CHARLES M BRENNER

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Nrt1 and Tna1-independent export of NAD+ precursor vitamins promotes NAD+ homeostasis and allows engineering of vitamin production
    Peter Belenky
    Department of Genetics and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
    PLoS ONE 6:e19710. 2011
  2. pmc An ultrasensitive high throughput screen for DNA methyltransferase 1-targeted molecular probes
    Rebecca L Fagan
    Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 8:e78752. 2013
  3. doi request reprint Changes in chemistry and biochemistry education: creative responses to medical college admissions test revisions in the age of the genome
    Charles Brenner
    Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Biochem Mol Biol Educ 41:1-4. 2013
  4. pmc NAD+ metabolite levels as a function of vitamins and calorie restriction: evidence for different mechanisms of longevity
    Charles Evans
    Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
    BMC Chem Biol 10:2. 2010
  5. pmc Microbial NAD metabolism: lessons from comparative genomics
    Francesca Gazzaniga
    Department of Genetics and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Microbiol Mol Biol Rev 73:529-41, Table of Contents. 2009

Research Grants

  1. Mechanism of Dnmt1 Up-regulation by Fhit Loss
    CHARLES M BRENNER; Fiscal Year: 2010
  2. Quantitative Analysis of RING E3 Ubiquitin Ligases
    Charles Brenner; Fiscal Year: 2009
  3. FUNCTIONAL AND STRUCTURAL ANALYSIS OF HIT PROTEINS
    Charles Brenner; Fiscal Year: 2005
  4. FUNCTIONAL AND STRUCTURAL ANALYSIS OF HIT PROTEINS
    Charles Brenner; Fiscal Year: 2003
  5. FUNCTIONAL AND STRUCTURAL ANALYSIS OF HIT PROTEINS
    Charles Brenner; Fiscal Year: 2004
  6. FUNCTIONAL AND STRUCTURAL ANALYSIS OF HIT PROTEINS
    Charles Brenner; Fiscal Year: 2002
  7. FUNCTIONAL AND STRUCTURAL ANALYSIS OF HIT PROTEINS
    Charles Brenner; Fiscal Year: 2001
  8. FUNCTIONAL AND STRUCTURAL ANALYSIS OF HIT PROTEINS
    Charles Brenner; Fiscal Year: 2000
  9. FUNCTIONAL AND STRUCTURAL ANALYSIS OF HIT PROTEINS
    Charles Brenner; Fiscal Year: 1999
  10. FUNCTIONAL AND STRUCTURAL ANALYSIS OF HIT PROTEINS
    Charles Brenner; Fiscal Year: 2006

Collaborators

  • Rebecca L Fagan
  • Peter Belenky
  • Katrina L Bogan
  • Rebecca Stebbins
  • Charles Evans
  • Francesca Gazzaniga
  • Meng Wu
  • Frederic Chedin
  • Charles R Evans
  • Peng Song
  • Robert T Kennedy
  • Charles F Burant
  • Mark A McPeek
  • Sheila Z Chang

Detail Information

Publications6

  1. pmc Nrt1 and Tna1-independent export of NAD+ precursor vitamins promotes NAD+ homeostasis and allows engineering of vitamin production
    Peter Belenky
    Department of Genetics and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
    PLoS ONE 6:e19710. 2011
    ..The data indicate that NAD(+) metabolism has a critical extracellular element in the yeast system and suggest that cells regulate intracellular NAD(+) metabolism by balancing import and export of NAD(+) precursor vitamins...
  2. pmc An ultrasensitive high throughput screen for DNA methyltransferase 1-targeted molecular probes
    Rebecca L Fagan
    Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 8:e78752. 2013
    ..Seven of nine inhibitors identified exhibited two to four-fold selectivity for DNMT1 versus DNMT3A. ..
  3. doi request reprint Changes in chemistry and biochemistry education: creative responses to medical college admissions test revisions in the age of the genome
    Charles Brenner
    Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Biochem Mol Biol Educ 41:1-4. 2013
    ..Getting these changes right is among the most important educational problems of our era...
  4. pmc NAD+ metabolite levels as a function of vitamins and calorie restriction: evidence for different mechanisms of longevity
    Charles Evans
    Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
    BMC Chem Biol 10:2. 2010
    ....
  5. pmc Microbial NAD metabolism: lessons from comparative genomics
    Francesca Gazzaniga
    Department of Genetics and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Microbiol Mol Biol Rev 73:529-41, Table of Contents. 2009
    ..Biochemical, genetic, and genomic analyses have advanced to the point at which the precursors and pathways utilized by a microorganism can be predicted. Challenges remain in dissecting regulation of pathways...

