John C Breitner

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint NSAIDs and Alzheimer's disease: how far to generalise from trials?
    John C S Breitner
    GRECC S 182, VA Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
    Lancet Neurol 2:527. 2003
  2. ncbi request reprint Dementia--epidemiological considerations, nomenclature, and a tacit consensus definition
    John C S Breitner
    Geriatric Research Education and Clinical Center, VA Puget Sound Health Care System, and Division of Geriatric Psychiatry, University of Washington School of Medicine, Seattle, WA 98108, USA
    J Geriatr Psychiatry Neurol 19:129-36. 2006
  3. pmc Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort
    J C S Breitner
    Geriatric Research Education and Clinical Center, Department of Veterans Affairs Medical Center, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Neurology 72:1899-905. 2009
  4. ncbi request reprint Statin use and the risk of incident dementia: the Cardiovascular Health Study
    Thomas D Rea
    Department of Medicine, University of Washington, Seattle 98101, USA
    Arch Neurol 62:1047-51. 2005
  5. ncbi request reprint Quantitative in vivo biomarkers of oxidative damage and their application to the diagnosis and management of Alzheimer's disease
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    J Alzheimers Dis 8:359-67. 2005
  6. ncbi request reprint Incidence and prevalence of dementia in the Cardiovascular Health Study
    Annette L Fitzpatrick
    Department of Epidemiology, University of Washington, Seattle, Washington 98115, USA
    J Am Geriatr Soc 52:195-204. 2004
  7. ncbi request reprint Antioxidant vitamin supplement use and risk of dementia or Alzheimer's disease in older adults
    Shelly L Gray
    School of Pharmacy, University of Washington, Seattle, Washington 98195, USA
    J Am Geriatr Soc 56:291-5. 2008
  8. pmc Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smoking
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, USA
    Ann Neurol 65:226-9. 2009
  9. pmc Cerebrospinal fluid biomarkers in mild cognitive impairment and dementia
    Joshua A Sonnen
    Department of Pathology, Division of Neuropathology, University of Washington, Seattle, WA 98104 2420, USA
    J Alzheimers Dis 19:301-9. 2010
  10. pmc Age-varying association between statin use and incident Alzheimer's disease
    Ge Li
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA
    J Am Geriatr Soc 58:1311-7. 2010

Research Grants

Detail Information

Publications52

  1. ncbi request reprint NSAIDs and Alzheimer's disease: how far to generalise from trials?
    John C S Breitner
    GRECC S 182, VA Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
    Lancet Neurol 2:527. 2003
  2. ncbi request reprint Dementia--epidemiological considerations, nomenclature, and a tacit consensus definition
    John C S Breitner
    Geriatric Research Education and Clinical Center, VA Puget Sound Health Care System, and Division of Geriatric Psychiatry, University of Washington School of Medicine, Seattle, WA 98108, USA
    J Geriatr Psychiatry Neurol 19:129-36. 2006
    ..Beyond this description, our knowledge of pathology and, ultimately, the etiology of individual cases is extremely variable. Whatever its antecedents, syndromically defined dementia presents a looming public health crisis...
  3. pmc Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort
    J C S Breitner
    Geriatric Research Education and Clinical Center, Department of Veterans Affairs Medical Center, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Neurology 72:1899-905. 2009
    ..Nonsteroidal anti-inflammatory drugs (NSAIDs) may prevent Alzheimer dementia (AD)...
  4. ncbi request reprint Statin use and the risk of incident dementia: the Cardiovascular Health Study
    Thomas D Rea
    Department of Medicine, University of Washington, Seattle 98101, USA
    Arch Neurol 62:1047-51. 2005
    ..Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) reduce cardiovascular risk through mechanisms that might affect the development of dementia...
  5. ncbi request reprint Quantitative in vivo biomarkers of oxidative damage and their application to the diagnosis and management of Alzheimer's disease
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    J Alzheimers Dis 8:359-67. 2005
    ..In addition, measurement of CSF F2-IsoPs can increase the accuracy of laboratory-based classification of geriatric dementias, and have been used to assess objectively the response to anti-oxidant interventions in AD...
