J A Bridge

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi request reprint Use of a novel FISH assay on paraffin-embedded tissues as an adjunct to diagnosis of alveolar rhabdomyosarcoma
    Jun Nishio
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, 68198 3135, USA
    Lab Invest 86:547-56. 2006
  2. ncbi request reprint Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: osteosarcoma and related tumors
    Avery A Sandberg
    Department of DNA Diagnostics, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
    Cancer Genet Cytogenet 145:1-30. 2003
  3. pmc Aberrations of 6q13 mapped to the COL12A1 locus in chondromyxoid fibroma
    Taketoshi Yasuda
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Mod Pathol 22:1499-506. 2009
  4. doi request reprint Identification of a novel, recurrent SLC44A1-PRKCA fusion in papillary glioneuronal tumor
    Julia A Bridge
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Brain Pathol 23:121-8. 2013
  5. pmc Pericytoma with t(7;12) and ACTB-GLI1 fusion arising in bone
    Julia A Bridge
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Hum Pathol 43:1524-9. 2012
  6. pmc Inhibition of phosphorylated c-Met in rhabdomyosarcoma cell lines by a small molecule inhibitor SU11274
    Jinxuan Hou
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68105, USA
    J Transl Med 9:64. 2011
  7. doi request reprint Molecular diagnostics of soft tissue tumors
    Julia A Bridge
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Arch Pathol Lab Med 135:588-601. 2011
  8. ncbi request reprint Novel genomic imbalances in embryonal rhabdomyosarcoma revealed by comparative genomic hybridization and fluorescence in situ hybridization: an intergroup rhabdomyosarcoma study
    J A Bridge
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Genes Chromosomes Cancer 27:337-44. 2000
  9. doi request reprint Contribution of cytogenetics to the management of poorly differentiated sarcomas
    Julia A Bridge
    Department of Pathology and Microbiology, 983135 Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Ultrastruct Pathol 32:63-71. 2008
  10. pmc Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor
    J A Bridge
    Department of Pathology, Center for Human Molecular Genetics, 983135 University of Nebraska Medical Center, Omaha, NE 68198, USA
    Am J Pathol 159:411-5. 2001

Collaborators

Detail Information

Publications77

  1. ncbi request reprint Use of a novel FISH assay on paraffin-embedded tissues as an adjunct to diagnosis of alveolar rhabdomyosarcoma
    Jun Nishio
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, 68198 3135, USA
    Lab Invest 86:547-56. 2006
    ..The findings also suggest that FISH may be a more sensitive assay than RT-PCR in some settings, capable of revealing variant translocations...
  2. ncbi request reprint Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: osteosarcoma and related tumors
    Avery A Sandberg
    Department of DNA Diagnostics, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
    Cancer Genet Cytogenet 145:1-30. 2003
  3. pmc Aberrations of 6q13 mapped to the COL12A1 locus in chondromyxoid fibroma
    Taketoshi Yasuda
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Mod Pathol 22:1499-506. 2009
    ..The latter could potentially be utilized as an adjunct in diagnostically challenging cases...
  4. doi request reprint Identification of a novel, recurrent SLC44A1-PRKCA fusion in papillary glioneuronal tumor
    Julia A Bridge
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Brain Pathol 23:121-8. 2013
    ..The FISH and RT-PCR assays developed in this study can serve as valuable diagnostic adjuncts for this rare disease entity...
  5. pmc Pericytoma with t(7;12) and ACTB-GLI1 fusion arising in bone
    Julia A Bridge
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Hum Pathol 43:1524-9. 2012
    ..To the best of our knowledge, this is the first case of pericytoma with t(7;12) arising in bone. Cytogenetic and molecular analyses were useful, if not essential, in classifying this rare diagnostic entity...
