
    ..Neither PcpA nor PsaR was found to be required for colonization of the nasopharynx in a carriage model. This is the first demonstration of Mn2+ acting as a signal for the expression of virulence factors within different host sites...
  14. pmc The proline-rich region of pneumococcal surface proteins A and C contains surface-accessible epitopes common to all pneumococci and elicits antibody-mediated protection against sepsis
    Calvin C Daniels
    Department of Microbiology, University of Alabama at Birmingham, 1530 3rd Ave South, Birmingham, AL 35294 2170, USA
    Infect Immun 78:2163-72. 2010
    ..Due to their conservation and cross-reactivity, the PR regions and NPB regions represent potential vaccine targets capable of eliciting cross-protection immunity against pneumococcal infection...
  15. ncbi request reprint Immunogenic protein contaminants in pneumococcal vaccines
    Jigui Yu
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Infect Dis 187:1019-23. 2003
    ..The degree of contamination was highly variable, and this should be considered in pneumococcal vaccine evaluations or when capsular polysaccharide is used for pneumococcal antibody assays...
  16. pmc Streptococcus pneumoniae surface protein PcpA elicits protection against lung infection and fatal sepsis
    David T Glover
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Infect Immun 76:2767-76. 2008
    ..In the model of sepsis using strain TIGR4, PcpA expression resulted in shorter times to become moribund and subcutaneous immunization with PcpA increased survival times of mice infected with wild-type PcpA-expressing pneumococci...
  17. pmc PspA and PspC minimize immune adherence and transfer of pneumococci from erythrocytes to macrophages through their effects on complement activation
    Jie Li
    Department of Microbiology, University of Alabama at Birmingham, AL 35294, USA
    Infect Immun 75:5877-85. 2007
    ..These data provide new insight into how PspA and PspC act in synergy to protect pneumococci from complement-dependent clearance during invasive infection...
  18. ncbi request reprint Structure of a complex of human lactoferrin N-lobe with pneumococcal surface protein a provides insight into microbial defense mechanism
    Olga Senkovich
    Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham, AL 35294, USA
    J Mol Biol 370:701-13. 2007
    ..Insights from the structure of the complex have implications for designing therapeutic strategies for treatment and prevention of pneumococcal diseases that remain a major public health problem worldwide...
  19. pmc Lipoprotein PsaA in virulence of Streptococcus pneumoniae: surface accessibility and role in protection from superoxide
    Jason W Johnston
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Infect Immun 72:5858-67. 2004
    ..This implies that superoxides are a key player in oxidative stress generated in the presence of iron...
  20. ncbi request reprint Capsule does not block antibody binding to PspA, a surface virulence protein of Streptococcus pneumoniae
    Calvin C Daniels
    Department of Microbiology, University of Alabama at Birmingham, BBRB, 1530 3rd Ave North, Birmingham, AL 35294, USA
    Microb Pathog 40:228-33. 2006
    ..The binding of antibody to PC was largely, but not completely, blocked by capsular polysaccharide...
  21. pmc Effects of PspA and antibodies to PspA on activation and deposition of complement on the pneumococcal surface
    Bing Ren
    Department of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Infect Immun 72:114-22. 2004
    ..Antibodies to PspA could overcome the anticomplementary effect of PspA, allowing for increased complement activation and C3 deposition onto PspA+ bacteria...
  22. pmc Pneumococcal carriage results in ganglioside-mediated olfactory tissue infection
    Frederik W van Ginkel
    Department of Microbiology, Immunobiology Vaccine Center, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    Proc Natl Acad Sci U S A 100:14363-7. 2003
    ..These findings, confirmed by PCR and immunohistochemistry, support a GLS-mediated process of infection and are consistent with pneumococci reaching the brain through retrograde axonal transport...
