CHARLES M BRENNER
Affiliation: University of Iowa
- Boosting NAD to spare hearingCharles Brenner
Roy J Carver Chair of Biochemistry and Professor of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA Electronic address
Cell Metab 20:926-7. 2014..In this issue of Cell Metabolism, Brown et al. (2014) demonstrate that cochlear NAD is diminished by deafening noise but protected by nicotinamide riboside or WldS mutation. Hearing protection by nicotinamide riboside depends on Sirt3...
- Nrt1 and Tna1-independent export of NAD+ precursor vitamins promotes NAD+ homeostasis and allows engineering of vitamin productionPeter Belenky
Department of Genetics and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
PLoS ONE 6:e19710. 2011..The data indicate that NAD(+) metabolism has a critical extracellular element in the yeast system and suggest that cells regulate intracellular NAD(+) metabolism by balancing import and export of NAD(+) precursor vitamins...
- An ultrasensitive high throughput screen for DNA methyltransferase 1-targeted molecular probesRebecca L Fagan
Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
PLoS ONE 8:e78752. 2013..Seven of nine inhibitors identified exhibited two to four-fold selectivity for DNMT1 versus DNMT3A. ..
- Changes in chemistry and biochemistry education: creative responses to medical college admissions test revisions in the age of the genomeCharles Brenner
Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Biochem Mol Biol Educ 41:1-4. 2013..Getting these changes right is among the most important educational problems of our era...
- NAD+ metabolite levels as a function of vitamins and calorie restriction: evidence for different mechanisms of longevityCharles Evans
Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
BMC Chem Biol 10:2. 2010....
- Microbial NAD metabolism: lessons from comparative genomicsFrancesca Gazzaniga
Department of Genetics and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Microbiol Mol Biol Rev 73:529-41, Table of Contents. 2009..Biochemical, genetic, and genomic analyses have advanced to the point at which the precursors and pathways utilized by a microorganism can be predicted. Challenges remain in dissecting regulation of pathways...
- Quantitative Analysis of RING E3 Ubiquitin LigasesCHARLES M BRENNER; Fiscal Year: 2010..Second, innovations in analysis of RING E3 ubiquitin ligases are necessary to understand the specificity of function of RING E3 ubiquitin ligases, which have key functions in the health of every organ system. ..