  6. pmc Inhibition of phosphorylated c-Met in rhabdomyosarcoma cell lines by a small molecule inhibitor SU11274
    Jinxuan Hou
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68105, USA
    J Transl Med 9:64. 2011
    ..In this study, we investigated the role of c-Met in rhabdomyosarcoma (RMS) using its small molecule inhibitor SU11274, which has been hypothesized to be a potential therapeutic target for RMS...
  7. doi request reprint Molecular diagnostics of soft tissue tumors
    Julia A Bridge
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Arch Pathol Lab Med 135:588-601. 2011
    ..During the past 3 decades, mesenchymal tumor-specific, cytogenetic and molecular genetic abnormalities have demonstrated an increasingly important, ancillary role in mesenchymal tumor diagnostics...
  8. ncbi request reprint Novel genomic imbalances in embryonal rhabdomyosarcoma revealed by comparative genomic hybridization and fluorescence in situ hybridization: an intergroup rhabdomyosarcoma study
    J A Bridge
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Genes Chromosomes Cancer 27:337-44. 2000
    ..In summary, CGH and FISH analyses of 12 E-RMS specimens revealed novel genomic imbalances that may be useful in directing further molecular studies for the determination of E-RMS critically involved genes...
  9. doi request reprint Contribution of cytogenetics to the management of poorly differentiated sarcomas
    Julia A Bridge
    Department of Pathology and Microbiology, 983135 Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Ultrastruct Pathol 32:63-71. 2008
    ..Consequently, demonstration of characteristic, tumor-specific chromosomal aberrations is especially useful in the management of poorly differentiated sarcomas...
  10. pmc Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor
    J A Bridge
    Department of Pathology, Center for Human Molecular Genetics, 983135 University of Nebraska Medical Center, Omaha, NE 68198, USA
    Am J Pathol 159:411-5. 2001
    ..One of these cases exhibited a 2;17 translocation in addition to other karyotypic anomalies [46,XX,t(2;17)(p23;q23),add(16)(q24)]...
  11. ncbi request reprint Genomic gains and losses are similar in genetic and histologic subsets of rhabdomyosarcoma, whereas amplification predominates in embryonal with anaplasia and alveolar subtypes
    Julia A Bridge
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Genes Chromosomes Cancer 33:310-21. 2002
    ....
  12. pmc The small round blue cell tumors of the sinonasal area
    Julia A Bridge
    Department of Pathology, 983135 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Head Neck Pathol 4:84-93. 2010
    ..Establishing an accurate diagnosis of a small round blue cell tumor of the sinonasal tract frequently requires adjunctive studies including immunohistochemical and molecular analyses...
  13. ncbi request reprint Regulation of MMP-9 (92 kDa type IV collagenase/gelatinase B) expression in stromal cells of human giant cell tumor of bone
    V H Rao
    Meyer Rehabilitation Institute and Department of Pediatrics, University of Nebraska Medical Center, Omaha 68198, USA
    Clin Exp Metastasis 15:400-9. 1997
    ..This suggests that multinucleated giant cells in primary cultures secrete a factor(s) that stimulates stromal cells to produce MMP-9, which, in turn, may contribute to the aggressive behavior of GCT...
  14. ncbi request reprint Translocation t(1;3)(p36.3;q25) is a nonrandom aberration in epithelioid hemangioendothelioma
    M R Mendlick
    Departments of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA
    Am J Surg Pathol 25:684-7. 2001
    ..Identification of the 1;3 translocation may be useful diagnostically. Should additional studies confirm these data, this could lead to the identification of the gene(s) central to this neoplastic process...
  15. ncbi request reprint Primary malignant neuroepithelial tumors of the kidney: a clinicopathologic analysis of 146 adult and pediatric cases from the National Wilms' Tumor Study Group Pathology Center
    D M Parham
    Department of Pathology, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock 72202, USA
    Am J Surg Pathol 25:133-46. 2001
    ....
