TERI BRENTNALL

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Arousal of cancer-associated stromal fibroblasts: palladin-activated fibroblasts promote tumor invasion
    Teresa A Brentnall
    Department of Medicine, University of Washington Medical Center, Seattle, WA USA
    Cell Adh Migr 6:488-94. 2012
  2. pmc Arousal of cancer-associated stroma: overexpression of palladin activates fibroblasts to promote tumor invasion
    Teresa A Brentnall
    GI Division, Department of Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 7:e30219. 2012
  3. ncbi Early diagnosis and treatment of pancreatic dysplasia in patients with a family history of pancreatic cancer
    T A Brentnall
    Division of Gastroenterology, University of Washington, Seattle 98195, USA
    Ann Intern Med 131:247-55. 1999
  4. ncbi Management strategies for patients with hereditary pancreatic cancer
    Teresa A Brentnall
    University of Washington Medical Center, Seattle, WA 98115, USA
    Curr Treat Options Oncol 6:437-45. 2005
  5. pmc New endoscopic and cytologic tools for cancer surveillance in the digestive tract
    Eric J Seibel
    Department of Mechanical Engineering, University of Washington, Seattle, 98195, USA
    Gastrointest Endosc Clin N Am 19:299-307. 2009
  6. pmc Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammation
    Rosa Ana Risques
    Department of Pathology, University of Washington, Seattle, Washington 98195 7705, USA
    Cancer Res 71:1669-79. 2011
  7. pmc Mass spectrometry based glycoproteomics--from a proteomics perspective
    Sheng Pan
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Mol Cell Proteomics 10:R110.003251. 2011
  8. pmc Elevated level of anterior gradient-2 in pancreatic juice from patients with pre-malignant pancreatic neoplasia
    Ru Chen
    GI Division Department of Medicine, University of Washington, Seattle, WA 98195 USA
    Mol Cancer 9:149. 2010
  9. pmc Clonal expansions in ulcerative colitis identify patients with neoplasia
    Jesse J Salk
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98105, USA
    Proc Natl Acad Sci U S A 106:20871-6. 2009
  10. pmc Mass spectrometry based targeted protein quantification: methods and applications
    Sheng Pan
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    J Proteome Res 8:787-97. 2009

Research Grants

  1. Pancreatic Cancer Protein Biomarkers for Early Detection
    Teresa A Brentnall; Fiscal Year: 2010
  2. Development of Chronic Pancreatitis Biomarkers
    Teresa Brentnall; Fiscal Year: 2009
  3. Biomarkers of UC Tumorigenesis
    Teresa A Brentnall; Fiscal Year: 2010
  4. Pancreatic Cancer Protein Biomarkers for Early Detection
    Teresa Brentnall; Fiscal Year: 2009
  5. Biomarkers of UC Tumorigenesis
    Teresa Brentnall; Fiscal Year: 2009
  6. Pancreatic Cancer Protein Biomarkers for Early Detection
    Teresa Brentnall; Fiscal Year: 2007
  7. Biomarkers of UC Tumorigenesis
    Teresa Brentnall; Fiscal Year: 2007
  8. HISTOLOGIC AND MOLECULAR CHANGES IN UC TUMORIGENESIS
    Teresa Brentnall; Fiscal Year: 2004
  9. Development of Chronic Pancreatitis Biomarkers
    Teresa A Brentnall; Fiscal Year: 2010

