EMERY BRESNICK

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Measurement of protein-DNA interactions in vivo by chromatin immunoprecipitation
    Hogune Im
    Department of Pharmacology, Molecular and Cellular Pharmacology Program, University of Wisconsin Medical School, Madison, USA
    Methods Mol Biol 284:129-46. 2004
  2. pmc Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies
    Emery H Bresnick
    Wisconsin Institutes for Medical Research, Paul Carbone Cancer Center, Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    Nucleic Acids Res 40:5819-31. 2012
  3. pmc Autophagy driven by a master regulator of hematopoiesis
    Yoon A Kang
    Wisconsin Institutes for Medical Research, Paul Carbone Cancer Center, Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Mol Cell Biol 32:226-39. 2012
  4. pmc Molecular determinants of NOTCH4 transcription in vascular endothelium
    Jing Wu
    Molecular and Cellular Pharmacology Program, Department of Pharmacology, University of Wisconsin Medical School, 1300 University Ave, 383 Medical Sciences Center, Madison, WI 53706, USA
    Mol Cell Biol 25:1458-74. 2005
  5. ncbi request reprint Developmental control via GATA factor interplay at chromatin domains
    Emery H Bresnick
    Department of Pharmacology, University of Wisconsin Medical School, Molecular and Cellular Pharmacology Program, Madison, Wisconsin 53706, USA
    J Cell Physiol 205:1-9. 2005
  6. pmc GATA switches as developmental drivers
    Emery H Bresnick
    Division of Hematology Oncology, Department of Pharmacology, Paul Carbone Comprehensive Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA
    J Biol Chem 285:31087-93. 2010
  7. pmc GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling
    Jeffrey A Grass
    Molecular and Cellular Pharmacology Program, Department of Pharmacology, University of Wisconsin Medical School, 383 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 100:8811-6. 2003
  8. pmc Hematopoietic-specific activators establish an overlapping pattern of histone acetylation and methylation within a mammalian chromatin domain
    Carol M Kiekhaefer
    Molecular and Cellular Pharmacology Program, Department of Pharmacology, University of Wisconsin Medical School, 1300 University Avenue, 383 Medical Sciences Center, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 99:14309-14. 2002
  9. pmc Glucocorticoid and growth factor synergism requirement for Notch4 chromatin domain activation
    Jing Wu
    Department of Pharmacology, University of Wisconsin School of Medicine, Madison, WI 53706, USA
    Mol Cell Biol 27:2411-22. 2007
  10. ncbi request reprint A WW domain-binding motif within the activation domain of the hematopoietic transcription factor NF-E2 is essential for establishment of a tissue-specific histone modification pattern
    Carol M Kiekhaefer
    University of Wisconsin Medical School, Department of Pharmacology, Madison, Wisconsin 53706, USA
    J Biol Chem 279:7456-61. 2004

Research Grants

  1. MECHANISM OF THE HUMAN BETA-GLOBIN LOCUS CONTROL REGION
    EMERY BRESNICK; Fiscal Year: 2005
  2. Transcriptional Control of Hematopoietic Stem Cells
    EMERY BRESNICK; Fiscal Year: 2005
  3. Coactivators that Mediate Beta-Globin LCR Function
    EMERY BRESNICK; Fiscal Year: 2006
  4. Hematopoietic Regulation of GATA Switches
    EMERY BRESNICK; Fiscal Year: 2007
  5. Hematopoietic Regulation of GATA Switches
    Emery H Bresnick; Fiscal Year: 2010
