D Brent

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Protecting adolescents from self-harm: a critical review of intervention studies
    David A Brent
    University of Pittsburgh and Western Psychiatric Institute and Clinic Electronic address
    J Am Acad Child Adolesc Psychiatry 52:1260-71. 2013
  2. pmc Longitudinal effects of parental bereavement on adolescent developmental competence
    David A Brent
    Western Psychiatric Institute and Clinic and University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Child Adolesc Psychol 41:778-91. 2012
  3. pmc Effect of parental bereavement on health risk behaviors in youth: a 3-year follow-up
    Sami Hamdan
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arch Pediatr Adolesc Med 166:216-23. 2012
  4. ncbi request reprint Treatment-resistant depression in adolescents: recognition and management
    David A Brent
    Department of Child and Adolescent Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, BFT 311, Pittsburgh, PA 15213 2592, USA
    Child Adolesc Psychiatr Clin N Am 15:1015-34, x. 2006
  5. ncbi request reprint Glad for what TADS adds, but many TADS grads still sad
    David A Brent
    Department of Psychiatry at Western Psychiatric Institute, PA 45213, USA
    J Am Acad Child Adolesc Psychiatry 45:1461-4. 2006
  6. pmc Switching to another SSRI or to venlafaxine with or without cognitive behavioral therapy for adolescents with SSRI-resistant depression: the TORDIA randomized controlled trial
    David Brent
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    JAMA 299:901-13. 2008
  7. ncbi request reprint Familial transmission of mood disorders: convergence and divergence with transmission of suicidal behavior
    David A Brent
    Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 43:1259-66. 2004
  8. ncbi request reprint Family genetic studies, suicide, and suicidal behavior
    David A Brent
    Child and Adolescent Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Med Genet C Semin Med Genet 133:13-24. 2005
  9. pmc Predictors of spontaneous and systematically assessed suicidal adverse events in the treatment of SSRI-resistant depression in adolescents (TORDIA) study
    David A Brent
    University of Pittsburgh School of Medicine, Western University School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Suite 112, Pittsburgh, PA 15213 2593, USA
    Am J Psychiatry 166:418-26. 2009
  10. pmc The incidence and course of depression in bereaved youth 21 months after the loss of a parent to suicide, accident, or sudden natural death
    David Brent
    Western Psychiatric Institute and Clinic, Rm 315, Bellefield Towers, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 166:786-94. 2009

Detail Information

Publications78

  1. pmc Protecting adolescents from self-harm: a critical review of intervention studies
    David A Brent
    University of Pittsburgh and Western Psychiatric Institute and Clinic Electronic address
    J Am Acad Child Adolesc Psychiatry 52:1260-71. 2013
    ..To review the studies that test treatments targeting adolescent suicidal ideation, suicide attempts, or self-harm, and to make recommendations for future intervention development...
  2. pmc Longitudinal effects of parental bereavement on adolescent developmental competence
    David A Brent
    Western Psychiatric Institute and Clinic and University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Child Adolesc Psychol 41:778-91. 2012
    ....
  3. pmc Effect of parental bereavement on health risk behaviors in youth: a 3-year follow-up
    Sami Hamdan
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arch Pediatr Adolesc Med 166:216-23. 2012
    ..To examine the course of health risk behaviors (HRBs) during a 3-year period after a parent's death in bereaved youth compared with nonbereaved youth (control subjects)...
  4. ncbi request reprint Treatment-resistant depression in adolescents: recognition and management
    David A Brent
    Department of Child and Adolescent Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, BFT 311, Pittsburgh, PA 15213 2592, USA
    Child Adolesc Psychiatr Clin N Am 15:1015-34, x. 2006
    ....
  5. ncbi request reprint Glad for what TADS adds, but many TADS grads still sad
    David A Brent
    Department of Psychiatry at Western Psychiatric Institute, PA 45213, USA
    J Am Acad Child Adolesc Psychiatry 45:1461-4. 2006
  6. pmc Switching to another SSRI or to venlafaxine with or without cognitive behavioral therapy for adolescents with SSRI-resistant depression: the TORDIA randomized controlled trial
    David Brent
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    JAMA 299:901-13. 2008
    ..There are no data to guide clinicians on subsequent treatment strategy...
