George Brewer

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Neurologically presenting Wilson's disease: epidemiology, pathophysiology and treatment
    George J Brewer
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109 0534, USA
    CNS Drugs 19:185-92. 2005
  2. doi request reprint Copper excess, zinc deficiency, and cognition loss in Alzheimer's disease
    George J Brewer
    Department of Human Genetics, Medical School University of Michigan, Ann Arbor, MI 48103, USA
    Biofactors 38:107-13. 2012
  3. pmc Issues raised involving the copper hypotheses in the causation of Alzheimer's disease
    George J Brewer
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Int J Alzheimers Dis 2011:537528. 2011
  4. doi request reprint Copper toxicity in Alzheimer's disease: cognitive loss from ingestion of inorganic copper
    George J Brewer
    The Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA
    J Trace Elem Med Biol 26:89-92. 2012
  5. doi request reprint The risks of free copper in the body and the development of useful anticopper drugs
    George J Brewer
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109 5720, USA
    Curr Opin Clin Nutr Metab Care 11:727-32. 2008
  6. ncbi request reprint The risks of copper toxicity contributing to cognitive decline in the aging population and to Alzheimer's disease
    George J Brewer
    Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, 3820 Gensley Road, Ann Arbor, MI 48103, USA
    J Am Coll Nutr 28:238-42. 2009
  7. ncbi request reprint The use of tetrathiomolybdate in treating fibrotic, inflammatory, and autoimmune diseases, including the non-obese diabetic mouse model
    George J Brewer
    Department of Human Genetics, University of Michigan Medical School, 5022 Kresge Building II, Ann Arbor MI 48109 0534, USA
    J Inorg Biochem 100:927-30. 2006
  8. ncbi request reprint Anticopper therapy against cancer and diseases of inflammation and fibrosis
    George J Brewer
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109 0534, USA
    Drug Discov Today 10:1103-9. 2005
  9. ncbi request reprint Copper lowering therapy with tetrathiomolybdate as an antiangiogenic strategy in cancer
    George J Brewer
    Department of Human Genetics, University of Michigan Medical School, 5024 Kresge Bldg II, Ann Arbor, MI 48109 0534, USA
    Curr Cancer Drug Targets 5:195-202. 2005
  10. ncbi request reprint Wilson's disease: clinical management and therapy
    George J Brewer
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109 0534, USA
    J Hepatol 42:S13-21. 2005

Collaborators

Detail Information

Publications68

  1. ncbi request reprint Neurologically presenting Wilson's disease: epidemiology, pathophysiology and treatment
    George J Brewer
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109 0534, USA
    CNS Drugs 19:185-92. 2005
    ..In the absence of availability of tetrathiomolybdate, zinc or trientine are the next best choices...
  2. doi request reprint Copper excess, zinc deficiency, and cognition loss in Alzheimer's disease
    George J Brewer
    Department of Human Genetics, Medical School University of Michigan, Ann Arbor, MI 48103, USA
    Biofactors 38:107-13. 2012
    ..These two factors may be linked in that zinc therapy significantly reduced free copper levels. Thus, zinc may act by lowering copper toxicity or by direct benefit on neuronal health, or both...
  3. pmc Issues raised involving the copper hypotheses in the causation of Alzheimer's disease
    George J Brewer
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Int J Alzheimers Dis 2011:537528. 2011
    ..I conclude that the hypothesis is well supported by the evidence and deserves serious consideration, because if it is valid, it indentifies a partially preventable cause of Alzheimer's disease...
  4. doi request reprint Copper toxicity in Alzheimer's disease: cognitive loss from ingestion of inorganic copper
    George J Brewer
    The Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA
    J Trace Elem Med Biol 26:89-92. 2012
    ..It is clear that some factor toxic to the brain is present in the environment in developed countries, but not undeveloped countries, and is a major risk factor for AD. I believe that that toxic factor is ingestion of inorganic copper...