  6. Transcriptional Control of Hemoglobin Synthesis
    Emery H Bresnick; Fiscal Year: 2010
  7. MECHANISM OF THE HUMAN BETA GLOBIN LOCUS CONTROL REGION
    EMERY BRESNICK; Fiscal Year: 1999
  8. COACTIVATORS THAT MEDIATE BETA GLOBIN LCR FUNCTION
    EMERY BRESNICK; Fiscal Year: 2002
  9. Transcriptional Control of Hemoglobin Synthesis
    Emery H Bresnick; Fiscal Year: 2010

Collaborators

  • Kyunghee Choi
  • GERD BLOBEL
  • Scott J Bultman
  • Alan B Cantor
  • Sunduz Keles
  • Peter Fraser
  • Cameron S Osborne
  • Yi Zhang
  • Michael J Nemeth
  • Stuart H Orkin
  • Ann Dean
  • Anthony N Imbalzano
  • Swee L Thein
  • Francois Guillemot
  • Timm Schroeder
  • Michael Rosenfeld
  • Xiaoyan Zhu
  • R Kageyama
  • Kirby D Johnson
  • Jeffrey A Grass
  • Meghan E Boyer
  • Shin Il Kim
  • Hogune Im
  • Saumen Pal
  • Jing Wu
  • Ryan J Wozniak
  • Melissa L Martowicz
  • Carol M Kiekhaefer
  • Yoon A Kang
  • Tohru Fujiwara
  • Jesse J Lugus
  • Jianlin Chu
  • Henriette O'Geen
  • Peggy J Farnham
  • Amelia K Linnemann
  • Nathaniel J Pope
  • Hsiang Ying Lee
  • Louis J Lurie
  • Tomoyuki Sawado
  • Konstanze Henning
  • Huie Jing
  • Maria E C Bruno
  • Changwon Park
  • Mitchell J Weiss
  • Jason E Norton
  • Rajendran Sanalkumar
  • Chan Jung Chang
  • Eric E Bouhassira
  • Christine M Kiefer
  • Kimberly Blahnik
  • Mark Groudine
  • Tobias Ragoczy
  • Ken H Young
  • Tuan M Tran
  • Jessica Halow
  • M A Bender
  • Michael Kyba
  • Ursula Just
  • Youngsook Lee
  • Jeff Grass
  • Amittha Wickrema
  • Jason C Mills
  • Jeong Ah Kang
  • Ralf Schwanbeck
  • Nikolaus Rieber
  • Yun Shin Chung
  • Jason M Doherty
  • Sean M Hasso
  • Patricia J Keely
  • Justin K Murray
  • Timothy M Gomez
  • Samuel H Gellman
  • John F Fallon
  • Michele A Wozniak
  • Osamu Ohneda
  • Masayuki Yamamoto
  • Laura Elnitski
  • James J Bieker
  • Hamza Guend
  • Fumiko Iwata
  • David Bodine
  • Jeffery L Miller
  • John Svaren
  • Philip J Lowry
  • Ryan B West
  • Tracey A Schneeman
  • Charlotte S Kaetzel
  • Tyler B Moran
  • Qin Feng
  • Heather M Christensen

Detail Information

Publications42

  1. ncbi request reprint Measurement of protein-DNA interactions in vivo by chromatin immunoprecipitation
    Hogune Im
    Department of Pharmacology, Molecular and Cellular Pharmacology Program, University of Wisconsin Medical School, Madison, USA
    Methods Mol Biol 284:129-46. 2004
    ..Chromatin-domain scanning coupled with quantitative analysis is a powerful means of dissecting mechanisms by which signaling pathways target genes within a complex genome...
  2. pmc Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies
    Emery H Bresnick
    Wisconsin Institutes for Medical Research, Paul Carbone Cancer Center, Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    Nucleic Acids Res 40:5819-31. 2012
    ..This article highlights GATA factor mechanistic principles, with a heavy emphasis on GATA-1 and GATA-2 functions in the hematopoietic system, and new links between GATA-2 dysregulation and human pathophysiologies...
  3. pmc Autophagy driven by a master regulator of hematopoiesis
    Yoon A Kang
    Wisconsin Institutes for Medical Research, Paul Carbone Cancer Center, Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Mol Cell Biol 32:226-39. 2012
    ..These results illustrate a novel mechanism by which a master regulator of development establishes a genetic network to instigate cell-type-specific autophagy...
