Research Topics
Genomes and Genes | G A BrentSummaryAffiliation: University of California Country: USA Publications
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Publications
Mechanisms of thyroid hormone actionGregory A Brent
Department of Medicine, VA Greater Los Angeles Healthcare System, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
J Clin Invest 122:3035-43. 2012....- Environmental exposures and autoimmune thyroid diseaseGregory A Brent
Endocrinology and Diabetes Division, VA Greater Los Angeles Healthcare System, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90073, USA
Thyroid 20:755-61. 2010..Although most of these agents are associated with reduced thyroid hormone levels or impaired thyroid hormone action, a number of environmental exposures confer an increased risk of autoimmune thyroid disease... 
Maternal hypothyroidism: recognition and managementG A Brent
Endocrinology Division, West Los Angeles VA Medical Center, Los Angeles, California 90073, USA
Thyroid 9:661-5. 1999..The magnitude of the increased T4 requirement is related to the etiology of hypothyroidism. Monitoring thyroid status and adjusting the T4 dose during pregnancy is a challenge due to changes in T4 metabolism throughout pregnancy...- Clinical practice. Graves' diseaseGregory A Brent
Veterans Affairs Greater Los Angeles Healthcare System, and the Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
N Engl J Med 358:2594-605. 2008 - Differential regulation of the human sodium/iodide symporter gene promoter in papillary thyroid carcinoma cell lines and normal thyroid cellsT Kogai
The Endocrinology Division, VA Greater Los Angeles Healthcare System and Department of Medicine, UCLA School of Medicine, Los Angeles, California 90073, USA
Endocrinology 142:3369-79. 2001..Reduced expression of potential novel nuclear factor(s) in these cell lines may contribute to reduced sodium/iodide symporter expression resulting in absence of iodide uptake in some papillary thyroid cancers... - Retinoic acid induces sodium/iodide symporter gene expression and radioiodide uptake in the MCF-7 breast cancer cell lineT Kogai
Molecular Endocrinology Laboratory, West Los Angeles Veterans Affairs Medical Center, Departments of Medicine and Physiology, University of California School of Medicine, Los Angeles, CA 90073, USA
Proc Natl Acad Sci U S A 97:8519-24. 2000..Stimulation of radioiodide uptake after systemic retinoid treatment may be useful for diagnosis and treatment of some differentiated breast cancers... - Thyroid hormone--sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform--specificM O Ribeiro
Molecular Endocrinology Laboratory, Veterans Affairs Greater Los Angeles Healthcare System, California 90073, USA
J Clin Invest 108:97-105. 2001..We conclude that two distinct thyroid-dependent pathways, stimulation of UCP1 and augmentation of adrenergic responsiveness, are mediated by different TR isoforms in the same tissue... - Ectopic expression of the thyroperoxidase gene augments radioiodide uptake and retention mediated by the sodium iodide symporter in non-small cell lung cancerM Huang
Pulmonary Immunology and Gene Medicine Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, UCLA and VA Greater Heathcare System, Los Angeles, California 90073, USA
Cancer Gene Ther 8:612-8. 2001..Thus, TPO could be used as a therapeutic strategy to enhance the NIS-based radioiodide concentrator gene therapy for locally advanced lung cancer... - Differential regulation of sodium/iodide symporter gene expression by nuclear receptor ligands in MCF-7 breast cancer cellsTakahiko Kogai
Molecular Endocrinology Laboratory, Veterans Affairs Greater Los Angeles Healthcare System, David Geffen School of Medicine at the University of California, Los Angeles, CA 90073, USA
Endocrinology 146:3059-69. 2005..The addition of Dex reduced the effective dose of retinoid and prolonged the induction of NIS, especially with AGN190168, suggesting higher efficacy of (131)I after combination treatment... - Retinoic acid stimulation of the sodium/iodide symporter in MCF-7 breast cancer cells is mediated by the insulin growth factor-I/phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase signaling pathwaysTakahiko Kogai
Molecular Endocrinology Laboratory, VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
J Clin Endocrinol Metab 93:1884-92. 2008..Radioiodine administration after systemic tRA treatment has been proposed as an approach to image and treat some differentiated breast cancer... - Activation of the PI3 kinase pathway by retinoic acid mediates sodium/iodide symporter induction and iodide transport in MCF-7 breast cancer cellsEmi Ohashi
Molecular Endocrinology Laboratory, VA Greater Los Angeles Healthcare System, Department of Medicine, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California 90073, USA
Cancer Res 69:3443-50. 2009..Defining these mechanisms should lead to methods to further enhance NIS expression, as well as retinoid targets that influence growth and differentiation of breast cancer... - Retinoic acid induces expression of the thyroid hormone transporter, monocarboxylate transporter 8 (Mct8)Takahiko Kogai
Molecular Endocrinology Laboratory, Veterans Affairs Greater Los Angeles Healthcare System, the Departments ofMedicine and Physiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90073, USA
J Biol Chem 285:27279-88. 2010..This finding demonstrates cross-talk between RA signaling and thyroid hormone signaling in early development at the level of the thyroid hormone transporter... - Regulation of regional expression in rat brain PC2 by thyroid hormone/characterization of novel negative thyroid hormone response elements in the PC2 promoterXiaoxiong Shen
Division of Endocrinology, Department of Medicine, Charles R Drew University of Medicine and Sciences, Los Angeles, CA 90059, USA
Am J Physiol Endocrinol Metab 288:E236-45. 2005..We conclude that there are two novel TRE-like sequences in the hPC2 promoter and that these regions act in concert in a unique manner to facilitate the effects of thyroid hormone and 9-cis-retinoic acid on PC2... - A thyroid hormone receptor alpha gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in miceYan Yun Liu
Molecular Endocrinology Laboratory, Veterans Affairs Greater Los Angeles Healthcare System, Departments of Medicine and Physiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90073, USA
J Biol Chem 278:38913-20. 2003..The physiologic significance of these findings will ultimately depend on understanding the full range of actions of this mutation... 