  5. doi request reprint The risks of free copper in the body and the development of useful anticopper drugs
    George J Brewer
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109 5720, USA
    Curr Opin Clin Nutr Metab Care 11:727-32. 2008
    ..We will also review the anticopper drugs and how lowering free copper levels with an anticopper drug inhibits fibrosis, inflammation, and autoimmunity...
  6. ncbi request reprint The risks of copper toxicity contributing to cognitive decline in the aging population and to Alzheimer's disease
    George J Brewer
    Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, 3820 Gensley Road, Ann Arbor, MI 48103, USA
    J Am Coll Nutr 28:238-42. 2009
    ..I review a web of animal and human data that tightens the noose around the hypothesis that copper toxicity is causing the epidemic of Alzeimer's disease and loss of cognition in our aging population...
  7. ncbi request reprint The use of tetrathiomolybdate in treating fibrotic, inflammatory, and autoimmune diseases, including the non-obese diabetic mouse model
    George J Brewer
    Department of Human Genetics, University of Michigan Medical School, 5022 Kresge Building II, Ann Arbor MI 48109 0534, USA
    J Inorg Biochem 100:927-30. 2006
    ..Possible mechanisms of tetrathiomolybdate's protective effect are briefly considered...
  8. ncbi request reprint Anticopper therapy against cancer and diseases of inflammation and fibrosis
    George J Brewer
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109 0534, USA
    Drug Discov Today 10:1103-9. 2005
    ..If clinical studies support the animal work, anticopper therapy holds promise for therapy of cancer, fibrotic disease and inflammatory and autoimmune diseases...
  9. ncbi request reprint Copper lowering therapy with tetrathiomolybdate as an antiangiogenic strategy in cancer
    George J Brewer
    Department of Human Genetics, University of Michigan Medical School, 5024 Kresge Bldg II, Ann Arbor, MI 48109 0534, USA
    Curr Cancer Drug Targets 5:195-202. 2005
    ..The inhibition of multiple angiogenic cytokines gives TM the potential to be a more global inhibitor of angiogenesis...
  10. ncbi request reprint Wilson's disease: clinical management and therapy
    George J Brewer
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109 0534, USA
    J Hepatol 42:S13-21. 2005
  11. ncbi request reprint Fundamental problems lie ahead in the drug discovery and commercialization process: restructuring of the pharmaceutical industry and an improved partnership with academia are required
    George J Brewer
    Department of Human Genetics and Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Investig Med 54:291-302. 2006
  12. ncbi request reprint Novel therapeutic approaches to the treatment of Wilson's disease
    George J Brewer
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109 0534, USA
    Expert Opin Pharmacother 7:317-24. 2006
    ....
  13. ncbi request reprint Treatment of Wilson disease with ammonium tetrathiomolybdate: IV. Comparison of tetrathiomolybdate and trientine in a double-blind study of treatment of the neurologic presentation of Wilson disease
    George J Brewer
    Department of Human Genetics, University of Michigan Medical School, 5024 Kresge Bldg II, Ann Arbor, MI 48109 0534, USA
    Arch Neurol 63:521-7. 2006
    ..To compare tetrathiomolybdate and trientine in treating patients with the neurologic presentation of Wilson disease for the frequency of neurologic worsening, adverse effects, and degree of neurologic recovery...
  14. ncbi request reprint Iron and copper toxicity in diseases of aging, particularly atherosclerosis and Alzheimer's disease
    George J Brewer
    Department of Human Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan USA
    Exp Biol Med (Maywood) 232:323-35. 2007
    ..Here, we examine the evidence that "normal" levels of iron and copper contribute to various diseases of aging...
  15. ncbi request reprint The use of copper-lowering therapy with tetrathiomolybdate in medicine
    George J Brewer
    University of Michigan Medical School, Departments of Human Genetics and Internal Medicine, G061XMBNI, Ann Arbor, MI 48109 5720, USA
    Expert Opin Investig Drugs 18:89-97. 2009
    ..Clinical testing has been done relatively extensively in Wilson's disease and advanced cancers, but remains in its infancy in other diseases...
