Research Topics
Species | TERI BRENTNALLSummaryAffiliation: University of Washington Country: USA Publications
Research Grants
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Detail Information
Publications
Arousal of cancer-associated stromal fibroblasts: palladin-activated fibroblasts promote tumor invasionTeresa A Brentnall
Department of Medicine, University of Washington Medical Center, Seattle, WA USA
Cell Adh Migr 6:488-94. 2012..Abrogation of palladin reduces the invasive capacity of these cells. CAF also play a role in cancer resistance and immuno-privilege, making the targeting of activators of these cells of interest for oncologists...- Arousal of cancer-associated stroma: overexpression of palladin activates fibroblasts to promote tumor invasionTeresa A Brentnall
GI Division, Department of Medicine, University of Washington, Seattle, Washington, United States of America
PLoS ONE 7:e30219. 2012..Using a pancreatic cancer model, we investigated the functional consequence of overexpression of exogenous palladin in normal fibroblasts in vitro and its effect on the early stages of tumor invasion... 
Early diagnosis and treatment of pancreatic dysplasia in patients with a family history of pancreatic cancerT A Brentnall
Division of Gastroenterology, University of Washington, Seattle 98195, USA
Ann Intern Med 131:247-55. 1999..Surveillance of patients with a familial predisposition for pancreatic cancer has not been systematically evaluated...- Management strategies for patients with hereditary pancreatic cancerTeresa A Brentnall
University of Washington Medical Center, Seattle, WA 98115, USA
Curr Treat Options Oncol 6:437-45. 2005.... - New endoscopic and cytologic tools for cancer surveillance in the digestive tractEric J Seibel
Department of Mechanical Engineering, University of Washington, Seattle, 98195, USA
Gastrointest Endosc Clin N Am 19:299-307. 2009..Advanced three-dimensional cell visualization techniques are described for increasing the sensitivity of early cancer diagnosis from hematoxylin-stained cells sampled from the pancreatic and biliary ducts... - Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammationRosa Ana Risques
Department of Pathology, University of Washington, Seattle, Washington 98195 7705, USA
Cancer Res 71:1669-79. 2011..Our findings argue that senescence acts as a tumor suppressor mechanism that is abrogated during the transition from LGD to HGD in UC... - Mass spectrometry based glycoproteomics--from a proteomics perspectiveSheng Pan
Department of Pathology, University of Washington, Seattle, WA 98195, USA
Mol Cell Proteomics 10:R110.003251. 2011..This report provides an overview of the recent advances in mass spectrometry based glycoproteomic methods and technology, in the context of biomarker discovery and clinical application... - Elevated level of anterior gradient-2 in pancreatic juice from patients with pre-malignant pancreatic neoplasiaRu Chen
GI Division Department of Medicine, University of Washington, Seattle, WA 98195 USA
Mol Cancer 9:149. 2010..We applied quantitative proteomics to identify aberrantly elevated proteins in pancreatic juice samples derived from patients with PanIN3... - Clonal expansions in ulcerative colitis identify patients with neoplasiaJesse J Salk
Department of Pathology, University of Washington School of Medicine, Seattle, WA 98105, USA
Proc Natl Acad Sci U S A 106:20871-6. 2009.... - Mass spectrometry based targeted protein quantification: methods and applicationsSheng Pan
Department of Pathology, University of Washington, Seattle, Washington 98195, USA
J Proteome Res 8:787-97. 2009..This report reviews recently developed platform technologies for emerging applications of clinical proteomics and biomarker development... - Quantitative proteomics analysis reveals that proteins differentially expressed in chronic pancreatitis are also frequently involved in pancreatic cancerRu Chen
Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
Mol Cell Proteomics 6:1331-42. 2007..Altogether our study provides some insights into the molecular events in chronic pancreatitis that may lead to diverse strategies for diagnosis and treatment of these diseases... - Telomere length in the colon declines with age: a relation to colorectal cancer?Jacintha O'Sullivan
Department of Pathology, University of Washington, Seattle, WA, USA
Cancer Epidemiol Biomarkers Prev 15:573-7. 2006..We suggest that the positive association between telomere length and age in the oldest patients is a consequence of selective survival of elderly patients with long colonocyte telomeres... - Comparison of pancreas juice proteins from cancer versus pancreatitis using quantitative proteomic analysisRu Chen
Division of Gastroenterology Department of Medicine, University of Washington, Seattle, WA, USA
Pancreas 34:70-9. 2007..Biomarkers present in pancreatic cancer frequently occur in the setting of pancreatitis. The efforts to develop diagnostic biomarkers for pancreatic cancer have thus been complicated by the false-positive involvement of pancreatitis... - Cost-effectiveness of pancreatic cancer screening in familial pancreatic cancer kindredsStephen J Rulyak
