Research Topics
Species | J A BridgeSummaryAffiliation: University of Nebraska Medical Center Country: USA Publications
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Publications
Use of a novel FISH assay on paraffin-embedded tissues as an adjunct to diagnosis of alveolar rhabdomyosarcomaJun Nishio
Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, 68198-3135, USA
Lab Invest 86:547-56. 2006..The findings also suggest that FISH may be a more sensitive assay than RT-PCR in some settings, capable of revealing variant translocations...- Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: osteosarcoma and related tumorsAvery A Sandberg
Department of DNA Diagnostics, St. Joseph's Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
Cancer Genet Cytogenet 145:1-30. 2003 
Identification of a novel, recurrent SLC44A1-PRKCA fusion in papillary glioneuronal tumorJulia A Bridge
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
Brain Pathol 23:121-8. 2013..The FISH and RT-PCR assays developed in this study can serve as valuable diagnostic adjuncts for this rare disease entity...
Pericytoma with t(7;12) and ACTB-GLI1 fusion arising in boneJulia A Bridge
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
Hum Pathol 43:1524-9. 2012..To the best of our knowledge, this is the first case of pericytoma with t(7;12) arising in bone. Cytogenetic and molecular analyses were useful, if not essential, in classifying this rare diagnostic entity...- Inhibition of phosphorylated c-Met in rhabdomyosarcoma cell lines by a small molecule inhibitor SU11274Jinxuan Hou
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68105, USA
J Transl Med 9:64. 2011..In this study, we investigated the role of c-Met in rhabdomyosarcoma (RMS) using its small molecule inhibitor SU11274, which has been hypothesized to be a potential therapeutic target for RMS... - Molecular diagnostics of soft tissue tumorsJulia A Bridge
Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198 3135, USA
Arch Pathol Lab Med 135:588-601. 2011..During the past 3 decades, mesenchymal tumor-specific, cytogenetic and molecular genetic abnormalities have demonstrated an increasingly important, ancillary role in mesenchymal tumor diagnostics... - Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumorJ A Bridge
Department of Pathology, Center for Human Molecular Genetics, 983135 University of Nebraska Medical Center, Omaha, NE 68198, USA
Am J Pathol 159:411-5. 2001..One of these cases exhibited a 2;17 translocation in addition to other karyotypic anomalies [46,XX,t(2;17)(p23;q23),add(16)(q24)]... - Genomic gains and losses are similar in genetic and histologic subsets of rhabdomyosarcoma, whereas amplification predominates in embryonal with anaplasia and alveolar subtypesJulia A Bridge
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
Genes Chromosomes Cancer 33:310-21. 2002.... - The small round blue cell tumors of the sinonasal areaJulia A Bridge
Department of Pathology, 983135 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
Head Neck Pathol 4:84-93. 2010..Establishing an accurate diagnosis of a small round blue cell tumor of the sinonasal tract frequently requires adjunctive studies including immunohistochemical and molecular analyses... - Contribution of cytogenetics to the management of poorly differentiated sarcomasJulia A Bridge
Department of Pathology and Microbiology, 983135 Nebraska Medical Center, Omaha, NE 68198 3135, USA
Ultrastruct Pathol 32:63-71. 2008..Consequently, demonstration of characteristic, tumor-specific chromosomal aberrations is especially useful in the management of poorly differentiated sarcomas... - Novel genomic imbalances in embryonal rhabdomyosarcoma revealed by comparative genomic hybridization and fluorescence in situ hybridization: an intergroup rhabdomyosarcoma studyJ A Bridge
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
Genes Chromosomes Cancer 27:337-44. 2000..In summary, CGH and FISH analyses of 12 E-RMS specimens revealed novel genomic imbalances that may be useful in directing further molecular studies for the determination of E-RMS critically involved genes... - Regulation of MMP-9 (92 kDa type IV collagenase/gelatinase B) expression in stromal cells of human giant cell tumor of boneV H Rao
Meyer Rehabilitation Institute and Department of Pediatrics, University of Nebraska Medical Center, Omaha 68198, USA
Clin Exp Metastasis 15:400-9. 1997..This suggests that multinucleated giant cells in primary cultures secrete a factor(s) that stimulates stromal cells to produce MMP-9, which, in turn, may contribute to the aggressive behavior of GCT... - Translocation t(1;3)(p36.3;q25) is a nonrandom aberration in epithelioid hemangioendotheliomaM R Mendlick