  6. ncbi request reprint Incidence and prevalence of dementia in the Cardiovascular Health Study
    Annette L Fitzpatrick
    Department of Epidemiology, University of Washington, Seattle, Washington 98115, USA
    J Am Geriatr Soc 52:195-204. 2004
    ..To estimate the incidence and prevalence of dementia, Alzheimer's disease (AD), and vascular dementia (VaD) in the Cardiovascular Health Study (CHS) cohort...
  7. ncbi request reprint Antioxidant vitamin supplement use and risk of dementia or Alzheimer's disease in older adults
    Shelly L Gray
    School of Pharmacy, University of Washington, Seattle, Washington 98195, USA
    J Am Geriatr Soc 56:291-5. 2008
    ..To examine whether use of vitamins C or E alone or in combination was associated with lower incidence of dementia or Alzheimer's disease (AD)...
  8. pmc Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smoking
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, USA
    Ann Neurol 65:226-9. 2009
    ....
  9. pmc Cerebrospinal fluid biomarkers in mild cognitive impairment and dementia
    Joshua A Sonnen
    Department of Pathology, Division of Neuropathology, University of Washington, Seattle, WA 98104 2420, USA
    J Alzheimers Dis 19:301-9. 2010
    ..A multimodal approach that brings independent information from risk factor assessment, neuroimaging, and biomarkers may soon guide physicians in the early diagnosis and management of cognitive impairment in the elderly...
  10. pmc Age-varying association between statin use and incident Alzheimer's disease
    Ge Li
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA
    J Am Geriatr Soc 58:1311-7. 2010
    ..To determine whether risk reduction of statins for Alzheimer's disease (AD) varies by age or presence of apolipoprotein E (APOE) epsilon4 allele...
  11. ncbi request reprint Age-varying association between blood pressure and risk of dementia in those aged 65 and older: a community-based prospective cohort study
    Ge Li
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA
    J Am Geriatr Soc 55:1161-7. 2007
    ..To assess variation in the association between blood pressure (BP) and risk for dementia across a spectrum of older ages and to examine BP changes before dementia onset...
  12. pmc Histamine-2 receptor antagonist use and incident dementia in an older cohort
    Shelly L Gray
    School of Pharmacy, University of Washington, Seattle, Washington, USA
    J Am Geriatr Soc 59:251-7. 2011
    ..To examine whether histamine-2 receptor antagonist medications (H2RAs) are associated with a lower incidence of all-cause dementia or Alzheimer's disease (AD), as some studies have suggested...
  13. pmc Biomarkers for cognitive impairment and dementia in elderly people
    Joshua A Sonnen
    Department of Pathology, Division of Neuropathology, University of Washington, Seattle, WA 98104, USA
    Lancet Neurol 7:704-14. 2008
    ..An approach that efficiently combines independent information from risk-factor assessment, neuroimaging measures, and biomarkers might soon guide clinicians in the early diagnosis and management of cognitive impairment in elderly people...
  14. ncbi request reprint Apolipoprotein E genotype and mortality: findings from the Cache County Study
    Kathleen M Hayden
    Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina
    J Am Geriatr Soc 53:935-42. 2005
    ..To evaluate the association between apolipoprotein E (apo E) epsilon4 and mortality, the population attributable risk for mortality with epsilon4, and relative contributions of cardiovascular disease (CVD) and Alzheimer's disease (AD)...
  15. pmc Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib
    Barbara K Martin
    Arch Neurol 65:896-905. 2008
    ..Observational studies have shown reduced risk of Alzheimer dementia in users of nonsteroidal anti-inflammatory drugs...
  16. ncbi request reprint A population study of Alzheimer's disease: findings from the Cache County Study on Memory, Health, and Aging
    JoAnn T Tschanz
    Department of Psychology, Center for Epidemiologic Studies, Utah State University, Logan 84322 4440, USA
    Care Manag J 6:107-14. 2005
    ....
  17. ncbi request reprint Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County Study
    Peter P Zandi
    Department of Mental Hygiene, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Neurology 59:880-6. 2002
    ..The authors re-examined these associations using data on incident AD...
  18. ncbi request reprint Vascular risk factors for incident Alzheimer disease and vascular dementia: the Cache County study
    Kathleen M Hayden
    Department of Medicine, Division of Neurology, Duke University Medical Center, Durham, NC 27705, USA
    Alzheimer Dis Assoc Disord 20:93-100. 2006
    ..Future studies should focus on specific causal pathways for each of these factors with regard to sex to determine if sex differences in the prevalence of vascular factors have an influence on sex differences in dementia risk...