University of Washington, Division of Gastroenterology, Department of Pharmacy, Seattle, Washington, USA
Gastrointest Endosc 57:23-9. 2003..Screening should be performed in centers that have experience with endoscopic screening for pancreatic dysplasia. The cost-effectiveness of repeated screening remains to be determined... - Screening and surveillance for hereditary pancreatic cancerMichael B Kimmey
Department of Medicine, University of Washington, Seattle, Washington 98195, USA
Gastrointest Endosc 56:S82-6. 2002 - Quantitative proteomic profiling of pancreatic cancer juiceRu Chen
GI Division/Department of Medicine, University of Washington, Seattle, WA 98195, USA
Proteomics 6:3871-9. 2006..One of the identified proteins, insulin-like growth factor binding protein-2 was further validated by Western blotting to be elevated in pancreatic cancer juice and overexpressed in pancreatic cancer tissue... - A new susceptibility locus for autosomal dominant pancreatic cancer maps to chromosome 4q32-34Michael A Eberle
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Am J Hum Genet 70:1044-8. 2002..56 in two-point analysis and 5.36 in three-point analysis) on chromosome 4q32-34, providing evidence for a major locus for pancreatic cancer... - DNA fingerprinting abnormalities can distinguish ulcerative colitis patients with dysplasia and cancer from those who are dysplasia/cancer-freeRu Chen
Departments of Pathology, Biostatistics, and Medicine, University of Washington, Seattle, Washington 98195, USA
Am J Pathol 162:665-72. 2003..These results suggest that UC patients who develop dysplasia or cancer have an underlying process of genomic instability in their colonic mucosa whereas UC patients who are dysplasia-free do not... - Inherited pancreatic cancer: improvements in our understanding of genetics and screeningStephen J Rulyak
Division of Gastroenterology, University of Washington Medical Center, Box 356424, 1959 NE Pacific St, Seattle, WA 98195, USA
Int J Biochem Cell Biol 36:1386-92. 2004..One promising strategy has used endoscopic ultrasound to detected pancreatic dysplasia in members of familial pancreatic cancer kindreds... - Proteomic profiling of pancreatic cancer for biomarker discoveryRu Chen
GI Division/Department of Medicine, University of Washington, Seattle, WA 98195, USA
Mol Cell Proteomics 4:523-33. 2005..In this article, we discuss recent progress and challenges for applying quantitative proteomics technologies for biomarker discovery in pancreatic cancer... - Ulcerative colitis is a disease of accelerated colon aging: evidence from telomere attrition and DNA damageRosa Ana Risques
Department of Pathology, University of Washington, Seattle, Washington, USA
Gastroenterology 135:410-8. 2008..We explored this hypothesis in ulcerative colitis (UC), a chronic inflammatory disease that predisposes to colorectal cancer and in which shorter telomeres have been associated with chromosomal instability and tumor progression... - The initiation of colon cancer in a chronic inflammatory settingRu Chen
Department of Medicine, University of Washington, Seattle, WA 98195, USA
Carcinogenesis 26:1513-9. 2005..This paradigm may apply to other inflammatory-induced cancers... - Chromosomal instability in pancreatic ductal cells from patients with chronic pancreatitis and pancreatic adenocarcinomaAlexander H Moskovitz
Department of Surgery, University of Washington, Seattle, Washington, USA
Genes Chromosomes Cancer 37:201-6. 2003..These results elucidate a potential mechanism linking chronic pancreatitis to pancreatic cancer and suggest that chromosomal instability may be an early event in the pathogenesis of pancreatic cancer... - Cancer surveillance in inflammatory bowel disease: new molecular approachesRosa Ana Risques
Department of Pathology, University of Washington, USA
Curr Opin Gastroenterol 22:382-90. 2006..Efforts are needed to prove the clinical utility of the most promising markers now identified... - A new indication for pancreas transplantation: high grade pancreatic dysplasiaKevin P Charpentier
Department of Surgery, Division of General Surgery, University of Washington Medical Center, Washington, DC, USA
Clin Transplant 18:105-7. 2004.... - Pancreatic cancer proteome: the proteins that underlie invasion, metastasis, and immunologic escapeRu Chen
Department of Medicine, University of Washington, Seattle, 98195, USA
Gastroenterology 129:1187-97. 2005..CONCLUSIONS: Our study is the first application of isotope-coded affinity tag technology for proteomic analysis of human cancer tissue and has shown the value of this technology in identifying differentially expressed proteins in cancer... - Quantitative proteomics investigation of pancreatic intraepithelial neoplasiaSheng Pan
Department of Pathology, University of Washington, Seattle, WA 98195, USA
Electrophoresis 30:1132-44. 2009..The dysregulated proteins identified in this study may assist in the selection of candidates for future development of biomarkers for detecting early and curable pancreatic neoplasia... - Association between the peroxisome proliferator-activated receptor gamma Pro12Ala variant and haplotype and pancreatic cancer in a high-risk cohort of smokers: a pilot studyMegan Dann Fesinmeyer