Departments of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA
Am J Surg Pathol 25:684-7. 2001..Identification of the 1;3 translocation may be useful diagnostically. Should additional studies confirm these data, this could lead to the identification of the gene(s) central to this neoplastic process... - Primary malignant neuroepithelial tumors of the kidney: a clinicopathologic analysis of 146 adult and pediatric cases from the National Wilms' Tumor Study Group Pathology CenterD M Parham
Department of Pathology, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock 72202, USA
Am J Surg Pathol 25:133-46. 2001.... - Prognostic impact of P53 status, TLS-CHOP fusion transcript structure, and histological grade in myxoid liposarcoma: a molecular and clinicopathologic study of 82 casesC R Antonescu
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Clin Cancer Res 7:3977-87. 2001..We also analyzed P53 status, because this parameter has been found to have a significant prognostic impact in other sarcomas with chromosomal translocations... - Recurrent chromosomal imbalances and structurally abnormal breakpoints within complex karyotypes of malignant peripheral nerve sheath tumour and malignant triton tumour: a cytogenetic and molecular cytogenetic studyR S Bridge
Department of Pathology, 983135 Nebraska Medical Center, Omaha, NE 68198-3135, USA
J Clin Pathol 57:1172-8. 2004..FISH analysis was negative for amplification. CONCLUSIONS: These cytogenetic and molecular cytogenetic findings expand the knowledge of chromosomal alterations in MPNST and MTT, and point to possible recurring regions of interest... - Cytogenetic analysis of a malignant triton tumor and a malignant peripheral nerve sheath tumor and a review of the literatureE N McComb
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198 5440, USA
Cancer Genet Cytogenet 91:8-12. 1996..The genes for peripheral neurofibromatosis (NF-1) and central neurofibromatosis (NF-2) have been mapped to these two chromosomes respectively... - Extra copies of chromosomes 7, 8, 12, 19, and 21 are recurrent in adamantinomaM Kanamori
Departments of Pathology and Microbiology, Center for Human Molecular Genetics, University of Nebraska Medical Center, Omaha, Nebraska, USA
J Mol Diagn 3:16-21. 2001..Adamantinoma may be confused with a variety of primary and metastatic epithelial and mesenchymal neoplasms. Observation of these aneuploidies may be useful in establishing the diagnosis of adamantinoma... - Trisomies 8 and 20 characterize a subgroup of benign fibrous lesions arising in both soft tissue and boneJ A Bridge
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5440, USA
Am J Pathol 154:729-33. 1999..Our findings demonstrate that trisomy 8 and trisomy 20 are also nonrandom aberrations in histologically similar, but clinically distinct, benign fibrous lesions of bone... - Alveolar rhabdomyosarcoma of the head and neck region in older adults: genetic characterization and a review of the literatureTaketoshi Yasuda
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
Hum Pathol 40:341-8. 2009..Further follow-up and additional cases are required to assess the prognostic relevance of these fusion transcripts in the context of advanced age... - Cytogenetic instability, predominantly involving chromosome 1, is characteristic of elastofibromaE N McComb
Departments of Pathology and Microbiology, University of Nebraska Medical Center, 68198-3135, Omaha, NE, USA
Cancer Genet Cytogenet 126:68-72. 2001..The observation of clonal abnormalities in elastofibroma suggests that this lesion may represent a neoplastic rather than a reactive process... - Primary renal neoplasms with the ASPL-TFE3 gene fusion of alveolar soft part sarcoma: a distinctive tumor entity previously included among renal cell carcinomas of children and adolescentsP Argani
Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21231 2410, USA
Am J Pathol 159:179-92. 2001..Finally, the finding of distinctive tumors being associated with balanced and unbalanced forms of the same translocation is to our knowledge, unprecedented... - Detection of chromosomal aberrations in renal tumors: a comparative study of conventional cytogenetics and virtual karyotyping with single-nucleotide polymorphism microarraysFederico A Monzon
Department of Pathology, The Methodist Hospital Research Institute, The Methodist Hospital, Houston, Texas 77030, USA
Arch Pathol Lab Med 133:1917-22. 2009.... - Clonal karyotypic abnormalities of the hereditary multiple exostoses chromosomal loci 8q24.1 (EXT1) and 11p11-12 (EXT2) in patients with sporadic and hereditary osteochondromasJ A Bridge
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198 5440, USA
