Matthew Brenner

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Sulfanegen sodium treatment in a rabbit model of sub-lethal cyanide toxicity
    Matthew Brenner
    Laser Microbeam and Medical Program, Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92612 1475, USA
    Toxicol Appl Pharmacol 248:269-76. 2010
  2. pmc Comparison of cobinamide to hydroxocobalamin in reversing cyanide physiologic effects in rabbits using diffuse optical spectroscopy monitoring
    Matthew Brenner
    University of California, Beckman Laser Institute, Irvine, California 92612 1475, USA
    J Biomed Opt 15:017001. 2010
  3. pmc Intramuscular cobinamide sulfite in a rabbit model of sublethal cyanide toxicity
    Matthew Brenner
    Laser Microbeam and Medical Program, Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA, USA
    Ann Emerg Med 55:352-63. 2010
  4. ncbi request reprint Detection of acute smoke-induced airway injury in a New Zealand white rabbit model using optical coherence tomography
    Matthew Brenner
    University of California Irvine, Beckman Laser Institute, Irvine, California 92612, USA
    J Biomed Opt 12:051701. 2007
  5. ncbi request reprint Innovative approaches to lung volume reduction for emphysema
    Matt Brenner
    Division of Pulmonary Medicine and Beckman Laser Institute, University of California Irvine Medical Center, Orange, 92868, USA
    Chest 126:238-48. 2004
  6. pmc In vivo optical coherence tomography detection of differences in regional large airway smoke inhalation induced injury in a rabbit model
    Matthew Brenner
    University of California, Irvine, Beckman Laser Institute, Irvine, California 92612, USA
    J Biomed Opt 13:034001. 2008
  7. ncbi request reprint Noninvasive in vivo monitoring of cyanide toxicity and treatment using diffuse optical spectroscopy in a rabbit model
    Jangwoen Lee
    Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, 1002 Health Sciences Road East, Irvine, CA 92612 1475, USA
    Mil Med 174:615-21. 2009
  8. pmc Noninvasive monitoring of treatment response in a rabbit cyanide toxicity model reveals differences in brain and muscle metabolism
    Jae G Kim
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, 1002 Health Sciences Road East, Irvine, California 92612, USA
    J Biomed Opt 17:105005. 2012
  9. pmc Real-time swept source optical coherence tomography imaging of the human airway using a microelectromechanical system endoscope and digital signal processor
    Jianping Su
    University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92612, USA
    J Biomed Opt 13:030506. 2008
  10. pmc Detection and monitoring of early airway injury effects of half-mustard (2-chloroethylethylsulfide) exposure using high-resolution optical coherence tomography
    Kelly A Kreuter
    University of California, Irvine, Beckman Laser Institute, Irvine, California 92612, USA
    J Biomed Opt 14:044037. 2009