  19. ncbi request reprint Do statins reduce risk of incident dementia and Alzheimer disease? The Cache County Study
    Peter P Zandi
    Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Arch Gen Psychiatry 62:217-24. 2005
    ..Prior reports suggest reduced occurrence of dementia and Alzheimer disease (AD) in statin users, but, to our knowledge, no prospective studies relate statin use and dementia incidence...
  20. pmc Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study
    Martin Steinberg
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Int J Geriatr Psychiatry 23:170-7. 2008
    ..Neuropsychiatric symptoms are nearly universal in dementia, yet little is known about their longitudinal course in the community...
  21. ncbi request reprint Apolipoprotein E epsilon4 count affects age at onset of Alzheimer disease, but not lifetime susceptibility: The Cache County Study
    Ara S Khachaturian
    Khachaturian and Associates Inc, Potomac, MD, USA
    Arch Gen Psychiatry 61:518-24. 2004
    ..APOE is a strong genetic risk factor for AD...
  22. ncbi request reprint Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study
    Peter P Zandi
    Department of Mental Health, Bloomberg School of Public Health, The Johns Hopkins University, Hampton House Room 857, 624 N Broadway, Baltimore, MD 21205, USA
    Arch Neurol 61:82-8. 2004
    ..Antioxidants may protect the aging brain against oxidative damage associated with pathological changes of Alzheimer disease (AD)...
  23. pmc Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: the Cache County Study
    Majid Fotuhi
    Department of Neurology, Johns Hopkins University School of Medicine, and Center for Memory and Brain Health, LifeBridge Health Brain and Spine Institute, Baltimore, MD, USA
    Alzheimers Dement 4:223-7. 2008
    ..05). These results suggest that among elderly individuals with an APOE epsilon4 allele, there is an association between using antioxidant supplements in combination with NSAIDs and less cognitive decline over time...
  24. ncbi request reprint Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study
    Peter P Zandi
    Department of Mental Hygiene, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, MD, USA
    JAMA 288:2123-9. 2002
    ..Basic neuroscience findings suggest that hormone replacement therapy (HRT) could reduce a woman's risk of AD. Epidemiologic findings on AD and HRT are mixed...
  25. ncbi request reprint Characteristics of a two-stage screen for incident dementia
    Kathleen M Hayden
    Department of Menral Hygiene, The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Clin Epidemiol 56:1038-45. 2003
    ..Two-stage screening may offer improvements over single-stage methods. We therefore investigated a two-stage screening protocol for incident dementia among 3,308 elderly...
  26. ncbi request reprint The epidemiology of psychosis in dementia
    Iracema Leroi
    Neuropsychiatry Service, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD 21287, USA
    Am J Geriatr Psychiatry 11:83-91. 2003
    ..Authors compared delusions, hallucinations, and misidentification delusions in Alzheimer disease (AD) and vascular dementia (VaD) patients...
  27. ncbi request reprint The incidence of mental and behavioral disturbances in dementia: the cache county study
    Martin Steinberg
    Johns Hopkins Hospital, Baltimore, MD 21287, USA
    J Neuropsychiatry Clin Neurosci 15:340-5. 2003
    ..These results argue for a routine assessment of psychiatric disturbances in all patients with dementia, even among those who have never experienced symptoms of mental or behavioral disturbances...
  28. doi request reprint Regional atrophy of the corpus callosum in dementia
    Bradley J Hallam
    The Travis Research Institute, Center for Biopsychosocial Research, Fuller Graduate School of Psychology, Pasadena, California, USA
    J Int Neuropsychol Soc 14:414-23. 2008
    ..Findings suggest that dementia-related CC atrophy occurs primarily in the anterior and posterior portions...
  29. doi request reprint Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease
    George J Siegel
    Neurology 71:383; author reply 383. 2008
  30. ncbi request reprint Paranoid psychoses in old age: much more common than previously thought?