  16. doi request reprint Treatment of Wilson's disease with tetrathiomolybdate: V. Control of free copper by tetrathiomolybdate and a comparison with trientine
    George J Brewer
    Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA
    Transl Res 154:70-7. 2009
    ..Tetrathiomolybdate controlled copper less well in the dose regimen study (study 3) than in the previous 2 studies of tetrathiomolybdate treatment, probably because of a change in the way "away from food" tetrathiomolybdate was given...
  17. doi request reprint Drug development for orphan diseases in the context of personalized medicine
    George J Brewer
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Mich 48109 0534, USA
    Transl Res 154:314-22. 2009
    ....
  18. doi request reprint Copper and ceruloplasmin abnormalities in Alzheimer's disease
    George J Brewer
    Department of Human Genetics, University of Michigan, Ann Arbor, 48103, USA
    Am J Alzheimers Dis Other Demen 25:490-7. 2010
    ..Increased exposure to environmental copper (eg, the spread of copper plumbing and the use of copper in supplements) and/or defective ceruloplasmin function may play a role in the current epidemic of Alzheimer's disease...
  19. doi request reprint Subclinical zinc deficiency in Alzheimer's disease and Parkinson's disease
    George J Brewer
    Deptartment of Human Genetics, University of Michigan, Ann Arbor, USA
    Am J Alzheimers Dis Other Demen 25:572-5. 2010
    ..Urine zinc excretion, normalized to urine creatinine excretion, was not significantly different in either patient group compared to controls. These patients are probably zinc deficient because of nutritional inadequacy...
  20. doi request reprint Zinc and tetrathiomolybdate for the treatment of Wilson's disease and the potential efficacy of anticopper therapy in a wide variety of diseases
    George J Brewer
    Department of Human Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 5720, USA
    Metallomics 1:199-206. 2009
    ..However, it should be understood that it is not completely free, always being bound to albumin and other molecules. It is this pool of free copper that is greatly expanded in untreated Wilson's patients undergoing copper toxicity...
  21. ncbi request reprint Inhibition of key cytokines by tetrathiomolybdate in the bleomycin model of pulmonary fibrosis
    George J Brewer
    Department of Human Genetics, University of Michigan, 5022 Kresge Building II, Ann Arbor, MI 48109 0534, USA
    J Inorg Biochem 98:2160-7. 2004
    ..The inhibition of tumor necrosis factor alpha suggests that diseases of tumor necrosis factor alpha overexpression are also potential targets of tetrathiomolybdate therapy...
  22. ncbi request reprint Recognition, diagnosis, and management of Wilson's disease
    G J Brewer
    Department of Human Genetics, University of Michigan, Ann Arbor, 48109 0618, USA
    Proc Soc Exp Biol Med 223:39-46. 2000
    ..Anticopper treatments have evolved considerably since the days when the only drug available was penicillamine. Zinc is now the recommended therapy for long-term management of the disease...
  23. ncbi request reprint Tetrathiomolybdate therapy protects against bleomycin-induced pulmonary fibrosis in mice
    George J Brewer
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109 0618, USA
    J Lab Clin Med 141:210-6. 2003
    ..The protection afforded by TM was also reflected in significantly reduced bleomycin-induced body-weight loss. In the next phase of this work, we will seek to determine the mechanisms by which TM brings about this therapeutic benefit...
  24. ncbi request reprint Treatment of Wilson disease with ammonium tetrathiomolybdate: III. Initial therapy in a total of 55 neurologically affected patients and follow-up with zinc therapy
    George J Brewer
    Department of Human Genetics, University of Michigan Medical School, 4909 Buhl, Ann Arbor, MI 48109 0618, USA
    Arch Neurol 60:379-85. 2003
    ..It is unclear what anticopper drug to use for patients with Wilson disease who present with neurologic manifestations because penicillamine often makes them neurologically worse and zinc is slow acting...
  25. ncbi request reprint Copper in medicine
    George J Brewer
    Department of Human Genetics, University of Michigan Medical School, 5024 Kresge Building II, Ann Arbor, MI 48109 0534, USA
    Curr Opin Chem Biol 7:207-12. 2003
    ..There have also been recent developments in the genetic and non-genetic abnormalities of copper, including the finding of new copper-related genes that potentially could cause disease if mutated...
