CHARLES M BRENNER

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. doi request reprint Boosting NAD to spare hearing
    Charles Brenner
    Roy J Carver Chair of Biochemistry and Professor of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA Electronic address
    Cell Metab 20:926-7. 2014
  2. pmc Nrt1 and Tna1-independent export of NAD+ precursor vitamins promotes NAD+ homeostasis and allows engineering of vitamin production
    Peter Belenky
    Department of Genetics and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
    PLoS ONE 6:e19710. 2011
  3. pmc An ultrasensitive high throughput screen for DNA methyltransferase 1-targeted molecular probes
    Rebecca L Fagan
    Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 8:e78752. 2013
  4. doi request reprint Changes in chemistry and biochemistry education: creative responses to medical college admissions test revisions in the age of the genome
    Charles Brenner
    Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Biochem Mol Biol Educ 41:1-4. 2013
  5. pmc NAD+ metabolite levels as a function of vitamins and calorie restriction: evidence for different mechanisms of longevity
    Charles Evans
    Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
    BMC Chem Biol 10:2. 2010
  6. pmc Microbial NAD metabolism: lessons from comparative genomics
    Francesca Gazzaniga
    Department of Genetics and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Microbiol Mol Biol Rev 73:529-41, Table of Contents. 2009

Research Grants

  1. Quantitative Analysis of RING E3 Ubiquitin Ligases
    CHARLES M BRENNER; Fiscal Year: 2010

Collaborators

  • Rebecca L Fagan
  • Peter Belenky
  • Katrina L Bogan
  • Rebecca Stebbins
  • Charles Evans
  • Francesca Gazzaniga
  • Frederic Chedin
  • Meng Wu
  • Charles R Evans
  • Peng Song
  • Charles F Burant
  • Robert T Kennedy
  • Mark A McPeek
  • Sheila Z Chang

Detail Information

Publications7

  1. doi request reprint Boosting NAD to spare hearing
    Charles Brenner
    Roy J Carver Chair of Biochemistry and Professor of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA Electronic address
    Cell Metab 20:926-7. 2014
    ..In this issue of Cell Metabolism, Brown et al. (2014) demonstrate that cochlear NAD is diminished by deafening noise but protected by nicotinamide riboside or WldS mutation. Hearing protection by nicotinamide riboside depends on Sirt3...
  2. pmc Nrt1 and Tna1-independent export of NAD+ precursor vitamins promotes NAD+ homeostasis and allows engineering of vitamin production
    Peter Belenky
    Department of Genetics and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
    PLoS ONE 6:e19710. 2011
    ..The data indicate that NAD(+) metabolism has a critical extracellular element in the yeast system and suggest that cells regulate intracellular NAD(+) metabolism by balancing import and export of NAD(+) precursor vitamins...
  3. pmc An ultrasensitive high throughput screen for DNA methyltransferase 1-targeted molecular probes
    Rebecca L Fagan
    Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 8:e78752. 2013
    ..Seven of nine inhibitors identified exhibited two to four-fold selectivity for DNMT1 versus DNMT3A. ..
  4. doi request reprint Changes in chemistry and biochemistry education: creative responses to medical college admissions test revisions in the age of the genome
    Charles Brenner
    Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Biochem Mol Biol Educ 41:1-4. 2013
    ..Getting these changes right is among the most important educational problems of our era...
  5. pmc NAD+ metabolite levels as a function of vitamins and calorie restriction: evidence for different mechanisms of longevity
    Charles Evans
    Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
    BMC Chem Biol 10:2. 2010
    ....
  6. pmc Microbial NAD metabolism: lessons from comparative genomics
    Francesca Gazzaniga
    Department of Genetics and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Microbiol Mol Biol Rev 73:529-41, Table of Contents. 2009
    ..Biochemical, genetic, and genomic analyses have advanced to the point at which the precursors and pathways utilized by a microorganism can be predicted. Challenges remain in dissecting regulation of pathways...

Research Grants1

  1. Quantitative Analysis of RING E3 Ubiquitin Ligases
    CHARLES M BRENNER; Fiscal Year: 2010
    ..Second, innovations in analysis of RING E3 ubiquitin ligases are necessary to understand the specificity of function of RING E3 ubiquitin ligases, which have key functions in the health of every organ system. ..