Cancer 82:1657-63. 1998..1 (EXT1), 11p11-12 (EXT2), and 19p (EXT3). Constitutional chromosomal microdeletions of 8q24.1 and 11p11-12 are features of the Langer-Giedion and DEFECT-11 syndromes, respectively. Cytogenetic studies of osteochondroma are rare... - Cytogenetic and molecular cytogenetic findings in 43 aneurysmal bone cysts: aberrations of 17p mapped to 17p13.2 by fluorescence in situ hybridizationPamela A Althof
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA
Mod Pathol 17:518-25. 2004..The latter could potentially be utilized as an adjunct in diagnostically challenging cases... - Aberrations of 6q13 mapped to the COL12A1 locus in chondromyxoid fibromaTaketoshi Yasuda
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
Mod Pathol 22:1499-506. 2009..The latter could potentially be utilized as an adjunct in diagnostically challenging cases... - Interleukin-1beta upregulates MMP-9 expression in stromal cells of human giant cell tumor of boneV H Rao
Center for Human Molecular Genetics, Munroe Meyer Institute for Genetics and Rehabilitation, and the Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198, USA
J Interferon Cytokine Res 19:1207-17. 1999.... - Cytogenetic and molecular cytogenetic evidence of recurrent 8q24.1 loss in osteochondromaMichael G Feely
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
Cancer Genet Cytogenet 137:102-7. 2002.... - C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipomaDali Huang
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
Genes Chromosomes Cancer 49:810-8. 2010..The FISH and RT-PCR assays developed in this study can serve as diagnostic adjuncts for the identification of this novel C11orf95-MKL2 fusion oncogene in chondroid lipoma... - Monoallelic deletion of the p53 gene through chromosomal translocation in a small cell osteosarcomaJun Nishio
Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198-3135, USA
Virchows Arch 448:852-6. 2006.... - Extraskeletal myxoid chondrosarcoma of the jugular foramenT J Cummings
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
Clin Neuropathol 23:232-7. 2004..The histological differential diagnosis includes chordoma, conventional chondrosarcoma and chordoid meningioma, among others. A distinguishing feature of EMC is their characteristic reciprocal translocation t(9;22)(q22;q12)... - USP6 (Tre2) fusion oncogenes in aneurysmal bone cystAndre M Oliveira
Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Cancer Res 64:1920-3. 2004..CDH11 is expressed strongly in bone, and our findings implicate a novel oncogenic mechanism in which deregulated USP6 transcription results from juxtaposition to the highly active CDH11 promoter... - Lack of a common or characteristic cytogenetic anomaly in solitary fibrous tumorAlireza Torabi
Department of Pathology and Microbiology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198 3135, USA
Cancer Genet Cytogenet 181:60-4. 2008..Clonal karyotypic abnormalities were lacking in three additional solitary fibrous tumors... - Performance characteristics of a reverse transcriptase-polymerase chain reaction assay for the detection of tumor-specific fusion transcripts from archival tissueMichael K Fritsch
Department of Pathology, The Johns Hopkins Medical Institutions, 401 N Broadway, Baltimore, MD 22131 2410, USA
Pediatr Dev Pathol 6:43-53. 2003..Additional studies such as FISH may be useful in clarifying the nature of equivocal or unexpected results... - Embryonal rhabdomyosarcoma with a der(16)t(1;16) translocationKayla M Kapels
Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198 3135, USA
Cancer Genet Cytogenet 174:68-73. 2007..These results suggest that the unbalanced t(1;16) translocation may be seen in RMSs lacking a primary genetic rearrangement... - Sclerosing rhabdomyosarcomas in children and adolescents: a clinicopathologic review of 13 cases from the Intergroup Rhabdomyosarcoma Study Group and Children's Oncology GroupMelissa C Chiles
Department of Pathology, Arkansas Children's Hospital and University of Arkansas for Medical Sciences, Slot 820, 800 Marshall Street, Little Rock, AR 72202, USA
Pediatr Dev Pathol 7:583-94. 2004..Sclerosing RMS may arise in children, have mixed ERMS-ARMS histology, originate from the head and neck, and lack strong myogenin staining... - Cytogenetic findings in clear cell chondrosarcomaJun Nishio
Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, N 68198-3135, USA
Cancer Genet Cytogenet 162:74-7. 2005..Clonal chromosomal abnormalities were detected in 3 cases. A tumor specific anomaly was not identified, however, extra copies of chromosome 20 and loss or rearrangements of 9p appear to be recurrent... - Cytogenetic findings in benign cartilaginous neoplasmsEmilie P Buddingh
Department of Pathology and Microbiology, Nebraska Medical Center, Omaha, NE 68198, USA
