George J Brewer

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. doi Risks of copper and iron toxicity during aging in humans
    George J Brewer
    Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Chem Res Toxicol 23:319-26. 2010
  2. doi Prognostic significance of neurologic examination findings in Wilson disease
    James F Burke
    Department of Neurology, University of Michigan, 1150 W Medical Center Dr, Ann Arbor, MI 48109 5604, USA
    Parkinsonism Relat Disord 17:551-6. 2011
  3. doi Efficacy of tetrathiomolybdate in a mouse model of multiple sclerosis
    Guoqing Hou
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Mich 48109 0534, USA
    Transl Res 152:239-44. 2008
  4. doi Subclinical zinc deficiency in Alzheimer's disease and Parkinson's disease
    George J Brewer
    Deptartment of Human Genetics, University of Michigan, Ann Arbor, USA
    Am J Alzheimers Dis Other Demen 25:572-5. 2010
  5. doi Treatment of primary biliary cirrhosis with tetrathiomolybdate: results of a double-blind trial
    Fred Askari
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 5720, USA
    Transl Res 155:123-30. 2010
  6. doi The risks of free copper in the body and the development of useful anticopper drugs
    George J Brewer
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109 5720, USA
    Curr Opin Clin Nutr Metab Care 11:727-32. 2008
  7. doi Improvement in dissolution of liver fibrosis in an animal model by tetrathiomolybdate
    Guoqing Hou
    Department of Human Genetics, University of Michigan Medical School, G061X MBNI, Ann Arbor, MI 48109, USA
    Exp Biol Med (Maywood) 234:662-5. 2009
  8. doi Tetrathiomolybdate is partially protective against hyperglycemia in rodent models of diabetes
    Chunhua Zeng
    University of Michigan Medical School, 5024 Kresge Bldg II, Ann Arbor, MI 48109 0534, USA
    Exp Biol Med (Maywood) 233:1021-5. 2008
  9. doi Copper and ceruloplasmin abnormalities in Alzheimer's disease
    George J Brewer
    Department of Human Genetics, University of Michigan, Ann Arbor, 48103, USA
    Am J Alzheimers Dis Other Demen 25:490-7. 2010
  10. doi Zinc and tetrathiomolybdate for the treatment of Wilson's disease and the potential efficacy of anticopper therapy in a wide variety of diseases
    George J Brewer
    Department of Human Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 5720, USA
    Metallomics 1:199-206. 2009

Collaborators

  • Matthew T Lorincz
  • John K Fink
  • Bin Nan
  • Guoqing Hou
  • Robert Dick
  • Fred Askari
  • Chunhua Zeng
  • James F Burke
  • Sara J Tallaksen-Greene
  • Praveen Dayalu
  • Joel Greenson
  • Jorge Marrero
  • Dawna Innis
  • Robert B Dick
  • Roger L Albin
  • Anita Janiszewska
  • Kasha Benton
  • Gerald D Abrams