  16. ncbi request reprint Prognostic impact of P53 status, TLS-CHOP fusion transcript structure, and histological grade in myxoid liposarcoma: a molecular and clinicopathologic study of 82 cases
    C R Antonescu
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Cancer Res 7:3977-87. 2001
    ..We also analyzed P53 status, because this parameter has been found to have a significant prognostic impact in other sarcomas with chromosomal translocations...
  17. pmc Recurrent chromosomal imbalances and structurally abnormal breakpoints within complex karyotypes of malignant peripheral nerve sheath tumour and malignant triton tumour: a cytogenetic and molecular cytogenetic study
    R S Bridge
    Department of Pathology, 983135 Nebraska Medical Center, Omaha, NE 68198 3135, USA
    J Clin Pathol 57:1172-8. 2004
    ..Cytogenetic studies of malignant peripheral nerve sheath tumours (MPNSTs) and malignant triton tumours (MTTs) are rare...
  18. ncbi request reprint Cytogenetic analysis of a malignant triton tumor and a malignant peripheral nerve sheath tumor and a review of the literature
    E N McComb
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198 5440, USA
    Cancer Genet Cytogenet 91:8-12. 1996
    ..The genes for peripheral neurofibromatosis (NF-1) and central neurofibromatosis (NF-2) have been mapped to these two chromosomes respectively...
  19. pmc Extra copies of chromosomes 7, 8, 12, 19, and 21 are recurrent in adamantinoma
    M Kanamori
    Departments of Pathology and Microbiology, Center for Human Molecular Genetics, University of Nebraska Medical Center, Omaha, Nebraska, USA
    J Mol Diagn 3:16-21. 2001
    ..Adamantinoma may be confused with a variety of primary and metastatic epithelial and mesenchymal neoplasms. Observation of these aneuploidies may be useful in establishing the diagnosis of adamantinoma...
  20. ncbi request reprint Cytogenetic instability, predominantly involving chromosome 1, is characteristic of elastofibroma
    E N McComb
    Departments of Pathology and Microbiology, University of Nebraska Medical Center, 68198-3135, Omaha, NE, USA
    Cancer Genet Cytogenet 126:68-72. 2001
    ..The observation of clonal abnormalities in elastofibroma suggests that this lesion may represent a neoplastic rather than a reactive process...
  21. pmc Trisomies 8 and 20 characterize a subgroup of benign fibrous lesions arising in both soft tissue and bone
    J A Bridge
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5440, USA
    Am J Pathol 154:729-33. 1999
    ..Our findings demonstrate that trisomy 8 and trisomy 20 are also nonrandom aberrations in histologically similar, but clinically distinct, benign fibrous lesions of bone...
  22. pmc Alveolar rhabdomyosarcoma of the head and neck region in older adults: genetic characterization and a review of the literature
    Taketoshi Yasuda
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Hum Pathol 40:341-8. 2009
    ..Further follow-up and additional cases are required to assess the prognostic relevance of these fusion transcripts in the context of advanced age...
  23. pmc Primary renal neoplasms with the ASPL-TFE3 gene fusion of alveolar soft part sarcoma: a distinctive tumor entity previously included among renal cell carcinomas of children and adolescents
    P Argani
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21231 2410, USA
    Am J Pathol 159:179-92. 2001
    ..Finally, the finding of distinctive tumors being associated with balanced and unbalanced forms of the same translocation is to our knowledge, unprecedented...
  24. doi request reprint Detection of chromosomal aberrations in renal tumors: a comparative study of conventional cytogenetics and virtual karyotyping with single-nucleotide polymorphism microarrays
    Federico A Monzon
    Department of Pathology, The Methodist Hospital Research Institute, The Methodist Hospital, Houston, Texas 77030, USA
    Arch Pathol Lab Med 133:1917-22. 2009
    ....