  26. ncbi request reprint Tetrathiomolybdate anticopper therapy for Wilson's disease inhibits angiogenesis, fibrosis and inflammation
    G J Brewer
    Department of Human Genetics and Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    J Cell Mol Med 7:11-20. 2003
    ..Most recently, it has been found that TM has antifibrotic and antiinflammatory effects through inhibition of profibrotic and proinflammatory cytokines...
  27. ncbi request reprint Wilson disease and canine copper toxicosis
    G J Brewer
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109 0618, USA
    Am J Clin Nutr 67:1087S-1090S. 1998
    ..Recently, we established linkage of the copper toxicosis gene to a microsatellite marker, which has made available a linkage test to breeders of Bedlington terriers...
  28. ncbi request reprint Copper control as an antiangiogenic anticancer therapy: lessons from treating Wilson's disease
    G J Brewer
    Department of Human Genetics, 4909 Buhl Building, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Exp Biol Med (Maywood) 226:665-73. 2001
    ..A hypothesis is advanced that copper availability has played a fundamental role in growth regulation throughout evolution and that is the reason that so many angiogenic promoters appear to be dependent upon copper levels...
  29. ncbi request reprint Treatment of Wilson's disease with zinc. XVII: treatment during pregnancy
    G J Brewer
    Department of Human Genetics, Division of Speech Pathology, Michigan Medical School, Ann Arbor, MI, USA
    Hepatology 31:364-70. 2000
    ..The evidence is good that zinc protects the health of the mother during pregnancy. Fetal outcomes were generally quite good, although one baby had a surgically correctable heart defect and one had microcephaly...
  30. ncbi request reprint Zinc acetate for the treatment of Wilson's disease
    G J Brewer
    University of Michigan School of Medicine, Ann Arbor 48109 0618, USA
    Expert Opin Pharmacother 2:1473-7. 2001
    ..As with all anticopper therapies, over a long period of time, overtreatment and induction of copper deficiency can occur. This is to be avoided particularly in children because copper is required for growth...
  31. ncbi request reprint Phase II trial of copper depletion with tetrathiomolybdate as an antiangiogenesis strategy in patients with hormone-refractory prostate cancer
    N Lynn Henry
    Department of Internal Medicine, Division of Hematology, University of Michigan School of Medicine, Ann Arbor, Mich, USA
    Oncology 71:168-75. 2006
    ..In tumor models, the copper-chelating agent tetrathiomolybdate (TM) has been shown to be antiangiogenic. We evaluated the antitumor activity of TM in patients with hormone-refractory prostate cancer (HRPC)...
  32. ncbi request reprint Antitumor and antiinflammatory effects of tetrathiotungstate in comparison with tetrathiomolybdate
    Guoqing Hou
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48019 0534, USA
    Transl Res 149:260-4. 2007
    ..It was found that the 2 drugs were comparable in their effects when doses were used that lowered copper availability to the same extent...
  33. ncbi request reprint Comparison of lowering copper levels with tetrathiomolybdate and zinc on mouse tumor and doxorubicin models
    Guoqing Hou
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Mich 48109 0543, USA
    Transl Res 148:309-14. 2006
    ..It is also hypothesized that the differences between TM and zinc may be caused by TM's mechanism of action in which it binds copper already in the body, whereas zinc does not...
  34. ncbi request reprint Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesis
    Quintin Pan
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cancer Res 62:4854-9. 2002
    ..Our study suggests that a major mechanism of the antiangiogenic effect of copper deficiency induced by TM is suppression of NFkappaB, contributing to a global inhibition of NFkappaB-mediated transcription of proangiogenic factors...
  35. doi request reprint Tetrathiomolybdate protects against bile duct ligation-induced cholestatic liver injury and fibrosis
    Ming Song
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Louisville School of Medicine, 550 S Jackson St, Louisville, KY 40202, USA
    J Pharmacol Exp Ther 325:409-16. 2008
    ..The protective mechanism seems to be independent of oxidative stress. Our data provide further evidence that TM might be a potential therapy for hepatic fibrosis...
