TIMOTHY JOHN BRENNAN

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Simultaneous disruption of mouse ASIC1a, ASIC2 and ASIC3 genes enhances cutaneous mechanosensitivity
    Sinyoung Kang
    Department of Anesthesia, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 7:e35225. 2012
  2. pmc Increased local concentration of complement C5a contributes to incisional pain in mice
    Jun H Jang
    Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    J Neuroinflammation 8:80. 2011
  3. ncbi request reprint Comparison of pre- versus post-incision administration of intrathecal bupivacaine and intrathecal morphine in a rat model of postoperative pain
    T J Brennan
    Department of Anesthesia, The University of Iowa, Iowa City 52242 1079, USA
    Anesthesiology 87:1517-28. 1997
  4. ncbi request reprint Epidural tezampanel, an AMPA/kainate receptor antagonist, produces postoperative analgesia in rats
    Hee Cheol Jin
    Department of Anesthesia, University of Iowa College of Medicine, Iowa City, IA 52242 1079, USA
    Anesth Analg 105:1152-9, table of contents. 2007
  5. ncbi request reprint Mechanisms of incisional pain
    Timothy J Brennan
    Departments of Anesthesia and Pharmacology, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242 1079, USA
    Anesthesiol Clin North America 23:1-20. 2005
  6. ncbi request reprint The effect of the AMPA/kainate receptor antagonist LY293558 in a rat model of postoperative pain
    Hae Jin Lee
    Department of Anesthesia, University of Iowa, Iowa City, 52242 1079, USA
    J Pain 7:768-77. 2006
  7. pmc Effect of capsaicin treatment on nociceptors in rat glabrous skin one day after plantar incision
    Sinyoung Kang
    Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Pain 148:128-40. 2010
  8. pmc Nociceptive sensitization by complement C5a and C3a in mouse
    Jun Ho Jang
    Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Pain 148:343-52. 2010
  9. pmc Trpv1 mediates spontaneous firing and heat sensitization of cutaneous primary afferents after plantar incision
    Ratan K Banik
    Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
    Pain 141:41-51. 2009
  10. pmc Comparison of skin incision vs. skin plus deep tissue incision on ongoing pain and spontaneous activity in dorsal horn neurons
    Jun Xu
    Department of Pharmacology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Pain 144:329-39. 2009

Research Grants

Collaborators

Detail Information

Publications46

  1. pmc Simultaneous disruption of mouse ASIC1a, ASIC2 and ASIC3 genes enhances cutaneous mechanosensitivity
    Sinyoung Kang
    Department of Anesthesia, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 7:e35225. 2012
    ..We speculate that physical and/or functional association of ASICs with other components of the mechanosensory transduction apparatus contributes to normal cutaneous mechanosensation...
  2. pmc Increased local concentration of complement C5a contributes to incisional pain in mice
    Jun H Jang
    Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    J Neuroinflammation 8:80. 2011
    ..In this study, we further examined the possible contribution of wound area C5a to incisional pain...
  3. ncbi request reprint Comparison of pre- versus post-incision administration of intrathecal bupivacaine and intrathecal morphine in a rat model of postoperative pain
    T J Brennan
    Department of Anesthesia, The University of Iowa, Iowa City 52242 1079, USA
    Anesthesiology 87:1517-28. 1997
    ..The purpose of this study is to examine the effect of pre- and post-incision administration of intrathecal bupivacaine and intrathecal morphine in a rat model for postoperative pain...
  4. ncbi request reprint Epidural tezampanel, an AMPA/kainate receptor antagonist, produces postoperative analgesia in rats
    Hee Cheol Jin
    Department of Anesthesia, University of Iowa College of Medicine, Iowa City, IA 52242 1079, USA
    Anesth Analg 105:1152-9, table of contents. 2007
    ..The effects of epidural tezampanel on pain-related behaviors in rats that underwent plantar incision were also studied...
  5. ncbi request reprint Mechanisms of incisional pain
    Timothy J Brennan
    Departments of Anesthesia and Pharmacology, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242 1079, USA
    Anesthesiol Clin North America 23:1-20. 2005
    ..This article reviews studies on a rat plantar hindpaw model for postoperative pain and proposes mechanisms for enhanced excitability of sensory neurons caused by incisions...