  4. pmc Molecular determinants of NOTCH4 transcription in vascular endothelium
    Jing Wu
    Molecular and Cellular Pharmacology Program, Department of Pharmacology, University of Wisconsin Medical School, 1300 University Ave, 383 Medical Sciences Center, Madison, WI 53706, USA
    Mol Cell Biol 25:1458-74. 2005
    ..These results reveal an AP-1-Notch4 pathway, which we propose to be crucial for transducing angiogenic signals and to be deregulated upon aberrant signal transduction in cancer...
  5. ncbi request reprint Developmental control via GATA factor interplay at chromatin domains
    Emery H Bresnick
    Department of Pharmacology, University of Wisconsin Medical School, Molecular and Cellular Pharmacology Program, Madison, Wisconsin 53706, USA
    J Cell Physiol 205:1-9. 2005
    ....
  6. pmc GATA switches as developmental drivers
    Emery H Bresnick
    Division of Hematology Oncology, Department of Pharmacology, Paul Carbone Comprehensive Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA
    J Biol Chem 285:31087-93. 2010
    ..GATA switches occur at numerous loci with critical functions, indicating that they are widely utilized developmental control tools...
  7. pmc GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling
    Jeffrey A Grass
    Molecular and Cellular Pharmacology Program, Department of Pharmacology, University of Wisconsin Medical School, 383 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 100:8811-6. 2003
    ..Such a mechanism is predicted to be critical for the control of hematopoiesis...
  8. pmc Hematopoietic-specific activators establish an overlapping pattern of histone acetylation and methylation within a mammalian chromatin domain
    Carol M Kiekhaefer
    Molecular and Cellular Pharmacology Program, Department of Pharmacology, University of Wisconsin Medical School, 1300 University Avenue, 383 Medical Sciences Center, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 99:14309-14. 2002
    ..As GATA-1 induced H3 acetylation, but not H3-meK4, at the promoter, H3 acetylation and H3-meK4 components of a composite histone modification pattern can be established independently...
  9. pmc Glucocorticoid and growth factor synergism requirement for Notch4 chromatin domain activation
    Jing Wu
    Department of Pharmacology, University of Wisconsin School of Medicine, Madison, WI 53706, USA
    Mol Cell Biol 27:2411-22. 2007
    ..These results establish the molecular basis for a novel AP-1/GR-Notch4 axis in vascular endothelium...
  10. ncbi request reprint A WW domain-binding motif within the activation domain of the hematopoietic transcription factor NF-E2 is essential for establishment of a tissue-specific histone modification pattern
    Carol M Kiekhaefer
    University of Wisconsin Medical School, Department of Pharmacology, Madison, Wisconsin 53706, USA
    J Biol Chem 279:7456-61. 2004
    ..These results indicate that PXY-1 confers chromatin-specific transcriptional activation via interaction with a co-regulator distinct from CBP/p300 or by regulating CBP/p300 function...
  11. ncbi request reprint Repression of activator protein-1-mediated transcriptional activation by the Notch-1 intracellular domain
    Jianlin Chu
    Department of Pharmacology, Molecular and Cellular Pharmacology Program, University of Wisconsin Medical School, 387 Medical Sciences Center, 1300 University Ave, Madison, WI 53706, USA
    J Biol Chem 277:7587-97. 2002
    ..These results provide evidence for negative cross-talk between Notch and AP-1, which may have important consequences for controlling diverse biological processes...
  12. pmc BRG1 requirement for long-range interaction of a locus control region with a downstream promoter
    Shin Il Kim
    Department of Pharmacology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 106:2259-64. 2009
    ....
  13. pmc Dissecting molecular steps in chromatin domain activation during hematopoietic differentiation
    Shin Il Kim
    University of Wisconsin School of Medicine, Department of Pharmacology, 383 Medical Sciences Center, Madison, WI 53706, USA
    Mol Cell Biol 27:4551-65. 2007
    ..These studies defined a hierarchical order of GATA-1-triggered events at a complex locus and establish a novel mechanism of long-range gene regulation...