Cancer Genet Cytogenet 141:164-8. 2003..Abnormal diploid or near-diploid clones were detected in all specimens analyzed. Although a tumor-specific anomaly did not emerge from these studies, involvement of certain chromosomes/chromosomal regions appears recurrent... - Aggressive angiomyxoma with t(12;21) and HMGA2 rearrangement: report of a case and review of the literatureNeil J Rawlinson
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
Cancer Genet Cytogenet 181:119-24. 2008..Karyotypic rearrangements of 12q13 approximately q15 are considered recurrent in aggressive angiomyxoma, although reported in only five previous cases. Translocation partner chromosome 21 is unique to the present case... - Loss of the PTCH1 gene locus in cardiac fibromaDavid Scanlan
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 8135, USA
Cardiovasc Pathol 17:93-7. 2008..CF is more commonly encountered in patients with Gorlin syndrome (3%) than the general population. Mutations of the tumor suppressor gene PTCH1 are the underlying cause of Gorlin syndrome... - An increased frequency of 13q deletions detected by fluorescence in situ hybridization and its impact on survival in children and adolescents with Burkitt lymphoma: results from the Children's Oncology Group study CCG-5961Marilu Nelson
Human Genetics Laboratories, Munroe Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, 985440 Nebraska Medical Center, Omaha, NE 68198, USA
Br J Haematol 148:600-10. 2010..95%, P = 0.012). These observations indicate that del(13q) occurs in childhood BL at frequencies higher than previously detected by classical cytogenetics and underscores the importance of molecular cytogenetics in risk stratification... - Renal carcinomas with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCRPedram Argani
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Am J Surg Pathol 29:230-40. 2005..Finally, the special molecular features of the Alpha-TFEB gene fusion allow its molecular detection by DNA PCR as a robust alternative to RT-PCR in clinical tumor samples... - Cytogenetic distinction among benign fibro-osseous lesions of bone in children and adolescents: value of karyotypic findings in differential diagnosisDavid M Parham
Department of Pathology, Arkansas Children Hospital and University of Arkansas for Medical Sciences, Slot 820, 800 Marshall Street, Little Rock, AR 72202, USA
Pediatr Dev Pathol 7:148-58. 2004..Our current and published results indicate that cytogenetics might be of ancillary use in the diagnosis of BFOL and that a characteristic chromosomal arrangement is associated with ossifying fibroma... - Establishment of a new human epithelioid sarcoma cell line, FU-EPS-1: molecular cytogenetic characterization by use of spectral karyotyping and comparative genomic hybridizationJun Nishio
Department of Pathology, University of Nebraska Medical Center, 985454 Nebraska Medical Center, Omaha, NE 68198 5454, USA
Int J Oncol 27:361-9. 2005..The FU-EPS-1 cell line will be exceedingly useful for biologic and molecular pathogenetic studies of human epithelioid sarcoma... - Clear cell sarcoma of soft tissue metastatic to the ovaries: a heretofore unreported occurrenceSummer L Nugent
Department of Pathology, University of Maryland Medical Center, Baltimore, Maryland 21201, USA
Int J Gynecol Pathol 28:234-8. 2009..To the best of our knowledge, this is the first reported case of CCSST metastatic to the ovaries... - Translocation der(13;21)(q10;q10) in skeletal and extraskeletal mesenchymal chondrosarcomaSabine Naumann
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
Mod Pathol 15:572-6. 2002..The observation of similar chromosomal abnormalities in both skeletal and extraskeletal mesenchymal chondrosarcoma supports a genetic as well as histopathologic relationship between these anatomically distinct neoplasms... - Analysis of HER2 gene amplification using an automated fluorescence in situ hybridization signal enumeration systemRachel Stevens
Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198 3135, USA
J Mol Diagn 9:144-50. 2007..59 versus 7.47 minutes for manual signal enumeration (savings of 2.88 minutes/slide). These data suggest that the Vysis AutoVysion System can correctly classify specimens and may increase the overall efficiency of HER2 testing... - Inconspicuous insertion 22;12 in myxoid/round cell liposarcoma accompanied by the secondary structural abnormality der(16)t(1;16)Nathan C Birch
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
J Mol Diagn 5:191-4. 2003.... - Monosomy 22 as a diagnostic aid in a case of late recurrence of adult granulosa cell tumor of the ovarySamuel K Caughron
Department of Pathology, Creighton University Medical Center, 601 North 30th Street, Omaha, NE 68131, USA