Collaborators

Detail Information

Publications37

  1. pmc Arousal of cancer-associated stromal fibroblasts: palladin-activated fibroblasts promote tumor invasion
    Teresa A Brentnall
    Department of Medicine, University of Washington Medical Center, Seattle, WA USA
    Cell Adh Migr 6:488-94. 2012
    ..Abrogation of palladin reduces the invasive capacity of these cells. CAF also play a role in cancer resistance and immuno-privilege, making the targeting of activators of these cells of interest for oncologists...
  2. pmc Arousal of cancer-associated stroma: overexpression of palladin activates fibroblasts to promote tumor invasion
    Teresa A Brentnall
    GI Division, Department of Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 7:e30219. 2012
    ..Using a pancreatic cancer model, we investigated the functional consequence of overexpression of exogenous palladin in normal fibroblasts in vitro and its effect on the early stages of tumor invasion...
  3. ncbi Early diagnosis and treatment of pancreatic dysplasia in patients with a family history of pancreatic cancer
    T A Brentnall
    Division of Gastroenterology, University of Washington, Seattle 98195, USA
    Ann Intern Med 131:247-55. 1999
    ..Surveillance of patients with a familial predisposition for pancreatic cancer has not been systematically evaluated...
  4. ncbi Management strategies for patients with hereditary pancreatic cancer
    Teresa A Brentnall
    University of Washington Medical Center, Seattle, WA 98115, USA
    Curr Treat Options Oncol 6:437-45. 2005
    ....
  5. pmc New endoscopic and cytologic tools for cancer surveillance in the digestive tract
    Eric J Seibel
    Department of Mechanical Engineering, University of Washington, Seattle, 98195, USA
    Gastrointest Endosc Clin N Am 19:299-307. 2009
    ..Advanced three-dimensional cell visualization techniques are described for increasing the sensitivity of early cancer diagnosis from hematoxylin-stained cells sampled from the pancreatic and biliary ducts...
  6. pmc Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammation
    Rosa Ana Risques
    Department of Pathology, University of Washington, Seattle, Washington 98195 7705, USA
    Cancer Res 71:1669-79. 2011
    ..Our findings argue that senescence acts as a tumor suppressor mechanism that is abrogated during the transition from LGD to HGD in UC...
  7. pmc Mass spectrometry based glycoproteomics--from a proteomics perspective
    Sheng Pan
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Mol Cell Proteomics 10:R110.003251. 2011
    ..This report provides an overview of the recent advances in mass spectrometry based glycoproteomic methods and technology, in the context of biomarker discovery and clinical application...
  8. pmc Elevated level of anterior gradient-2 in pancreatic juice from patients with pre-malignant pancreatic neoplasia
    Ru Chen
    GI Division Department of Medicine, University of Washington, Seattle, WA 98195 USA
    Mol Cancer 9:149. 2010
    ..We applied quantitative proteomics to identify aberrantly elevated proteins in pancreatic juice samples derived from patients with PanIN3...
  9. pmc Clonal expansions in ulcerative colitis identify patients with neoplasia
    Jesse J Salk
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98105, USA
    Proc Natl Acad Sci U S A 106:20871-6. 2009
    ....
  10. pmc Mass spectrometry based targeted protein quantification: methods and applications
    Sheng Pan
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    J Proteome Res 8:787-97. 2009
    ..This report reviews recently developed platform technologies for emerging applications of clinical proteomics and biomarker development...
  11. ncbi Quantitative proteomics analysis reveals that proteins differentially expressed in chronic pancreatitis are also frequently involved in pancreatic cancer
    Ru Chen
    Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Mol Cell Proteomics 6:1331-42. 2007
    ..Altogether our study provides some insights into the molecular events in chronic pancreatitis that may lead to diverse strategies for diagnosis and treatment of these diseases...
  12. ncbi Telomere length in the colon declines with age: a relation to colorectal cancer?
    Jacintha O'Sullivan
    Department of Pathology, University of Washington, Seattle, WA, USA
    Cancer Epidemiol Biomarkers Prev 15:573-7. 2006
    ..We suggest that the positive association between telomere length and age in the oldest patients is a consequence of selective survival of elderly patients with long colonocyte telomeres...
  13. pmc Comparison of pancreas juice proteins from cancer versus pancreatitis using quantitative proteomic analysis
    Ru Chen
    Division of Gastroenterology Department of Medicine, University of Washington, Seattle, WA, USA
    Pancreas 34:70-9. 2007
    ..Biomarkers present in pancreatic cancer frequently occur in the setting of pancreatitis. The efforts to develop diagnostic biomarkers for pancreatic cancer have thus been complicated by the false-positive involvement of pancreatitis...
  14. ncbi Cost-effectiveness of pancreatic cancer screening in familial pancreatic cancer kindreds
    Stephen J Rulyak
    University of Washington, Division of Gastroenterology, Department of Pharmacy, Seattle, Washington, USA
    Gastrointest Endosc 57:23-9. 2003
    ..Endoscopic screening of families predisposed to pancreatic cancer is increasingly used, but the cost-effectiveness of screening is unknown...
  15. ncbi Screening and surveillance for hereditary pancreatic cancer
    Michael B Kimmey
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Gastrointest Endosc 56:S82-6. 2002
  16. ncbi Quantitative proteomic profiling of pancreatic cancer juice
    Ru Chen
    GI Division Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Proteomics 6:3871-9. 2006
    ..One of the identified proteins, insulin-like growth factor binding protein-2 was further validated by Western blotting to be elevated in pancreatic cancer juice and overexpressed in pancreatic cancer tissue...
  17. pmc A new susceptibility locus for autosomal dominant pancreatic cancer maps to chromosome 4q32-34
    Michael A Eberle
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Am J Hum Genet 70:1044-8. 2002
    ..56 in two-point analysis and 5.36 in three-point analysis) on chromosome 4q32-34, providing evidence for a major locus for pancreatic cancer...
  18. pmc DNA fingerprinting abnormalities can distinguish ulcerative colitis patients with dysplasia and cancer from those who are dysplasia/cancer-free
    Ru Chen
    Departments of Pathology, Biostatistics, and Medicine, University of Washington, Seattle, Washington 98195, USA
    Am J Pathol 162:665-72. 2003
    ..These results suggest that UC patients who develop dysplasia or cancer have an underlying process of genomic instability in their colonic mucosa whereas UC patients who are dysplasia-free do not...
  19. ncbi Inherited pancreatic cancer: improvements in our understanding of genetics and screening
    Stephen J Rulyak