  6. ncbi request reprint The effect of the AMPA/kainate receptor antagonist LY293558 in a rat model of postoperative pain
    Hae Jin Lee
    Department of Anesthesia, University of Iowa, Iowa City, 52242 1079, USA
    J Pain 7:768-77. 2006
    ..Local administration did not decrease response after incision. LY293558 was most effective for evoked pain when administered intrathecally...
  7. pmc Effect of capsaicin treatment on nociceptors in rat glabrous skin one day after plantar incision
    Sinyoung Kang
    Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Pain 148:128-40. 2010
    ..These putative TRPV1-expressing C-fibers are sensitized to heat and acid after incision, and the transduction of heat and chemical stimuli after plantar incision is impaired by dilute capsaicin...
  8. pmc Nociceptive sensitization by complement C5a and C3a in mouse
    Jun Ho Jang
    Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Pain 148:343-52. 2010
    ..The results suggest a potential role for complement fragments C5a and C3a in nociception by activating and sensitizing cutaneous nociceptors...
  9. pmc Trpv1 mediates spontaneous firing and heat sensitization of cutaneous primary afferents after plantar incision
    Ratan K Banik
    Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
    Pain 141:41-51. 2009
    ..KO of TrpV1 influences SA in these unclassified afferents in incised skin. SA in these afferents is perhaps a manifestation of heat sensitization...
  10. pmc Comparison of skin incision vs. skin plus deep tissue incision on ongoing pain and spontaneous activity in dorsal horn neurons
    Jun Xu
    Department of Pharmacology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Pain 144:329-39. 2009
    ..These data demonstrate that incised deep tissue rather than skin is critical for the development of guarding pain and increased SA of DHNs. Skin incision alone is sufficient for primary mechanical and heat hyperalgesia...
  11. pmc Guarding pain and spontaneous activity of nociceptors after skin versus skin plus deep tissue incision
    Jun Xu
    Department of Pharmacology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Anesthesiology 112:153-64. 2010
    ..Spontaneous activity (SA) in nociceptive pathways quite likely transmits such ongoing pain. This study examined the extent of tissue injury by incision on pain behaviors and nociceptor SA...
  12. ncbi request reprint Characterization of Adelta- and C-fibers innervating the plantar rat hindpaw one day after an incision
    Esther M Pogatzki
    Department of Anesthesia, College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    J Neurophysiol 87:721-31. 2002
    ..Spontaneous activity in Adelta- and C-fibers may account for nonevoked pain behavior and may also contribute to mechanical hyperalgesia by amplifying responses centrally...
  13. ncbi request reprint Persistent secondary hyperalgesia after gastrocnemius incision in the rat
    Esther M Pogatzki
    Department of Anesthesia, College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Eur J Pain 6:295-305. 2002
    ....
  14. pmc Hind paw incision in the rat produces long-lasting colon hypersensitivity
    David M Cameron
    Department of Pharmacology, University of Iowa, Iowa City, Iowa 52242, USA
    J Pain 9:246-53. 2008
    ..These results support the hypothesis that somatic injury and visceral inflammation can alter central processing of visceral and somatic inputs, respectively...
  15. ncbi request reprint Acute effect of an incision on mechanosensitive afferents in the plantar rat hindpaw
    Minna M Hamalainen
    Department of Pharmacology, College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    J Neurophysiol 87:712-20. 2002
    ....
  16. ncbi request reprint Role of the rostral medial medulla in the development of primary and secondary hyperalgesia after incision in the rat
    Esther M Pogatzki
    Department of Pharmacology, University of Iowa, Iowa City, Iowa, USA
    Anesthesiology 96:1153-60. 2002
    ..The current study examined if descending inhibition or facilitation from the RMM modulates primary and secondary hyperalgesia after incision in the rat hind limb...
  17. ncbi request reprint Changes in tissue pH and temperature after incision indicate acidosis may contribute to postoperative pain
    Young Cheol Woo
    Department of Anesthesia, University of Iowa, 200 Hawkins Drive, 6 JCP, Iowa City, Iowa 52242, USA
    Anesthesiology 101:468-75. 2004
    ..In this study, the authors measured tissue pH and hind paw temperature before and after incision to understand factors that may activate and sensitize nociceptors in the incision...
  18. ncbi request reprint Spontaneous discharge and increased heat sensitivity of rat C-fiber nociceptors are present in vitro after plantar incision
    Ratan K Banik
    Department of Anesthesia, University of Iowa Hospitals and Clinics, 3000 ML, Iowa City, IA 52242, USA
    Pain 112:204-13. 2004
    ....