  25. ncbi request reprint Clonal karyotypic abnormalities of the hereditary multiple exostoses chromosomal loci 8q24.1 (EXT1) and 11p11-12 (EXT2) in patients with sporadic and hereditary osteochondromas
    J A Bridge
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198 5440, USA
    Cancer 82:1657-63. 1998
    ..1 (EXT1), 11p11-12 (EXT2), and 19p (EXT3). Constitutional chromosomal microdeletions of 8q24.1 and 11p11-12 are features of the Langer-Giedion and DEFECT-11 syndromes, respectively. Cytogenetic studies of osteochondroma are rare...
  26. ncbi request reprint Cytogenetic and molecular cytogenetic findings in 43 aneurysmal bone cysts: aberrations of 17p mapped to 17p13.2 by fluorescence in situ hybridization
    Pamela A Althof
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Mod Pathol 17:518-25. 2004
    ..The latter could potentially be utilized as an adjunct in diagnostically challenging cases...
  27. ncbi request reprint Extraskeletal myxoid chondrosarcoma of the jugular foramen
    T J Cummings
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Clin Neuropathol 23:232-7. 2004
    ..The histological differential diagnosis includes chordoma, conventional chondrosarcoma and chordoid meningioma, among others. A distinguishing feature of EMC is their characteristic reciprocal translocation t(9;22)(q22;q12)...
  28. ncbi request reprint Interleukin-1beta upregulates MMP-9 expression in stromal cells of human giant cell tumor of bone
    V H Rao
    Center for Human Molecular Genetics, Munroe Meyer Institute for Genetics and Rehabilitation, and the Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198, USA
    J Interferon Cytokine Res 19:1207-17. 1999
    ....
  29. pmc C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma
    Dali Huang
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Genes Chromosomes Cancer 49:810-8. 2010
    ..The FISH and RT-PCR assays developed in this study can serve as diagnostic adjuncts for the identification of this novel C11orf95-MKL2 fusion oncogene in chondroid lipoma...
  30. ncbi request reprint Monoallelic deletion of the p53 gene through chromosomal translocation in a small cell osteosarcoma
    Jun Nishio
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Virchows Arch 448:852-6. 2006
    ....
  31. ncbi request reprint Cytogenetic and molecular cytogenetic evidence of recurrent 8q24.1 loss in osteochondroma
    Michael G Feely
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
    Cancer Genet Cytogenet 137:102-7. 2002
    ....
  32. pmc Lack of a common or characteristic cytogenetic anomaly in solitary fibrous tumor
    Alireza Torabi
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Cancer Genet Cytogenet 181:60-4. 2008
    ..Clonal karyotypic abnormalities were lacking in three additional solitary fibrous tumors...
  33. ncbi request reprint Sclerosing rhabdomyosarcomas in children and adolescents: a clinicopathologic review of 13 cases from the Intergroup Rhabdomyosarcoma Study Group and Children's Oncology Group
    Melissa C Chiles
    Department of Pathology, Arkansas Children s Hospital and University of Arkansas for Medical Sciences, Slot 820, 800 Marshall Street, Little Rock, AR 72202, USA
    Pediatr Dev Pathol 7:583-94. 2004
    ..Sclerosing RMS may arise in children, have mixed ERMS-ARMS histology, originate from the head and neck, and lack strong myogenin staining...
  34. ncbi request reprint Embryonal rhabdomyosarcoma with a der(16)t(1;16) translocation
    Kayla M Kapels
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Cancer Genet Cytogenet 174:68-73. 2007
    ..These results suggest that the unbalanced t(1;16) translocation may be seen in RMSs lacking a primary genetic rearrangement...
  35. ncbi request reprint USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst
    Andre M Oliveira
    Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Cancer Res 64:1920-3. 2004
    ..CDH11 is expressed strongly in bone, and our findings implicate a novel oncogenic mechanism in which deregulated USP6 transcription results from juxtaposition to the highly active CDH11 promoter...
  36. pmc Aggressive angiomyxoma with t(12;21) and HMGA2 rearrangement: report of a case and review of the literature
    Neil J Rawlinson
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Cancer Genet Cytogenet 181:119-24. 2008
    ..Karyotypic rearrangements of 12q13 approximately q15 are considered recurrent in aggressive angiomyxoma, although reported in only five previous cases. Translocation partner chromosome 21 is unique to the present case...
