Research Topics
| TIMOTHY JOHN BRENNANSummaryAffiliation: University of Iowa Country: USA Publications
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Publications
Increased local concentration of complement C5a contributes to incisional pain in miceJun H Jang
Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
J Neuroinflammation 8:80. 2011..In this study, we further examined the possible contribution of wound area C5a to incisional pain...
Comparison of pre- versus post-incision administration of intrathecal bupivacaine and intrathecal morphine in a rat model of postoperative painT J Brennan
Department of Anesthesia, The University of Iowa, Iowa City 52242 1079, USA
Anesthesiology 87:1517-28. 1997..The purpose of this study is to examine the effect of pre- and post-incision administration of intrathecal bupivacaine and intrathecal morphine in a rat model for postoperative pain...- Epidural tezampanel, an AMPA/kainate receptor antagonist, produces postoperative analgesia in ratsHee Cheol Jin
Department of Anesthesia, University of Iowa College of Medicine, Iowa City, IA 52242 1079, USA
Anesth Analg 105:1152-9, table of contents. 2007..The effects of epidural tezampanel on pain-related behaviors in rats that underwent plantar incision were also studied... - Mechanisms of incisional painTimothy J Brennan
Departments of Anesthesia and Pharmacology, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242 1079, USA
Anesthesiol Clin North America 23:1-20. 2005..This article reviews studies on a rat plantar hindpaw model for postoperative pain and proposes mechanisms for enhanced excitability of sensory neurons caused by incisions... - The effect of the AMPA/kainate receptor antagonist LY293558 in a rat model of postoperative painHae-Jin Lee
Department of Anesthesia, University of Iowa, Iowa City, 52242-1079, USA
J Pain 7:768-77. 2006..These data suggest that non-NMDA receptor antagonists like LY293558 will be most effective for evoked pain in postoperative patients if administered spinally... - Effect of capsaicin treatment on nociceptors in rat glabrous skin one day after plantar incisionSinyoung Kang
Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
Pain 148:128-40. 2010..These putative TRPV1-expressing C-fibers are sensitized to heat and acid after incision, and the transduction of heat and chemical stimuli after plantar incision is impaired by dilute capsaicin... - Nociceptive sensitization by complement C5a and C3a in mouseJun Ho Jang
Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
Pain 148:343-52. 2010..The results suggest a potential role for complement fragments C5a and C3a in nociception by activating and sensitizing cutaneous nociceptors... - Comparison of skin incision vs. skin plus deep tissue incision on ongoing pain and spontaneous activity in dorsal horn neuronsJun Xu
Department of Pharmacology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
Pain 144:329-39. 2009..These data demonstrate that incised deep tissue rather than skin is critical for the development of guarding pain and increased SA of DHNs. Skin incision alone is sufficient for primary mechanical and heat hyperalgesia... - Guarding pain and spontaneous activity of nociceptors after skin versus skin plus deep tissue incisionJun Xu
Department of Pharmacology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
Anesthesiology 112:153-64. 2010..Spontaneous activity (SA) in nociceptive pathways quite likely transmits such ongoing pain. This study examined the extent of tissue injury by incision on pain behaviors and nociceptor SA... - Trpv1 mediates spontaneous firing and heat sensitization of cutaneous primary afferents after plantar incisionRatan K Banik
Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
Pain 141:41-51. 2009..KO of TrpV1 influences SA in these unclassified afferents in incised skin. SA in these afferents is perhaps a manifestation of heat sensitization... - Characterization of Adelta- and C-fibers innervating the plantar rat hindpaw one day after an incisionEsther M Pogatzki
Department of Anesthesia, College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
J Neurophysiol 87:721-31. 2002..Spontaneous activity in Adelta- and C-fibers may account for nonevoked pain behavior and may also contribute to mechanical hyperalgesia by amplifying responses centrally... - Persistent secondary hyperalgesia after gastrocnemius incision in the ratEsther M Pogatzki
Department of Anesthesia, College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
Eur J Pain 6:295-305. 2002.... - Hind paw incision in the rat produces long-lasting colon hypersensitivityDavid M Cameron
Department of Pharmacology, University of Iowa, Iowa City, Iowa 52242, USA
J Pain 9:246-53. 2008..This report establishes in a model of postsurgical pain and hyperalgesia that a long-lasting visceral hypersensitivity may also accompany postsurgical hyperalgesia... - Changes in tissue pH and temperature after incision indicate acidosis may contribute to postoperative painYoung Cheol Woo
Department of Anesthesia, University of Iowa, 200 Hawkins Drive, 6 JCP, Iowa City, Iowa 52242, USA
Anesthesiology 101:468-75. 2004..The magnitude of the pH change varies among tissues. An increase in hind paw skin temperature does not play a role in these pain-related behaviors... - Acute effect of an incision on mechanosensitive afferents in the plantar rat hindpawMinna M Hamalainen
Department of Pharmacology, College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
J Neurophysiol 87:712-20. 2002.... - Role of the rostral medial medulla in the development of primary and secondary hyperalgesia after incision in the ratEsther M Pogatzki
Department of Pharmacology, University of Iowa, Iowa City, Iowa, USA
Anesthesiology 96:1153-60. 2002.... - Spontaneous discharge and increased heat sensitivity of rat C-fiber nociceptors are present in vitro after plantar incisionRatan K Banik
Department of Anesthesia, University of Iowa Hospitals and Clinics, 3000 ML, Iowa City, IA 52242, USA
Pain 112:204-13. 2004.... - Effect of blockade of nerve growth factor and tumor necrosis factor on pain behaviors after plantar incisionPeter K Zahn
Department of Anesthesia, University of Iowa, Iowa City 52242, USA
J Pain 5:157-63. 2004..One endogenous factor that contributes to pain after incision is NGF. Inhibition of NGF may provide a new way to treat pain after surgery with minimal side effects. This could improve outcome after surgery... 