    John C S Breitner
    Bloomberg School of Public Health, Johns Hopkins University, 624 N Broadway, Hampton House, Room 850, Baltimore, MD 21205, USA
    Arch Gen Psychiatry 59:60-1. 2002
  31. pmc Vascular factors and risk for neuropsychiatric symptoms in Alzheimer's disease: the Cache County Study
    Katherine A Treiber
    Department of Psychology, Utah State University, Logan, U S A
    Int Psychogeriatr 20:538-53. 2008
    ..To examine, in an exploratory analysis, the association between vascular conditions and the occurrence of neuropsychiatric symptoms (NPS) in a population-based sample of incident Alzheimer's disease (AD)...
  32. doi request reprint Chronic disease long-term drug prevention trials: lessons from the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT)
    Curtis L Meinert
    Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, USA
    Alzheimers Dement 4:S7-S14. 2008
    ....
  33. pmc Church attendance and new episodes of major depression in a community study of older adults: the Cache County Study
    Maria C Norton
    Department of Family, Consumer and Human Development, Cache County Study on Memory Health and Aging, Utah State University, 4440 Old Main Hill, Logan, UT 84322 4440, USA
    J Gerontol B Psychol Sci Soc Sci 63:P129-37. 2008
    ..28-0.92). Results suggest that there may be a threshold of church attendance that is necessary for a person to garner long-term protection from depression. We discuss sociological factors relevant to LDS culture...
  34. pmc A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium
    Zaven S Khachaturian
    Alzheimers Dement 4:156-63. 2008
  35. ncbi request reprint The trialist, meta-analyst, and journal editor: lessons from ADAPT
    Barbara K Martin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Am J Med 120:192-3. 2007
  36. ncbi request reprint Risk of mortality with vitamin E supplements: the Cache County study
    Kathleen M Hayden
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Am J Med 120:180-4. 2007
    ..We sought to determine whether these mortality risks with vitamin E reflect adverse consequences of its use in the presence of cardiovascular disease...
  37. ncbi request reprint An adaptation of the modified mini-mental state examination: analysis of demographic influences and normative data: the cache county study
    JoAnn T Tschanz
    Department of Psychology, Utah State University, Logan, Utah 84322 4440, USA
    Neuropsychiatry Neuropsychol Behav Neurol 15:28-38. 2002
    ..To present a new version of the Modified Mini-Mental State Examination (3MS-R), provide normative information extending to individuals in the 10th decade, and examine the effects of demographic variables on test performance...
  38. ncbi request reprint H2 histamine receptor blockade in the treatment of Alzheimer disease: a randomized, double-blind, placebo-controlled trial of nizatidine
    Michelle C Carlson
    Department of Mental Hygiene, and Center on Aging and Health, The Johns Hopkins University School of Public Health, Baltimore, Maryland 21205, USA
    Alzheimer Dis Assoc Disord 16:24-30. 2002
    ..To evaluate the efficacy of nizatidine, a histamine H2-blocking drug, in delaying the progression of cognitive impairment in older adults with Alzheimer disease (AD)...
  39. ncbi request reprint Is pharmacological prevention of Alzheimer's a realistic goal?
    Peter P Zandi
    Department of Mental Hygiene, Bloomberg School of Public Health, Johns Hopkins University, Hampton House 884, 624 N Broadway, Baltimore, MD 21205, USA
    Expert Opin Pharmacother 3:365-80. 2002
    ....
  40. ncbi request reprint White matter lesions, quantitative magnetic resonance imaging, and dementia
    Erin D Bigler
    Bringham Young University, Provo, Utah, USA
    Alzheimer Dis Assoc Disord 16:161-70. 2002
    ..There were no significant qualitative or quantitative findings related to presence of the epsilon4 allele and MMSE performance. The role of WMLs in aging and dementia is discussed...
  41. ncbi request reprint Alzheimer disease in Turkey too
    John C S Breitner
    Alzheimer Dis Assoc Disord 17:137-8. 2003
  42. ncbi request reprint Effects of estrogen plus progestin on risk of dementia
    John C S Breitner
    JAMA 290:1706-7; author reply 1707-8. 2003
  43. ncbi request reprint "At my wits' end": neuroticism and dementia
    John C S Breitner
    Neurology 61:1468-9. 2003
  44. ncbi request reprint The persistence of neuropsychiatric symptoms in dementia: the Cache County Study
    Martin Steinberg
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Int J Geriatr Psychiatry 19:19-26. 2004
    ..To estimate the 18-month persistence of neuropsychiatric symptoms in dementia in a population-based sample, and to compare the severity of neuropsychiatric symptoms at baseline to the severity at 18-month follow-up...