  23. pmc Evolution and virulence of serogroup 6 pneumococci on a global scale
    D Ashley Robinson
    Department of Microbiology, University of Alabama at Birmingham, 35294, USA
    J Bacteriol 184:6367-75. 2002
    ..001), and the ancestors tended to be less virulent than their descendents in a mouse model of infection. These data suggested that virulent serogroup 6 clones have evolved multiple times from less-virulent ancestral clones...
  24. pmc Both family 1 and family 2 PspA proteins can inhibit complement deposition and confer virulence to a capsular serotype 3 strain of Streptococcus pneumoniae
    Bing Ren
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Infect Immun 71:75-85. 2003
    ..These results suggest that family 1 and family 2 PspA proteins play similar roles in virulence and that surface accessibility of PspA is important for their function...
  25. doi request reprint Secretory-IgA antibodies play an important role in the immunity to Streptococcus pneumoniae
    Yoshiko Fukuyama
    Department of Pediatric Dentistry, Immunobiology Vaccine Center, Institute of Oral Health Research, University of Alabama at Birmingham, SDB 801A1, 1919 7th Avenue South, Birmingham, AL 35294 0007, USA
    J Immunol 185:1755-62. 2010
    ..These results show that PspA-based vaccine-induced specific S-IgA Abs play a necessary role in the regulation of S. pneumoniae colonization in the nasal cavity...
  26. ncbi request reprint Pneumococcal surface protein A (PspA) family distribution among clinical isolates from adults over 50 years of age collected in seven countries
    Susan K Hollingshead
    Department of Microbiology, University of Alabama at Birmingham, BBRB 658, AL 35294, USA
    J Med Microbiol 55:215-21. 2006
    ..In conclusion, inclusion of PspA family 1 and family 2 in future pneumococcal vaccines would ensure broad coverage of pneumococcal strains infecting people over 50 years of age...
  27. pmc PspA protects Streptococcus pneumoniae from killing by apolactoferrin, and antibody to PspA enhances killing of pneumococci by apolactoferrin [corrected]
    Mirza Shaper
    Department of Microbiology, University of Alabama at Birmingham, USA
    Infect Immun 72:5031-40. 2004
    ..Antibody to PspA enhanced killing by lactoferrin. These findings suggested that the binding of ALF to PspA probably blocks the active site(s) of ALF that is responsible for killing...
  28. pmc Complement receptor 1 expression on mouse erythrocytes mediates clearance of Streptococcus pneumoniae by immune adherence
    Jie Li
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Infect Immun 78:3129-35. 2010
    ..These data support that immune adherence via CR1 on erythrocytes likely plays an important role in the clearance of opsonized bacteria from human blood...
  29. pmc Relative fitness of fluoroquinolone-resistant Streptococcus pneumoniae
    Crystal N Johnson
    University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Emerg Infect Dis 11:814-20. 2005
    ..However, the strain was equally able to cause competitive or noncompetitive lung infections as well as EF3030...
  30. pmc Antibody to the type 3 capsule facilitates immune adherence of pneumococci to erythrocytes and augments their transfer to macrophages
    Jie Li
    Department of Microbiology, University of Alabama at Birmingham, 1530 3rd Ave South, Birmingham, AL 35294 2170, USA
    Infect Immun 77:464-71. 2009
    ....
  31. ncbi request reprint Characterization of the dihydrolipoamide dehydrogenase from Streptococcus pneumoniae and its role in pneumococcal infection
    Alexander W Smith
    Department of Microbiology, University of Alabama at Birmingham, BBRB 673 Box 10, 658 Bevill Building, 854 19th Street South, 35294, USA
    Mol Microbiol 44:431-48. 2002
    ..The DLDH-negative bacteria produced only 50% of normal capsular polysaccharide, a phenotype that may be associated with impaired carbohydrate metabolism...
  32. pmc PIR-B-deficient mice are susceptible to Salmonella infection
    Ikuko Torii
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294 3300, USA
    J Immunol 181:4229-39. 2008
    ..These findings suggest that the disruption of PIR-A and PIR-B balance affects their regulatory roles in host defense to bacterial infection...