Collaborators

Detail Information

Publications39

  1. pmc Sulfanegen sodium treatment in a rabbit model of sub-lethal cyanide toxicity
    Matthew Brenner
    Laser Microbeam and Medical Program, Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92612 1475, USA
    Toxicol Appl Pharmacol 248:269-76. 2010
    ..DOS and CWNIRS demonstrated their usefulness in optimizing the dose of sulfanegen sodium treatment...
  2. pmc Comparison of cobinamide to hydroxocobalamin in reversing cyanide physiologic effects in rabbits using diffuse optical spectroscopy monitoring
    Matthew Brenner
    University of California, Beckman Laser Institute, Irvine, California 92612 1475, USA
    J Biomed Opt 15:017001. 2010
    ....
  3. pmc Intramuscular cobinamide sulfite in a rabbit model of sublethal cyanide toxicity
    Matthew Brenner
    Laser Microbeam and Medical Program, Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA, USA
    Ann Emerg Med 55:352-63. 2010
    ....
  4. ncbi request reprint Detection of acute smoke-induced airway injury in a New Zealand white rabbit model using optical coherence tomography
    Matthew Brenner
    University of California Irvine, Beckman Laser Institute, Irvine, California 92612, USA
    J Biomed Opt 12:051701. 2007
    ..These studies suggest that OCT may have the ability to provide information on potential early indicators of impending smoke-inhalation-induced airway compromise...
  5. ncbi request reprint Innovative approaches to lung volume reduction for emphysema
    Matt Brenner
    Division of Pulmonary Medicine and Beckman Laser Institute, University of California Irvine Medical Center, Orange, 92868, USA
    Chest 126:238-48. 2004
    ..Extensive research in the near future will help to determine the potential clinical applicability of these new approaches to the treatment of emphysema symptoms...
  6. pmc In vivo optical coherence tomography detection of differences in regional large airway smoke inhalation induced injury in a rabbit model
    Matthew Brenner
    University of California, Irvine, Beckman Laser Institute, Irvine, California 92612, USA
    J Biomed Opt 13:034001. 2008
    ..OCT is capable of quantitatively detecting regional changes in airway swelling following inhalation injury...
  7. ncbi request reprint Noninvasive in vivo monitoring of cyanide toxicity and treatment using diffuse optical spectroscopy in a rabbit model
    Jangwoen Lee
    Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, 1002 Health Sciences Road East, Irvine, CA 92612 1475, USA
    Mil Med 174:615-21. 2009
    ..Therefore, DOS enables detection and monitoring of CN toxicity and treatment with NaNO2...
  8. pmc Noninvasive monitoring of treatment response in a rabbit cyanide toxicity model reveals differences in brain and muscle metabolism
    Jae G Kim
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, 1002 Health Sciences Road East, Irvine, California 92612, USA
    J Biomed Opt 17:105005. 2012
    ..In vivo monitoring of multiple organs may provide important clinical information regarding the extent of CN toxicity and subsequent recovery, and facilitate antidote drug development...
  9. pmc Real-time swept source optical coherence tomography imaging of the human airway using a microelectromechanical system endoscope and digital signal processor
    Jianping Su
    University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92612, USA
    J Biomed Opt 13:030506. 2008
    ..To couple with the system speed, an endoscope based on an improved 3-D microelectromechanical motor (diameter 1.5 mm, length 9.4 mm) was developed. In vivo 3-D imaging of the human airway was demonstrated...
  10. pmc Detection and monitoring of early airway injury effects of half-mustard (2-chloroethylethylsulfide) exposure using high-resolution optical coherence tomography
    Kelly A Kreuter
    University of California, Irvine, Beckman Laser Institute, Irvine, California 92612, USA
    J Biomed Opt 14:044037. 2009
    ..OCT has the potential to be a high resolution imaging modality capable of detecting, assessing, and monitoring treatment for airway injury following mustard vesicant agent exposures...
  11. ncbi request reprint Potential interference by hydroxocobalamin on cooximetry hemoglobin measurements during cyanide and smoke inhalation treatments
    Jangwoen Lee
    Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, CA, USA
    Ann Emerg Med 49:802-5. 2007
    ....
  12. ncbi request reprint Feasibility of three-dimensional optical coherence tomography and optical Doppler tomography of malignancy in hamster cheek pouches
    Nevine M Hanna
    Irvine Beckman Laser Institute, University of California Irvine, Irvine, California, USA
    Photomed Laser Surg 24:402-9. 2006
    ....
  13. pmc Broadband diffuse optical spectroscopy assessment of hemorrhage- and hemoglobin-based blood substitute resuscitation
    Jangwoen Lee
    University of California, Irvine, Beckman Laser Institute and Medical Clinic, 1002 Health Sciences Road East, Irvine, California 92612, USA
    J Biomed Opt 14:044027. 2009
    ....
  14. doi request reprint Tissue hemoglobin monitoring of progressive central hypovolemia in humans using broadband diffuse optical spectroscopy
    Jangwoen Lee
    University of California, Irvine, Beckman Laser Institute and Medical Clinic, 1002 Health Sciences Road East, Irvine, California 92612, USA
    J Biomed Opt 13:064027. 2008
    ....
  15. pmc In vivo three-dimensional imaging of normal tissue and tumors in the rabbit pleural cavity using endoscopic swept source optical coherence tomography with thoracoscopic guidance