Effect of AMG0347, a transient receptor potential type V1 receptor antagonist, and morphine on pain behavior after plantar incisionChaoran Wu
Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
Anesthesiology 108:1100-8. 2008..Doses of morphine lower than those used in most rodent studies were also examined...- Chemosensitivity and mechanosensitivity of nociceptors from incised rat hindpaw skinSinyoung Kang
Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
Anesthesiology 111:155-64. 2009..In this study, the authors characterized the acid-responsiveness of nociceptors innervating the plantar aspect of the rat hind paw 1 day after plantar incision and compared this to plantar skin from unincised control rats... - Sensitization of primary afferents to mechanical and heat stimuli after incision in a novel in vitro mouse glabrous skin-nerve preparationRatan K Banik
Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
Pain 138:380-91. 2008..The preparation allows us to study afferent function of the same tissue that is examined for in vivo pain behavior assays in mice... - Ketoprofen produces modality-specific inhibition of pain behaviors in rats after plantar incisionChristina M Spofford
Department of Anesthesia, University of Iowa, Iowa City, IA 52242, USA
Anesth Analg 109:1992-9. 2009..Postoperative pain remains a significant problem despite optimal treatment with current drugs. Nonsteroidal antiinflammatory drugs reduce inflammation and provide analgesia but are associated with adverse side effects... - Continuous cervical paravertebral catheter knotSteven C Pulley
Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
J Clin Anesth 22:135-8. 2010..Imaging showed no entanglement of nerve or vascular structures. Using a small skin incision, the catheter was successfully removed... - Nerve growth factor expression after plantar incision in the ratChaoran Wu
Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
Anesthesiology 107:128-35. 2007..The purpose of this study is to examine the expression of NGF in skin after planter incision... - Strain and sex influence on pain sensitivity after plantar incision in the mouseRatan K Banik
Department of Anesthesia, 3000 ML, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
Anesthesiology 105:1246-53. 2006..The increasing popularity of this animal model in drug discovery necessitates the understanding of genetic and sex influence on this animal model... - Bradykinin antagonists have no analgesic effect on incisional painPaul A Leonard
Department of Anesthesia, University of Iowa, Iowa City, USA
Anesth Analg 99:1166-72, table of contents. 2004..Although inflammation may represent a component of incisional pain, the etiology of inflammation and its role seem different than in other models... - Effect of intrathecal non-NMDA EAA receptor antagonist LY293558 in rats: a new class of drugs for spinal anesthesiaNicholas H Von Bergen
Department of Anesthesia, College of Medicine, University of Iowa, Iowa City, Iowa 52242-1079, USA
Anesthesiology 97:177-82. 2002..CONCLUSION: Drugs like LY293558 that block alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA)/kainate receptors may be an alternative to local anesthetics for spinal anesthesia in humans... - Increased nerve growth factor after rat plantar incision contributes to guarding behavior and heat hyperalgesiaRatan K Banik
Department of Anesthesia, 3000 ML, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
Pain 117:68-76. 2005..NGF contributes to some incision-induced pain behaviors, guarding and heat hyperalgesia. Anti-NGF did not affect the extent of sensitization of C-fibers observed in vitro... - Lactate concentrations in incisions indicate ischemic-like conditions may contribute to postoperative painTae Jung Kim
Department of Anesthesia, University of Iowa, Iowa City, IA 52242, USA
J Pain 8:59-66. 2007..Lactate and low pH are present in incisions and indicate an ischemic pain mechanism that may contribute to postsurgical pain... - Spinal glutamate receptor antagonists differentiate primary and secondary mechanical hyperalgesia caused by incisionEsther M Pogatzki
Department of Anesthesia, University of Iowa, 200 Hawkins Drive 6 JCP, Iowa City, IA 52242, USA
Pain 105:97-107. 2003..Mechanisms for central sensitization causing secondary hyperalgesia in postoperative patients may therefore be separated from spontaneous pain and hyperalgesia that arises adjacent to the area of the incision... - Expression profile of nerve growth factor after muscle incision in the ratChaoran Wu
Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
Anesthesiology 110:140-9. 2009..This study examined pain behaviors and the expression of NGF in incised hind paw flexor digitorum brevis muscle... - Thermoregulatory behavior is disrupted in rats with lesions of the anteroventral third ventricular area (AV3V)Douglas G Whyte
Department of Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA
