George Breese

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Prior multiple ethanol withdrawals enhance stress-induced anxiety-like behavior: inhibition by CRF1- and benzodiazepine-receptor antagonists and a 5-HT1a-receptor agonist
    George R Breese
    Bowles Center for Alcohol Studies, Department of Psychiatry, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7178, USA
    Neuropsychopharmacology 30:1662-9. 2005
  2. pmc Stress enhancement of craving during sobriety: a risk for relapse
    George R Breese
    Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 29:185-95. 2005
  3. ncbi request reprint The neonate-6-hydroxydopamine-lesioned rat: a model for clinical neuroscience and neurobiological principles
    George R Breese
    Department of Psychiatry, UNC School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7178, USA
    Brain Res Brain Res Rev 48:57-73. 2005
  4. pmc Conceptual framework for the etiology of alcoholism: a "kindling"/stress hypothesis
    George R Breese
    Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina School of Medicine, 3007 Thurston Bowles Building CB 7178, Chapel Hill, NC 27599 7178, USA
    Psychopharmacology (Berl) 178:367-80. 2005
  5. pmc Basis of the gabamimetic profile of ethanol
    G R Breese
    Bowles Center for Alcohol Studies, UNC School of Medicine, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 30:731-44. 2006
  6. pmc Repeated lipopolysaccharide (LPS) or cytokine treatments sensitize ethanol withdrawal-induced anxiety-like behavior
    George R Breese
    Department of Psychiatry, UNC School of Medicine, Chapel Hill, NC, USA
    Neuropsychopharmacology 33:867-76. 2008
  7. pmc Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse
    George R Breese
    Bowles Center for Alcohol Research and the UNC Neuroscience Center, UNC School of Medicine, Chapel Hill, NC 27599, USA
    Pharmacol Ther 129:149-71. 2011
  8. ncbi request reprint Integrative role for serotonergic and glutamatergic receptor mechanisms in the action of NMDA antagonists: potential relationships to antipsychotic drug actions on NMDA antagonist responsiveness
    George R Breese
    Department of Psychiatry, UNC School of Medicine, University of North Carolina, 3007 Thurston Bowles Bldg, Chapel Hill, NC 27599 7178, USA
    Neurosci Biobehav Rev 26:441-55. 2002
  9. pmc Sustained extracellular signal-regulated kinase 1/2 phosphorylation in neonate 6-hydroxydopamine-lesioned rats after repeated D1-dopamine receptor agonist administration: implications for NMDA receptor involvement
    Sophia T Papadeas
    Neurobiology Curriculum, Department of Psychiatry and University of North Carolina Neuroscience Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7178, USA
    J Neurosci 24:5863-76. 2004
  10. pmc Corticotropin-releasing factor (CRF) sensitization of ethanol withdrawal-induced anxiety-like behavior is brain site specific and mediated by CRF-1 receptors: relation to stress-induced sensitization
    Mae M Huang
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
    J Pharmacol Exp Ther 332:298-307. 2010