  36. ncbi request reprint Tetrathiomolybdate is effective in a mouse model of arthritis
    Mark D McCubbin
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109 0534, USA
    J Rheumatol 33:2501-6. 2006
    ..To test for protective effects of therapy with tetrathiomolybdate, a copper-lowering drug, against collagen-induced arthritis in mice...
  37. ncbi request reprint Tetrathiomolybdate therapy protects against concanavalin a and carbon tetrachloride hepatic damage in mice
    Fred K Askari
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Exp Biol Med (Maywood) 229:857-63. 2004
    ..In conclusion, tetrathiomolybdate protects against the hepatitis and fibrosis produced by these hepatotoxins, probably by inhibiting the excessive increase in inflammatory and fibrotic cytokines...
  38. ncbi request reprint Effects of tetrathiomolybdate in a mouse model of retinal neovascularization
    Susan G Elner
    Department of Ophthalmology, University of Michigan, Ann Arbor, MI 48105, USA
    Invest Ophthalmol Vis Sci 46:299-303. 2005
    ..To determine the effects of tetrathiomolybdate (TM), a copper-chelating agent, on retinal angiogenesis and vascular endothelial growth factor (VEGF) in a mouse model of retinal neovascularization...
  39. pmc Radiotherapy and antiangiogenic TM in lung cancer
    Mohamed K Khan
    Department of Radiation Oncology, The University of Michigan Medical Center, Ann Arbor, MI 48109 0936, USA
    Neoplasia 4:164-70. 2002
    ..We also show that their therapeutic effects are additive, with no additional toxicity. We show that TM has no significant cytotoxicity in vitro against LLHM tumor cells, further supporting the antiangiogenic mechanism for its action...
  40. doi request reprint Risks of copper and iron toxicity during aging in humans
    George J Brewer
    Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Chem Res Toxicol 23:319-26. 2010
    ..In the last part of this review, I will provide advice on how to lower risks from copper and iron toxicity...
  41. ncbi request reprint Cancer therapy with tetrathiomolybdate: antiangiogenesis by lowering body copper--a review
    George J Brewer
    Department of Human Genetics and Department of Internal Medicine, University of Michigan Medical School, 4009 Buhl Building, Ann Arbor, MI 48109 0618, USA
    Integr Cancer Ther 1:327-37. 2002
    ..The authors speculate that the copper level is a primitive angiogenesis and growth-signaling regulator that has been retained throughout evolution...
  42. ncbi request reprint Tetrathiomolybdate protects against cardiac damage by doxorubicin in mice
    Guoqing Hou
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, 48109, USA
    J Lab Clin Med 146:299-303. 2005
    ..Our working hypothesis, based on the inhibition of interleukin-2 by tetrathiomolybdate as shown here, is that tetrathiomolybdate interrupts the inflammatory cascade at the activated-T-lymphocyte stage...
  43. pmc Suppression of tumor recurrence and metastasis by a combination of the PHSCN sequence and the antiangiogenic compound tetrathiomolybdate in prostate carcinoma
    Kenneth L van Golen
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109 0948, USA
    Neoplasia 4:373-9. 2002
    ..Improved survival, fewer metastatic lesions, and excellent tolerability were observed with the combination therapy...
  44. ncbi request reprint Phase II trial of tetrathiomolybdate in patients with advanced kidney cancer
    Bruce G Redman
    Division of Hematology and Oncology, University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor 48109 0948, USA
    Clin Cancer Res 9:1666-72. 2003
    ..Tetrathiomolybdate (TM), a copper-lowering agent, has been shown in preclinical murine tumor models to be antiangiogenic. We evaluated the antitumor activity of TM in patients with advanced kidney cancer in a Phase II trial...
  45. ncbi request reprint Control of copper status for cancer therapy
    Vicki L Goodman
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    Curr Cancer Drug Targets 5:543-9. 2005
    ..Promising results from in vitro experiments, in pre-clinical animal models, and in a phase I clinical trial have led to several phase II trials of TM in patients with advanced cancers...