Physiol Behav 87:493-9. 2006..These results demonstrate that the AV3V region is pivotal in the regulation of both autonomic and behavioral thermoregulatory effector mechanisms... - Prevalence and risk factors predisposing to coagulopathy in patients receiving epidural analgesia for hepatic surgeryRobert Shontz
Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
Reg Anesth Pain Med 34:308-11. 2009..We evaluated the prevalence and types of coagulopathic conditions that occur in patients with epidural catheters undergoing hepatic resection... - Mechanisms for pain caused by incisionsPeter K Zahn
Department of Anesthesia and Intensive Care, University of Muenster, Muenster, Germany
Reg Anesth Pain Med 27:514-6. 2002 - Opioids: more to learn, improvements to be madeCharles B Berde
Anesthesiology 98:1309-12. 2003 - Effect of plantar local anesthetic injection on dorsal horn neuron activity and pain behaviors caused by incisionEsther M Pogatzki
Klinik und Poliklinik fuer Anesthesiologie und operative Intensivmedizin, Westfaelische Wilhelms-Universitaet, 48129 Muenster, Germany
Pain 97:151-61. 2002..Because sensitization was reversed 90 min after plantar incision and then re-established as the local anesthetic effect diminished, enhanced responsiveness of DHN requires ongoing afferent input during the first day after incision... - Preventive analgesia to reduce wound hyperalgesia and persistent postsurgical pain: not an easy pathTimothy J Brennan
Anesthesiology 103:681-3. 2005 - Postoperative pain--clinical implications of basic researchEsther M Pogatzki-Zahn
Department of Anesthesiology and Intensive Care Medicine, University of Muenster, Albert Schweitzer Str 33, 48149 Muenster, Germany
Best Pract Res Clin Anaesthesiol 21:3-13. 2007..In the present review, recent developments in experimental postsurgical incisional pain research will be described and their possible relevance for clinical practice discussed... - Incisional sensitivity and pain measurements: dissecting mechanisms for postoperative painTimothy J Brennan
Anesthesiology 103:3-4. 2005 - The ion channel ASIC1 contributes to visceral but not cutaneous mechanoreceptor functionAmanda J Page
Nerve Gut Research Laboratroy, Hanson Institute, Department of Gastroenterology, Royal Adelaide Hospital, Adelaide, SA 5000, Australia
Gastroenterology 127:1739-47. 2004..We examined the influence of the DEG/ENaC channel ASIC1 on gastrointestinal mechanosensory function, on gastric emptying, and on fecal output. We also compared its role in gastrointestinal and somatic sensory function... - Immediate early genes after pulsed radiofrequency treatment: neurobiology in need of clinical trialsPhilippe Richebe
Anesthesiology 102:1-3. 2005 - Excitatory amino acid release in the spinal cord caused by plantar incision in the ratPeter K Zahn
Department of Anesthesia and Intensive Care Medicine, University of Muenster, Von Esmarch Strasse 56, 48149 Muenster, Germany
Pain 100:65-76. 2002..This profile of EAA release further explains why models of inflammation and chemical irritation do not translate well to human postoperative pain... - Perioperative pain management in the opioid-tolerant individualDeb Gordon
VA Connecticut Healthcare System, Yale University School of Medicine, New Haven, CT, USA
J Pain 9:383-7. 2008 - Frontiers in translational research: the etiology of incisional and postoperative painTimothy J Brennan
Anesthesiology 97:535-7. 2002 - Spinal administration of MK-801 and NBQX demonstrates NMDA-independent dorsal horn sensitization in incisional painPeter K Zahn
Department of Anesthesia, University of Muenster, Germany
Pain 114:499-510. 2005..Thus, nonNMDA receptors are critical and NMDA-independent factors influence the increased responsiveness of dorsal horn neurons that occur early after incision...
Research Grants
- TRPV1 Expressing Sensory Afferents in Postoperative PainTimothy Brennan; Fiscal Year: 2009..A separate pathway, likely an A-fiber mediated pathway, is sufficient to transmit the enhanced mechanical responses. ..
- TRPV1 Expressing Sensory Afferents in Postoperative PainTimothy Brennan; Fiscal Year: 2007..A separate pathway, likely an A-fiber mediated pathway, is sufficient to transmit the enhanced mechanical responses. ..
- Primary Afferent Sensitization in Postoperative PainTimothy Brennan; Fiscal Year: 2006..The proposed experiments will advance our understanding of postoperative incisional pain and provide a basis for rationale design of new pharmacologic treatment modalities. ..
- Spinal Excitatory Amino Acids in Postoperative PainTimothy Brennan; Fiscal Year: 2005..excitatory amino acids, and in particular the role of calcium-permeable AMPA and kainate receptors, will advance our understanding of postoperative incisional pain and provide a basis for rationale design of new pharmacologic treatment ..
- Nociception from Deep Muscle IncisionTIMOTHY JOHN BRENNAN; Fiscal Year: 2010..From this research, new mechanisms and treatments will become available so that pain at rest and with movement will be reduced, perioperative morbidity will decline, and health care costs will decrease. ..