Research Topics
Genomes and GenesSpecies | Carrie V BretonSummaryAffiliation: University of Southern California Country: USA Publications
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Detail Information
Publications
Particulate matter, DNA methylation in nitric oxide synthase, and childhood respiratory diseaseCarrie V Breton
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Environ Health Perspect 120:1320-6. 2012..Conclusions: PM2.5 exposure was associated with percent DNA methylation of several CpG loci in NOS genes, suggesting an epigenetic mechanism through which these pollutants may alter production of nitric oxide...- Childhood air pollutant exposure and carotid artery intima-media thickness in young adultsCarrie V Breton
Department of Preventive Medicine, USC Keck School of Medicine, 2001 N Soto Street, Los Angeles, CA 90089, USA
Circulation 126:1614-20. 2012..Exposure to ambient air pollutants increases risk for cardiovascular health outcomes in adults. The contribution of childhood air pollutant exposure to cardiovascular health has not been thoroughly evaluated... - Carotid artery intima-media thickness in college students: race/ethnicity mattersCarrie V Breton
University of Southern California, Dept of Preventive Medicine, Los Angeles, CA, United States
Atherosclerosis 217:441-6. 2011..We aimed to characterize racial/ethnic differences CIMT and other cardiovascular risk factors in a healthy, young-adult population... - Heritability and role for the environment in DNA methylation in AXL receptor tyrosine kinaseCarrie V Breton
Departments of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Epigenetics 6:895-8. 2011..These results present compelling evidence that environmental exposure to tobacco smoke during pregnancy may alter DNA methylation levels in subtle but potentially important ways, and that these changes are persistent years after birth... - DNA methylation in the arginase-nitric oxide synthase pathway is associated with exhaled nitric oxide in children with asthmaCarrie V Breton
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Am J Respir Crit Care Med 184:191-7. 2011..Genetic variation in arginase (ARG) and nitric oxide synthase (NOS) has been associated with exhaled nitric oxide (FeNO) levels in children. Little is known about whether epigenetic variation in these genes modulates FeNO... - Genetic variation in the glutathione synthesis pathway, air pollution, and children's lung function growthCarrie V Breton
Department of Preventive Medicine, USC Keck School of Medicine, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033, USA
Am J Respir Crit Care Med 183:243-8. 2011..Glutathione plays an important role in antioxidant and inflammatory processes in the lung. Alterations in glutathione metabolism are a central feature of several chronic lung diseases... - GSTM1 and APE1 genotypes affect arsenic-induced oxidative stress: a repeated measures studyCarrie V Breton
Harvard School of Public Health, Dept of Environmental Health, 665 Huntington Avenue, Boston, MA 02115, USA
Environ Health 6:39. 2007..Chronic arsenic exposure is associated with an increased risk of skin, bladder and lung cancers. Generation of oxidative stress may contribute to arsenic carcinogenesis... 
Susceptibility to arsenic-induced skin lesions from polymorphisms in base excision repair genesCarrie V Breton
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Carcinogenesis 28:1520-5. 2007..Future research on arsenic-induced skin lesions should consider the impact of genetic variation to individual susceptibility to arsenic toxicity...- Genetic and epigenetic variations in inducible nitric oxide synthase promoter, particulate pollution, and exhaled nitric oxide levels in childrenMuhammad T Salam
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, Calif 90089, USA
J Allergy Clin Immunol 129:232-9.e1-7. 2012..Short-term exposure to air pollution, haplotypes, and DNA methylation in the NOS2 promoter has been associated independently with iNOS expression, Feno levels, or both... - Gender-specific protective effect of hemoglobin on arsenic-induced skin lesionsCarrie V Breton
Department of Environmental Health, Harvard School of Public Health, Room 1420, Building I, 665 Huntington Avenue, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 15:902-7. 2006.... - Association between total ingested arsenic and toenail arsenic concentrationsMolly L Kile
Harvard School of Public Health, Boston, Massachusetts 02115, USA
J Environ Sci Health A Tox Hazard Subst Environ Eng 42:1827-34. 2007..26-0.38) explained the most variability in toenail arsenic concentrations (R(2)(a)=0.71). The effect estimates for food and drinking water are similar suggesting that both sources have a similar contribution to internal dose... - Maternal arsenic exposure associated with low birth weight in BangladeshKaren L Huyck
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
J Occup Environ Med 49:1097-104. 2007..To characterize the effects of maternal arsenic exposure on birth weight... - Variation in the GST mu locus and tobacco smoke exposure as determinants of childhood lung functionCarrie V Breton
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, 90033 USA
Am J Respir Crit Care Med 179:601-7. 2009..The glutathione S-transferases (GSTs) are important detoxification enzymes... - Dietary arsenic exposure in bangladeshMolly L Kile
Harvard School of Public Health, Boston, Massachusetts 02115, USA
Environ Health Perspect 115:889-93. 2007..Millions of people in Bangladesh are at risk of chronic arsenic toxicity from drinking contaminated groundwater, but little is known about diet as an additional source of As exposure... - A pathway-based analysis of urinary arsenic metabolites and skin lesionsMolly L Kile
Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Am J Epidemiol 173:778-86. 2011..This novel analysis confirmed that persons who excrete a higher proportion of MMA have a greater risk of skin lesions after data are adequately controlled for urinary arsenic metabolites, current arsenic exposure, and other risk factors... - Prenatal tobacco smoke exposure affects global and gene-specific DNA methylationCarrie V Breton
Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
Am J Respir Crit Care Med 180:462-7. 2009..Prenatal exposure to tobacco smoke increases the risk for diseases later in the child's life that may be mediated through alterations in DNA methylation... - Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationshipsVictoria K Cortessis
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, USC Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA
Hum Genet 131:1565-89. 2012..We discuss some of the challenges in studying epigenetic mediation of pathogenesis and describe some unique opportunities for exploring these phenomena...