  7. ncbi request reprint Familial transmission of mood disorders: convergence and divergence with transmission of suicidal behavior
    David A Brent
    Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 43:1259-66. 2004
    ..In this study, the authors examine the factors associated with the familial transmission of these two related conditions to learn which are shared or unique risk factors for familial transmission...
  8. ncbi request reprint Family genetic studies, suicide, and suicidal behavior
    David A Brent
    Child and Adolescent Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Med Genet C Semin Med Genet 133:13-24. 2005
    ..Shared environment effects such as abuse, imitation, or transmission of psychopathology are other possible explanations...
  9. pmc Predictors of spontaneous and systematically assessed suicidal adverse events in the treatment of SSRI-resistant depression in adolescents (TORDIA) study
    David A Brent
    University of Pittsburgh School of Medicine, Western University School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Suite 112, Pittsburgh, PA 15213 2593, USA
    Am J Psychiatry 166:418-26. 2009
    ..The authors sought to identify predictors of self-harm adverse events in treatment-resistant, depressed adolescents during the first 12 weeks of treatment...
  10. pmc The incidence and course of depression in bereaved youth 21 months after the loss of a parent to suicide, accident, or sudden natural death
    David Brent
    Western Psychiatric Institute and Clinic, Rm 315, Bellefield Towers, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 166:786-94. 2009
    ..This study examined effects of bereavement 21 months after a parent's death, particularly death by suicide...
  11. pmc The Treatment of Adolescent Suicide Attempters study (TASA): predictors of suicidal events in an open treatment trial
    David A Brent
    University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 48:987-96. 2009
    ..To identify the predictors of suicidal events and attempts in adolescent suicide attempters with depression treated in an open treatment trial...
  12. pmc Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study
    David Brent
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Rm 315 Bellefield Towers, Pittsburgh, PA 15213, USA
    Am J Psychiatry 167:190-7. 2010
    ..The authors sought to assess the relationship between candidate genes and two clinical outcomes, namely, symptomatic improvement and the occurrence of suicidal events, in a sample of treatment-resistant depressed adolescents...
  13. ncbi request reprint What family studies teach us about suicidal behavior: implications for research, treatment, and prevention
    D Brent
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Eur Psychiatry 25:260-3. 2010
    ..Moreover, high family loading for mood disorder and suicidal behavior are related to multi-generational abuse, impulsive aggression, and early-onset of mood disorder and of suicidal behavior...
  14. pmc Pharmacogenomics of suicidal events
    David Brent
    Western Psychiatric Institute and Clinic, 3811 O Hara Street, Room 315 Bellefield Towers, Pittsburgh, PA 15213, USA
    Pharmacogenomics 11:793-807. 2010
    ....
  15. pmc Familial transmission of suicidal behavior
    David A Brent
    Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychiatr Clin North Am 31:157-77. 2008
    ..However, so-called family environmental factors often are related to risk factors that are heritable. Conversely, genetic factors exert their impact on depression and suicidal behavior via interaction with a stressful environment...
  16. pmc Familial pathways to early-onset suicidal behavior: familial and individual antecedents of suicidal behavior
    Nadine M Melhem
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Psychiatry 164:1364-70. 2007
    ..The authors sought to identify clinical predictors of new-onset suicidal behavior in children of parents with a history of mood disorder and suicidal behavior...
  17. ncbi request reprint Phenomenology of panic disorder in youth
    Rasim Somer Diler
    Division of Child Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
    Depress Anxiety 20:39-43. 2004
    ..Subjects with both panic and non-panic anxiety disorders were more likely to have comorbid major depression and conduct disorders than those with other non-anxiety disorders...
  18. ncbi request reprint Screen for Child Anxiety-Related Emotional Disorders (SCARED): convergent and divergent validity
    S Monga
    Child Psychiatry Department, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 12:85-91. 2000
    ..05), thus demonstrating the discriminant validity of the SCARED. The SCARED is a reliable and valid screening tool for clinically referred children and adolescents with anxiety disorders...