  37. ncbi request reprint Cytogenetic findings in clear cell chondrosarcoma
    Jun Nishio
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, N 68198 3135, USA
    Cancer Genet Cytogenet 162:74-7. 2005
    ..Clonal chromosomal abnormalities were detected in 3 cases. A tumor specific anomaly was not identified, however, extra copies of chromosome 20 and loss or rearrangements of 9p appear to be recurrent...
  38. ncbi request reprint Translocation der(13;21)(q10;q10) in skeletal and extraskeletal mesenchymal chondrosarcoma
    Sabine Naumann
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Mod Pathol 15:572-6. 2002
    ..The observation of similar chromosomal abnormalities in both skeletal and extraskeletal mesenchymal chondrosarcoma supports a genetic as well as histopathologic relationship between these anatomically distinct neoplasms...
  39. pmc Inconspicuous insertion 22;12 in myxoid/round cell liposarcoma accompanied by the secondary structural abnormality der(16)t(1;16)
    Nathan C Birch
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    J Mol Diagn 5:191-4. 2003
    ....
  40. pmc Analysis of HER2 gene amplification using an automated fluorescence in situ hybridization signal enumeration system
    Rachel Stevens
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198 3135, USA
    J Mol Diagn 9:144-50. 2007
    ..59 versus 7.47 minutes for manual signal enumeration (savings of 2.88 minutes/slide). These data suggest that the Vysis AutoVysion System can correctly classify specimens and may increase the overall efficiency of HER2 testing...
  41. ncbi request reprint Performance characteristics of a reverse transcriptase-polymerase chain reaction assay for the detection of tumor-specific fusion transcripts from archival tissue
    Michael K Fritsch
    Department of Pathology, The Johns Hopkins Medical Institutions, 401 N Broadway, Baltimore, MD 22131 2410, USA
    Pediatr Dev Pathol 6:43-53. 2003
    ..Additional studies such as FISH may be useful in clarifying the nature of equivocal or unexpected results...
  42. pmc Loss of the PTCH1 gene locus in cardiac fibroma
    David Scanlan
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 8135, USA
    Cardiovasc Pathol 17:93-7. 2008
    ..CF is more commonly encountered in patients with Gorlin syndrome (3%) than the general population. Mutations of the tumor suppressor gene PTCH1 are the underlying cause of Gorlin syndrome...
  43. ncbi request reprint Renal carcinomas with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCR
    Pedram Argani
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Surg Pathol 29:230-40. 2005
    ..Finally, the special molecular features of the Alpha-TFEB gene fusion allow its molecular detection by DNA PCR as a robust alternative to RT-PCR in clinical tumor samples...
  44. ncbi request reprint Establishment of a new human epithelioid sarcoma cell line, FU-EPS-1: molecular cytogenetic characterization by use of spectral karyotyping and comparative genomic hybridization
    Jun Nishio
    Department of Pathology, University of Nebraska Medical Center, 985454 Nebraska Medical Center, Omaha, NE 68198 5454, USA
    Int J Oncol 27:361-9. 2005
    ..The FU-EPS-1 cell line will be exceedingly useful for biologic and molecular pathogenetic studies of human epithelioid sarcoma...
  45. ncbi request reprint Cytogenetic findings in benign cartilaginous neoplasms
    Emilie P Buddingh
    Department of Pathology and Microbiology, Nebraska Medical Center, Omaha, NE 68198, USA
    Cancer Genet Cytogenet 141:164-8. 2003
    ..Abnormal diploid or near-diploid clones were detected in all specimens analyzed. Although a tumor-specific anomaly did not emerge from these studies, involvement of certain chromosomes/chromosomal regions appears recurrent...
