Emery H Bresnick


Affiliation: University of Wisconsin
Country: USA


  1. Tanimura N, Miller E, Igarashi K, Yang D, Burstyn J, Dewey C, et al. Mechanism governing heme synthesis reveals a GATA factor/heme circuit that controls differentiation. EMBO Rep. 2016;17:249-65 pubmed publisher
    ..Through this dual mechanism, heme and a master regulator collaborate to orchestrate a cell type-specific transcriptional program that promotes cellular differentiation. ..
  2. Bresnick E, Lee H, Fujiwara T, Johnson K, Keles S. GATA switches as developmental drivers. J Biol Chem. 2010;285:31087-93 pubmed publisher
    ..GATA switches occur at numerous loci with critical functions, indicating that they are widely utilized developmental control tools. ..
  3. Katsumura K, Mehta C, Hewitt K, Soukup A, Fraga de Andrade I, Ranheim E, et al. Human leukemia mutations corrupt but do not abrogate GATA-2 function. Proc Natl Acad Sci U S A. 2018;115:E10109-E10118 pubmed publisher
  4. Tanimura N, Liao R, Wilson G, Dent M, Cao M, Burstyn J, et al. GATA/Heme Multi-omics Reveals a Trace Metal-Dependent Cellular Differentiation Mechanism. Dev Cell. 2018;46:581-594.e4 pubmed publisher
    ..This analysis established a conserved paradigm in which a GATA-1/heme circuit controls trace metal transport machinery and trace metal levels as a mechanism governing cellular differentiation. ..
  5. Hewitt K, Kim D, Devadas P, Prathibha R, Zuo C, Sanalkumar R, et al. Hematopoietic Signaling Mechanism Revealed from a Stem/Progenitor Cell Cistrome. Mol Cell. 2015;59:62-74 pubmed publisher
    ..Thus, the hematopoietic stem/progenitor cell cistrome revealed a mediator of a signaling pathway that has broad importance for stem/progenitor cell biology. ..
  6. Hewitt K, Johnson K, Gao X, Keles S, Bresnick E. The Hematopoietic Stem and Progenitor Cell Cistrome: GATA Factor-Dependent cis-Regulatory Mechanisms. Curr Top Dev Biol. 2016;118:45-76 pubmed publisher
    ..This chapter reviews the structure/function of E-box-GATA composite cis-elements, which collectively constitute an important sector of the hematopoietic stem and progenitor cell cistrome. ..
  7. DeVilbiss A, Tanimura N, McIver S, Katsumura K, Johnson K, Bresnick E. Navigating Transcriptional Coregulator Ensembles to Establish Genetic Networks: A GATA Factor Perspective. Curr Top Dev Biol. 2016;118:205-44 pubmed publisher
    ..This review will consider these issues in the context of GATA factor-regulated hematopoiesis and from a broader perspective. ..
  8. Bresnick E, Hewitt K, Mehta C, Keles S, Paulson R, Johnson K. Mechanisms of erythrocyte development and regeneration: implications for regenerative medicine and beyond. Development. 2018;145: pubmed publisher
    ..Here, we review the cellular and molecular mechanisms governing erythrocyte development and regeneration, and discuss the potential links between these events and other regenerative processes. ..
  9. Katsumura K, Yang C, Boyer M, Li L, Bresnick E. Molecular basis of crosstalk between oncogenic Ras and the master regulator of hematopoiesis GATA-2. EMBO Rep. 2014;15:938-47 pubmed publisher

More Information


  1. Bresnick E, Katsumura K, Lee H, Johnson K, Perkins A. Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies. Nucleic Acids Res. 2012;40:5819-31 pubmed publisher
    ..This article highlights GATA factor mechanistic principles, with a heavy emphasis on GATA-1 and GATA-2 functions in the hematopoietic system, and new links between GATA-2 dysregulation and human pathophysiologies. ..
  2. Gao X, Wu T, Johnson K, Lahvic J, Ranheim E, Zon L, et al. GATA Factor-G-Protein-Coupled Receptor Circuit Suppresses Hematopoiesis. Stem Cell Reports. 2016;6:368-82 pubmed publisher
    ..5 site, restricted occupancy by the activator Scl/TAL1, and repressed Gata2 transcription. Thus, a Gata2 cis element creates a GATA-2-GPCR circuit that limits positive regulators that promote hematopoiesis. ..
  3. Katsumura K, Ong I, Devilbiss A, Sanalkumar R, Bresnick E. GATA Factor-Dependent Positive-Feedback Circuit in Acute Myeloid Leukemia Cells. Cell Rep. 2016;16:2428-41 pubmed publisher
    ..As GATA2 mRNA correlated with IL1B and CXCL2 mRNAs in AML-M5 and high expression of these genes predicted poor prognosis of cytogenetically normal AML, we propose that the circuit is functionally important in specific AML contexts. ..
  4. Hewitt K, Katsumura K, Matson D, Devadas P, Tanimura N, Hebert A, et al. GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia. Dev Cell. 2017;42:213-225.e4 pubmed publisher
  5. Devilbiss A, Sanalkumar R, Hall B, Katsumura K, de Andrade I, Bresnick E. Epigenetic Determinants of Erythropoiesis: Role of the Histone Methyltransferase SetD8 in Promoting Erythroid Cell Maturation and Survival. Mol Cell Biol. 2015;35:2073-87 pubmed publisher
    ..These results establish SetD8 as a determinant of erythroid cell maturation and provide a framework for understanding how a broadly expressed histone-modifying enzyme mediates cell-type-specific GATA factor function. ..
  6. Mehta C, Johnson K, Gao X, Ong I, Katsumura K, McIver S, et al. Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program. Cell Rep. 2017;20:2966-2979 pubmed publisher
    ..The -77 generated burst-forming unit-erythroid through the induction of GATA-1 and other GATA-2 targets. The enhancer circuits controlled signaling pathways that orchestrate a GATA factor-dependent blood development program. ..
  7. McIver S, Hewitt K, Gao X, Mehta C, Zhang J, Bresnick E. Dissecting Regulatory Mechanisms Using Mouse Fetal Liver-Derived Erythroid Cells. Methods Mol Biol. 2018;1698:67-89 pubmed publisher
    ..We described a robust method for isolation, culture, and analysis of primary mouse erythroid precursor cells and their progeny. ..
  8. Wu J, Iwata F, Grass J, Osborne C, Elnitski L, Fraser P, et al. Molecular determinants of NOTCH4 transcription in vascular endothelium. Mol Cell Biol. 2005;25:1458-74 pubmed
    ..These results reveal an AP-1-Notch4 pathway, which we propose to be crucial for transducing angiogenic signals and to be deregulated upon aberrant signal transduction in cancer. ..