  19. ncbi request reprint Emergent suicidality in a clinical psychotherapy trial for adolescent depression
    Jeffrey A Bridge
    Western Psychiatric Institute and Clinic, Child and Adolescent Psychiatry, 3811 O Hara St, BFT 311, Pittsburgh, PA 15213 2592, USA
    Am J Psychiatry 162:2173-5. 2005
    ..The authors' goal was to examine the incidence and predictors of emergent suicidality that occurred during a clinical trial of psychotherapy for adolescent depression...
  20. ncbi request reprint Antidepressants and pediatric depression--the risk of doing nothing
    David A Brent
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, USA
    N Engl J Med 351:1598-601. 2004
  21. pmc Antecedents and sequelae of sudden parental death in offspring and surviving caregivers
    Nadine M Melhem
    Western Psychiatric Institute and Clinic and the Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Arch Pediatr Adolesc Med 162:403-10. 2008
    ..To examine the psychiatric antecedents that put parents at risk for early death, and the psychological sequelae of bereavement in offspring and caregivers...
  22. ncbi request reprint Anxiety disorders in suicidal youth
    J Strauss
    Division of Child Psychiatry, University of Pittsburgh Medical Center, Pennsylvania, USA
    Can J Psychiatry 45:739-45. 2000
    ..To test the hypothesis that anxiety disorders are associated with suicidal ideation and suicide attempts in a child and adolescent sample referred to a clinic...
  23. ncbi request reprint The stressful life events schedule for children and adolescents: development and validation
    Douglas E Williamson
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Psychiatry Res 119:225-41. 2003
    ..48). The results of this study indicate that the SLES has good psychometric properties. The SLES is a useful, cost-effective tool for assessing stressful life events in children and adolescents...
  24. ncbi request reprint Platelet serotonin reuptake inhibition and response to SSRIs in depressed adolescents
    David A Axelson
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 162:802-4. 2005
    ..The authors examined platelet serotonin reuptake inhibition and response to selective serotonin reuptake inhibitor (SSRI) treatment in depressed adolescents...
  25. ncbi request reprint Familial pathways to early-onset suicide attempt: risk for suicidal behavior in offspring of mood-disordered suicide attempters
    David A Brent
    Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 59:801-7. 2002
    ..Although adoption, twin, and family studies have shown that suicidal behavior is familial, the risk factors for familial transmission from parent to child remain unclear...
  26. ncbi request reprint Steady-state clinical pharmacokinetics of bupropion extended-release in youths
    W Burleson Daviss
    Western Psychiatric Institute and Clinic, University of Pittsburgh, USA
    J Am Acad Child Adolesc Psychiatry 45:1503-9. 2006
    ..To examine in children and adolescents the 24-hour, steady-state clinical pharmacokinetics of an extended-release (XL) formulation of bupropion (Wellbutrin XL)...
  27. ncbi request reprint Fluoxetine for the treatment of childhood anxiety disorders
    Boris Birmaher
    Department of Child Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 42:415-23. 2003
    ..To assess the efficacy and tolerability of fluoxetine for the acute treatment of children and adolescents with generalized anxiety disorder, separation anxiety disorder, and/or social phobia...
  28. pmc Dialectical behavior therapy for adolescents with bipolar disorder: a 1-year open trial
    Tina R Goldstein
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 46:820-30. 2007
    ..To describe an adapted version of dialectical behavior therapy for adolescents with bipolar disorder...
  29. ncbi request reprint Recurrent abdominal pain, anxiety, and depression in primary care
    John V Campo
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Pediatrics 113:817-24. 2004
    ..Our aim was to determine whether RAP is associated with psychiatric symptoms and disorders, anxious temperament, and functional impairment in pediatric primary care...
  30. pmc Sleep disturbance preceding completed suicide in adolescents
    Tina R Goldstein
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Consult Clin Psychol 76:84-91. 2008
    ..Sleep difficulties should therefore be carefully considered in prevention and intervention efforts for adolescents at risk for suicide...
