Research Topics
Species | James B BrewerSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Fully-automated quantification of regional brain volumes for improved detection of focal atrophy in Alzheimer diseaseJ B Brewer
Department of Radiology and Neurosciences, University of California, San Diego, San Diego, CA 92093, USA
AJNR Am J Neuroradiol 30:578-80. 2009..The system yielded results that correlated highly with independent computer-aided manual segmentation and were sensitive to the anatomic atrophy characteristic of mild AD...- Fully-automated volumetric MRI with normative ranges: translation to clinical practiceJ B Brewer
Department of Radiology and Neurosciences, University of California, San Diego, CA, USA
Behav Neurol 21:21-8. 2009..Such advances are critical for providing physicians a framework for assessing the pattern and degree of regional atrophy in a patient's brain and applying vMRI in clinical practice... 
Neuroimaging enrichment strategy for secondary prevention trials in Alzheimer diseaseLinda K McEvoy
Department of Radiology, University of California, San Diego, La Jolla, CA 92093 0841, USA
Alzheimer Dis Assoc Disord 24:269-77. 2010..Failure to take into account normal age-related changes risks under-powering trials designed to test disease-modifying properties of potential treatments...- Relative capability of MR imaging and FDG PET to depict changes associated with prodromal and early Alzheimer diseaseDavid S Karow
Department of Radiology, University of California, San Diego, La Jolla, CA 92093, USA
Radiology 256:932-42. 2010..To quantify the effect sizes of regional metabolic and morphometric measures in patients with preclinical and mild Alzheimer disease (AD) to aid in the identification of noninvasive biomarkers for the early detection of AD... - Mild cognitive impairment: baseline and longitudinal structural MR imaging measures improve predictive prognosisLinda K McEvoy
Department of Radiology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
Radiology 259:834-43. 2011..To assess whether single-time-point and longitudinal volumetric magnetic resonance (MR) imaging measures provide predictive prognostic information in patients with amnestic mild cognitive impairment (MCI)... - Subregional neuroanatomical change as a biomarker for Alzheimer's diseaseDominic Holland
Department of Neurosciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 106:20954-9. 2009..The findings indicate that regional temporal lobe cortical changes would have great utility as outcome measures in clinical trials and may also have utility in clinical practice for aiding early diagnosis of neurodegenerative disease... - Applications of neuroimaging to disease-modification trials in Alzheimer's diseaseAdam S Fleisher
Department of Neurosciences, University of California, San Diego, USA
Behav Neurol 21:129-36. 2009..This review discusses recently presented data from the ADNI dataset, and the importance of imaging in the future of drug development in AD... - Parietal activity in episodic retrieval measured by fMRI and MEGTyler M Seibert
Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0949, USA
Neuroimage 55:788-93. 2011.... - CETP polymorphisms associate with brain structure, atrophy rate, and Alzheimer's disease risk in an APOE-dependent mannerElizabeth A Murphy
Department of Neurosciences, University of California, San Diego, CA, USA
Brain Imaging Behav 6:16-26. 2012..These results suggest CETP may contribute to the genetic variability of brain structure and dementia susceptibility in an APOE-dependent manner... - Interregional correlations in Parkinson disease and Parkinson-related dementia with resting functional MR imagingTyler M Seibert
Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0949, USA
Radiology 263:226-34. 2012.... - Early parietal response in episodic retrieval revealed with MEGTyler M Seibert
Department of Bioengineering, University of California, San Diego, California 92093 0949, USA
Hum Brain Mapp 32:171-81. 2011..We conclude that this early and transient pattern of activity in lateral parietal cortex is most consistent with a preretrieval role, possibly in directing attention to episodic memory retrieval... - Going their separate ways: dissociation of hippocampal and dorsolateral prefrontal activation during episodic retrieval and post-retrieval processingSarah L Israel
University of California, San Diego La Jolla, CA 92037, USA
J Cogn Neurosci 22:513-25. 2010.... - Amyloid-β associated volume loss occurs only in the presence of phospho-tauRahul S Desikan
Department of Radiology, University of California San Diego, La Jolla 92037, CA