  19. ncbi request reprint Effect of blockade of nerve growth factor and tumor necrosis factor on pain behaviors after plantar incision
    Peter K Zahn
    Department of Anesthesia, University of Iowa, Iowa City 52242, USA
    J Pain 5:157-63. 2004
    ..One endogenous factor that contributes to pain after incision is NGF. Inhibition of NGF may provide a new way to treat pain after surgery with minimal side effects. This could improve outcome after surgery...
  20. pmc Ketoprofen produces modality-specific inhibition of pain behaviors in rats after plantar incision
    Christina M Spofford
    Department of Anesthesia, University of Iowa, Iowa City, IA 52242, USA
    Anesth Analg 109:1992-9. 2009
    ..Postoperative pain remains a significant problem despite optimal treatment with current drugs. Nonsteroidal antiinflammatory drugs reduce inflammation and provide analgesia but are associated with adverse side effects...
  21. ncbi request reprint Effect of AMG0347, a transient receptor potential type V1 receptor antagonist, and morphine on pain behavior after plantar incision
    Chaoran Wu
    Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Anesthesiology 108:1100-8. 2008
    ..Doses of morphine lower than those used in most rodent studies were also examined...
  22. pmc Sensitization of primary afferents to mechanical and heat stimuli after incision in a novel in vitro mouse glabrous skin-nerve preparation
    Ratan K Banik
    Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Pain 138:380-91. 2008
    ..The preparation allows us to study afferent function of the same tissue that is examined for in vivo pain behavior assays in mice...
  23. ncbi request reprint Effect of intrathecal non-NMDA EAA receptor antagonist LY293558 in rats: a new class of drugs for spinal anesthesia
    Nicholas H Von Bergen
    Department of Anesthesia, College of Medicine, University of Iowa, Iowa City, Iowa 52242 1079, USA
    Anesthesiology 97:177-82. 2002
    ....
  24. doi request reprint Continuous cervical paravertebral catheter knot
    Steven C Pulley
    Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    J Clin Anesth 22:135-8. 2010
    ..Imaging showed no entanglement of nerve or vascular structures. Using a small skin incision, the catheter was successfully removed...
  25. ncbi request reprint Strain and sex influence on pain sensitivity after plantar incision in the mouse
    Ratan K Banik
    Department of Anesthesia, 3000 ML, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Anesthesiology 105:1246-53. 2006
    ..The increasing popularity of this animal model in drug discovery necessitates the understanding of genetic and sex influence on this animal model...
  26. pmc Chemosensitivity and mechanosensitivity of nociceptors from incised rat hindpaw skin
    Sinyoung Kang
    Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Anesthesiology 111:155-64. 2009
    ..In this study, the authors characterized the acid-responsiveness of nociceptors innervating the plantar aspect of the rat hind paw 1 day after plantar incision and compared this to plantar skin from unincised control rats...
  27. ncbi request reprint Bradykinin antagonists have no analgesic effect on incisional pain
    Paul A Leonard
    Department of Anesthesia, University of Iowa, Iowa City, USA
    Anesth Analg 99:1166-72, table of contents. 2004
    ..Although inflammation may represent a component of incisional pain, the etiology of inflammation and its role seem different than in other models...
  28. ncbi request reprint Nerve growth factor expression after plantar incision in the rat
    Chaoran Wu
    Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Anesthesiology 107:128-35. 2007
    ..The purpose of this study is to examine the expression of NGF in skin after planter incision...
  29. ncbi request reprint Increased nerve growth factor after rat plantar incision contributes to guarding behavior and heat hyperalgesia
    Ratan K Banik
    Department of Anesthesia, 3000 ML, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Pain 117:68-76. 2005
    ..NGF contributes to some incision-induced pain behaviors, guarding and heat hyperalgesia. Anti-NGF did not affect the extent of sensitization of C-fibers observed in vitro...
  30. ncbi request reprint Lactate concentrations in incisions indicate ischemic-like conditions may contribute to postoperative pain
    Tae Jung Kim
    Department of Anesthesia, University of Iowa, Iowa City, IA 52242, USA
    J Pain 8:59-66. 2007
    ..Lactate and low pH are present in incisions and indicate an ischemic pain mechanism that may contribute to postsurgical pain...