  31. ncbi request reprint Lifetime history of sexual abuse, clinical presentation, and outcome in a clinical trial for adolescent depression
    Rémy P Barbe
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 65:77-83. 2004
    ..To investigate the impact of sexual abuse on clinical presentation and treatment outcome in depressed adolescents...
  32. pmc Brief interpersonal psychotherapy for depressed mothers whose children are receiving psychiatric treatment
    Holly A Swartz
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA
    Am J Psychiatry 165:1155-62. 2008
    ....
  33. pmc Schedule for affective disorders and schizophrenia for school-age children (K-SADS-PL) for the assessment of preschool children--a preliminary psychometric study
    Boris Birmaher
    University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Psychiatr Res 43:680-6. 2009
    ....
  34. ncbi request reprint Pediatric depression: is there evidence to improve evidence-based treatments?
    David A Brent
    University of Pittsburgh Medical Center, 200 Lothrop St, Pittsburgh, PA 15213 2582, USA
    J Child Psychol Psychiatry 50:143-52. 2009
    ..More effective treatments may emerge from being able to personalize interventions to the patient's cognitive, emotional, and developmental profile...
  35. ncbi request reprint Major depressive disorder in adolescents exposed to a friend's suicide
    Jeffrey A Bridge
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 42:1294-300. 2003
    ....
  36. ncbi request reprint Peripubertal suicide attempts in offspring of suicide attempters with siblings concordant for suicidal behavior
    David A Brent
    Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Am J Psychiatry 160:1486-93. 2003
    ....
  37. ncbi request reprint Sertraline pharmacokinetics and dynamics in adolescents
    David A Axelson
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 41:1037-44. 2002
    ..To determine the pharmacokinetics of sertraline in adolescents and assess its effect on a surrogate marker of serotonin transport...
  38. ncbi request reprint Psychosocial functioning in youths at high risk to develop major depressive disorder
    Boris Birmaher
    Department of Child Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 43:839-46. 2004
    ..To compare the psychosocial functioning of children and adolescents at high risk of major depressive disorder with youths with acute major depressive disorder and healthy controls...
  39. ncbi request reprint Acute antidepressant response and plasma levels of bupropion and metabolites in a pediatric-aged sample: an exploratory study
    W Burleson Daviss
    Western Psychiatric Institute and Clinic, Pittsburgh, PA, and the University of Pittsburgh, Pittsburgh, PA 15213, USA
    Ther Drug Monit 28:190-8. 2006
    ..009). These preliminary findings suggest that plasma levels of bupropion and metabolites, particularly hydroxybupropion, may predict acute antidepressant response in depressed youths taking bupropion SR...
  40. pmc History of suicide attempts in pediatric bipolar disorder: factors associated with increased risk
    Tina R Goldstein
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Bipolar Disord 7:525-35. 2005
    ..Despite evidence indicating high morbidity associated with pediatric bipolar disorder (BP), little is known about the prevalence and clinical correlates of suicidal behavior among this population...
  41. ncbi request reprint Steady-state pharmacokinetics of bupropion SR in juvenile patients
    W Burleson Daviss
    Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 44:349-57. 2005
    ..To examine the steady-state pharmacokinetic properties of bupropion sustained release (SR) and their potential developmental differences in youths...
  42. ncbi request reprint Citalopram treatment of pediatric recurrent abdominal pain and comorbid internalizing disorders: an exploratory study
    John V Campo
    Department of Pyschiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 43:1234-42. 2004
    ..To assess the potential efficacy, tolerability, and safety of citalopram in the treatment of functional pediatric recurrent abdominal pain and comorbid internalizing disorders...
  43. ncbi request reprint Recent trends in suicide among U.S. adolescent males, 1992-2001
    Jeffrey A Bridge
    University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213 2592, USA
    Psychiatr Serv 56:522. 2005
  44. pmc Family-based interpersonal psychotherapy for depressed preadolescents: an open-treatment trial
    Laura J Dietz
    University of Pittsburgh School of Medicine Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15206, USA
    Early Interv Psychiatry 2:154-61. 2008
    ....
  45. ncbi request reprint Adult outcomes of pediatric recurrent abdominal pain: do they just grow out of it?