Ann Neurol 70:657-61. 2011..Our findings indicate that Aβ-associated volume loss occurs only in the presence of phospho-tau in humans at risk for dementia... - Stability of resting fMRI interregional correlations analyzed in subject-native space: a one-year longitudinal study in healthy adults and premanifest Huntington's diseaseTyler M Seibert
Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0949, USA
Neuroimage 59:2452-63. 2012..Within the premanifest Huntington's group, though, there was evidence that decreased striatal functional correlations might be associated with disease severity, as gauged by estimated years to symptom onset or by striatal volume... - Quantitative structural MRI for early detection of Alzheimer's diseaseLinda K McEvoy
Department of Radiology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
Expert Rev Neurother 10:1675-88. 2010.... - The path to memory is guided by strategy: distinct networks are engaged in associative encoding under visual and verbal strategy and influence memory performance in healthy and impaired individualsJena B Hales
University of California, San Diego, USA
J Cogn Neurosci 24:1398-410. 2012..The clinical relevance of these findings, probed in a patient with a recent aphasic stroke, suggest that training with strategies utilizing unaffected cortical regions might improve memory ability in patients with brain damage... - Early stages of figure-ground segregation during perception of the face-vaseMichael A Pitts
School of Medicine, Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive MC 0608, La Jolla, CA 92093 0608, USA
J Cogn Neurosci 23:880-95. 2011..Results from these experiments suggest sequential stages of processing underlying figure-ground perception, each which are subject to modifications by selective attention... - High-throughput, fully automated volumetry for prediction of MMSE and CDR decline in mild cognitive impairmentSanja Kovacevic
Department of Radiology, University of California, San Diego, La Jolla, CA 92093 094, USA
Alzheimer Dis Assoc Disord 23:139-45. 2009..Fully automated and rapid measurement of segmental MTL volumes may help clinicians predict clinical decline in MCI patients... - Alzheimer disease: quantitative structural neuroimaging for detection and prediction of clinical and structural changes in mild cognitive impairmentLinda K McEvoy
Department of Radiology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0841, USA
Radiology 251:195-205. 2009.... - Default network correlations analyzed on native surfacesTyler M Seibert
Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0949, USA
J Neurosci Methods 198:301-11. 2011.... - Search-Related Suppression of Hippocampus and Default Network Activity during Associative Memory RetrievalEmilie T Reas
Department of Neurosciences, University of California San Diego, CA, USA
Front Hum Neurosci 5:112. 2011..Engagement in intensive mental search may reduce neural and attentional resources that are otherwise tonically devoted to encoding an individual's stream of experience into episodic memory... - Effortful retrieval reduces hippocampal activity and impairs incidental encodingEmilie T Reas
Department of Neurosciences, University of California, San Diego, California
Hippocampus 23:367-79. 2013..These findings highlight potential contributions from background encoding processes to hippocampal activations during neuroimaging studies of episodic memory retrieval. © 2013 Wiley Periodicals, Inc... - Retrieval search and strength evoke dissociable brain activity during episodic memory recallEmilie T Reas
University of California, San Diego, CA, USA
J Cogn Neurosci 25:219-33. 2013..These findings suggest that, although highly correlated and partially subserved by overlapping cognitive control mechanisms, search and memory strength engage dissociable regions of frontoparietal attention and default networks... - Dissociation of frontal and medial temporal lobe activity in maintenance and binding of sequentially presented paired associatesJena B Hales
University of California, San Diego, USA
J Cogn Neurosci 21:1244-54. 2009..These findings present new evidence that prefrontal and medial-temporal regions provide distinct temporal contributions during associative memory formation... - The timing of associative memory formation: frontal lobe and anterior medial temporal lobe activity at associative binding predicts memoryJ B Hales
Department of Neurosciences, University of California, San Diego, California, USA
J Neurophysiol 105:1454-63. 2011..The temporal separation within each pair, however, allowed extension of these findings by isolating the timing of regional involvement, showing that increased response in these regions occurs during binding but not during maintenance...
Research Grants
- MRI Studies of MTL Structure and Function in MCI and ADJames Brewer; Fiscal Year: 2007..abstract_text> ..