  46. pmc An increased frequency of 13q deletions detected by fluorescence in situ hybridization and its impact on survival in children and adolescents with Burkitt lymphoma: results from the Children's Oncology Group study CCG-5961
    Marilu Nelson
    Human Genetics Laboratories, Munroe Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, 985440 Nebraska Medical Center, Omaha, NE 68198, USA
    Br J Haematol 148:600-10. 2010
    ..95%, P = 0.012). These observations indicate that del(13q) occurs in childhood BL at frequencies higher than previously detected by classical cytogenetics and underscores the importance of molecular cytogenetics in risk stratification...
  47. ncbi request reprint Cytogenetic distinction among benign fibro-osseous lesions of bone in children and adolescents: value of karyotypic findings in differential diagnosis
    David M Parham
    Department of Pathology, Arkansas Children Hospital and University of Arkansas for Medical Sciences, Slot 820, 800 Marshall Street, Little Rock, AR 72202, USA
    Pediatr Dev Pathol 7:148-58. 2004
    ..Our current and published results indicate that cytogenetics might be of ancillary use in the diagnosis of BFOL and that a characteristic chromosomal arrangement is associated with ossifying fibroma...
  48. doi request reprint Clear cell sarcoma of soft tissue metastatic to the ovaries: a heretofore unreported occurrence
    Summer L Nugent
    Department of Pathology, University of Maryland Medical Center, Baltimore, Maryland 21201, USA
    Int J Gynecol Pathol 28:234-8. 2009
    ..To the best of our knowledge, this is the first reported case of CCSST metastatic to the ovaries...
  49. ncbi request reprint Fusion of ALK to the Ran-binding protein 2 (RANBP2) gene in inflammatory myofibroblastic tumor
    Zhigui Ma
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Genes Chromosomes Cancer 37:98-105. 2003
    ..These findings expand the spectrum of ALK abnormalities observed in IMT and further confirm the clonal, neoplastic nature of these lesions...
  50. doi request reprint Osteoblastoma characterized by a three-way translocation: report of a case and review of the literature
    Giovanna Giannico
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Cancer Genet Cytogenet 195:168-71. 2009
    ..Rearrangement of 1q42 has been identified in a previously reported case...
  51. ncbi request reprint Imbalances of chromosomes 4, 9, and 12 are recurrent in the thecoma-fibroma group of ovarian stromal tumors
    Renae C Streblow
    Departments of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Cancer Genet Cytogenet 178:135-40. 2007
    ..In contrast, loss of chromosomes 4 and/or 9 are recurrent in fibroma. In summary, imbalances of chromosomes 4 and 9 appear to represent important secondary abnormalities in the thecoma-fibroma ovarian tumor group...
  52. ncbi request reprint Translocation (1;4)(p31;q34) in nonossifying fibroma
    Marilu Nelson
    Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, USA
    Cancer Genet Cytogenet 142:142-4. 2003
    ..Conventional cytogenetic analysis revealed a reciprocal translocation involving bands 1p31 and 4q34 [t(1;4)(p31;q34)]. To the best of our knowledge, this is only the second reported case of a clonally aberrant nonossifying fibroma...
  53. ncbi request reprint Chromosome 6 abnormalities are recurrent in synovial chondromatosis
    Emilie P Buddingh
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
    Cancer Genet Cytogenet 140:18-22. 2003
    ..These findings support a neoplastic origin for synovial chondromatosis and suggest that chromosome 6 aberrations are recurrent in this lesion...
  54. ncbi request reprint Translocation (2;11)(q31;q12) is recurrent in collagenous fibroma (desmoplastic fibroblastoma)
    Kerry Bernal
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Cancer Genet Cytogenet 149:161-3. 2004
    ..This finding confirms the nonrandom association of t(2;11)(q31;q12) with collagenous fibroma...