  33. pmc Serine protease PrtA from Streptococcus pneumoniae plays a role in the killing of S. pneumoniae by apolactoferrin
    Shaper Mirza
    Department of Microbiology, Division of Epidemiology, University of Alabama at Birmingham, 845 19th Street South, Birmingham, AL 35294 2170, USA
    Infect Immun 79:2440-50. 2011
    ....
  34. pmc Development of a vaccine against invasive pneumococcal disease based on combinations of virulence proteins of Streptococcus pneumoniae
    Abiodun D Ogunniyi
    School of Molecular and Biomedical Science, The University of Adelaide, SA 5005, Australia
    Infect Immun 75:350-7. 2007
    ..To date, the combination of PdB, PspA, and PspC offers the best protection...
  35. pmc Differential PsaA-, PspA-, PspC-, and PdB-specific immune responses in a mouse model of pneumococcal carriage
    Ravichandran Palaniappan
    Department of Pharmaceutical Sciences, Southern School of Pharmacy, Atlanta, GA 30310 1495, USA
    Infect Immun 73:1006-13. 2005
    ..Taken together, these findings suggest that PsaA- and PspA-specific mucosal responses as well as systemic humoral and T helper cell cytokine responses are predominantly yet differentially induced during pneumococcal carriage...
  36. pmc Distribution of pneumococcal surface protein A families 1 and 2 among Streptococcus pneumoniae isolates from children in finland who had acute otitis media or were nasopharyngeal carriers
    Merit M Melin
    National Public Health Institute KTL, Department of Vaccines, Mannerheimintie 166, 00300 Helsinki, Finland
    Clin Vaccine Immunol 15:1555-63. 2008
    ..The majority of the isolates (97%) belonged to either PspA family 1 or family 2, suggesting that a combination including the two main PspA families would make a good vaccine candidate...
  37. pmc Development of antibodies to PspA families 1 and 2 in children after exposure to Streptococcus pneumoniae
    Merit M Melin
    National Public Health Institute KTL, Department of Vaccines, Mannerheimintie 166, 00300 Helsinki, Finland
    Clin Vaccine Immunol 15:1529-35. 2008
    ..The results suggest that children have a relatively family-specific antibody response to the PspA family they have been exposed to and that any PspA vaccine for children should contain members of both major PspA families...
  38. ncbi request reprint Characterization of antibodies to PspA and PsaA in adults over 50 years of age with invasive pneumococcal disease
    Laurence Baril
    Aventis Pasteur, Lyon, France
    Vaccine 23:789-93. 2004
    ..In contrast, acute and convalescent antibody levels were similar in control patients with invasive diseases due to other microorganisms...
  39. pmc Increased protection against pneumococcal disease by mucosal administration of conjugate vaccine plus interleukin-12
    Joyce M Lynch
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208, USA
    Infect Immun 71:4780-8. 2003
    ..We conclude that i.n vaccination in the presence of IL-12 is able to enhance systemic and mucosal immune responses to pneumococci and efficiently protect against both invasive infection and bacterial carriage...
  40. pmc Effects of zinc deficiency and pneumococcal surface protein a immunization on zinc status and the risk of severe infection in mice
    Tor A Strand
    Centre for International Health and Department of Microbiology and Immunology, The Gade Institute, University of Bergen, Bergen N 5021, Norway
    Infect Immun 71:2009-13. 2003
    ..PspA immunization reduced the risk of severe disease, and the reduction in severity was reflected in substantially reduced zinc depletion from bones...
  41. ncbi request reprint Antibodies to pneumococcal surface protein A families 1 and 2 in serum and saliva of children and the risk of pneumococcal acute otitis media
    Birgit Simell
    Department of Vaccines, National Public Health Institute, Mannerheimintie 166, Helsinki, Finland
    J Infect Dis 196:1528-36. 2007
    ..We assessed the development of human serum and salivary antibodies against the PspA families 1 (PspA1) and 2 (PspA2) in early childhood and their role in the prevention of pneumococcal acute otitis media (AOM)...