    J V Campo
    University of Pittsburgh School of Medicine, Children s Hospital of Pittsburgh, and Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
    Pediatrics 108:E1. 2001
    ..To determine whether medically unexplained recurrent abdominal pain (RAP) in childhood predicts abdominal pain, irritable bowel syndrome (IBS), other somatic complaints, and psychiatric symptoms and disorders in young adulthood...
  46. ncbi request reprint Clinical practice. Adolescent depression
    David A Brent
    Western Psychiatric Institute and Clinic, Division of Child and Adolescent Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, USA
    N Engl J Med 347:667-71. 2002
  47. ncbi request reprint The prevalence and impact of large sudden improvements during adolescent therapy for depression: a comparison across cognitive-behavioral, family, and supportive therapy
    Scott T Gaynor
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    J Consult Clin Psychol 71:386-93. 2003
    ..These findings suggest pretreatment and sudden within-treatment gains are important therapeutic events worthy of further investigation...
  48. ncbi request reprint Adolescent suicide and suicidal behavior
    Jeffrey A Bridge
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Child Psychol Psychiatry 47:372-94. 2006
    ..On the basis of this review, clinical and public health approaches to the reduction in youth suicide and recommendations for further research will be discussed...
  49. ncbi request reprint Familial pathways to suicidal behavior--understanding and preventing suicide among adolescents
    David A Brent
    Services for Teens at Risk STAR Center at the University of Pittsburgh School of Medicine, Pittsburgh, USA
    N Engl J Med 355:2719-21. 2006
  50. ncbi request reprint The risks and benefits of antidepressant treatment for youth depression
    Jeffrey A Bridge
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2592, USA
    Ann Med 37:404-12. 2005
    ....
  51. ncbi request reprint Suicidality and its relationship to treatment outcome in depressed adolescents
    Rémy P Barbe
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2592, USA
    Suicide Life Threat Behav 34:44-55. 2004
    ..Hopelessness should be specifically targeted early in treatment. Suicidal depressed adolescents should not receive NST but a specific treatment like CBT...
  52. pmc Health risk behaviors in parentally bereaved youth
    Melissa Muñiz-Cohen
    Child and Adolescent Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Arch Pediatr Adolesc Med 164:621-4. 2010
    ..To investigate whether parentally bereaved offspring are more likely to engage in health risk behaviors than nonbereaved control offspring...
  53. pmc Family-focused treatment for adolescents with bipolar disorder: results of a 2-year randomized trial
    David J Miklowitz
    Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
    Arch Gen Psychiatry 65:1053-61. 2008
    ..Family interventions have been found to hasten episode recovery and delay recurrences among adults with bipolar disorder...
  54. ncbi request reprint A comparison of the medical lethality of suicide attempts in bipolar and major depressive disorders
    Gil Zalsman
    Division of Neuroscience, Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
    Bipolar Disord 8:558-65. 2006
    ....
  55. ncbi request reprint Posttraumatic stress disorder comorbid with major depression: factors mediating the association with suicidal behavior
    Maria Oquendo
    Department of Neuroscience, New York State Psychiatric Institute Columbia University, 1051 Riverside Dr, Unit 42, New York, NY 10032, USA
    Am J Psychiatry 162:560-6. 2005
    ....
  56. ncbi request reprint Human 5-HT1A receptor C(-1019)G polymorphism and psychopathology
    Yung Yu Huang
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Int J Neuropsychopharmacol 7:441-51. 2004
    ..The relationship does not appear to be explained by binding differences, although we cannot rule out altered receptor affinity and transduction...
  57. ncbi request reprint Adolescents with depression
    Jeffrey A Bridge
    JAMA 292:2578; author reply 2578-9. 2004
  58. ncbi request reprint Cognitive behavioral therapy for depression in youth
    V Robin Weersing
    Joint Doctoral Program in Clinical Psychology, San Diego State University University of California at San Diego, 6363 Alvarado Court, Suite 103, San Diego, CA 92120, USA
    Child Adolesc Psychiatr Clin N Am 15:939-57, ix. 2006
    ....