  46. ncbi request reprint Antiangiogenic tetrathiomolybdate enhances the efficacy of doxorubicin against breast carcinoma
    Quintin Pan
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Mol Cancer Ther 2:617-22. 2003
    ..4 +/- 14.3% greater than that in doxorubicin-treated mice. These results suggest that TM may enhance the rate of pathological complete response when used in combination with an anthracycline in neoadjuvant therapy of breast carcinoma...
  47. pmc Tetrathiomolybdate as an antiangiogenesis therapy for subfoveal choroidal neovascularization secondary to age-related macular degeneration
    Andrew K Vine
    Department of Ophthalmology and Visual Sciences, University of Michigan Medical Center, Ann Arbor, USA
    Trans Am Ophthalmol Soc 100:73-6; discussion 76-7. 2002
    ....
  48. ncbi request reprint Treatment of Wilson's disease with zinc. XVIII. Initial treatment of the hepatic decompensation presentation with trientine and zinc
    Fred K Askari
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    J Lab Clin Med 142:385-90. 2003
    ..Moreover, TM warrants study to determine whether therapy for hepatic Wilson's disease can be further improved...
  49. doi request reprint Efficacy of tetrathiomolybdate in a mouse model of multiple sclerosis
    Guoqing Hou
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Mich 48109 0534, USA
    Transl Res 152:239-44. 2008
    ..Finally, we find marked increases of inflammatory and immune-related cytokines in this model, and we find that TM strongly and significantly suppresses these increases...
  50. ncbi request reprint Inhibition of the growth of squamous cell carcinoma by tetrathiomolybdate-induced copper suppression in a murine model
    Claudell Cox
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, 48109, USA
    Arch Otolaryngol Head Neck Surg 129:781-5. 2003
    ..To determine whether long-term therapy with tetrathiomolybdate suppresses tumor growth in an animal model...
  51. doi request reprint Treatment of primary biliary cirrhosis with tetrathiomolybdate: results of a double-blind trial
    Fred Askari
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 5720, USA
    Transl Res 155:123-30. 2010
    ....
  52. doi request reprint Improvement in dissolution of liver fibrosis in an animal model by tetrathiomolybdate
    Guoqing Hou
    Department of Human Genetics, University of Michigan Medical School, G061X MBNI, Ann Arbor, MI 48109, USA
    Exp Biol Med (Maywood) 234:662-5. 2009
    ..It now becomes important to evaluate whether this approach will work in the human epidemic of cirrhotic disease resulting from diseases such as alcoholism, nonalcoholic steatohepatitis, and hepatitis C...
  53. doi request reprint Tetrathiomolybdate is partially protective against hyperglycemia in rodent models of diabetes
    Chunhua Zeng
    University of Michigan Medical School, 5024 Kresge Bldg II, Ann Arbor, MI 48109 0534, USA
    Exp Biol Med (Maywood) 233:1021-5. 2008
    ..A metabolic effect of TM on blood glucose is possible but seems less likely. TM is also likely inhibiting inflammatory and/or fibrogenic effects in the kidneys of db/db mice...
  54. ncbi request reprint Tetrathiomolybdate blocks bFGF- but not VEGF-induced incipient angiogenesis in vitro
    Fatema Mamou
    Department of Radiation Oncology, Comprehensive Cancer and Geriatrics Center, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Anticancer Res 26:1753-8. 2006
    ..These inhibitory effects of TM are attributed to its potent copper level-reducing property. Copper is needed for activation of various angiogenic pathways at the transcriptional and protein levels...
  55. ncbi request reprint XIAP Is a copper binding protein deregulated in Wilson's disease and other copper toxicosis disorders
    Arjmand R Mufti
    Department of Pathology, University of Michigan Medical School, Ann Arbor, 48109, USA
    Mol Cell 21:775-85. 2006
    ..These data provide an unsuspected link between copper homeostasis and the regulation of cell death through XIAP and may contribute to the pathophysiology of copper toxicosis disorders...