Detail Information

Publications18

  1. doi Risks of copper and iron toxicity during aging in humans
    George J Brewer
    Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Chem Res Toxicol 23:319-26. 2010
    ..In the last part of this review, I will provide advice on how to lower risks from copper and iron toxicity...
  2. doi Prognostic significance of neurologic examination findings in Wilson disease
    James F Burke
    Department of Neurology, University of Michigan, 1150 W Medical Center Dr, Ann Arbor, MI 48109 5604, USA
    Parkinsonism Relat Disord 17:551-6. 2011
    ..Our goal was to determine whether presenting clinical features of neurologic Wilson disease (WD) predict longer term neurologic outcomes in patients receiving anticopper treatment...
  3. doi Efficacy of tetrathiomolybdate in a mouse model of multiple sclerosis
    Guoqing Hou
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Mich 48109 0534, USA
    Transl Res 152:239-44. 2008
    ..Finally, we find marked increases of inflammatory and immune-related cytokines in this model, and we find that TM strongly and significantly suppresses these increases...
  4. doi Subclinical zinc deficiency in Alzheimer's disease and Parkinson's disease
    George J Brewer
    Deptartment of Human Genetics, University of Michigan, Ann Arbor, USA
    Am J Alzheimers Dis Other Demen 25:572-5. 2010
    ..Urine zinc excretion, normalized to urine creatinine excretion, was not significantly different in either patient group compared to controls. These patients are probably zinc deficient because of nutritional inadequacy...
  5. doi Treatment of primary biliary cirrhosis with tetrathiomolybdate: results of a double-blind trial
    Fred Askari
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 5720, USA
    Transl Res 155:123-30. 2010
    ....
  6. doi The risks of free copper in the body and the development of useful anticopper drugs
    George J Brewer
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109 5720, USA
    Curr Opin Clin Nutr Metab Care 11:727-32. 2008
    ..We will also review the anticopper drugs and how lowering free copper levels with an anticopper drug inhibits fibrosis, inflammation, and autoimmunity...
  7. doi Improvement in dissolution of liver fibrosis in an animal model by tetrathiomolybdate
    Guoqing Hou
    Department of Human Genetics, University of Michigan Medical School, G061X MBNI, Ann Arbor, MI 48109, USA
    Exp Biol Med (Maywood) 234:662-5. 2009
    ..It now becomes important to evaluate whether this approach will work in the human epidemic of cirrhotic disease resulting from diseases such as alcoholism, nonalcoholic steatohepatitis, and hepatitis C...
  8. doi Tetrathiomolybdate is partially protective against hyperglycemia in rodent models of diabetes
    Chunhua Zeng
    University of Michigan Medical School, 5024 Kresge Bldg II, Ann Arbor, MI 48109 0534, USA
    Exp Biol Med (Maywood) 233:1021-5. 2008
    ..A metabolic effect of TM on blood glucose is possible but seems less likely. TM is also likely inhibiting inflammatory and/or fibrogenic effects in the kidneys of db/db mice...
  9. doi Copper and ceruloplasmin abnormalities in Alzheimer's disease
    George J Brewer
    Department of Human Genetics, University of Michigan, Ann Arbor, 48103, USA
    Am J Alzheimers Dis Other Demen 25:490-7. 2010
    ..Increased exposure to environmental copper (eg, the spread of copper plumbing and the use of copper in supplements) and/or defective ceruloplasmin function may play a role in the current epidemic of Alzheimer's disease...
  10. doi Zinc and tetrathiomolybdate for the treatment of Wilson's disease and the potential efficacy of anticopper therapy in a wide variety of diseases
    George J Brewer
    Department of Human Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 5720, USA
    Metallomics 1:199-206. 2009
    ..However, it should be understood that it is not completely free, always being bound to albumin and other molecules. It is this pool of free copper that is greatly expanded in untreated Wilson's patients undergoing copper toxicity...
  11. doi Copper toxicity in Alzheimer's disease: cognitive loss from ingestion of inorganic copper
    George J Brewer
    The Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA
    J Trace Elem Med Biol 26:89-92. 2012
    ..It is clear that some factor toxic to the brain is present in the environment in developed countries, but not undeveloped countries, and is a major risk factor for AD. I believe that that toxic factor is ingestion of inorganic copper...
  12. doi Copper excess, zinc deficiency, and cognition loss in Alzheimer's disease
    George J Brewer
    Department of Human Genetics, Medical School University of Michigan, Ann Arbor, MI 48103, USA
    Biofactors 38:107-13. 2012
    ..These two factors may be linked in that zinc therapy significantly reduced free copper levels. Thus, zinc may act by lowering copper toxicity or by direct benefit on neuronal health, or both...
  13. doi Treatment of Wilson's disease with tetrathiomolybdate: V. Control of free copper by tetrathiomolybdate and a comparison with trientine
    George J Brewer
    Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA
    Transl Res 154:70-7. 2009
    ..Tetrathiomolybdate controlled copper less well in the dose regimen study (study 3) than in the previous 2 studies of tetrathiomolybdate treatment, probably because of a change in the way "away from food" tetrathiomolybdate was given...
  14. doi Evaluation of tetrathiomolybdate in the R6/2 model of Huntington disease
    Sara J Tallaksen-Greene
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Neurosci Lett 452:60-2. 2009
    ..Given its known tolerability in humans with neurodegeneration, ammonium tetrathiomolybdate could be considered as a candidate for clinical trials in Huntington disease...
  15. ncbi The risks of copper toxicity contributing to cognitive decline in the aging population and to Alzheimer's disease
    George J Brewer
    Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, 3820 Gensley Road, Ann Arbor, MI 48103, USA
    J Am Coll Nutr 28:238-42. 2009
    ..I review a web of animal and human data that tightens the noose around the hypothesis that copper toxicity is causing the epidemic of Alzeimer's disease and loss of cognition in our aging population...
  16. ncbi The use of copper-lowering therapy with tetrathiomolybdate in medicine
    George J Brewer
    University of Michigan Medical School, Departments of Human Genetics and Internal Medicine, G061XMBNI, Ann Arbor, MI 48109 5720, USA
    Expert Opin Investig Drugs 18:89-97. 2009
    ..Clinical testing has been done relatively extensively in Wilson's disease and advanced cancers, but remains in its infancy in other diseases...
  17. ncbi Iron and copper toxicity in diseases of aging, particularly atherosclerosis and Alzheimer's disease
    George J Brewer
    Department of Human Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan USA
    Exp Biol Med (Maywood) 232:323-35. 2007
    ..Here, we examine the evidence that "normal" levels of iron and copper contribute to various diseases of aging...
  18. ncbi Antitumor and antiinflammatory effects of tetrathiotungstate in comparison with tetrathiomolybdate
    Guoqing Hou
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48019 0534, USA
    Transl Res 149:260-4. 2007
    ..It was found that the 2 drugs were comparable in their effects when doses were used that lowered copper availability to the same extent...