  14. pmc Coregulator-dependent facilitation of chromatin occupancy by GATA-1
    Saumen Pal
    Department of Pharmacology, University of Wisconsin Medical School, 1300 University Avenue, 383 Medical Sciences Center, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 101:980-5. 2004
    ..We propose that FOG-1 is a prototype of a new class of coregulators termed chromatin occupancy facilitators, which confer coregulation in certain contexts via enhancing trans-acting factor binding to chromatin in vivo...
  15. ncbi request reprint Evidence that C promoter-binding factor 1 binding is required for Notch-1-mediated repression of activator protein-1
    Jianlin Chu
    Department of Pharmacology, Molecular and Cellular Pharmacology Program, University of Wisconsin Medical School, 383 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
    J Biol Chem 279:12337-45. 2004
    ..These results support a model in which the binding of NIC-1 to CBF1 is required for AP-1 repression and reveal a powerful cell-sensing mechanism that suppresses the levels of transcriptionally competent NIC-1...
  16. pmc Controlling hematopoiesis through sumoylation-dependent regulation of a GATA factor
    Hsiang Ying Lee
    University of Wisconsin School of Medicine and Public Health, Wisconsin Institutes for Medical Research, Madison, 53705, USA
    Mol Cell 36:984-95. 2009
    ..These results illustrate a mechanism that controls trans-acting factor function in a locus-specific manner, and differentially regulated members of the target gene ensemble reside in distinct subnuclear compartments...
  17. ncbi request reprint Dynamic regulation of histone H3 methylated at lysine 79 within a tissue-specific chromatin domain
    Hogune Im
    Molecular and Cellular Pharmacology Program, Department of Pharmacology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    J Biol Chem 278:18346-52. 2003
    ..As H3-meK79 is highly regulated at the beta-globin locus, we propose that the murine ortholog of Disruptor of Telomeric Silencing-1-like (mDOT1L) methyltransferase, which synthesizes H3-meK79, regulates beta-globin transcription...
  18. ncbi request reprint Dissecting long-range transcriptional mechanisms by chromatin immunoprecipitation
    Kirby D Johnson
    Molecular and Cellular Pharmacology Program, Department of Pharmacology, University of Wisconsin Medical School, 387 Medical Sciences Center, 1300 University Avenue, Madison 53706, USA
    Methods 26:27-36. 2002
    ..The central focus of this review is the use of ChIP to study transcriptional activation over long distances on chromosomes...
  19. pmc Cooperative activities of hematopoietic regulators recruit RNA polymerase II to a tissue-specific chromatin domain
    Kirby D Johnson
    Department of Pharmacology, Molecular and Cellular Pharmacology Program, University of Wisconsin Medical School, 383 Medical Science Center, 1300 University Avenue, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 99:11760-5. 2002
    ..The hematopoietic factor NF-E2 cooperated with GATA-1 to recruit pol II to the promoters. We propose that only when GATA-1 attracts pol II to the locus control region can pol II access the promoter in a NF-E2-dependent manner...
  20. pmc Molecular hallmarks of endogenous chromatin complexes containing master regulators of hematopoiesis
    Ryan J Wozniak
    University of Wisconsin School of Medicine and Public Health, Department of Pharmacology, Madison, WI 53706, USA
    Mol Cell Biol 28:6681-94. 2008
    ....
  21. ncbi request reprint GATA-1-mediated transcriptional repression yields persistent transcription factor IIB-chromatin complexes
    Melissa L Martowicz
    Molecular and Cellular Pharmacology Program, University of Wisconsin School of Medicine, Madison, Wisconsin 53706, USA
    J Biol Chem 281:37345-52. 2006
    ..These results indicate that GATA-2-bound extragenic regulatory elements recruit Pol II, GATA-1 binding expels Pol II, and despite the persistent TFIIB-chromatin complexes, Pol II recruitment is blocked...