Institute for Public Health Genetics, University of Washington, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Department of Epidemiology, Seattle, WA 98195, USA
Pancreas 38:631-7. 2009..This pilot study tested for the association between Pro12Ala and pancreatic cancer risk in a high-risk sample of smokers... - Risk factors for the development of pancreatic cancer in familial pancreatic cancer kindredsStephen J Rulyak
Division of Gastroenterology, University of Washington, Seattle, USA
Gastroenterology 124:1292-9. 2003..These factors may be useful in selecting candidates for pancreatic cancer screening. Members of families with multiple pancreatic cancers should be counseled not to smoke... - Characterization of the neoplastic phenotype in the familial atypical multiple-mole melanoma-pancreatic carcinoma syndromeStephen J Rulyak
Division of Gastroenterology, University of Washington, Seattle, Washington 98195, USA
Cancer 98:798-804. 2003..Other malignancies may be a part of the phenotype in these families, although this hypothesis requires additional study... - Chromosomal instability in ulcerative colitis is related to telomere shorteningMary P Bronner
Department of Pathology, University of Washington, Seattle, Washington 98195-7705, USA
Nat Genet 32:280-4. 2002..Our study shows that telomere length is correlated with chromosomal instability in a precursor of human cancer... - Characterization of genomic instability in ulcerative colitis neoplasia leads to discovery of putative tumor suppressor regionsRu Chen
Division of Gastroenterology, Department of Pathology, University of Washington, Seattle 98195, USA
Cancer Genet Cytogenet 162:99-106. 2005..Both regions are likely to contain tumor-suppressor genes. In conclusion, the genomic instability in UC Progressors can occur in regions that are susceptible to change and are locations of putative tumor-suppressor genes... - Proteomic analysis of chronic pancreatitis and pancreatic adenocarcinomaTatjana Crnogorac-Jurcevic
Molecular Oncology Unit, Cancer Research UK, Barts and the London School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, London, United Kingdom
Gastroenterology 129:1454-63. 2005..This study was therefore designed to analyze the proteome of such specimens and identify new candidate proteins for differential diagnosis... - Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancerSally E Dowen
Molecular Oncology Unit, Barts and the London School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK
Am J Pathol 166:81-92. 2005..These data suggest that S100P can be added to the genetic progression model for PDAC... - Advances in counselling and surveillance of patients at risk for pancreatic cancerRandall E Brand
Evanston Northwestern Healthcare, Evanston, Illinois, USA
Gut 56:1460-9. 2007 - Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanismKay L Pogue-Geile
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
PLoS Med 3:e516. 2006..In this study, our goal was to discover the identity of the familial pancreatic cancer gene on 4q32 and determine the function of that gene... - Pancreatic cancer in mice and man: the Penn Workshop 2004Ralph H Hruban
Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Cancer Res 66:14-7. 2006..The working groups presented their reports on the final day of the conference, and highlights of selected individual presentations and working group recommendations are summarized here and in an accompanying pathology consensus report...
Research Grants
- Pancreatic Cancer Protein Biomarkers for Early DetectionTeresa A Brentnall; Fiscal Year: 2010....
- Development of Chronic Pancreatitis BiomarkersTeresa Brentnall; Fiscal Year: 2009..An accurate biomarker for chronic pancreatitis would be of enormous clinical benefit and could save time and costs in comparison to the current gold standard of endoscopic testing for the disease. ..
- Biomarkers of UC TumorigenesisTeresa A Brentnall; Fiscal Year: 2010..Both of these goals will help provide the underpinnings for development of cancer prevention strategies in the future. ..
- Pancreatic Cancer Protein Biomarkers for Early DetectionTeresa Brentnall; Fiscal Year: 2009....
- Biomarkers of UC TumorigenesisTeresa Brentnall; Fiscal Year: 2009..Both of these goals will help provide the underpinnings for development of cancer prevention strategies in the future. ..
- Pancreatic Cancer Protein Biomarkers for Early DetectionTeresa Brentnall; Fiscal Year: 2007....
- Biomarkers of UC TumorigenesisTeresa Brentnall; Fiscal Year: 2007..Both of these goals will help provide the underpinnings for development of cancer prevention strategies in the future. ..
- HISTOLOGIC AND MOLECULAR CHANGES IN UC TUMORIGENESISTeresa Brentnall; Fiscal Year: 2004..Moreover, this knowledge could help provide the underpinnings for development of cancer prevention strategies. ..
- Development of Chronic Pancreatitis BiomarkersTeresa A Brentnall; Fiscal Year: 2010..An accurate biomarker for chronic pancreatitis would be of enormous clinical benefit and could save time and costs in comparison to the current gold standard of endoscopic testing for the disease. ..