Research Topics
| Matthew BrennerSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Sulfanegen sodium treatment in a rabbit model of sub-lethal cyanide toxicityMatthew Brenner
Laser Microbeam and Medical Program, Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92612 1475, USA
Toxicol Appl Pharmacol 248:269-76. 2010..DOS and CWNIRS demonstrated their usefulness in optimizing the dose of sulfanegen sodium treatment...- Comparison of cobinamide to hydroxocobalamin in reversing cyanide physiologic effects in rabbits using diffuse optical spectroscopy monitoringMatthew Brenner
University of California, Beckman Laser Institute, Irvine, California 92612 1475, USA
J Biomed Opt 15:017001. 2010.... - Intramuscular cobinamide sulfite in a rabbit model of sublethal cyanide toxicityMatthew Brenner
Laser Microbeam and Medical Program, Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA, USA
Ann Emerg Med 55:352-63. 2010.... 
Detection of acute smoke-induced airway injury in a New Zealand white rabbit model using optical coherence tomographyMatthew Brenner
University of California Irvine, Beckman Laser Institute, Irvine, California 92612, USA
J Biomed Opt 12:051701. 2007..These studies suggest that OCT may have the ability to provide information on potential early indicators of impending smoke-inhalation-induced airway compromise...- Innovative approaches to lung volume reduction for emphysemaMatt Brenner
Division of Pulmonary Medicine and Beckman Laser Institute, University of California Irvine Medical Center, Orange, 92868, USA
Chest 126:238-48. 2004..Extensive research in the near future will help to determine the potential clinical applicability of these new approaches to the treatment of emphysema symptoms... - In vivo optical coherence tomography detection of differences in regional large airway smoke inhalation induced injury in a rabbit modelMatthew Brenner
University of California, Irvine, Beckman Laser Institute, Irvine, California 92612, USA
J Biomed Opt 13:034001. 2008..OCT is capable of quantitatively detecting regional changes in airway swelling following inhalation injury... - Noninvasive in vivo monitoring of cyanide toxicity and treatment using diffuse optical spectroscopy in a rabbit modelJangwoen Lee
Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, 1002 Health Sciences Road East, Irvine, CA 92612 1475, USA
Mil Med 174:615-21. 2009..Therefore, DOS enables detection and monitoring of CN toxicity and treatment with NaNO2... 
Noninvasive monitoring of treatment response in a rabbit cyanide toxicity model reveals differences in brain and muscle metabolismJae G Kim
Beckman Laser Institute and Medical Clinic, University of California, Irvine, 1002 Health Sciences Road East, Irvine, California 92612, USA
J Biomed Opt 17:105005. 2012..In vivo monitoring of multiple organs may provide important clinical information regarding the extent of CN toxicity and subsequent recovery, and facilitate antidote drug development...- Real-time swept source optical coherence tomography imaging of the human airway using a microelectromechanical system endoscope and digital signal processorJianping Su
University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92612, USA
J Biomed Opt 13:030506. 2008..To couple with the system speed, an endoscope based on an improved 3-D microelectromechanical motor (diameter 1.5 mm, length 9.4 mm) was developed. In vivo 3-D imaging of the human airway was demonstrated... - Detection and monitoring of early airway injury effects of half-mustard (2-chloroethylethylsulfide) exposure using high-resolution optical coherence tomographyKelly A Kreuter
University of California, Irvine, Beckman Laser Institute, Irvine, California 92612, USA
J Biomed Opt 14:044037. 2009..OCT has the potential to be a high resolution imaging modality capable of detecting, assessing, and monitoring treatment for airway injury following mustard vesicant agent exposures... - Potential interference by hydroxocobalamin on cooximetry hemoglobin measurements during cyanide and smoke inhalation treatmentsJangwoen Lee
Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, CA, USA
Ann Emerg Med 49:802-5. 2007.... - Feasibility of three-dimensional optical coherence tomography and optical Doppler tomography of malignancy in hamster cheek pouchesNevine M Hanna
Irvine Beckman Laser Institute, University of California Irvine, Irvine, California, USA
Photomed Laser Surg 24:402-9. 2006..ODT demonstrated increased vascularity in the area of neoplasia. OCT/ODT is a promising new technology for oral airway diagnostics... - Broadband diffuse optical spectroscopy assessment of hemorrhage- and hemoglobin-based blood substitute resuscitationJangwoen Lee
University of California, Irvine, Beckman Laser Institute and Medical Clinic, 1002 Health Sciences Road East, Irvine, California 92612, USA
J Biomed Opt 14:044027. 2009.... - Tissue hemoglobin monitoring of progressive central hypovolemia in humans using broadband diffuse optical spectroscopyJangwoen Lee
University of California, Irvine, Beckman Laser Institute and Medical Clinic, 1002 Health Sciences Road East, Irvine, California 92612, USA