    Tuqiang Xie
    University of California Irvine, Beckman Laser Institute, 1002 Health Sciences Road East, Irvine, California 92612, USA
    J Biomed Opt 14:064045. 2009
    ..The imaging probe of the system was found to be easily adaptable to various sites within the thoracic cavity and can be readily adapted to other sites, including rigid airway endoscopic examinations...
  16. ncbi request reprint Fiber-optic-bundle-based optical coherence tomography
    Tuqiang Xie
    Beckman Laser Institute, Department of Biomedical Engineering, Pulmonary and Critical Care Division, UC Irvine Medical Center, University of California, Irvine, Irvine, California 92612, USA
    Opt Lett 30:1803-5. 2005
    ....
  17. ncbi request reprint Evaluation of tracheal imaging by optical coherence tomography
    Sukgu Han
    Department of Biomedical Engineering, Beckman Laser Institute Irvine, Irvine, California, USA
    Respiration 72:537-41. 2005
    ..Recent advances in data acquisition, analysis, and processing enable real-time imaging, and make OCT a potentially valuable tool for pulmonary airway diagnostic applications, including assisting directed airway biopsies...
  18. ncbi request reprint Evaluation of rabbit tracheal inflammation using optical coherence tomography
    Usama Mahmood
    Beckman Laser Institute, UC Irvine Medical Center, Building 53, Room 119, 101 City Dr South, Orange, CA 92868, USA
    Chest 130:863-8. 2006
    ..The purpose of this study was to evaluate the feasibility of using OCT for detecting airway pathology in a septic animal model...
  19. pmc Linking optics and mechanics in an in vivo model of airway fibrosis and epithelial injury
    Christopher B Raub
    University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92697 2730, USA
    J Biomed Opt 15:015004. 2010
    ..SHG depth decay is sensitive to changes in extracellular matrix content and correlates with bulk Young's modulus...
  20. ncbi request reprint Noninvasive in vivo monitoring of methemoglobin formation and reduction with broadband diffuse optical spectroscopy
    Jangwoen Lee
    Laser Microbeam and Medical Program, Beckman Laser Institute, 1002 Health Sciences Rd East, University of California, Irvine, CA 92612 1475, USA
    J Appl Physiol 100:615-22. 2006
    ..These techniques are expected to be useful in evaluating dynamics of drug delivery and therapeutic efficacy in blood chemistry, human, and preclinical animal models...
  21. pmc Use of an oxygen-carrying blood substitute to improve intravascular optical coherence tomography imaging
    Khiet C Hoang
    University of California, Irvine, Department of Medicine, Division of Cardiology, 101 The City Drive, Building 53, Room 100, Route 81, Orange, California 92868, USA
    J Biomed Opt 14:034028. 2009
    ..From this proof-of-concept study, we demonstrate that endovascular flushing with an oxygen-carrying blood substitute (PFD) is optically superior to saline flushing for intravascular imaging...
  22. pmc Investigating in vivo airway wall mechanics during tidal breathing with optical coherence tomography
    Claire Robertson
    University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92697, USA
    J Biomed Opt 16:106011. 2011
    ..The technique may have applications in assessing airway mechanics in diseases such as asthma that are characterized by significant airway remodeling...
  23. pmc Development of a rabbit pleural cancer model by using VX2 tumors
    Kelly A Kreuter
    Beckman Laser Institute, University of California Irvine, Irvine, CA, USA
    Comp Med 58:287-93. 2008
    ..This novel pleural tumor model induction method likely will facilitate a broad range of investigations of pleural cancer diagnostics and therapeutics...
  24. ncbi request reprint Non-invasive in vivo diffuse optical spectroscopy monitoring of cyanide poisoning in a rabbit model
    Jangwoen Lee
    Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, CA 92612 1475, USA
    Physiol Meas 28:1057-66. 2007
    ..Changes in tissue scattering properties in all six animals were detected during these events, confirming the need for DOS-based methods over traditional NIR spectroscopy to obtain accurate results...
  25. ncbi request reprint In vivo optical coherence tomography for the diagnosis of oral malignancy
    Petra Wilder-Smith
    Beckman Laser Institute, University of California Irvine, 1002 Health Sciences Road East, Irvine, CA 92612, USA
    Lasers Surg Med 35:269-75. 2004
    ..Objective was to investigate in vivo non-invasive optical coherence tomography (OCT) techniques for imaging and diagnosing neoplasia-related epithelial, sub-epithelial changes throughout carcinogenesis...
  26. ncbi request reprint In vivo endoscopic optical coherence tomography by use of a rotational microelectromechanical system probe
    Peter H Tran
    Department of Biomedical Engineering and Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA
    Opt Lett 29:1236-8. 2004
    ..Because our MEMS scanner does not require the coupling of a rotational single-mode fiber, a high scanning speed is possible while eliminating unstable optical signals caused by nonuniform coupling...
  27. ncbi request reprint Noninvasive monitoring of hemodynamic stress using quantitative near-infrared frequency-domain photon migration spectroscopy
    Tuan H Pham
    University of California, Beckman Laser Institute and Medical Clinic, Irvine, California, USA
    J Biomed Opt 7:34-44. 2002