  22. pmc Chromatin domain activation via GATA-1 utilization of a small subset of dispersed GATA motifs within a broad chromosomal region
    Hogune Im
    Department of Pharmacology, University of Wisconsin Medical School, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 102:17065-70. 2005
    ..The differential utilization of dispersed GATA motifs therefore establishes spatial/temporal regulation and underlies the multistep activation mechanism...
  23. pmc Highly restricted localization of RNA polymerase II within a locus control region of a tissue-specific chromatin domain
    Kirby D Johnson
    Molecular and Cellular Pharmacology Program, Department of Pharmacology, Medical School, University of Wisconsin, 1300 University Avenue, 383 Medical Sciences Center, Madison, WI 53706, USA
    Mol Cell Biol 23:6484-93. 2003
    ..However, blocking elongation did not disrupt the histone modification pattern of the beta-globin locus, indicating that Pol II tracking is not required to maintain the pattern...
  24. ncbi request reprint Dynamic GATA factor interplay at a multicomponent regulatory region of the GATA-2 locus
    Melissa L Martowicz
    University of Wisconsin Medical School, Molecular and Cellular Pharmacology Program, Department of Pharmacology, Madison, Wisconsin 53706, USA
    J Biol Chem 280:1724-32. 2005
    ..We propose that GATA-2 transcription is regulated via the collective actions of complexes assembled at the -2.8- and -1.8-kb regions, which share similar properties, and through a qualitatively distinct activity of the -3.9-kb complex...
  25. pmc BRG1 directly regulates nucleosome structure and chromatin looping of the alpha globin locus to activate transcription
    Shin Il Kim
    Department of Pharmacology, University of Wisconsin School of Medicine and Public Health, Medical Sciences Center, Madison, WI, USA
    Nucleic Acids Res 37:6019-27. 2009
    ..These data also demonstrate that chromatin looping between the MRE and alpha2 promoter is required as part of the transcriptional activation mechanism...
  26. ncbi request reprint Differential GATA factor stabilities: implications for chromatin occupancy by structurally similar transcription factors
    Louis J Lurie
    Department of Pharmacology, University of Wisconsin School of Medicine and Public Health, 1300 University Avenue, 385 Medical Sciences Center, Madison, Wisconsin 53706, USA
    Biochemistry 47:859-69. 2008
    ....
  27. pmc Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy
    Tohru Fujiwara
    University of Wisconsin School of Medicine and Public Health, Wisconsin Institutes for Medical Research, Madison, 53705, USA
    Mol Cell 36:667-81. 2009
    ..These results establish fundamental principles underlying GATA factor mechanisms in chromatin and illustrate a complex network of considerable importance for the control of hematopoiesis...
  28. ncbi request reprint Context-dependent GATA factor function: combinatorial requirements for transcriptional control in hematopoietic and endothelial cells
    Ryan J Wozniak
    Department of Pharmacology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
    J Biol Chem 282:14665-74. 2007
    ....
  29. ncbi request reprint Establishment and regulation of chromatin domains: mechanistic insights from studies of hemoglobin synthesis
    Emery H Bresnick
    Department of Pharmacology, University of Wisconsin Medical School, 383 Medical Sciences Center, Madison, Wisconsin 53706, USA
    Prog Nucleic Acid Res Mol Biol 81:435-71. 2006
  30. pmc Requirements for utilization of CREB binding protein by hypersensitive site two of the beta-globin locus control region
    Kirby D Johnson
    University of Wisconsin Medical School, Department of Pharmacology, Molecular and Cellular Pharmacology Program, 383 Medical Science Center, 1300 University Avenue, Madison, WI 53706, USA
    Nucleic Acids Res 30:1522-30. 2002
    ..These results suggest that NF-E2 recruits CBP as a critical step in transactivation, but additional components of HS2 are required to achieve maximal enhancer activity...