  59. ncbi request reprint Clinical response and risk for reported suicidal ideation and suicide attempts in pediatric antidepressant treatment: a meta-analysis of randomized controlled trials
    Jeffrey A Bridge
    Department of Pediatrics and Columbus Children s Research Institute, The Ohio State University, Columbus, USA
    JAMA 297:1683-96. 2007
    ..The US Food and Drug Administration (FDA) has issued warnings that use of antidepressant medications poses a small but significantly increased risk of suicidal ideation/suicide attempt for children and adolescents...
  60. pmc Family-focused treatment for adolescents with bipolar disorder
    David J Miklowitz
    Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
    J Affect Disord 82:S113-28. 2004
    ..The adult version of FFT has been shown to be effective in forestalling relapses in two randomized clinical trials involving bipolar adults...
  61. ncbi request reprint Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression
    Gil Zalsman
    Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Dr, Box 42, New York, NY 10032, USA
    Am J Psychiatry 163:1588-93. 2006
    ..The authors examined the relationship of a triallelic 5-HTTLPR polymorphism to stressful life events, severity of major depression, and suicidality...
  62. ncbi request reprint Criterion validity of the Mood and Feelings Questionnaire for depressive episodes in clinic and non-clinic subjects
    W Burleson Daviss
    Western Psychiatric Institute and Clinic and the University of Pittsburgh, USA
    J Child Psychol Psychiatry 47:927-34. 2006
    ..The current study re-examines the criterion validity of child- and parent-versions of the Mood and Feelings Questionnaire (MFQ-C, MFQ-P) in a heterogeneous sample of children and adolescents from clinic and non-clinic sources...
  63. ncbi request reprint Depressed patients with co-occurring alcohol use disorders: a unique patient population
    Leo Sher
    Department of Psychiatry, Columbia University, and New York State Psychiatric Institute, New York, NY 10032, USA
    J Clin Psychiatry 69:907-15. 2008
    ..Few studies have assessed the impact of comorbid alcohol use disorders (AUDs) on clinical aspects of major depression. We compared depressed subjects with and without co-occurring AUDs with respect to demographic and clinical parameters...
  64. ncbi request reprint Adolescent suicide and suicidal behavior: a time to assess and a time to treat
    David A Brent
    Isr J Psychiatry Relat Sci 40:159-62. 2003
  65. ncbi request reprint Is the medication bottle for pediatric and adolescent depression half-full or half-empty?
    David A Brent
    J Adolesc Health 37:431-3. 2005
  66. ncbi request reprint Decline in treatment of pediatric depression after FDA advisory on risk of suicidality with SSRIs
    Anne M Libby
    University of Colorado at Denver and Health Sciences Center, School of Medicine, Nighthorse Campbell Native Health Building, PO Box 6508, Campus Box F800, Aurora, CO 80045 0508, USA
    Am J Psychiatry 164:884-91. 2007
    ....
  67. ncbi request reprint The rewards of reducing risk
    David A Brent
    Arch Pediatr Adolesc Med 158:824-5. 2004
  68. ncbi request reprint Physical and emotional health of mothers of youth with functional abdominal pain
    John V Campo
    Department of Psychiatry, Columbus Children s Hospital, The Ohio State University, Columbus 43205, USA
    Arch Pediatr Adolesc Med 161:131-7. 2007
    ..To determine if mothers of youth with functional abdominal pain (FAP) experience more anxiety, depressive, and somatic symptoms and disorders than mothers of unaffected children...
  69. ncbi request reprint Frequency of provider contact after FDA advisory on risk of pediatric suicidality with SSRIs
    Elaine H Morrato
    University of Colorado, Denver, CO 80262, USA
    Am J Psychiatry 165:42-50. 2008
    ..In this study, the authors compared trends in the frequency of provider contacts for patients with depression before and after the advisory was issued...
  70. ncbi request reprint Family history of suicidal behavior and mood disorders in probands with mood disorders
    J John Mann
    Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Dr, Box 42, New York, NY 10032, USA
    Am J Psychiatry 162:1672-9. 2005
    ..This study examined the shared and distinctive factors associated with familial mood disorders and familial suicidal behavior...