    ..These results suggest that FDPM spectroscopy may be used in clinical settings to noninvasively monitor central hemodynamic parameters and to directly assess oxygenation of tissues...
  28. ncbi request reprint Feasibility study of normal and septic tracheal imaging using optical coherence tomography
    Woonggyu Jung
    Beckman Laser Institute, University of California, Irvine, California 92612, USA
    Lasers Surg Med 35:121-7. 2004
    ..The goal of this study was to evaluate the feasibility of OCT to image tracheal pathology...
  29. pmc New facile method to measure cyanide in blood
    William C Blackledge
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0652, USA
    Anal Chem 82:4216-21. 2010
    ..Moreover, we adapted it for rapid qualitative assessment of cyanide concentration, which could be used in the field to identify cyanide-poisoned subjects for immediate treatment...
  30. ncbi request reprint In vivo multiphoton fluorescence imaging: a novel approach to oral malignancy
    Petra Wilder-Smith
    Beckman Laser Institute, University of California, Irvine, California 92612, USA
    Lasers Surg Med 35:96-103. 2004
    ..These studies evaluated in vivo multiphoton excited fluorescence (MPM) techniques to (1) map epithelial and subepithelial changes through out oral carcinogenesis and (2) serve as an effective diagnostic modality...
  31. doi request reprint Multimodality bronchoscopic [corrected] imaging of tracheopathica osteochondroplastica
    Henri Colt
    University of California School of Medicine, Pulmonary and Critical Care Medicine, Department of Medicine, 101 The City Drive South, Building 53, Room 119, Route 81 Orange, California 92868, USA
    J Biomed Opt 14:034035. 2009
    ..Further studies are needed to optimize these systems for pulmonary applications and to determine how new-generation imaging modalities will be integrated into a multimodality bronchoscopy platform...
  32. doi request reprint Multimodal imaging guidance for laser ablation in tracheal stenosis
    Septimiu D Murgu
    Pulmonary and Critical Care Medicine, Department of Medicine, University of California School of Medicine, Irvine, California, USA
    Laryngoscope 120:1840-6. 2010
    ....
  33. pmc Multimodality bronchoscopic imaging of recurrent respiratory papillomatosis
    Henri G Colt
    Pulmonary and Critical Care Medicine, Department of Medicine, University of California School of Medicine, Irvine, California, USA
    Laryngoscope 120:468-72. 2010
    ....
  34. ncbi request reprint Optical coherence tomography of malignancy in hamster cheek pouches
    Erin S Matheny
    Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA
    J Biomed Opt 9:978-81. 2004
    ..The feasibility of high-resolution functional imaging is demonstrated in this hamster cheek pouch tumor model. ODT accurately detects vascular change associated with carcinogenesis...
  35. ncbi request reprint New National Emphysema Treatment Trial paradigm of Health Care Financing Administration-sponsored clinical research trials: advances and dilemmas
    Matthew Brenner
    Division of Pulmonary Medicine, Beckman Laser Institute, UCI Medical Center, Orange, CA 92868 3298, USA
    J Investig Med 50:95-100. 2002
  36. pmc Airway epithelium stimulates smooth muscle proliferation
    Nikita K Malavia
    Department of Chemical, Biochemical Engineering and Material Science, 3120 Natural Sciences II, University of California, Irvine, Irvine, CA 92697 2715, USA
    Am J Respir Cell Mol Biol 41:297-304. 2009
    ....
  37. doi request reprint Integrated intravascular optical coherence tomography (OCT) - ultrasound (US) catheter for characterization of atherosclerotic plaques in vivo
    Jiawen Li
    Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA
    Conf Proc IEEE Eng Med Biol Soc 2012:3175-8. 2012
    ..In addition, in vitro imaging of cadaver coronary arteries were conducted to demonstrate the imaging capabilities of this integrated catheter to classify different atherosclerotic plaque types...
  38. ncbi request reprint Effects of a novel implantable elastomer device for lung volume reduction surgery in a rabbit model of elastase-induced emphysema
    Matthew Brenner
    Pulmonary and Critical Care Medicine Division, University of California Irvine Medical Center, Orange, CA 92868 3298, USA
    Chest 121:201-9. 2002
    ..The purpose of this investigation was to determine the applicability, physiologic effects, complications, and air-leak results of this lung volume reducer (LVR) approach...
  39. ncbi request reprint In vivo three-dimensional spectral domain endoscopic optical coherence tomography using a microelectromechanical system mirror
    Woonggyu Jung
    Beckman Laser Institute and Department of Biomedical Engineering, University of California, Irvine, USA
    Opt Lett 32:3239-41. 2007
    ..The device was integrated with a conventional endoscope and utilized to generate in vivo 3-D clinical images in humans and animals...

Research Grants4

  1. High Resolution Optical Coherence Tomography for Early Airway Cancer Detection
    Matthew Brenner; Fiscal Year: 2007
    ..This extension of novel engineering imaging ideas to the treatment should also enable a range of other pulmonary and non-pulmonary scope imaging applications ..
  2. High Resolution Optical Coherence Tomography for Early Airway Cancer Detection
    Matthew Brenner; Fiscal Year: 2010
    ..This extension of novel engineering imaging ideas to the treatment should also enable a range of other pulmonary and non-pulmonary scope imaging applications ..