  31. ncbi request reprint Histone deacetylase-dependent establishment and maintenance of broad low-level histone acetylation within a tissue-specific chromatin domain
    Hogune Im
    Department of Pharmacology, Molecular and Cellular Pharmacology Program, University of Wisconsin Medical School, 383 Medical Science Center, 1300 University Avenue, Madison, Wisconsin 53706, USA
    Biochemistry 41:15152-60. 2002
    ..We propose that an HDAC-dependent surveillance mechanism counteracts constitutive histone acetyltransferase (HAT) access, thereby maintaining low-level H4 acetylation throughout the subdomain...
  32. ncbi request reprint Neurokinin-B transcription in erythroid cells: direct activation by the hematopoietic transcription factor GATA-1
    Saumen Pal
    University of Wisconsin Medical School, Molecular and Cellular Pharmacology Program, Department of Pharmacology, Madison, Wisconsin 53706, USA
    J Biol Chem 279:31348-56. 2004
    ..Since NK-B induced cAMP accumulation in yolk sac endothelial cells, these results suggest a new mode of vascular regulation in which GATA-1 controls NK-B synthesis in erythroid cells...
  33. pmc Friend of GATA-1-independent transcriptional repression: a novel mode of GATA-1 function
    Kirby D Johnson
    Department of Pharmacology, University of Wisconsin School of Medicine, Madison, WI, USA
    Blood 109:5230-3. 2007
    ..The identification of genes repressed by GATA-1 independent of FOG-1 defines a novel mode of GATA-1-mediated transcriptional regulation...
  34. pmc Differential coregulator requirements for function of the hematopoietic transcription factor GATA-1 at endogenous loci
    Nathaniel J Pope
    University of Wisconsin School of Medicine and Public Health, Wisconsin Institute for Medical Research, Madison, WI 53705, USA
    Nucleic Acids Res 38:2190-200. 2010
    ..These results illustrate both similarities and differences between GATA-1-mediated recruitment of FOG-1 and Med1 to chromatin, with a fundamental difference being the quantitatively greater requirement for FOG-1...
  35. pmc Distinct functions of dispersed GATA factor complexes at an endogenous gene locus
    Jeffrey A Grass
    University of Wisconsin Medical School, Department of Pharmacology, 1300 University Avenue, Madison, WI 53706, USA
    Mol Cell Biol 26:7056-67. 2006
    ..These results indicate that dispersed GATA factor complexes function via long-range chromatin interactions and qualitatively distinct activities to regulate Gata2 transcription...
  36. pmc An antiangiogenic neurokinin-B/thromboxane A2 regulatory axis
    Saumen Pal
    Department of Pharmacology, University of Wisconsin Medical School, Madison, WI 53706, USA
    J Cell Biol 174:1047-58. 2006
    ..These results establish a conserved mechanism in which NK-B instigates multiple activities that collectively oppose vascular remodeling...
  37. doi request reprint Epigenetic control of complex loci during erythropoiesis
    Ryan J Wozniak
    Department of Pharmacology, University of Wisconsin School of Medicine and Public Health, 385 Medical Sciences Center, Madison, Wisconsin 53706, USA
    Curr Top Dev Biol 82:55-83. 2008
    ..This chapter reviews progress in elucidating principles underlying epigenetic control of complex loci, specifically focusing on genes differentially expressed during hematopoiesis...
  38. pmc Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis
    Xiaoyan Zhu
    Howard Hughes Medical Institute, Department and School of Medicine, University of California at San Diego, La Jolla, California 92093, USA
    Genes Dev 20:2739-53. 2006
    ....
  39. ncbi request reprint Upstream stimulatory factor but not c-Myc enhances transcription of the human polymeric immunoglobulin receptor gene
    Maria E C Bruno
    Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY 40536, USA
    Mol Immunol 40:695-708. 2004
    ..The results of our experiments may shed light on the mechanisms of dysregulated expression of pIgR in inflammatory bowel disease and colorectal cancer, diseases associated with aberrant expression of c-Myc...