  31. ncbi request reprint Spinal glutamate receptor antagonists differentiate primary and secondary mechanical hyperalgesia caused by incision
    Esther M Pogatzki
    Department of Anesthesia, University of Iowa, 200 Hawkins Drive 6 JCP, Iowa City, IA 52242, USA
    Pain 105:97-107. 2003
    ..Mechanisms for central sensitization causing secondary hyperalgesia in postoperative patients may therefore be separated from spontaneous pain and hyperalgesia that arises adjacent to the area of the incision...
  32. pmc Expression profile of nerve growth factor after muscle incision in the rat
    Chaoran Wu
    Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Anesthesiology 110:140-9. 2009
    ..This study examined pain behaviors and the expression of NGF in incised hind paw flexor digitorum brevis muscle...
  33. ncbi request reprint Thermoregulatory behavior is disrupted in rats with lesions of the anteroventral third ventricular area (AV3V)
    Douglas G Whyte
    Department of Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA
    Physiol Behav 87:493-9. 2006
    ..These results demonstrate that the AV3V region is pivotal in the regulation of both autonomic and behavioral thermoregulatory effector mechanisms...
  34. ncbi request reprint Prevalence and risk factors predisposing to coagulopathy in patients receiving epidural analgesia for hepatic surgery
    Robert Shontz
    Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Reg Anesth Pain Med 34:308-11. 2009
    ..We evaluated the prevalence and types of coagulopathic conditions that occur in patients with epidural catheters undergoing hepatic resection...
  35. ncbi request reprint Effect of plantar local anesthetic injection on dorsal horn neuron activity and pain behaviors caused by incision
    Esther M Pogatzki
    Klinik und Poliklinik fuer Anesthesiologie und operative Intensivmedizin, Westfaelische Wilhelms Universitaet, 48129 Muenster, Germany
    Pain 97:151-61. 2002
    ..Because sensitization was reversed 90 min after plantar incision and then re-established as the local anesthetic effect diminished, enhanced responsiveness of DHN requires ongoing afferent input during the first day after incision...
  36. ncbi request reprint Mechanisms for pain caused by incisions
    Peter K Zahn
    Department of Anesthesia and Intensive Care, University of Muenster, Muenster, Germany
    Reg Anesth Pain Med 27:514-6. 2002
  37. ncbi request reprint Preventive analgesia to reduce wound hyperalgesia and persistent postsurgical pain: not an easy path
    Timothy J Brennan
    Anesthesiology 103:681-3. 2005
  38. ncbi request reprint Opioids: more to learn, improvements to be made
    Charles B Berde
    Anesthesiology 98:1309-12. 2003
  39. doi request reprint Perioperative pain management in the opioid-tolerant individual
    Deb Gordon
    VA Connecticut Healthcare System, Yale University School of Medicine, New Haven, CT, USA
    J Pain 9:383-7. 2008
  40. ncbi request reprint Frontiers in translational research: the etiology of incisional and postoperative pain
    Timothy J Brennan
    Anesthesiology 97:535-7. 2002
  41. ncbi request reprint Excitatory amino acid release in the spinal cord caused by plantar incision in the rat
    Peter K Zahn
    Department of Anesthesia and Intensive Care Medicine, University of Muenster, Von Esmarch Strasse 56, 48149 Muenster, Germany
    Pain 100:65-76. 2002
    ..This profile of EAA release further explains why models of inflammation and chemical irritation do not translate well to human postoperative pain...
  42. ncbi request reprint Postoperative pain--clinical implications of basic research
    Esther M Pogatzki-Zahn
    Department of Anesthesiology and Intensive Care Medicine, University of Muenster, Albert Schweitzer Str 33, 48149 Muenster, Germany
    Best Pract Res Clin Anaesthesiol 21:3-13. 2007
    ..In the present review, recent developments in experimental postsurgical incisional pain research will be described and their possible relevance for clinical practice discussed...
  43. ncbi request reprint Immediate early genes after pulsed radiofrequency treatment: neurobiology in need of clinical trials
    Philippe Richebe
    Anesthesiology 102:1-3. 2005
  44. ncbi request reprint Spinal administration of MK-801 and NBQX demonstrates NMDA-independent dorsal horn sensitization in incisional pain
    Peter K Zahn
    Department of Anesthesia, University of Muenster, Germany
    Pain 114:499-510. 2005
    ..Thus, nonNMDA receptors are critical and NMDA-independent factors influence the increased responsiveness of dorsal horn neurons that occur early after incision...