  45. ncbi request reprint Nonsteroidal anti-inflammatory drugs for the prevention of Alzheimer's disease: a systematic review
    Christine A Szekely
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Neuroepidemiology 23:159-69. 2004
    ..The purpose of this meta-analysis is to summarize and evaluate available evidence regarding exposure to nonaspirin NSAIDs and risk of Alzheimer's disease using meta-analyses of published studies...
  46. ncbi request reprint Population-based study of medical comorbidity in early dementia and "cognitive impairment, no dementia (CIND)": association with functional and cognitive impairment: The Cache County Study
    Constantine G Lyketsos
    Division of Geriatric Psychiatry and Neuropsychiatry, Dept of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Am J Geriatr Psychiatry 13:656-64. 2005
    ..Authors investigated medical comorbidity in persons with dementia and "Cognitive Impairment, No Dementia" (CIND)...
  47. ncbi request reprint Is cholesterol a culprit in Alzheimer's disease?
    D Larry Sparks
    Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, Arizona 85351, USA
    Int Psychogeriatr 15:153-9. 2003
    ..Nevertheless, the foregoing suggests that routine monitoring and intervention for elevated cholesterol levels among the elderly could promote more than a healthy heart...
  48. ncbi request reprint Three-year incidence of first-onset depressive syndrome in a population sample of older adults: the Cache County study
    Maria C Norton
    Department of Family, Consumer and Human Development, Utah State University, Logan, 84322, USA
    Am J Geriatr Psychiatry 14:237-45. 2006
    ....
  49. ncbi request reprint Antihypertensive medication use and incident Alzheimer disease: the Cache County Study
    Ara S Khachaturian
    Khachaturian and Associates Inc, Potomac, MD, USA
    Arch Neurol 63:686-92. 2006
    ..Recent reports suggest that antihypertensive (AH) medications may reduce the risk of dementing illnesses...
  50. ncbi request reprint A population-based study of the association between coronary artery bypass graft surgery (CABG) and cognitive decline: the Cache County study
    Constantine G Lyketsos
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA
    Int J Geriatr Psychiatry 21:509-18. 2006
    ..The relationship between coronary artery bypass graft (CABG) surgery and cognitive decline remains uncertain, in particular with regard to whether there is delayed cognitive decline associated with this procedure...
  51. ncbi request reprint Duke Twins Study of Memory in Aging in the NAS-NRC Twin Registry
    Brenda L Plassman
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27701, USA
    Twin Res Hum Genet 9:950-7. 2006
    ..We provide an overview of the study's methodology and describe the focus of recent research...
  52. ncbi request reprint Double placebo design in a prevention trial for Alzheimer's disease
    Barbara K Martin
    Department of Epidemiology, Center for Clinical Trials, Bloomberg School of Hygiene and Public Health, The Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Control Clin Trials 23:93-9. 2002
    ..The authors outline the placebo designs considered in ADAPT, discuss their advantages and disadvantages, and provide their rationale for and the consequences of the selection of the double placebo design...

Research Grants12

  1. PREVENTION OF ALZHEIMER DEMENTIA & COGNITIVE DECLINE
    John Breitner; Fiscal Year: 2006
    ..25 to 4 years of observation and a final analysis. As a secondary outcome, we will examine the trajectory of cognitive scores to assess ARCD. ..
  2. Prostaglandins & Oxidative Damage in ADAPT Participants
    John Breitner; Fiscal Year: 2006
    ..These studies will provide important insights into the mechanisms by which NSAIDs prevent AD. ..
  3. EPIDEMIOLOGY OF DEMENTIA IN CACHE COUNTY, UTAH
    John Breitner; Fiscal Year: 2001
    ..These exposures will receive emphasis in the incidence phase of the study as a likely preface to randomized primary prevention trials. ..
  4. Prostaglandins & Oxidative Damage in ADAPT Participants
    John Breitner; Fiscal Year: 2007
    ..These studies will provide important insights into the mechanisms by which NSAIDs prevent AD. ..