  55. ncbi request reprint Monosomy 22 as a diagnostic aid in a case of late recurrence of adult granulosa cell tumor of the ovary
    Samuel K Caughron
    Department of Pathology, Creighton University Medical Center, 601 North 30th Street, Omaha, NE 68131, USA
    Cancer Genet Cytogenet 156:83-5. 2005
    ..This anomaly, typical of granulosa cell tumor, coupled with the pathologic and immunophenotypic findings assisted in establishing the proper diagnosis of this lesion in the absence of the original histopathologic slides...
  56. ncbi request reprint Differentially amplified chromosome 12 sequences in low- and high-grade osteosarcoma
    David Gisselsson
    Department of Clinical Genetics, University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 33:133-40. 2002
    ..These findings indicate that gain of sequences from the short arm of chromosome 12 could be a possible genetic pathway in the development of aggressive osteosarcoma...
  57. ncbi request reprint Loss of 13q14-q21 and gain of 5p14-pter in the progression of leiomyosarcoma
    Rubin Wang
    Molecular Cytogenetics, Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, Surrey, United Kingdom
    Mod Pathol 16:778-85. 2003
    ..These results suggest that 13q14-q21 loss and 5p14-pter gain at diagnosis could be used to identify patients with leiomyosarcoma who are likely to have a shorter survival time and who might benefit from early treatment intensification...
  58. ncbi request reprint Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. Synovial sarcoma
    Avery A Sandberg
    Department of DNA Diagnostics, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
    Cancer Genet Cytogenet 133:1-23. 2002
  59. ncbi request reprint Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: congenital (infantile) fibrosarcoma and mesoblastic nephroma
    Avery A Sandberg
    Department of DNA Diagnostics, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
    Cancer Genet Cytogenet 132:1-13. 2002
  60. ncbi request reprint Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. desmoplastic small round-cell tumors
    Avery A Sandberg
    Department of DNA Diagnostics, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
    Cancer Genet Cytogenet 138:1-10. 2002
  61. ncbi request reprint Sclerosing rhabdomyosarcoma in adults: report of four cases of a hyalinizing, matrix-rich variant of rhabdomyosarcoma that may be confused with osteosarcoma, chondrosarcoma, or angiosarcoma
    Andrew L Folpe
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    Am J Surg Pathol 26:1175-83. 2002
    ..Study of additional cases will be necessary to more fully elucidate its place among RMS and its prognostic significance...
  62. ncbi request reprint Genetic heterogeneity in the alveolar rhabdomyosarcoma subset without typical gene fusions
    Frederic G Barr
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 62:4704-10. 2002
    ....
  63. ncbi request reprint Spectral karyotyping identifies recurrent complex rearrangements of chromosomes 8, 17, and 20 in osteosarcomas
    Jane Bayani
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
    Genes Chromosomes Cancer 36:7-16. 2003
    ..These findings suggest that specific sequences mapping to these chromosomal regions will likely have a role in the development and progression of OS...
  64. ncbi request reprint The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas
    Cynthia Laflamme
    Human and Molecular Genetic Research Unit, Pavillon Saint Francois d Assise, CHUQ, Quebec, QC, G1L 3L5 Canada
    Cancer Res 63:449-54. 2003
    ....
  65. ncbi request reprint Clinical evaluation of a multi-target fluorescent in situ hybridization assay for detection of bladder cancer
    Michael F Sarosdy
    South Texas Urology and Urologic Oncology, San Antonio 78229, USA
    J Urol 168:1950-4. 2002
    ..In a separate study of healthy volunteers and patients with other (nontransitional cell carcinoma) conditions we determined the specificity of the FISH assay...