Phosphoinositide-3-kinase inhibition induces sodium/iodide symporter expression in rat thyroid cells and human papillary thyroid cancer cellsTakahiko Kogai
Department of Medicine, David Geffen School of Medicine at UCLA, Endocrinology and Diabetes Division, VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Building 114, Room 230, Los Angeles, California 90073, USA
J Endocrinol 199:243-52. 2008..PI3K inhibitors have the potential to increase radioiodide accumulation in some differentiated thyroid cancer...- A thyroid-specific far-upstream enhancer in the human sodium/iodide symporter gene requires Pax-8 binding and cyclic adenosine 3',5'-monophosphate response element-like sequence binding proteins for full activity and is differentially regulated in normal Katsumi Taki
Endocrinology Division, Veterans Affairs Greater Los Angeles Healthcare System and Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, California 90073, USA
Mol Endocrinol 16:2266-82. 2002..Deficient CRE-like sequence binding protein(s) that bind to the hNUE in normal thyroid cells may be responsible for reduced NIS gene expression in some thyroid carcinomas... - Nonthyroidal illness syndrome: evaluation of thyroid function in sick patientsJoanne E Langton
Division of Endocrinology, Department of Medicine, VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, Los Angeles, CA, USA
Endocrinol Metab Clin North Am 31:159-72. 2002..In the future, thyroid hormone receptor isoform-specific agonists and antagonists may allow for more specific treatment of select patients with nonthyroidal illness syndrome... - Thyroid hormone regulation of prohormone convertase 1 (PC1): regional expression in rat brain and in vitro characterization of negative thyroid hormone response elementsX Shen
Division of Endocrinology, Charles R Drew University of Medicine and Sciences UCLA School of Medicine, Los Angeles, CA 90059, USA
J Mol Endocrinol 33:21-33. 2004..We conclude that there are multiple novel TRE-like sequences in the hPC1 promoter and that these regions act in a unique manner to facilitate the negative effect of thyroid hormone on PC1... - A targeted thyroid hormone receptor alpha gene dominant-negative mutation (P398H) selectively impairs gene expression in differentiated embryonic stem cellsYan Yun Liu
Molecular Endocrinology Laboratory and Research Service, Veterans Affairs Greater Los Angeles Healthcare System, Department of Medicine, University of California Los Angeles School of Medicine, 90073, USA
Endocrinology 143:2664-72. 2002..This system could also be used to identify novel T(3)-regulated genes. The modulation of the apoptotic effects of RA by T(3) may have implications for stem cell therapy... - Systemic retinoic acid treatment induces sodium/iodide symporter expression and radioiodide uptake in mouse breast cancer modelsTakahiko Kogai
Molecular Endocrinology Laboratory, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Cancer Res 64:415-22. 2004..Treatment with short-term systemic retinoic acid, followed by radioiodide administration, is a potential tool in the diagnosis and treatment of some differentiated breast cancer... - Thyroid hormone stimulation of osteocalcin gene expression in ROS 17/2.8 cells is mediated by transcriptional and post-transcriptional mechanismsC H Gouveia
Molecular Endocrinology Laboratory, VA Greater Los Angeles Healthcare System and Department of Medicine, UCLA School of Medicine, Los Angeles, California 90073, USA
J Endocrinol 170:667-75. 2001..The greater T3 induction of OC expression in ROS 17/2.8 cells at low cell density is consistent with findings of thyroid hormone action on bone development... - Prospective studies of thyroid function in patients receiving gold therapyS J Mandel
Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Thyroid 5:113-6. 1995..The most likely explanation for this is that gold principally accumulates in the Kupffer cells and renal cortex and these cells do not express Type I deiodinase... - A GC box in the human sodium iodide symporter gene promoter is essential for full activityJimin Xu
Endocrinology and Metabolism Division, VA Greater Los Angeles Healthcare System and UCLA School of Medicine, California 90073, USA
Thyroid 12:107-14. 2002..Sp1 and an "Sp1-like" protein bound to the wild-type GC box sequence but not to the GC box mutant. In summary, the GC box is a positive regulatory element in the hNIS basal promoter... - Rapid progression from subclinical to symptomatic overt hypothyroidismRobert Heymann