    Division of Gastroenterology, University of Washington Medical Center, Box 356424, 1959 NE Pacific St, Seattle, WA 98195, USA
    Int J Biochem Cell Biol 36:1386-92. 2004
    ..One promising strategy has used endoscopic ultrasound to detected pancreatic dysplasia in members of familial pancreatic cancer kindreds...
  20. ncbi Proteomic profiling of pancreatic cancer for biomarker discovery
    Ru Chen
    GI Division Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Mol Cell Proteomics 4:523-33. 2005
    ..In this article, we discuss recent progress and challenges for applying quantitative proteomics technologies for biomarker discovery in pancreatic cancer...
  21. pmc Ulcerative colitis is a disease of accelerated colon aging: evidence from telomere attrition and DNA damage
    Rosa Ana Risques
    Department of Pathology, University of Washington, Seattle, Washington, USA
    Gastroenterology 135:410-8. 2008
    ..We explored this hypothesis in ulcerative colitis (UC), a chronic inflammatory disease that predisposes to colorectal cancer and in which shorter telomeres have been associated with chromosomal instability and tumor progression...
  22. ncbi The initiation of colon cancer in a chronic inflammatory setting
    Ru Chen
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Carcinogenesis 26:1513-9. 2005
    ..This paradigm may apply to other inflammatory-induced cancers...
  23. ncbi Chromosomal instability in pancreatic ductal cells from patients with chronic pancreatitis and pancreatic adenocarcinoma
    Alexander H Moskovitz
    Department of Surgery, University of Washington, Seattle, Washington, USA
    Genes Chromosomes Cancer 37:201-6. 2003
    ..These results elucidate a potential mechanism linking chronic pancreatitis to pancreatic cancer and suggest that chromosomal instability may be an early event in the pathogenesis of pancreatic cancer...
  24. ncbi Cancer surveillance in inflammatory bowel disease: new molecular approaches
    Rosa Ana Risques
    Department of Pathology, University of Washington, USA
    Curr Opin Gastroenterol 22:382-90. 2006
    ..Thus, there is intensive research to identify molecular factors with prognostic value. This review summarizes recent research, with a special emphasis on the mechanisms underlying these molecular alterations...
  25. ncbi A new indication for pancreas transplantation: high grade pancreatic dysplasia
    Kevin P Charpentier
    Department of Surgery, Division of General Surgery, University of Washington Medical Center, Washington, DC, USA
    Clin Transplant 18:105-7. 2004
    ....
  26. ncbi Pancreatic cancer proteome: the proteins that underlie invasion, metastasis, and immunologic escape
    Ru Chen
    Department of Medicine, University of Washington, Seattle, 98195, USA
    Gastroenterology 129:1187-97. 2005
    ....
  27. pmc Quantitative proteomics investigation of pancreatic intraepithelial neoplasia
    Sheng Pan
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Electrophoresis 30:1132-44. 2009
    ..The dysregulated proteins identified in this study may assist in the selection of candidates for future development of biomarkers for detecting early and curable pancreatic neoplasia...
  28. pmc Association between the peroxisome proliferator-activated receptor gamma Pro12Ala variant and haplotype and pancreatic cancer in a high-risk cohort of smokers: a pilot study
    Megan Dann Fesinmeyer
    Institute for Public Health Genetics, University of Washington, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Department of Epidemiology, Seattle, WA 98195, USA
    Pancreas 38:631-7. 2009
    ..This pilot study tested for the association between Pro12Ala and pancreatic cancer risk in a high-risk sample of smokers...
  29. ncbi Risk factors for the development of pancreatic cancer in familial pancreatic cancer kindreds
    Stephen J Rulyak
    Division of Gastroenterology, University of Washington, Seattle, USA
    Gastroenterology 124:1292-9. 2003
    ..We sought to determine whether smoking or other factors could predict cancer risk in familial pancreatic cancer kindreds...
  30. ncbi Characterization of the neoplastic phenotype in the familial atypical multiple-mole melanoma-pancreatic carcinoma syndrome
    Stephen J Rulyak
    Division of Gastroenterology, University of Washington, Seattle, Washington 98195, USA
    Cancer 98:798-804. 2003
    ..It has been found that many of these families harbor mutations in the CDKN2A gene on chromosome 9p21. The phenotypic expression of CDKN2A mutations in these families has not been characterized fully...
  31. ncbi Chromosomal instability in ulcerative colitis is related to telomere shortening
    Jacintha N O'Sullivan
    Department of Pathology, University of Washington, Seattle, Washington 98195 7705, USA
    Nat Genet 32:280-4. 2002
    ..Our study shows that telomere length is correlated with chromosomal instability in a precursor of human cancer...
  32. ncbi Characterization of genomic instability in ulcerative colitis neoplasia leads to discovery of putative tumor suppressor regions
    Ru Chen
    Division of Gastroenterology, Department of Pathology, University of Washington, Seattle 98195, USA
    Cancer Genet Cytogenet 162:99-106. 2005
    ..Both regions are likely to contain tumor-suppressor genes. In conclusion, the genomic instability in UC Progressors can occur in regions that are susceptible to change and are locations of putative tumor-suppressor genes...
  33. ncbi Proteomic analysis of chronic pancreatitis and pancreatic adenocarcinoma
    Tatjana Crnogorac-Jurcevic
    Molecular Oncology Unit, Cancer Research UK, Barts and the London School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, London, United Kingdom
    Gastroenterology 129:1454-63. 2005
    ..This study was therefore designed to analyze the proteome of such specimens and identify new candidate proteins for differential diagnosis...
  34. pmc Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancer
    Sally E Dowen
    Molecular Oncology Unit, Barts and the London School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK
    Am J Pathol 166:81-92. 2005
    ..These data suggest that S100P can be added to the genetic progression model for PDAC...
  35. pmc Advances in counselling and surveillance of patients at risk for pancreatic cancer
    Randall E Brand
    Evanston Northwestern Healthcare, Evanston, Illinois, USA
    Gut 56:1460-9. 2007
  36. pmc Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism
    Kay L Pogue-Geile
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS Med 3:e516. 2006
    ..In this study, our goal was to discover the identity of the familial pancreatic cancer gene on 4q32 and determine the function of that gene...
  37. ncbi Pancreatic cancer in mice and man: the Penn Workshop 2004
    Ralph H Hruban
    Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer Res 66:14-7. 2006
    ..The working groups presented their reports on the final day of the conference, and highlights of selected individual presentations and working group recommendations are summarized here and in an accompanying pathology consensus report...