  71. ncbi request reprint Paroxetine and the FDA
    David A Brent
    J Am Acad Child Adolesc Psychiatry 43:127-8. 2004
  72. ncbi request reprint Association of serotonin 5-HT2A receptor binding and the T102C polymorphism in depressed and healthy Caucasian subjects
    Vadim D Khait
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 30:166-72. 2005
    ..The TT genotype appears associated with higher platelet 5-HT2A Bmax in the healthy population, but this genotypic effect appears absent in mood disorders and unrelated to psychopathology...
  73. pmc Comorbid anxiety in bipolar disorder: does it have an independent effect on suicidality?
    Atsuo Nakagawa
    Department of Neuropsychiatry, School of Medicine, Keio University, Tokyo, Japan
    Bipolar Disord 10:530-8. 2008
    ..This study examined the impact of comorbid Cluster B personality disorder and anxiety disorder on suicidality in bipolar disorder...
  74. ncbi request reprint British warnings on SSRIs questioned
    David A Brent
    J Am Acad Child Adolesc Psychiatry 43:379-80. 2004
  75. ncbi request reprint [Depression in children and adolescents]
    Gil Zalsman
    Neuroscience Division, Columbia University, USA
    Harefuah 145:286-91, 318. 2006
    ..Further research is needed to assess the efficacy and safety of these interventions and to better understand the etiological factors...
  76. doi request reprint Completed suicide in childhood
    Kanita Dervic
    Department of Child and Adolescent Psychiatry University Hospital, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Psychiatr Clin North Am 31:271-91. 2008
    ..Cognitive immaturity/misjudgment, age-related impulsivity, and availability of suicide methods play an important role. Psychologic autopsy studies that focus on suicides in this age group are needed...
  77. ncbi request reprint Effectiveness of cognitive-behavioral therapy for adolescent depression: a benchmarking investigation
    V Robin Weersing
    Yale University School of Medicine, USA
    Behav Ther 37:36-48. 2006
    ..Results support further efforts to test the effectiveness of CBT in clinically representative community practice settings and samples...
  78. ncbi request reprint Delinquent accounts: does delinquency account for suicidal behavior?
    David A Brent
    J Adolesc Health 40:204-5. 2007

Research Grants28

  1. Impact of Parental Suicide in Children and Families
    David Brent; Fiscal Year: 2002
    ..The results of this study should be very useful in the design of preventive interventions for bereaved children and their families. ..
  2. TREATMENT OF SSRI-RESISTANT DEPRESSION IN ADOLESCENTS
    David Brent; Fiscal Year: 2006
    ..This site is based in Pittsburgh, which also serves as the Data Coordinating Center for the study ..
  3. ACISR - Early-Onset Mood & Anxiety Disorder
    David Brent; Fiscal Year: 2006
    ..The Center will enhance the development of the next generation of intervention and services researchers and will disseminate new research information to families, practitioners, and researchers. ..
  4. Prevention of Depression in At-Risk Adolescents
    David Brent; Fiscal Year: 2007
    ..This application is based in Nashville (Judy Garber, PI), and interlocks with applications from Boston (William Beardslee, PI), Pittsburgh (David Brent, PI), and Portland (Greg Clarke, PI). ..
  5. CLINICAL RESEARCH TRAINING IN CHILD PSYCHIATRY
    David Brent; Fiscal Year: 2007
    ..abstract_text> ..
  6. Impact of Sudden Parental Death on Children and Families
    David Brent; Fiscal Year: 2009
    ..However, there have been no long-term, controlled, prospective studies of the effects of parental bereavement on children. ..
  7. 1/2-Familial Pathways to Early-Onset Suicide Attempt
    David Brent; Fiscal Year: 2009
    ....
  8. 3/4-Prevention of Depression: Impact on the Transition to Early Adulthood
    David Brent; Fiscal Year: 2009
    ..This study also will identify youth who are most likely to benefit from this program, and will inform us about how to create future prevention programs that help those youth who did not benefit. ..
  9. Impact of Sudden Parental Death on Children and Families
    David A Brent; Fiscal Year: 2010
    ..However, there have been no long-term, controlled, prospective studies of the effects of parental bereavement on children. ..