  40. pmc H3 K79 dimethylation marks developmental activation of the beta-globin gene but is reduced upon LCR-mediated high-level transcription
    Tomoyuki Sawado
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Blood 112:406-14. 2008
    ..We propose that H3 K79 dimethylation is destabilized on a highly transcribed template...
  41. ncbi request reprint GATA2 functions at multiple steps in hemangioblast development and differentiation
    Jesse J Lugus
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 134:393-405. 2007
    ..Collectively, we provide compelling evidence that GATA2 plays specific, contextual roles in the generation of Flk-1+ mesoderm, the Flk-1+Scl+ hemangioblast, primitive erythroid and endothelial cells...
  42. ncbi request reprint mNotch1 signaling and erythropoietin cooperate in erythroid differentiation of multipotent progenitor cells and upregulate beta-globin
    Konstanze Henning
    Department of Biochemistry, Christian Albrechts University Kiel, Kiel, Germany
    Exp Hematol 35:1321-32. 2007
    ..Notch receptors are expressed on hematopoietic cells and cognate ligands on bone marrow stromal cells. Here, we investigate the role of mNotch1 signaling in the control of erythroid differentiation of multipotent progenitor cells...

Research Grants34

  1. MECHANISM OF THE HUMAN BETA-GLOBIN LOCUS CONTROL REGION
    EMERY BRESNICK; Fiscal Year: 2005
    ..The long-term objective is to therapeutically modulate beta-globin gene expression in humans with hemoglobinopathies by perturbing specific steps of the mechanism by which the LCR regulate the beta-globin genes. ..
  2. Transcriptional Control of Hematopoietic Stem Cells
    EMERY BRESNICK; Fiscal Year: 2005
    ..The studies will define the regulation and function of GATA-2 as a prelude to developing principles for how chromatin domains and transcriptional networks assemble in and control HSCs. ..
  3. Coactivators that Mediate Beta-Globin LCR Function
    EMERY BRESNICK; Fiscal Year: 2006
    ..The long-term objective is to therapeutically control beta-globin genes in humans with hemoglobinopathies by regulating specific steps of the LCR mechanism. ..
  4. Hematopoietic Regulation of GATA Switches
    EMERY BRESNICK; Fiscal Year: 2007
    ..The studies will reveal how GATA switches regulate GATA-2 transcription, how GATA-1 and GATA-2 select DMA motifs, and insights of broad relevance to diverse developmental processes. ..
  5. Hematopoietic Regulation of GATA Switches
    Emery H Bresnick; Fiscal Year: 2010
    ..The studies will reveal how GATA switches regulate GATA-2 transcription, how GATA-1 and GATA-2 select DMA motifs, and insights of broad relevance to diverse developmental processes. ..
  6. Transcriptional Control of Hemoglobin Synthesis
    Emery H Bresnick; Fiscal Year: 2010
    ..Through the assembly of a database of GRC parameters and computational/statistical analysis, hypotheses regarding determinants of GATA factor occupancy will be tested. ..
  7. MECHANISM OF THE HUMAN BETA GLOBIN LOCUS CONTROL REGION
    EMERY BRESNICK; Fiscal Year: 1999
    ..Understanding how the LCR functions may also help in the design of synthetic LCRs that are more effective than natural ones and could lead to new approaches to the treatment of hematologic disorders. ..
  8. COACTIVATORS THAT MEDIATE BETA GLOBIN LCR FUNCTION
    EMERY BRESNICK; Fiscal Year: 2002
    ..abstract_text> ..
  9. Transcriptional Control of Hemoglobin Synthesis
    Emery H Bresnick; Fiscal Year: 2010
    ..Through the assembly of a database of GRC parameters and computational/statistical analysis, hypotheses regarding determinants of GATA factor occupancy will be tested. ..