Endocrinology and Diabetes Division, VA Greater Los Angeles Healthcare System, David Geffen School of Medicine at UCLA, California 90073, USA
Endocr Pract 11:115-9. 2005..Elderly patients with high antithyroid antibody titers may have a higher than previously recognized risk of rapid development of overt hypothyroidism, and earlier intervention with levothyroxine treatment may be indicated... - Enhancement of sodium/iodide symporter expression in thyroid and breast cancerT Kogai
Molecular Endocrinology Laboratory, VA Greater Los Angeles Healthcare System, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90073, USA
Endocr Relat Cancer 13:797-826. 2006..Agents that promote tumor differentiation, or directly stimulate NIS gene expression, may result in iodine concentration in 'scan-negative' thyroid cancer and some breast cancer... - Interactions between the prohormone convertase 2 promoter and the thyroid hormone receptorQ L Li
Department of Medicine, Cedars Sinai Research Institute, University of California School of Medicine, Los Angeles 90048, USA
Endocrinology 141:3256-66. 2000..We postulate that the alterations of PC2 activity may mediate some of the pathophysiological consequences of hypo- or hyperthyroidism... - Characterization of the promoter of the rat sarcoplasmic endoplasmic reticulum Ca2+-ATPase 1 gene and analysis of thyroid hormone responsivenessW S Simonides
Thyroid Division, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 271:32048-56. 1996..T3 regulation of SERCA1 expression is mediated by a complex thyroid hormone response element that may serve to provide a greater range of response in interaction with nuclear receptor partners or cell-specific transcription factors... - Enhanced expression of nicotinamide N-methyltransferase in human papillary thyroid carcinoma cellsJimin Xu
Endocrinology and Diabetes Division, Veterans Affairs Medical Center, University of California School of Medicine, Los Angeles, California 90073, USA
J Clin Endocrinol Metab 88:4990-6. 2003..These results indicate that NNMT is a potential biomarker for papillary thyroid carcinoma... - Anaplastic thyroid carcinoma with thyrotoxicosis and hypoparathyroidismRobert S Heymann
Endocrinology and Diabetes Division, Veterans Affairs Greater Los Angeles Healthcare System, David Geffen School of Medicine at UCLA, CA 90073, USA
Endocr Pract 11:281-4. 2005..CONCLUSION: Thyrotoxicosis due to thyroiditis is a rare initial manifestation of anaplastic thyroid carcinoma. Hypoparathyroidism due to anaplastic thyroid carcinoma has not been reported previously... - Nonradioactive iodide effectively induces apoptosis in genetically modified lung cancer cellsLing Zhang
Division of Pulmonary and Critical Care Medicine, University of California Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System, California 90073, USA
Cancer Res 63:5065-72. 2003.... - Thyroid hormone gene targets in ROS 17/2.8 osteoblast-like cells identified by differential display analysisCecilia H Gouveia
Molecular Endocrinology Laboratory, VA Greater Los Angeles Healthcare System, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90073, USA
Thyroid 12:663-71. 2002..Cell type, and the extent of cell differentiation, influences T(3) regulation of genes in osteoblast-derived cells... - Thyroid hormone and COUP-TF1 regulate kallikrein-binding protein (KBP) gene expressionYan Yun Liu
Molecular Endocrinology Laboratory, Building 114, Room 230, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, California 90073, USA
Endocrinology 152:1143-53. 2011..Endogenous KBP expression is repressed by T(3) and two functional nTREs, both of which are required, have been characterized in the KBP gene. COUP-TF1 may be an important factor to modulate expression of genes that are repressed by T(3)... - Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-beta isoform specific and required for adaptive thermogenesisMiriam O Ribeiro
Molecular Endocrinology Laboratory, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, California 90073, USA
Endocrinology 151:432-40. 2010..Defective adaptive thermogenesis in TR beta PV mutant mice is due to reduced UCP1 expression and reduced adrenergic responsiveness. TR beta mediates T(3) regulation of UCP1 in BAT and is required for adaptive thermogenesis... - Thyroid hormone-dependent gene expression in differentiated embryonic stem cells and embryonal carcinoma cells: identification of novel thyroid hormone target genes by deoxyribonucleic acid microarray analysisYan-Yun Liu
