James B Brewer

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Fully-automated quantification of regional brain volumes for improved detection of focal atrophy in Alzheimer disease
    J B Brewer
    Department of Radiology and Neurosciences, University of California, San Diego, San Diego, CA 92093, USA
    AJNR Am J Neuroradiol 30:578-80. 2009
  2. pmc Search-Related Suppression of Hippocampus and Default Network Activity during Associative Memory Retrieval
    Emilie T Reas
    Department of Neurosciences, University of California San Diego, CA, USA
    Front Hum Neurosci 5:112. 2011
  3. doi request reprint Elaboration versus suppression of cued memories: influence of memory recall instruction and success on parietal lobe, default network, and hippocampal activity
    Sarah I Gimbel
    Department of Neurosciences, University of California San Diego, San Diego, California, United States of America
    PLoS ONE 9:e89037. 2014
  4. pmc Functional brain imaging in the clinical assessment of consciousness
    Michael S Rafii
    Department of Neurosciences, University of California San Diego, San Diego, California, United States of America
    PLoS Biol 8:e1000548. 2010
  5. ncbi request reprint Fully-automated volumetric MRI with normative ranges: translation to clinical practice
    J B Brewer
    Department of Radiology and Neurosciences, University of California, San Diego, CA, USA
    Behav Neurol 21:21-8. 2009
  6. ncbi request reprint The role of clusterin in amyloid-β-associated neurodegeneration
    Rahul S Desikan
    Department of Radiology, University of California, San Diego, La Jolla
    JAMA Neurol 71:180-7. 2014
  7. pmc Amyloid-β--associated clinical decline occurs only in the presence of elevated P-tau
    Rahul S Desikan
    Department of Radiology, University of California San Diego, 8950 Villa La Jolla Dr, Ste C101, La Jolla, CA 92037 0841, USA
    Arch Neurol 69:709-13. 2012
  8. ncbi request reprint Effortful retrieval reduces hippocampal activity and impairs incidental encoding
    Emilie T Reas
    Department of Neurosciences, University of California, San Diego, California, USA
    Hippocampus 23:367-79. 2013
  9. pmc Neuroimaging enrichment strategy for secondary prevention trials in Alzheimer disease
    Linda K McEvoy
    Department of Radiology, University of California, San Diego, La Jolla, CA 92093 0841, USA
    Alzheimer Dis Assoc Disord 24:269-77. 2010
  10. doi request reprint Retrieval search and strength evoke dissociable brain activity during episodic memory recall
    Emilie T Reas
    University of California, San Diego, CA, USA
    J Cogn Neurosci 25:219-33. 2013