  66. ncbi request reprint Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. gastrointestinal stromal tumors
    Avery A Sandberg
    Department of DNA Diagnostics, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
    Cancer Genet Cytogenet 135:1-22. 2002
  67. ncbi request reprint Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: chondrosarcoma and other cartilaginous neoplasms
    Avery A Sandberg
    Department of DNA Diagnostics, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
    Cancer Genet Cytogenet 143:1-31. 2003
  68. doi request reprint Best cases from the AFIP: Adamantinoma of the tibia and fibula with cytogenetic analysis
    Morgan D Camp
    Departments of Radiology and Pathology, University of Florida and Shands Hospital, 3450 Hull Rd, Gainesville, FL 32609, USA
    Radiographics 28:1215-20. 2008
  69. ncbi request reprint Intracranial Ewing sarcoma
    Melissa A Mazur
    Department of Pediatric Hematology Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Pediatr Blood Cancer 45:850-6. 2005
    ..Demonstration of t(11;22)(q24;q12) by molecular analysis essentially confirms the diagnosis and enables the oncologist to choose appropriate therapy...
  70. ncbi request reprint Sclerosing rhabdomyosarcomas in children and adolescents: a clinicopathologic review of 13 cases from the Intergroup Rhabdomyosarcoma Study Group and Children's Oncology Group
    Melissa C Chiles
    Department of Pathology and Pediatrics, Arkansas Children s Hospital and University of Arkansas for Medical Sciences, Slot 820, 800 Marshall Street, Little Rock, AR 72202, USA
    Pediatr Dev Pathol 8:141. 2005
  71. ncbi request reprint C-erb-B2 (HER2/neu) expression in synovial sarcoma of the head and neck
    Randall J Olsen
    Department of Pathology and Laboratory Medicine, Baylor College of Medicine, Houston, Texas, USA
    Head Neck 27:883-92. 2005
    ....
  72. ncbi request reprint Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. Dermatofibrosarcoma protuberans and giant cell fibroblastoma
    Avery A Sandberg
    Department of DNA Diagnostics, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
    Cancer Genet Cytogenet 140:1-12. 2003
  73. ncbi request reprint Use of a multitarget fluorescence in situ hybridization assay to diagnose bladder cancer in patients with hematuria
    Michael F Sarosdy
    South Texas Urology and Urologic Oncology, 4499 Medical 218, San Antonio, TX 78229, USA
    J Urol 176:44-7. 2006
    ..We evaluated the multitarget UroVysion fluorescence in situ hybridization assay for the diagnosis of bladder cancer in patients with hematuria and no history of bladder cancer...
  74. ncbi request reprint Paraganglioma-like dermal melanocytic tumor: a unique entity distinct from cellular blue nevus, clear cell sarcoma, and cutaneous melanoma
    Andrea T Deyrup
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    Am J Surg Pathol 28:1579-86. 2004
    ..PDMT comprises a clinically and pathologically unique subtype of dermal melanocytic tumors. Our study suggests a benign course, although a lesion of low malignant potential cannot be excluded...
  75. ncbi request reprint EWS/FLI-1 fusion signal inserted into chromosome 11 in one patient with morphologic features of Ewing sarcoma, but lacking t(11;22)
    Jacqueline R Batanian
    Department of Pediatrics, Cardinal Glennon Children s Hospital, St Louis, MO, USA
    Cancer Genet Cytogenet 133:72-5. 2002
    ..Reverse transcriptase-polymerase chain reaction studies revealed the presence of two EWS/FLI1 fusion gene products...
  76. ncbi request reprint Identification of a ring chromosome with spectral karyotyping in a pleural synovial sarcoma
    Jun Nishio
    Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan
    Cancer Genet Cytogenet 160:174-8. 2005
    ..Subsequent FISH analysis with a whole-chromosome 8 paint probe confirmed the SKY results. This study demonstrates the usefulness of SKY as an adjunct for determining the chromosomal composition of ring chromosomes...
  77. ncbi request reprint PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group
    Poul H B Sorensen
    Department of Pathology, Children s and Women s Hospital of British Columbia, Vancouver, British Columbia, Canada
    J Clin Oncol 20:2672-9. 2002
    ..We wished to confirm the diagnostic specificity of gene fusion detection in a large cohort of RMS patients and to evaluate whether these alterations influence clinical outcome in ARMS...