  42. pmc Relationship between surface accessibility for PpmA, PsaA, and PspA and antibody-mediated immunity to systemic infection by Streptococcus pneumoniae
    Dennis O Gor
    Institute of Pathology, Case Western Reserve University, Cleveland, OH, USA
    Infect Immun 73:1304-12. 2005
    ..These experiments support the hypothesis that the extent of protection against systemic pneumococcal infection is influenced by target antigen accessibility to circulating host antibodies...
  43. pmc Contributions of pneumolysin, pneumococcal surface protein A (PspA), and PspC to pathogenicity of Streptococcus pneumoniae D39 in a mouse model
    Abiodun D Ogunniyi
    School of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia 5005, Australia
    Infect Immun 75:1843-51. 2007
    ..These findings further demonstrate that the mechanism of pneumococcal pathogenesis is highly complex and multifactorial but ascribes a role for each of these virulence proteins, alone or in combination, in the process...
  44. ncbi request reprint Lung-specific overexpression of CC chemokine ligand (CCL) 2 enhances the host defense to Streptococcus pneumoniae infection in mice: role of the CCL2-CCR2 axis
    Christine Winter
    Department of Pulmonary Medicine, Laboratory for Experimental Lung Research, Hannover School of Medicine, Hannover 30625, Germany
    J Immunol 178:5828-38. 2007
    ....
  45. ncbi request reprint CCL5 modulates pneumococcal immunity and carriage
    Ravichandran Palaniappan
    Mercer University, Atlanta, GA 30341, USA
    J Immunol 176:2346-56. 2006
    ..These data suggest that CCL5 is an essential factor for the induction and maintenance of protective pneumococcal immunity...
  46. pmc Vaccine-induced human antibodies to PspA augment complement C3 deposition on Streptococcus pneumoniae
    Martina M Ochs
    Sanofi Pasteur, Toronto, Ontario, Canada
    Microb Pathog 44:204-14. 2008
    ..A vaccine candidate that can elicit immunity that neutralizes or compensates for S. pneumoniae's ability to thwart host immunity would be of value...
  47. pmc Antibody-independent, CD4+ T-cell-dependent protection against pneumococcal colonization elicited by intranasal immunization with purified pneumococcal proteins
    Alan Basset
    Division of Infectious Diseases, Children s Hospital Boston, Enders 861 3, 300 Longwood Avenue, Boston, MA 02115, USA
    Infect Immun 75:5460-4. 2007
    ..Overall, our results show that intranasal immunization with a mixture of pneumococcal proteins protects against colonization in an antibody-independent, CD4+ T-cell-dependent manner...
  48. ncbi request reprint FMS-like tyrosine kinase 3 ligand aggravates the lung inflammatory response to Streptococcus pneumoniae infection in mice: role of dendritic cells
    Christine Winter
    Department of Pulmonary Medicine, Laboratory for Experimental Lung Research, Hannover School of Medicine, Hannover 30625, Germany
    J Immunol 179:3099-108. 2007
    ..pneumoniae, and support the concept that CCR2-dependent mononuclear phagocyte as opposed to neutrophil recruitment contributes to increased lung leakage in Flt3L-pretreated mice challenged with S. pneumoniae...
  49. ncbi request reprint Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections
    Jae Hyang Lim
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Immunity 27:349-60. 2007
    ..Thus, CYLD is detrimental for host survival, thereby indicating a mechanism underlying the high early mortality of pneumococcal pneumonia...