  45. ncbi request reprint Incisional sensitivity and pain measurements: dissecting mechanisms for postoperative pain
    Timothy J Brennan
    Anesthesiology 103:3-4. 2005
  46. ncbi request reprint The ion channel ASIC1 contributes to visceral but not cutaneous mechanoreceptor function
    Amanda J Page
    Nerve Gut Research Laboratroy, Hanson Institute, Department of Gastroenterology, Royal Adelaide Hospital, Adelaide, SA 5000, Australia
    Gastroenterology 127:1739-47. 2004
    ..We examined the influence of the DEG/ENaC channel ASIC1 on gastrointestinal mechanosensory function, on gastric emptying, and on fecal output. We also compared its role in gastrointestinal and somatic sensory function...

Research Grants14

  1. Primary Afferent Sensitization in Postoperative Pain
    Timothy Brennan; Fiscal Year: 2003
    ..The proposed experiments will advance our understanding of postoperative incisional pain and provide a basis for rationale design of new pharmacologic treatment modalities. ..
  2. Nociception from Deep Muscle Incision
    Timothy Brennan; Fiscal Year: 2009
    ..From this research, new mechanisms and treatments will become available so that pain at rest and with movement will be reduced, perioperative morbidity will decline, and health care costs will decrease. ..
  3. Spinal Excitatory Amino Acids in Postoperative Pain
    Timothy Brennan; Fiscal Year: 2004
    ..excitatory amino acids, and in particular the role of calcium-permeable AMPA and kainate receptors, will advance our understanding of postoperative incisional pain and provide a basis for rationale design of new pharmacologic treatment ..
  4. Spinal Excitatory Amino Acids in Postoperative Pain
    Timothy Brennan; Fiscal Year: 2005
    ..excitatory amino acids, and in particular the role of calcium-permeable AMPA and kainate receptors, will advance our understanding of postoperative incisional pain and provide a basis for rationale design of new pharmacologic treatment ..
  5. TRPV1 Expressing Sensory Afferents in Postoperative Pain
    Timothy Brennan; Fiscal Year: 2006
    ..A separate pathway, likely an A-fiber mediated pathway, is sufficient to transmit the enhanced mechanical responses. ..
  6. Spinal Excitatory Amino Acids in Postoperative Pain
    Timothy Brennan; Fiscal Year: 2002
    ..excitatory amino acids, and in particular the role of calcium-permeable AMPA and kainate receptors, will advance our understanding of postoperative incisional pain and provide a basis for rationale design of new pharmacologic treatment ..
  7. TRPV1 Expressing Sensory Afferents in Postoperative Pain
    Timothy Brennan; Fiscal Year: 2009
    ..A separate pathway, likely an A-fiber mediated pathway, is sufficient to transmit the enhanced mechanical responses. ..
  8. TRPV1 Expressing Sensory Afferents in Postoperative Pain
    Timothy Brennan; Fiscal Year: 2007
    ..A separate pathway, likely an A-fiber mediated pathway, is sufficient to transmit the enhanced mechanical responses. ..
  9. Primary Afferent Sensitization in Postoperative Pain
    Timothy Brennan; Fiscal Year: 2006
    ..The proposed experiments will advance our understanding of postoperative incisional pain and provide a basis for rationale design of new pharmacologic treatment modalities. ..
  10. Primary Afferent Sensitization in Postoperative Pain
    Timothy Brennan; Fiscal Year: 2005
    ..The proposed experiments will advance our understanding of postoperative incisional pain and provide a basis for rationale design of new pharmacologic treatment modalities. ..
  11. Primary Afferent Sensitization in Postoperative Pain
    Timothy Brennan; Fiscal Year: 2004
    ..The proposed experiments will advance our understanding of postoperative incisional pain and provide a basis for rationale design of new pharmacologic treatment modalities. ..
  12. Spinal Excitatory Amino Acids in Postoperative Pain
    Timothy Brennan; Fiscal Year: 2003
    ..excitatory amino acids, and in particular the role of calcium-permeable AMPA and kainate receptors, will advance our understanding of postoperative incisional pain and provide a basis for rationale design of new pharmacologic treatment ..
  13. Nociception from Deep Muscle Incision
    TIMOTHY JOHN BRENNAN; Fiscal Year: 2010
    ..From this research, new mechanisms and treatments will become available so that pain at rest and with movement will be reduced, perioperative morbidity will decline, and health care costs will decrease. ..