J Biomed Opt 13:064027. 2008.... - In vivo three-dimensional imaging of normal tissue and tumors in the rabbit pleural cavity using endoscopic swept source optical coherence tomography with thoracoscopic guidanceTuqiang Xie
University of California Irvine, Beckman Laser Institute, 1002 Health Sciences Road East, Irvine, California 92612, USA
J Biomed Opt 14:064045. 2009..The imaging probe of the system was found to be easily adaptable to various sites within the thoracic cavity and can be readily adapted to other sites, including rigid airway endoscopic examinations... - Fiber-optic-bundle-based optical coherence tomographyTuqiang Xie
Beckman Laser Institute, Department of Biomedical Engineering, Pulmonary and Critical Care Division, UC Irvine Medical Center, University of California, Irvine, Irvine, California 92612, USA
Opt Lett 30:1803-5. 2005.... - Evaluation of tracheal imaging by optical coherence tomographySukgu Han
Department of Biomedical Engineering, Beckman Laser Institute Irvine, Irvine, California, USA
Respiration 72:537-41. 2005..Conclusion: These findings suggest that integration of OCT with flexible fiberoptic bronchoscopy could enhance pulmonary diagnostic medicine and detection of pathologic tissue changes in various respiratory diseases... - Evaluation of rabbit tracheal inflammation using optical coherence tomographyUsama Mahmood
Beckman Laser Institute, UC Irvine Medical Center, Building 53, Room 119, 101 City Dr South, Orange, CA 92868, USA
Chest 130:863-8. 2006..Numerous applications of OCT can be envisioned in the realm of pulmonary medicine and thoracic surgery that may substantially increase the precision and accuracy of current bronchoscopic diagnostic and surgical techniques... - Linking optics and mechanics in an in vivo model of airway fibrosis and epithelial injuryChristopher B Raub
University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92697 2730, USA
J Biomed Opt 15:015004. 2010..SHG depth decay is sensitive to changes in extracellular matrix content and correlates with bulk Young's modulus... - Noninvasive in vivo monitoring of methemoglobin formation and reduction with broadband diffuse optical spectroscopyJangwoen Lee
Laser Microbeam and Medical Program, Beckman Laser Institute, 1002 Health Sciences Rd. East, University of California, Irvine, CA 92612-1475, USA
J Appl Physiol 100:615-22. 2006..These techniques are expected to be useful in evaluating dynamics of drug delivery and therapeutic efficacy in blood chemistry, human, and preclinical animal models... - Use of an oxygen-carrying blood substitute to improve intravascular optical coherence tomography imagingKhiet C Hoang
University of California, Irvine, Department of Medicine, Division of Cardiology, 101 The City Drive, Building 53, Room 100, Route 81, Orange, California 92868, USA
J Biomed Opt 14:034028. 2009..From this proof-of-concept study, we demonstrate that endovascular flushing with an oxygen-carrying blood substitute (PFD) is optically superior to saline flushing for intravascular imaging... - Investigating in vivo airway wall mechanics during tidal breathing with optical coherence tomographyClaire Robertson
University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92697, USA
J Biomed Opt 16:106011. 2011..The technique may have applications in assessing airway mechanics in diseases such as asthma that are characterized by significant airway remodeling... - Development of a rabbit pleural cancer model by using VX2 tumorsKelly A Kreuter
Beckman Laser Institute, University of California Irvine, Irvine, CA, USA
Comp Med 58:287-93. 2008..This novel pleural tumor model induction method likely will facilitate a broad range of investigations of pleural cancer diagnostics and therapeutics... - Non-invasive in vivo diffuse optical spectroscopy monitoring of cyanide poisoning in a rabbit modelJangwoen Lee
Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, CA 92612 1475, USA
Physiol Meas 28:1057-66. 2007..Changes in tissue scattering properties in all six animals were detected during these events, confirming the need for DOS-based methods over traditional NIR spectroscopy to obtain accurate results... - In vivo optical coherence tomography for the diagnosis of oral malignancyPetra Wilder-Smith
Beckman Laser Institute, University of California Irvine, 1002 Health Sciences Road East, Irvine, CA 92612, USA
Lasers Surg Med 35:269-75. 2004..Objective was to investigate in vivo non-invasive optical coherence tomography (OCT) techniques for imaging and diagnosing neoplasia-related epithelial, sub-epithelial changes throughout carcinogenesis... - In vivo endoscopic optical coherence tomography by use of a rotational microelectromechanical system probePeter H Tran
Department of Biomedical Engineering and Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA
Opt Lett 29:1236-8. 2004..Because our MEMS scanner does not require the coupling of a rotational single-mode fiber, a high scanning speed is possible while eliminating unstable optical signals caused by nonuniform coupling... - Noninvasive monitoring of hemodynamic stress using quantitative near-infrared frequency-domain photon migration spectroscopyTuan H Pham
University of California, Beckman Laser Institute and Medical Clinic, Irvine, California, USA