  50. ncbi request reprint Effect of high dose oral zinc in mice with severe infection with Streptococcus pneumoniae
    Berit S H Hembre
    Department of Medicine, Lovisenberg Diakonale Sykehus, Oslo, Norway
    Scand J Infect Dis 40:363-7. 2008
    ..There were no differences in the numbers of S. pneumoniae colony forming units (CFUs) in blood or nasal wash between the groups. Thus, high doses of zinc did not alter the severity of systemic pneumococcal infection in mice...
  51. ncbi request reprint Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses
    Karen M Haas
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Immunity 17:713-23. 2002
    ..Thus, CD21/35 expression is critical for early protective antibody responses to lethal pathogens that rapidly multiply and quickly overwhelm the immune system...
  52. doi request reprint Basophils enhance immunological memory responses
    Andrea Denzel
    Department of Internal Medicine II, University Hospital Regensburg, 93042 Regensburg, Germany
    Nat Immunol 9:733-42. 2008
    ..These basophil-dependent effects on B cells required interleukins 6 and 4 and increased the capacity of CD4(+) T cells to provide B cell help. Thus, basophils are important contributors to humoral memory immune responses...
  53. ncbi request reprint Macrophage Turnover Kinetics in the Lungs of Mice Infected with Streptococcus pneumoniae
    Katharina Taut
    Department of Pulmonary Medicine, Laboratory for Experimental Lung Research, Hannover School of Medicine, Hannover, Germany
    Am J Respir Cell Mol Biol 38:105-13. 2008
    ....

Research Grants30

  1. IMMUNITY TO PNEUMOCOCCAL SURFACE PROTEIN A AND C
    David Briles; Fiscal Year: 2002
    ..The data obtained will assist with the development of correlates of protective immunity for PspA and PspC that can be applied to vaccine development. ..
  2. Mechanism of Action of Antibody to PspA
    David Briles; Fiscal Year: 2003
    ..Our analyses of the protection-eliciting and non-protection-eliciting epitopes on PspA should make it possible to design even better PspA vaccines in the future. ..
  3. Mechanism of Action of Antibody to PspA
    David Briles; Fiscal Year: 2006
    ..Our analyses of the protection-eliciting and non-protection-eliciting epitopes on PspA should make it possible to design even better PspA vaccines in the future. ..
  4. Mechanism of Action of Antibody to PspA
    David Briles; Fiscal Year: 2007
    ..Our analyses of the protection-eliciting and non-protection-eliciting epitopes on PspA should make it possible to design even better PspA vaccines in the future. ..
  5. MOLECULAR AND CELLULAR BACTERIAL PATHOGENESIS
    David Briles; Fiscal Year: 2007
    ..The MCBP advisory committee will advise the trainees in their research and training programs and in their search for a job or postdoctoral position at the completion of their MCBP training. ..
  6. PspA: A Potential Pneumococcal Vaccine Component
    David Briles; Fiscal Year: 2009
    ..pneumoniae is important because of the high complexity and cost of the polysaccharide-protein conjugate vaccine and the rapid evolution of pneumococci to evade the capsule-type-specific protection elicited by the conjugate vaccine. ..
  7. PspA: A Potential Pneumococcal Vaccine Component
    David E Briles; Fiscal Year: 2010
    ..pneumoniae is important because of the high complexity and cost of the polysaccharide-protein conjugate vaccine and the rapid evolution of pneumococci to evade the capsule-type-specific protection elicited by the conjugate vaccine. ..
  8. PROTECTIVE IMMUNITY TO PNEUMOCOCCAL SURFACE PROTEIN A
    David Briles; Fiscal Year: 1993
    ....
  9. PROTECTIVE IMMUNITY TO PNEUMOCOCCAL SURFACE PROTEINS
    David Briles; Fiscal Year: 1991
    ....
  10. PspA: A Potential Pneumococcal Vaccine Component
    David Briles; Fiscal Year: 2009
    ..pneumoniae is important because of the high complexity and cost of the polysaccharide-protein conjugate vaccine and the rapid evolution of pneumococci to evade the capsule-type-specific protection elicited by the conjugate vaccine. ..