Cancer Genet Cytogenet 156:83-5. 2005..This anomaly, typical of granulosa cell tumor, coupled with the pathologic and immunophenotypic findings assisted in establishing the proper diagnosis of this lesion in the absence of the original histopathologic slides... - Imbalances of chromosomes 4, 9, and 12 are recurrent in the thecoma-fibroma group of ovarian stromal tumorsRenae C Streblow
Departments of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198 3135, USA
Cancer Genet Cytogenet 178:135-40. 2007..In contrast, loss of chromosomes 4 and/or 9 are recurrent in fibroma. In summary, imbalances of chromosomes 4 and 9 appear to represent important secondary abnormalities in the thecoma-fibroma ovarian tumor group... - Osteoblastoma characterized by a three-way translocation: report of a case and review of the literatureGiovanna Giannico
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Cancer Genet Cytogenet 195:168-71. 2009..Rearrangement of 1q42 has been identified in a previously reported case... - Translocation (1;4)(p31;q34) in nonossifying fibromaMarilu Nelson
Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, USA
Cancer Genet Cytogenet 142:142-4. 2003..Conventional cytogenetic analysis revealed a reciprocal translocation involving bands 1p31 and 4q34 [t(1;4)(p31;q34)]. To the best of our knowledge, this is only the second reported case of a clonally aberrant nonossifying fibroma... - Translocation (2;11)(q31;q12) is recurrent in collagenous fibroma (desmoplastic fibroblastoma)Kerry Bernal
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA
Cancer Genet Cytogenet 149:161-3. 2004..This finding confirms the nonrandom association of t(2;11)(q31;q12) with collagenous fibroma... - Chromosome 6 abnormalities are recurrent in synovial chondromatosisEmilie P Buddingh
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
Cancer Genet Cytogenet 140:18-22. 2003..These findings support a neoplastic origin for synovial chondromatosis and suggest that chromosome 6 aberrations are recurrent in this lesion... - Fusion of ALK to the Ran-binding protein 2 (RANBP2) gene in inflammatory myofibroblastic tumorZhigui Ma
Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA
Genes Chromosomes Cancer 37:98-105. 2003..These findings expand the spectrum of ALK abnormalities observed in IMT and further confirm the clonal, neoplastic nature of these lesions... - Sclerosing rhabdomyosarcoma in adults: report of four cases of a hyalinizing, matrix-rich variant of rhabdomyosarcoma that may be confused with osteosarcoma, chondrosarcoma, or angiosarcomaAndrew L Folpe
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
Am J Surg Pathol 26:1175-83. 2002..Study of additional cases will be necessary to more fully elucidate its place among RMS and its prognostic significance... - Loss of 13q14-q21 and gain of 5p14-pter in the progression of leiomyosarcomaRubin Wang
Molecular Cytogenetics, Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, Surrey, United Kingdom
Mod Pathol 16:778-85. 2003..These results suggest that 13q14-q21 loss and 5p14-pter gain at diagnosis could be used to identify patients with leiomyosarcoma who are likely to have a shorter survival time and who might benefit from early treatment intensification... - Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. Synovial sarcomaAvery A Sandberg
Department of DNA Diagnostics, St. Joseph's Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
Cancer Genet Cytogenet 133:1-23. 2002 - Genetic heterogeneity in the alveolar rhabdomyosarcoma subset without typical gene fusionsFrederic G Barr
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Cancer Res 62:4704-10. 2002.... - Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: congenital (infantile) fibrosarcoma and mesoblastic nephromaAvery A Sandberg
Department of DNA Diagnostics, St. Joseph's Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
Cancer Genet Cytogenet 132:1-13. 2002 - Differentially amplified chromosome 12 sequences in low- and high-grade osteosarcomaDavid Gisselsson
Department of Clinical Genetics, University Hospital, Lund, Sweden
Genes Chromosomes Cancer 33:133-40. 2002..These findings indicate that gain of sequences from the short arm of chromosome 12 could be a possible genetic pathway in the development of aggressive osteosarcoma... - Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. desmoplastic small round-cell tumorsAvery A Sandberg
Department of DNA Diagnostics, St. Joseph's Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
Cancer Genet Cytogenet 138:1-10. 2002 - The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomasCynthia Laflamme
Human and Molecular Genetic Research Unit, Pavillon Saint Francois d Assise, CHUQ, Quebec, QC, G1L 3L5 Canada