J Biomed Opt 7:34-44. 2002..These results suggest that FDPM spectroscopy may be used in clinical settings to noninvasively monitor central hemodynamic parameters and to directly assess oxygenation of tissues... - Feasibility study of normal and septic tracheal imaging using optical coherence tomographyWoonggyu Jung
Beckman Laser Institute, University of California, Irvine, California 92612, USA
Lasers Surg Med 35:121-7. 2004..Marked differences between normal and septic trachea were apparent in OCT images. In the future, OCT may be a valuable tool for evaluating tracheal pathology in situ with high image resolution... - New facile method to measure cyanide in bloodWilliam C Blackledge
Department of Medicine, University of California, San Diego, La Jolla, California 92093 0652, USA
Anal Chem 82:4216-21. 2010..Moreover, we adapted it for rapid qualitative assessment of cyanide concentration, which could be used in the field to identify cyanide-poisoned subjects for immediate treatment... - In vivo multiphoton fluorescence imaging: a novel approach to oral malignancyPetra Wilder-Smith
Beckman Laser Institute, University of California, Irvine, California 92612, USA
Lasers Surg Med 35:96-103. 2004..These studies evaluated in vivo multiphoton excited fluorescence (MPM) techniques to (1) map epithelial and subepithelial changes through out oral carcinogenesis and (2) serve as an effective diagnostic modality... - Multimodality bronchoscopic [corrected] imaging of tracheopathica osteochondroplasticaHenri Colt
University of California School of Medicine, Pulmonary and Critical Care Medicine, Department of Medicine, 101 The City Drive South, Building 53, Room 119, Route 81 Orange, California 92868, USA
J Biomed Opt 14:034035. 2009..Further studies are needed to optimize these systems for pulmonary applications and to determine how new-generation imaging modalities will be integrated into a multimodality bronchoscopy platform... - Multimodal imaging guidance for laser ablation in tracheal stenosisSeptimiu D Murgu
Pulmonary and Critical Care Medicine, Department of Medicine, University of California School of Medicine, Irvine, California, USA
Laryngoscope 120:1840-6. 2010.... - Multimodality bronchoscopic imaging of recurrent respiratory papillomatosisHenri G Colt
Pulmonary and Critical Care Medicine, Department of Medicine, University of California School of Medicine, Irvine, California, USA
Laryngoscope 120:468-72. 2010.... - Optical coherence tomography of malignancy in hamster cheek pouchesErin S Matheny
Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA
J Biomed Opt 9:978-81. 2004..The feasibility of high-resolution functional imaging is demonstrated in this hamster cheek pouch tumor model. ODT accurately detects vascular change associated with carcinogenesis... - New National Emphysema Treatment Trial paradigm of Health Care Financing Administration-sponsored clinical research trials: advances and dilemmasMatthew Brenner
Division of Pulmonary Medicine, Beckman Laser Institute, UCI Medical Center, Orange, CA 92868-3298, USA
J Investig Med 50:95-100. 2002 - Airway epithelium stimulates smooth muscle proliferationNikita K Malavia
Department of Chemical, Biochemical Engineering and Material Science, 3120 Natural Sciences II, University of California, Irvine, Irvine, CA 92697 2715, USA
Am J Respir Cell Mol Biol 41:297-304. 2009.... - Effects of a novel implantable elastomer device for lung volume reduction surgery in a rabbit model of elastase-induced emphysemaMatthew Brenner
Pulmonary and Critical Care Medicine Division, University of California Irvine Medical Center, Orange, CA 92868-3298, USA
Chest 121:201-9. 2002..Limitations include the short-term follow-up and moderate degree of emphysema in this animal model. Further research is required to assess long-term effects and complications of this method for lung volume reduction... - Integrated intravascular optical coherence tomography (OCT) - ultrasound (US) catheter for characterization of atherosclerotic plaques in vivoJiawen Li
Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA
Conf Proc IEEE Eng Med Biol Soc 2012:3175-8. 2012..In addition, in vitro imaging of cadaver coronary arteries were conducted to demonstrate the imaging capabilities of this integrated catheter to classify different atherosclerotic plaque types... - In vivo three-dimensional spectral domain endoscopic optical coherence tomography using a microelectromechanical system mirrorWoonggyu Jung
Beckman Laser Institute and Department of Biomedical Engineering, University of California, Irvine, USA
Opt Lett 32:3239-41. 2007..The device was integrated with a conventional endoscope and utilized to generate in vivo 3-D clinical images in humans and animals...
Research Grants
- High Resolution Optical Coherence Tomography for Early Airway Cancer DetectionMatthew Brenner; Fiscal Year: 2007..This extension of novel engineering imaging ideas to the treatment should also enable a range of other pulmonary and non-pulmonary scope imaging applications ..
- High Resolution Optical Coherence Tomography for Early Airway Cancer DetectionMatthew Brenner; Fiscal Year: 2010..This extension of novel engineering imaging ideas to the treatment should also enable a range of other pulmonary and non-pulmonary scope imaging applications ..