Karoline J Briegel

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc The embryonic transcription cofactor LBH is a direct target of the Wnt signaling pathway in epithelial development and in aggressive basal subtype breast cancers
    Megan E Rieger
    Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Mol Cell Biol 30:4267-79. 2010
  2. pmc The T box transcription factor TBX2 promotes epithelial-mesenchymal transition and invasion of normal and malignant breast epithelial cells
    Bin Wang
    Department of Biochemistry and Molecular Biology, Braman Family Breast Cancer Institute, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 7:e41355. 2012
  3. ncbi request reprint Congenital heart disease reminiscent of partial trisomy 2p syndrome in mice transgenic for the transcription factor Lbh
    Karoline J Briegel
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Development 132:3305-16. 2005
  4. ncbi request reprint Embryonic transcription factors in human breast cancer
    Karoline J Briegel
    Department of Biochemistry and Molecular Biology, Braman Family Breast Cancer Institute, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA
    IUBMB Life 58:123-32. 2006
  5. doi request reprint Generation of mice with a conditional Lbh null allele
    Linsey E Lindley
    Department of Biochemistry and Molecular Biology, Braman Family Breast Cancer Institute at the Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA
    Genesis 51:491-7. 2013
  6. doi request reprint Molecular characterization of TGFbeta-induced epithelial-mesenchymal transition in normal finite lifespan human mammary epithelial cells
    Linsey E Lindley
    Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Biochem Biophys Res Commun 399:659-64. 2010
  7. pmc Biophysical characterization reveals structural disorder in the developmental transcriptional regulator LBH
    Hassan Al-Ali
    Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Biochem Biophys Res Commun 391:1104-9. 2010

Collaborators

Detail Information

Publications7

  1. pmc The embryonic transcription cofactor LBH is a direct target of the Wnt signaling pathway in epithelial development and in aggressive basal subtype breast cancers
    Megan E Rieger
    Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Mol Cell Biol 30:4267-79. 2010
    ..Taken together, our findings link LBH for the first time to the Wnt signaling pathway in both development and cancer and highlight LBH as a potential new marker for therapeutically challenging basal-like breast cancers...
  2. pmc The T box transcription factor TBX2 promotes epithelial-mesenchymal transition and invasion of normal and malignant breast epithelial cells
    Bin Wang
    Department of Biochemistry and Molecular Biology, Braman Family Breast Cancer Institute, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 7:e41355. 2012
    ..Collectively, our results uncover an unanticipated link between TBX2 deregulation in cancer and the acquisition of EMT and invasive features of epithelial tumor cells...
  3. ncbi request reprint Congenital heart disease reminiscent of partial trisomy 2p syndrome in mice transgenic for the transcription factor Lbh
    Karoline J Briegel
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Development 132:3305-16. 2005
    ..Our findings implicate LBH as a candidate gene for CHD associated with partial trisomy 2p syndrome and suggest an important role of Lbh in transcriptional control during normal cardiogenesis...
  4. ncbi request reprint Embryonic transcription factors in human breast cancer
    Karoline J Briegel
    Department of Biochemistry and Molecular Biology, Braman Family Breast Cancer Institute, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA
    IUBMB Life 58:123-32. 2006
    ..Because of their pivotal roles in breast tumor progression, these factors represent valuable new biomarkers for breast cancer detection as well as promising new targets for anti-invasive drugs...
  5. doi request reprint Generation of mice with a conditional Lbh null allele
    Linsey E Lindley
    Department of Biochemistry and Molecular Biology, Braman Family Breast Cancer Institute at the Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA
    Genesis 51:491-7. 2013
    ..Thus, the conditional Lbh allele will be a valuable tool to uncover the currently unknown tissue-specific roles of LBH in postnatal development and disease...
  6. doi request reprint Molecular characterization of TGFbeta-induced epithelial-mesenchymal transition in normal finite lifespan human mammary epithelial cells
    Linsey E Lindley
    Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Biochem Biophys Res Commun 399:659-64. 2010
    ..Our results may have important implications for understanding potential changes that might occur in normal breast epithelium under pathological conditions triggering elevated TGFbeta levels...
  7. pmc Biophysical characterization reveals structural disorder in the developmental transcriptional regulator LBH
    Hassan Al-Ali
    Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Biochem Biophys Res Commun 391:1104-9. 2010
    ..We propose that LBH is a member of the intrinsically disordered protein (IDP) family, and that conformational plasticity may play a significant role in modulating LBH-dependent transcriptional processes...