Research Topics
| George J BrewerSummaryAffiliation: University of Michigan Country: USA Publications
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Publications
Risks of copper and iron toxicity during aging in humansGeorge J Brewer
Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
Chem Res Toxicol 23:319-26. 2010..In the last part of this review, I will provide advice on how to lower risks from copper and iron toxicity...- Prognostic significance of neurologic examination findings in Wilson diseaseJames F Burke
Department of Neurology, University of Michigan, 1150 W Medical Center Dr, Ann Arbor, MI 48109 5604, USA
Parkinsonism Relat Disord 17:551-6. 2011..Our goal was to determine whether presenting clinical features of neurologic Wilson disease (WD) predict longer term neurologic outcomes in patients receiving anticopper treatment... - Efficacy of tetrathiomolybdate in a mouse model of multiple sclerosisGuoqing Hou
Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Mich 48109 0534, USA
Transl Res 152:239-44. 2008..Finally, we find marked increases of inflammatory and immune-related cytokines in this model, and we find that TM strongly and significantly suppresses these increases... - Subclinical zinc deficiency in Alzheimer's disease and Parkinson's diseaseGeorge J Brewer
Deptartment of Human Genetics, University of Michigan, Ann Arbor, USA
Am J Alzheimers Dis Other Demen 25:572-5. 2010..Urine zinc excretion, normalized to urine creatinine excretion, was not significantly different in either patient group compared to controls. These patients are probably zinc deficient because of nutritional inadequacy... - Treatment of primary biliary cirrhosis with tetrathiomolybdate: results of a double-blind trialFred Askari
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 5720, USA
Transl Res 155:123-30. 2010.... - The risks of free copper in the body and the development of useful anticopper drugsGeorge J Brewer
Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109 5720, USA
Curr Opin Clin Nutr Metab Care 11:727-32. 2008..We will also review the anticopper drugs and how lowering free copper levels with an anticopper drug inhibits fibrosis, inflammation, and autoimmunity... - Improvement in dissolution of liver fibrosis in an animal model by tetrathiomolybdateGuoqing Hou
Department of Human Genetics, University of Michigan Medical School, G061X MBNI, Ann Arbor, MI 48109, USA
Exp Biol Med (Maywood) 234:662-5. 2009..It now becomes important to evaluate whether this approach will work in the human epidemic of cirrhotic disease resulting from diseases such as alcoholism, nonalcoholic steatohepatitis, and hepatitis C... - Tetrathiomolybdate is partially protective against hyperglycemia in rodent models of diabetesChunhua Zeng
University of Michigan Medical School, 5024 Kresge Bldg II, Ann Arbor, MI 48109 0534, USA
Exp Biol Med (Maywood) 233:1021-5. 2008..A metabolic effect of TM on blood glucose is possible but seems less likely. TM is also likely inhibiting inflammatory and/or fibrogenic effects in the kidneys of db/db mice... - Copper and ceruloplasmin abnormalities in Alzheimer's diseaseGeorge J Brewer
Department of Human Genetics, University of Michigan, Ann Arbor, 48103, USA
Am J Alzheimers Dis Other Demen 25:490-7. 2010..Increased exposure to environmental copper (eg, the spread of copper plumbing and the use of copper in supplements) and/or defective ceruloplasmin function may play a role in the current epidemic of Alzheimer's disease... - Zinc and tetrathiomolybdate for the treatment of Wilson's disease and the potential efficacy of anticopper therapy in a wide variety of diseasesGeorge J Brewer
Department of Human Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 5720, USA
Metallomics 1:199-206. 2009..However, it should be understood that it is not completely free, always being bound to albumin and other molecules. It is this pool of free copper that is greatly expanded in untreated Wilson's patients undergoing copper toxicity... - Copper toxicity in Alzheimer's disease: cognitive loss from ingestion of inorganic copperGeorge J Brewer
The Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA
J Trace Elem Med Biol 26:89-92. 2012..It is clear that some factor toxic to the brain is present in the environment in developed countries, but not undeveloped countries, and is a major risk factor for AD. I believe that that toxic factor is ingestion of inorganic copper... - Copper excess, zinc deficiency, and cognition loss in Alzheimer's diseaseGeorge J Brewer
Department of Human Genetics, Medical School University of Michigan, Ann Arbor, MI 48103, USA
Biofactors 38:107-13. 2012..These two factors may be linked in that zinc therapy significantly reduced free copper levels. Thus, zinc may act by lowering copper toxicity or by direct benefit on neuronal health, or both... - Treatment of Wilson's disease with tetrathiomolybdate: V. Control of free copper by tetrathiomolybdate and a comparison with trientineGeorge J Brewer
Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA
Transl Res 154:70-7. 2009..Tetrathiomolybdate controlled copper less well in the dose regimen study (study 3) than in the previous 2 studies of tetrathiomolybdate treatment, probably because of a change in the way "away from food" tetrathiomolybdate was given... - Evaluation of tetrathiomolybdate in the R6/2 model of Huntington diseaseSara J Tallaksen-Greene
Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
Neurosci Lett 452:60-2. 2009..Given its known tolerability in humans with neurodegeneration, ammonium tetrathiomolybdate could be considered as a candidate for clinical trials in Huntington disease... 
The risks of copper toxicity contributing to cognitive decline in the aging population and to Alzheimer's diseaseGeorge J Brewer
Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, 3820 Gensley Road, Ann Arbor, MI 48103, USA
J Am Coll Nutr 28:238-42. 2009..I review a web of animal and human data that tightens the noose around the hypothesis that copper toxicity is causing the epidemic of Alzeimer's disease and loss of cognition in our aging population...- The use of copper-lowering therapy with tetrathiomolybdate in medicineGeorge J Brewer
University of Michigan Medical School, Departments of Human Genetics and Internal Medicine, G061XMBNI, Ann Arbor, MI 48109 5720, USA
Expert Opin Investig Drugs 18:89-97. 2009..Clinical testing has been done relatively extensively in Wilson's disease and advanced cancers, but remains in its infancy in other diseases... - Iron and copper toxicity in diseases of aging, particularly atherosclerosis and Alzheimer's diseaseGeorge J Brewer
Department of Human Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan USA
Exp Biol Med (Maywood) 232:323-35. 2007..Here, we examine the evidence that "normal" levels of iron and copper contribute to various diseases of aging... - Antitumor and antiinflammatory effects of tetrathiotungstate in comparison with tetrathiomolybdateGuoqing Hou
Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48019 0534, USA
Transl Res 149:260-4. 2007..It was found that the 2 drugs were comparable in their effects when doses were used that lowered copper availability to the same extent...