Research Grants17

  1. Pancreatic Cancer Protein Biomarkers for Early Detection
    Teresa A Brentnall; Fiscal Year: 2010
    ....
  2. Development of Chronic Pancreatitis Biomarkers
    Teresa Brentnall; Fiscal Year: 2009
    ..An accurate biomarker for chronic pancreatitis would be of enormous clinical benefit and could save time and costs in comparison to the current gold standard of endoscopic testing for the disease. ..
  3. Biomarkers of UC Tumorigenesis
    Teresa A Brentnall; Fiscal Year: 2010
    ..Both of these goals will help provide the underpinnings for development of cancer prevention strategies in the future. ..
  4. Pancreatic Cancer Protein Biomarkers for Early Detection
    Teresa Brentnall; Fiscal Year: 2009
    ....
  5. Biomarkers of UC Tumorigenesis
    Teresa Brentnall; Fiscal Year: 2009
    ..Both of these goals will help provide the underpinnings for development of cancer prevention strategies in the future. ..
  6. Pancreatic Cancer Protein Biomarkers for Early Detection
    Teresa Brentnall; Fiscal Year: 2007
    ....
  7. Biomarkers of UC Tumorigenesis
    Teresa Brentnall; Fiscal Year: 2007
    ..Both of these goals will help provide the underpinnings for development of cancer prevention strategies in the future. ..
  8. HISTOLOGIC AND MOLECULAR CHANGES IN UC TUMORIGENESIS
    Teresa Brentnall; Fiscal Year: 2004
    ..Moreover, this knowledge could help provide the underpinnings for development of cancer prevention strategies. ..
  9. Development of Chronic Pancreatitis Biomarkers
    Teresa A Brentnall; Fiscal Year: 2010
    ..An accurate biomarker for chronic pancreatitis would be of enormous clinical benefit and could save time and costs in comparison to the current gold standard of endoscopic testing for the disease. ..