Cancer Res 63:449-54. 2003.... - EWS/FLI-1 fusion signal inserted into chromosome 11 in one patient with morphologic features of Ewing sarcoma, but lacking t(11;22)Jacqueline R Batanian
Department of Pediatrics, Cardinal Glennon Children s Hospital, St Louis, MO, USA
Cancer Genet Cytogenet 133:72-5. 2002..Reverse transcriptase-polymerase chain reaction studies revealed the presence of two EWS/FLI1 fusion gene products... - Spectral karyotyping identifies recurrent complex rearrangements of chromosomes 8, 17, and 20 in osteosarcomasJane Bayani
Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
Genes Chromosomes Cancer 36:7-16. 2003..These findings suggest that specific sequences mapping to these chromosomal regions will likely have a role in the development and progression of OS... - Identification of a ring chromosome with spectral karyotyping in a pleural synovial sarcomaJun Nishio
Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan
Cancer Genet Cytogenet 160:174-8. 2005..Subsequent FISH analysis with a whole-chromosome 8 paint probe confirmed the SKY results. This study demonstrates the usefulness of SKY as an adjunct for determining the chromosomal composition of ring chromosomes... - Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: chondrosarcoma and other cartilaginous neoplasmsAvery A Sandberg
Department of DNA Diagnostics, St. Joseph's Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
Cancer Genet Cytogenet 143:1-31. 2003 - Intracranial Ewing sarcomaMelissa A Mazur
Department of Pediatric Hematology-Oncology, Duke University Medical Center, Durham, NC 27710, USA
Pediatr Blood Cancer 45:850-6. 2005..Demonstration of t(11;22)(q24;q12) by molecular analysis essentially confirms the diagnosis and enables the oncologist to choose appropriate therapy... - Sclerosing rhabdomyosarcomas in children and adolescents: a clinicopathologic review of 13 cases from the Intergroup Rhabdomyosarcoma Study Group and Children's Oncology GroupMelissa C Chiles
Department of Pathology and Pediatrics, Arkansas Children's Hospital and University of Arkansas for Medical Sciences, Slot 820, 800 Marshall Street, Little Rock, AR 72202, USA
Pediatr Dev Pathol 8:141. 2005 - C-erb-B2 (HER2/neu) expression in synovial sarcoma of the head and neckRandall J Olsen
Department of Pathology and Laboratory Medicine, Baylor College of Medicine, Houston, Texas, USA
Head Neck 27:883-92. 2005.... - Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. Dermatofibrosarcoma protuberans and giant cell fibroblastomaAvery A Sandberg
Department of DNA Diagnostics, St. Joseph's Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
Cancer Genet Cytogenet 140:1-12. 2003 - Use of a multitarget fluorescence in situ hybridization assay to diagnose bladder cancer in patients with hematuriaMichael F Sarosdy
South Texas Urology and Urologic Oncology, 4499 Medical #218, San Antonio, TX 78229, USA
J Urol 176:44-7. 2006..Based on these data UroVysion was approved by the Food and Drug Administration for use in patients with hematuria... - Paraganglioma-like dermal melanocytic tumor: a unique entity distinct from cellular blue nevus, clear cell sarcoma, and cutaneous melanomaAndrea T Deyrup
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
Am J Surg Pathol 28:1579-86. 2004..PDMT comprises a clinically and pathologically unique subtype of dermal melanocytic tumors. Our study suggests a benign course, although a lesion of low malignant potential cannot be excluded... - Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. gastrointestinal stromal tumorsAvery A Sandberg
Department of DNA Diagnostics, St. Joseph's Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
Cancer Genet Cytogenet 135:1-22. 2002 - Clinical evaluation of a multi-target fluorescent in situ hybridization assay for detection of bladder cancerMichael F Sarosdy
South Texas Urology and Urologic Oncology, San Antonio 78229, USA
J Urol 168:1950-4. 2002..Its specificity approaches that of cytology. Further testing of its clinical use is warranted... - PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology groupPoul H B Sorensen
Department of Pathology, Children s and Women s Hospital of British Columbia, Vancouver, British Columbia, Canada
J Clin Oncol 20:2672-9. 2002..We wished to confirm the diagnostic specificity of gene fusion detection in a large cohort of RMS patients and to evaluate whether these alterations influence clinical outcome in ARMS... - Best cases from the AFIP: Adamantinoma of the tibia and fibula with cytogenetic analysisMorgan D Camp
Departments of Radiology and Pathology, University of Florida and Shands Hospital, 3450 Hull Rd, Gainesville, FL 32609, USA
Radiographics 28:1215-20. 2008