  10. 3/4-Prevention of Depression: Impact on the Transition to Early Adulthood
    David A Brent; Fiscal Year: 2010
    ..This study also will identify youth who are most likely to benefit from this program, and will inform us about how to create future prevention programs that help those youth who did not benefit. ..
  11. 1/2-Familial Pathways to Early-Onset Suicide Attempt
    David A Brent; Fiscal Year: 2010
    ....
  12. Impact of Parental Suicide in Children and Families
    David Brent; Fiscal Year: 2006
    ..The results of this study should be very useful in the design of preventive interventions for bereaved children and their families. ..
  13. FAMILIAL PATHWAYS TO EARLY-ONSET SUICIDE ATTEMPTS
    David Brent; Fiscal Year: 2006
    ..This study should lead to an empirical basis for the prevention and treatment of suicidal behavior. ..
  14. FAMILIAL PATHWAYS TO EARLY-ONSET SUICIDE ATTEMPTS
    David Brent; Fiscal Year: 2002
    ..This study should lead to an empirical basis for the prevention and treatment of suicidal behavior. ..
  15. RUPP-PI
    David Brent; Fiscal Year: 2002
    ..The expertise and experience at this RUPP-PI site also will be directed to train new investigators. In creating TASA, a collaborative group of 8 applicants forged the ability to work together. ..
  16. Prevention of Depression in At-Risk Adolescents
    David Brent; Fiscal Year: 2003
    ..This application is based in Nashville (Judy Garber, PI), and interlocks with applications from Boston (William Beardslee, PI), Pittsburgh (David Brent, PI), and Portland (Greg Clarke, PI). ..
  17. FAMILIAL PATHWAYS TO EARLY-ONSET SUICIDE ATTEMPTS
    David Brent; Fiscal Year: 2003
    ..This study should lead to an empirical basis for the prevention and treatment of suicidal behavior. ..
  18. Impact of Parental Suicide in Children and Families
    David Brent; Fiscal Year: 2003
    ..The results of this study should be very useful in the design of preventive interventions for bereaved children and their families. ..
  19. Prevention of Depression in At-Risk Adolescents
    David Brent; Fiscal Year: 2004
    ..This application is based in Nashville (Judy Garber, PI), and interlocks with applications from Boston (William Beardslee, PI), Pittsburgh (David Brent, PI), and Portland (Greg Clarke, PI). ..
  20. FAMILIAL PATHWAYS TO EARLY-ONSET SUICIDE ATTEMPTS
    David Brent; Fiscal Year: 2004
    ..This study should lead to an empirical basis for the prevention and treatment of suicidal behavior. ..
  21. Impact of Parental Suicide in Children and Families
    David Brent; Fiscal Year: 2004
    ..The results of this study should be very useful in the design of preventive interventions for bereaved children and their families. ..
  22. Prevention of Depression in At-Risk Adolescents
    David Brent; Fiscal Year: 2005
    ..This application is based in Nashville (Judy Garber, PI), and interlocks with applications from Boston (William Beardslee, PI), Pittsburgh (David Brent, PI), and Portland (Greg Clarke, PI). ..
  23. FAMILIAL PATHWAYS TO EARLY-ONSET SUICIDE ATTEMPTS
    David Brent; Fiscal Year: 2005
    ..This study should lead to an empirical basis for the prevention and treatment of suicidal behavior. ..
  24. Impact of Parental Suicide in Children and Families
    David Brent; Fiscal Year: 2005
    ..The results of this study should be very useful in the design of preventive interventions for bereaved children and their families. ..
  25. Prevention of Depression in At-Risk Adolescents
    David Brent; Fiscal Year: 2006
    ..This application is based in Nashville (Judy Garber, PI), and interlocks with applications from Boston (William Beardslee, PI), Pittsburgh (David Brent, PI), and Portland (Greg Clarke, PI). ..
  26. 2/2-Brief CBT for Pediatric Anxiety and Depression in Primary Care
    David A Brent; Fiscal Year: 2010
    ..This will be the first study to assess if anxiety and depression can be treated with one, simple program, and results may help move effective treatments for these serious problems into community practice. ..