Research Grants

Detail Information

Publications32

  1. doi request reprint Fully-automated quantification of regional brain volumes for improved detection of focal atrophy in Alzheimer disease
    J B Brewer
    Department of Radiology and Neurosciences, University of California, San Diego, San Diego, CA 92093, USA
    AJNR Am J Neuroradiol 30:578-80. 2009
    ..The system yielded results that correlated highly with independent computer-aided manual segmentation and were sensitive to the anatomic atrophy characteristic of mild AD...
  2. pmc Search-Related Suppression of Hippocampus and Default Network Activity during Associative Memory Retrieval
    Emilie T Reas
    Department of Neurosciences, University of California San Diego, CA, USA
    Front Hum Neurosci 5:112. 2011
    ..Engagement in intensive mental search may reduce neural and attentional resources that are otherwise tonically devoted to encoding an individual's stream of experience into episodic memory...
  3. doi request reprint Elaboration versus suppression of cued memories: influence of memory recall instruction and success on parietal lobe, default network, and hippocampal activity
    Sarah I Gimbel
    Department of Neurosciences, University of California San Diego, San Diego, California, United States of America
    PLoS ONE 9:e89037. 2014
    ..In parietal lobe, default network, and hippocampus, top-down control can override the commonly identified effects of memory strength. ..
  4. pmc Functional brain imaging in the clinical assessment of consciousness
    Michael S Rafii
    Department of Neurosciences, University of California San Diego, San Diego, California, United States of America
    PLoS Biol 8:e1000548. 2010
    ..Michael Rafii and James Brewer discuss the potential for fMRI's wider implementation in clinical practice, and associated caveats...
  5. ncbi request reprint Fully-automated volumetric MRI with normative ranges: translation to clinical practice
    J B Brewer
    Department of Radiology and Neurosciences, University of California, San Diego, CA, USA
    Behav Neurol 21:21-8. 2009
    ..Such advances are critical for providing physicians a framework for assessing the pattern and degree of regional atrophy in a patient's brain and applying vMRI in clinical practice...
  6. ncbi request reprint The role of clusterin in amyloid-β-associated neurodegeneration
    Rahul S Desikan
    Department of Radiology, University of California, San Diego, La Jolla
    JAMA Neurol 71:180-7. 2014
    ..Converging evidence indicates that clusterin, a chaperone glycoprotein, influences Alzheimer disease neurodegeneration. However, the precise role of clusterin in Alzheimer disease pathogenesis is still not well understood...
  7. pmc Amyloid-β--associated clinical decline occurs only in the presence of elevated P-tau
    Rahul S Desikan
    Department of Radiology, University of California San Diego, 8950 Villa La Jolla Dr, Ste C101, La Jolla, CA 92037 0841, USA
    Arch Neurol 69:709-13. 2012
    ..To elucidate the relationship between the 2 hallmark proteins of Alzheimer disease (AD), amyloid-(Aβ) and tau, and clinical decline over time among cognitively normal older individuals...
  8. ncbi request reprint Effortful retrieval reduces hippocampal activity and impairs incidental encoding
    Emilie T Reas
    Department of Neurosciences, University of California, San Diego, California, USA
    Hippocampus 23:367-79. 2013
    ..These findings highlight potential contributions from background encoding processes to hippocampal activations during neuroimaging studies of episodic memory retrieval...
  9. pmc Neuroimaging enrichment strategy for secondary prevention trials in Alzheimer disease
    Linda K McEvoy
    Department of Radiology, University of California, San Diego, La Jolla, CA 92093 0841, USA
    Alzheimer Dis Assoc Disord 24:269-77. 2010
    ..Failure to take into account normal age-related changes risks under-powering trials designed to test disease-modifying properties of potential treatments...
  10. doi request reprint Retrieval search and strength evoke dissociable brain activity during episodic memory recall
    Emilie T Reas
    University of California, San Diego, CA, USA
    J Cogn Neurosci 25:219-33. 2013
    ..These findings suggest that, although highly correlated and partially subserved by overlapping cognitive control mechanisms, search and memory strength engage dissociable regions of frontoparietal attention and default networks...
  11. pmc Relative capability of MR imaging and FDG PET to depict changes associated with prodromal and early Alzheimer disease
    David S Karow
    Department of Radiology, University of California, San Diego, La Jolla, CA 92093, USA
    Radiology 256:932-42. 2010
    ..To quantify the effect sizes of regional metabolic and morphometric measures in patients with preclinical and mild Alzheimer disease (AD) to aid in the identification of noninvasive biomarkers for the early detection of AD...
  12. pmc Mild cognitive impairment: baseline and longitudinal structural MR imaging measures improve predictive prognosis
    Linda K McEvoy
    Department of Radiology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Radiology 259:834-43. 2011
    ..To assess whether single-time-point and longitudinal volumetric magnetic resonance (MR) imaging measures provide predictive prognostic information in patients with amnestic mild cognitive impairment (MCI)...
  13. pmc Parietal activity in episodic retrieval measured by fMRI and MEG
    Tyler M Seibert
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0949, USA
    Neuroimage 55:788-93. 2011
    ....
  14. pmc Amyloid-β associated volume loss occurs only in the presence of phospho-tau
    Rahul S Desikan
    Department of Radiology, University of California San Diego, La Jolla 92037, CA
    Ann Neurol 70:657-61. 2011
    ..Our findings indicate that Aβ-associated volume loss occurs only in the presence of phospho-tau in humans at risk for dementia...
  15. pmc Heart fatty acid binding protein and Aβ-associated Alzheimer's neurodegeneration
    Rahul S Desikan
    Department of Radiology, University of California, San Diego, 8950 Villa La Jolla Drive, Suite C101, La Jolla, CA 92037 0841, USA
    Mol Neurodegener 8:39. 2013
    ..Epidemiological and molecular findings suggest a relationship between Alzheimer's disease (AD) and dyslipidemia, although the nature of this association is not well understood...