  56. ncbi request reprint Atypical childhood Wilson's disease
    Martha D Carlson
    Division of Pediatric Neurology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109 0202, USA
    Pediatr Neurol 30:57-60. 2004
    ..Neurologic Wilson's disease may have diverse presentations, and should be considered in children who present with cortical features and signal change on magnetic resonance imaging...
  57. doi request reprint Evaluation of tetrathiomolybdate in the R6/2 model of Huntington disease
    Sara J Tallaksen-Greene
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Neurosci Lett 452:60-2. 2009
    ..Given its known tolerability in humans with neurodegeneration, ammonium tetrathiomolybdate could be considered as a candidate for clinical trials in Huntington disease...
  58. ncbi request reprint Myelopolyneuropathy and pancytopenia due to copper deficiency and high zinc levels of unknown origin: further support for existence of a new zinc overload syndrome
    Peter Hedera
    Department of Neurology, University of Michigan, Ann Arbor, USA
    Arch Neurol 60:1303-6. 2003
    ..To describe a patient with idiopathic zinc overload without an identifiable source and secondary copper deficiency causing myelopolyneuropathy and pancytopenia...
  59. pmc A novel role for XIAP in copper homeostasis through regulation of MURR1
    Ezra Burstein
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    EMBO J 23:244-54. 2004
    ..These findings represent the first described phenotypic alteration in Xiap-deficient mice and demonstrate that XIAP can function through MURR1 to regulate copper homeostasis...
  60. ncbi request reprint Behavioral abnormalities in Wilson's disease
    George J Brewer
    Department of Human Genetics and Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Adv Neurol 96:262-74. 2005
  61. ncbi request reprint White matter changes in Wilson disease
    Peter Hedera
    Department of Neurology, University of Michigan Medical Center, Ann Arbor, Mich 48109 0940, USA
    Arch Neurol 59:866-7. 2002
  62. ncbi request reprint Kayser-Fleischer ring as the presenting sign of Wilson disease
    Mimi Liu
    Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Ophthalmol 133:832-4. 2002
    ..To describe a case in which the recognition by the ophthalmologist of Kayser-Fleischer rings played a crucial role in the diagnosis of Wilson disease (hepatolenticular degeneration)...
  63. doi request reprint A phase II trial of tetrathiomolybdate after surgery for malignant mesothelioma: final results
    Harvey I Pass
    Department of Cardiothoracic Surgery, New York University School of Medicine, New York, New York 10016, USA
    Ann Thorac Surg 86:383-9; discussion 390. 2008
    ..We hypothesized that cytoreduction of malignant pleural mesothelioma followed by TM will delay time to progression...
  64. ncbi request reprint Autonomic dysfunction in Wilson's disease
    George J Brewer
    Clin Auton Res 12:139-40. 2002
  65. doi request reprint Comment on: "High concentration of zinc in sub-retinal pigment epithelial deposits" (Lengyel et al.) (Exp. Eye Res. 772-780, 84/4, 2007)
    David Newsome
    Exp Eye Res 86:860-1; author reply 862-3. 2008
  66. ncbi request reprint Causes and diagnosis of copper deficiency
    George J Brewer
    Am J Hematol 83:87-8. 2008
  67. ncbi request reprint Rediscovery of the susceptibility of G6PD deficient persons to methemoglobinemia from oxidant drugs, and to hemolysis from methylene blue
    George J Brewer
    Am J Hematol 82:87-8. 2007

Research Grants3

  1. PHASE III TRIAL OF TETRATHIOMOLYBDATE IN PRIMARY BILIAR*
    George Brewer; Fiscal Year: 2007
    ..Abstract Not Provided ..
  2. PHASE III TRIAL OF TETRATHIOMOLYBDATE IN PRIMARY BILIAR*
    George Brewer; Fiscal Year: 2005
    ..Abstract Not Provided ..
  3. PHASE III TRIAL OF TETRATHIOMOLYBDATE IN PRIMARY BILIAR*
    George Brewer; Fiscal Year: 2006
    ..Abstract Not Provided ..