Molecular Endocrinology Laboratory, VA Greater Los Angeles Healthcare System, Building 114, Room 230, 11301 Wilshire Boulevard, Los Angeles, California 90073, USA
Endocrinology 146:776-83. 2005..These genes identified in a novel stem cell system, including those induced and repressed in response to T3, may mediate thyroid hormone actions in early development... - A complex deoxyribonucleic acid response element in the rat Ca(2+)/calmodulin-dependent protein kinase IV gene 5'-flanking region mediates thyroid hormone induction and chicken ovalbumin upstream promoter transcription factor 1 repressionYan Yun Liu
Molecular Endocrinology Laboratory, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Mol Endocrinol 16:2439-51. 2002..COUP-TF1 binding did not influence TR/retinoid X receptor binding but modestly augmented RAR/retinoid X receptor binding. A single element confers T(3) and COUP-TF1 regulation of CaMKIV expression... - The modified firefly luciferase reporter gene (luc+) but not Renilla luciferase is induced by all-trans retinoic acid in MCF-7 breast cancer cellsTakahiko Kogai
Molecular Endocrinology Laboratory, VA Greater Los Angeles Healthcare System, Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90073, USA
Breast Cancer Res Treat 78:119-26. 2003..Caution is needed in analysis of retinoid responsive gene regulation with the luciferase reporter system in MCF-7 cells, especially at high retinoid concentrations... - Spared bone mass in rats treated with thyroid hormone receptor TR beta-selective compound GC-1Fatima R S Freitas
Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, 05508-900, Brazil
Am J Physiol Endocrinol Metab 285:E1135-41. 2003..In addition, our findings suggest that the development of TR-selective T3 analogs that spare bone mass represents a significant improvement toward long-term TSH-suppressive therapy... - Follow-up of newborns with elevated screening T4 concentrationsStephen H LaFranchi
Department of Pediatrics, Oregon Health and Science University, Pediatric Endocrinology, Legacy Emanuel Children s Hospital, and Oregon State Public Health Laboratory, Portland, Oregon, USA
J Pediatr 143:296-301. 2003..To determine the type and incidence of hyperthyroxinemic disorders detected by follow-up of infants with elevated screening total T4 (TT4) values... - Diagnosing thyroid dysfunction in pregnant women: Is case finding enough?Gregory A Brent
J Clin Endocrinol Metab 92:39-41. 2007 - Resistance to thyroid hormone in Hashimoto's thyroiditisShuji Fukata
N Engl J Med 352:517-8. 2005 - Stealth sequences in reporter gene vectors confound studies of T3-regulated negative gene expressionYan-Yun Liu
Thyroid 18:593-5. 2008 - Thyroid hormone regulates endogenous amyloid-beta precursor protein gene expression and processing in both in vitro and in vivo modelsJin S Oh
Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, USA
Thyroid 16:1207-13. 2006..Pharmacologic supplementation of thyroid hormone, or its analogs, may reduce APP gene expression and beta amyloid peptide accumulation... - Thyroid health and the environmentGregory A Brent
Thyroid 17:807-9. 2007
Research Grants
- REGULATION OF THE SODIUM/IODIDE SYMPORTER IN BREASTGregory Brent; Fiscal Year: 2009..The findings from this study can potentially be applied to radioiodine imaging and treatment of breast cancer and further understanding the factors that regulate breast cancer growth and differentiation. ..
- REGULATION OF THE SODIUM/IODIDE SYMPORTER IN BREASTGregory Brent; Fiscal Year: 2007..The findings from this study can potentially be applied to radioiodine imaging and treatment of breast cancer and further understanding the factors that regulate breast cancer growth and differentiation. ..
- Thyroid Hormone Receptor Isoform-Specific ActionsGregory Brent; Fiscal Year: 2007..abstract_text> ..
- REGULATION OF THE SODIUM/IODIDE SYMPORTER IN BREASTGregory Brent; Fiscal Year: 2004..RA raioiodide uptake may be useful for diagnosis and treatment of some differentiated breast cancer. ..
- REGULATION OF THE SODIUM/IODIDE SYMPORTER IN BREASTGregory A Brent; Fiscal Year: 2010..The findings from this study can potentially be applied to radioiodine imaging and treatment of breast cancer and further understanding the factors that regulate breast cancer growth and differentiation. ..