  16. ncbi request reprint Applications of neuroimaging to disease-modification trials in Alzheimer's disease
    Adam S Fleisher
    Department of Neurosciences, University of California, San Diego, USA
    Behav Neurol 21:129-36. 2009
    ..This review discusses recently presented data from the ADNI dataset, and the importance of imaging in the future of drug development in AD...
  17. pmc Subregional neuroanatomical change as a biomarker for Alzheimer's disease
    Dominic Holland
    Department of Neurosciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:20954-9. 2009
    ..The findings indicate that regional temporal lobe cortical changes would have great utility as outcome measures in clinical trials and may also have utility in clinical practice for aiding early diagnosis of neurodegenerative disease...
  18. ncbi request reprint Neuropsychiatric symptoms and regional neocortical atrophy in mild cognitive impairment and Alzheimer's disease
    Michael S Rafii
    1Department of Neurosciences, University of California, San Diego, CA, USA
    Am J Alzheimers Dis Other Demen 29:159-65. 2014
    ..To assess the relationship between regional neocortical atrophy and psychotic symptoms in adults with mild cognitive impairment (MCI) and Alzheimer's disease (AD)...
  19. pmc Stability of resting fMRI interregional correlations analyzed in subject-native space: a one-year longitudinal study in healthy adults and premanifest Huntington's disease
    Tyler M Seibert
    Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0949, USA
    Neuroimage 59:2452-63. 2012
    ..Within the premanifest Huntington's group, though, there was evidence that decreased striatal functional correlations might be associated with disease severity, as gauged by estimated years to symptom onset or by striatal volume...
  20. doi request reprint CETP polymorphisms associate with brain structure, atrophy rate, and Alzheimer's disease risk in an APOE-dependent manner
    Elizabeth A Murphy
    Department of Neurosciences, University of California, San Diego, CA, USA
    Brain Imaging Behav 6:16-26. 2012
    ..These results suggest CETP may contribute to the genetic variability of brain structure and dementia susceptibility in an APOE-dependent manner...
  21. pmc Interregional correlations in Parkinson disease and Parkinson-related dementia with resting functional MR imaging
    Tyler M Seibert
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0949, USA
    Radiology 263:226-34. 2012
    ....
  22. doi request reprint Going their separate ways: dissociation of hippocampal and dorsolateral prefrontal activation during episodic retrieval and post-retrieval processing
    Sarah L Israel
    University of California, San Diego La Jolla, CA 92037, USA
    J Cogn Neurosci 22:513-25. 2010
    ....
  23. pmc Early parietal response in episodic retrieval revealed with MEG
    Tyler M Seibert
    Department of Bioengineering, University of California, San Diego, California 92093 0949, USA
    Hum Brain Mapp 32:171-81. 2011
    ..We conclude that this early and transient pattern of activity in lateral parietal cortex is most consistent with a preretrieval role, possibly in directing attention to episodic memory retrieval...
  24. pmc High-throughput, fully automated volumetry for prediction of MMSE and CDR decline in mild cognitive impairment
    Sanja Kovacevic
    Department of Radiology, University of California, San Diego, La Jolla, CA 92093 094, USA
    Alzheimer Dis Assoc Disord 23:139-45. 2009
    ..Fully automated and rapid measurement of segmental MTL volumes may help clinicians predict clinical decline in MCI patients...
  25. pmc Quantitative structural MRI for early detection of Alzheimer's disease
    Linda K McEvoy
    Department of Radiology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Expert Rev Neurother 10:1675-88. 2010
    ....
  26. doi request reprint The path to memory is guided by strategy: distinct networks are engaged in associative encoding under visual and verbal strategy and influence memory performance in healthy and impaired individuals
    Jena B Hales
    University of California, San Diego, USA
    J Cogn Neurosci 24:1398-410. 2012
    ..The clinical relevance of these findings, probed in a patient with a recent aphasic stroke, suggest that training with strategies utilizing unaffected cortical regions might improve memory ability in patients with brain damage...
  27. pmc Alzheimer disease: quantitative structural neuroimaging for detection and prediction of clinical and structural changes in mild cognitive impairment
    Linda K McEvoy
    Department of Radiology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0841, USA
    Radiology 251:195-205. 2009
    ....
  28. pmc Early stages of figure-ground segregation during perception of the face-vase
    Michael A Pitts
    School of Medicine, Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive MC 0608, La Jolla, CA 92093 0608, USA
    J Cogn Neurosci 23:880-95. 2011
    ..Results from these experiments suggest sequential stages of processing underlying figure-ground perception, each which are subject to modifications by selective attention...
  29. pmc Dissociation of frontal and medial temporal lobe activity in maintenance and binding of sequentially presented paired associates
    Jena B Hales
    University of California, San Diego, USA
    J Cogn Neurosci 21:1244-54. 2009
    ..These findings present new evidence that prefrontal and medial-temporal regions provide distinct temporal contributions during associative memory formation...
  30. pmc Default network correlations analyzed on native surfaces
    Tyler M Seibert
    Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0949, USA
    J Neurosci Methods 198:301-11. 2011
    ....
  31. pmc The timing of associative memory formation: frontal lobe and anterior medial temporal lobe activity at associative binding predicts memory
    J B Hales
    Department of Neurosciences, University of California, San Diego, California, USA
    J Neurophysiol 105:1454-63. 2011
    ..The temporal separation within each pair, however, allowed extension of these findings by isolating the timing of regional involvement, showing that increased response in these regions occurs during binding but not during maintenance...

Research Grants2

  1. MRI Studies of MTL Structure and Function in MCI and AD
    James Brewer; Fiscal Year: 2007
    ..abstract_text> ..