Research Grants14

  1. Mechanism of Dnmt1 Up-regulation by Fhit Loss
    CHARLES M BRENNER; Fiscal Year: 2010
    ..Even a 10% reduction in lung cancer incidence could save more than 16,000 U.S. lives per year. ..
  2. Quantitative Analysis of RING E3 Ubiquitin Ligases
    Charles Brenner; Fiscal Year: 2009
    ..Second, innovations in analysis of RING E3 ubiquitin ligases are necessary to understand the specificity of function of RING E3 ubiquitin ligases, which have key functions in the health of every organ system. ..
  3. FUNCTIONAL AND STRUCTURAL ANALYSIS OF HIT PROTEINS
    Charles Brenner; Fiscal Year: 2005
    ..Work on Fhit/Hnt2 is designed to uncover the pathway of one of the most frequently lost cancer genes and may lead to identification of novel targets for prevention and treatment of lung and stomach cancer. ..
  4. FUNCTIONAL AND STRUCTURAL ANALYSIS OF HIT PROTEINS
    Charles Brenner; Fiscal Year: 2003
    ..Work on Fhit/Hnt2 is designed to uncover the pathway of one of the most frequently lost cancer genes and may lead to identification of novel targets for prevention and treatment of lung and stomach cancer. ..
  5. FUNCTIONAL AND STRUCTURAL ANALYSIS OF HIT PROTEINS
    Charles Brenner; Fiscal Year: 2004
    ..Work on Fhit/Hnt2 is designed to uncover the pathway of one of the most frequently lost cancer genes and may lead to identification of novel targets for prevention and treatment of lung and stomach cancer. ..
  6. FUNCTIONAL AND STRUCTURAL ANALYSIS OF HIT PROTEINS
    Charles Brenner; Fiscal Year: 2002
    ..Work on Fhit/Hnt2 is designed to uncover the pathway of one of the most frequently lost cancer genes and may lead to identification of novel targets for prevention and treatment of lung and stomach cancer. ..
  7. FUNCTIONAL AND STRUCTURAL ANALYSIS OF HIT PROTEINS
    Charles Brenner; Fiscal Year: 2001
    ..This integrated strategy is expected to provide a detailed understanding of the functions of HINT and FHIT in eukaryotic cells and a cellular and structural basis for understanding FHIT lesions in tumors. ..
  8. FUNCTIONAL AND STRUCTURAL ANALYSIS OF HIT PROTEINS
    Charles Brenner; Fiscal Year: 2000
    ..This integrated strategy is expected to provide a detailed understanding of the functions of HINT and FHIT in eukaryotic cells and a cellular and structural basis for understanding FHIT lesions in tumors. ..
  9. FUNCTIONAL AND STRUCTURAL ANALYSIS OF HIT PROTEINS
    Charles Brenner; Fiscal Year: 1999
    ..This integrated strategy is expected to provide a detailed understanding of the functions of HINT and FHIT in eukaryotic cells and a cellular and structural basis for understanding FHIT lesions in tumors. ..
  10. FUNCTIONAL AND STRUCTURAL ANALYSIS OF HIT PROTEINS
    Charles Brenner; Fiscal Year: 2006
    ..Work on Fhit/Hnt2 is designed to uncover the pathway of one of the most frequently lost cancer genes and may lead to identification of novel targets for prevention and treatment of lung and stomach cancer. ..
  11. Mechanism of Dnmt1 Up-regulation by Fhit Loss
    Charles Brenner; Fiscal Year: 2009
    ..Even a 10% reduction in lung cancer incidence could save more than 16,000 U.S. lives per year. ..
  12. Quantitative Analysis of RING E3 Ubiquitin Ligases
    CHARLES M BRENNER; Fiscal Year: 2010
    ..Second, innovations in analysis of RING E3 ubiquitin ligases are necessary to understand the specificity of function of RING E3 ubiquitin ligases, which have key functions in the health of every organ system. ..