Collaborators

Detail Information

Publications53

  1. pmc Prior multiple ethanol withdrawals enhance stress-induced anxiety-like behavior: inhibition by CRF1- and benzodiazepine-receptor antagonists and a 5-HT1a-receptor agonist
    George R Breese
    Bowles Center for Alcohol Studies, Department of Psychiatry, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7178, USA
    Neuropsychopharmacology 30:1662-9. 2005
    ....
  2. pmc Stress enhancement of craving during sobriety: a risk for relapse
    George R Breese
    Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 29:185-95. 2005
    ..b>George Breese presented data demonstrating that stress could substitute for repeated withdrawals from chronic ethanol to ..
  3. ncbi request reprint The neonate-6-hydroxydopamine-lesioned rat: a model for clinical neuroscience and neurobiological principles
    George R Breese
    Department of Psychiatry, UNC School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7178, USA
    Brain Res Brain Res Rev 48:57-73. 2005
    ..Despite an extraordinary legacy from studies of the neurobiology of this treatment, a host of unknowns remain that will inspire future investigations...
  4. pmc Conceptual framework for the etiology of alcoholism: a "kindling"/stress hypothesis
    George R Breese
    Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina School of Medicine, 3007 Thurston Bowles Building CB 7178, Chapel Hill, NC 27599 7178, USA
    Psychopharmacology (Berl) 178:367-80. 2005
    ..The rationale for proposing the "kindling"/stress hypothesis is to provide a conceptual basis for the insidious development and maintenance of alcohol abuse...
  5. pmc Basis of the gabamimetic profile of ethanol
    G R Breese
    Bowles Center for Alcohol Studies, UNC School of Medicine, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 30:731-44. 2006
    ..Collectively, this series of reports support the GABAmimetic profile of acutely administered ethanol being dependent on several specific mechanisms distinct from a direct effect on the major synaptic isoforms of GABA(A) receptors...
  6. pmc Repeated lipopolysaccharide (LPS) or cytokine treatments sensitize ethanol withdrawal-induced anxiety-like behavior
    George R Breese
    Department of Psychiatry, UNC School of Medicine, Chapel Hill, NC, USA
    Neuropsychopharmacology 33:867-76. 2008
    ..Together, these findings indicate that increased cytokine activity induces adaptive change that supports sensitization of ethanol withdrawal-induced anxiety that may be linked to GABA(A)-receptor function...
  7. pmc Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse
    George R Breese
    Bowles Center for Alcohol Research and the UNC Neuroscience Center, UNC School of Medicine, Chapel Hill, NC 27599, USA
    Pharmacol Ther 129:149-71. 2011
    ....
  8. ncbi request reprint Integrative role for serotonergic and glutamatergic receptor mechanisms in the action of NMDA antagonists: potential relationships to antipsychotic drug actions on NMDA antagonist responsiveness
    George R Breese
    Department of Psychiatry, UNC School of Medicine, University of North Carolina, 3007 Thurston Bowles Bldg, Chapel Hill, NC 27599 7178, USA
    Neurosci Biobehav Rev 26:441-55. 2002
    ....
  9. pmc Sustained extracellular signal-regulated kinase 1/2 phosphorylation in neonate 6-hydroxydopamine-lesioned rats after repeated D1-dopamine receptor agonist administration: implications for NMDA receptor involvement
    Sophia T Papadeas
    Neurobiology Curriculum, Department of Psychiatry and University of North Carolina Neuroscience Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7178, USA
    J Neurosci 24:5863-76. 2004
    ..Ultimately, long-lasting phosphorylation of ERK and CREB in MPC may play a pivotal role in any permanent adaptive change(s) in these animals...
  10. pmc Corticotropin-releasing factor (CRF) sensitization of ethanol withdrawal-induced anxiety-like behavior is brain site specific and mediated by CRF-1 receptors: relation to stress-induced sensitization
    Mae M Huang
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
    J Pharmacol Exp Ther 332:298-307. 2010
    ..These results indicate that CRF released by stress acts on CRF-1 receptors within specific brain regions to produce a cumulative adaptation that sensitizes anxiety-like behavior during withdrawal from chronic ethanol exposure...
  11. ncbi request reprint Changes in the effect of isoflurane on N-methyl-D-aspartic acid-gated currents in cultured cerebral cortical neurons with time in culture: evidence for subunit specificity
    Zhen Ming
    Anesthesiology, Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, 27599, USA
    Anesthesiology 97:856-67. 2002
    ..The authors have investigated changes in the effect of isoflurane on NMDA-gated currents from cultured cortical neurons with time in culture and related these changes to the subunit composition of the NMDA receptors...
  12. pmc Sensitization, duration, and pharmacological blockade of anxiety-like behavior following repeated ethanol withdrawal in adolescent and adult rats
    Tiffany A Wills
    Neurobiology Curriculum, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 33:455-63. 2009
    ..Current experiments determined if adolescent rats exhibit sensitized anxiety-like behavior, the duration of this effect, if drug pretreatments blocked these effects, and if these effects differed from those seen in adults...
  13. pmc The alcohol deprivation effect in C57BL/6J mice is observed using operant self-administration procedures and is modulated by CRF-1 receptor signaling
    Dennis R Sparta
    Department of Psychology, University of North Carolina, Chapel Hill, NC 27599 3270, USA
    Alcohol Clin Exp Res 33:31-42. 2009
    ..Therefore, we determined whether the ADE can be observed in C57BL/6J mice using operant self-administration procedures and if expression of the ADE is modulated by the corticotropin releasing factor-1 (CRF-1) receptor...
  14. pmc Genetic essential tremor in gamma-aminobutyric acidA receptor alpha1 subunit knockout mice
    Jason E Kralic
    Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7178, USA
    J Clin Invest 115:774-9. 2005
    ..This genetic animal model elucidates a mechanism of GABAergic dysfunction in the major motor pathway and potential targets for pharmacotherapy of essential tremor...
  15. pmc The CRF-1 receptor antagonist, CP-154,526, attenuates stress-induced increases in ethanol consumption by BALB/cJ mice
    Emily G Lowery
    Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599 3270, USA
    Alcohol Clin Exp Res 32:240-8. 2008
    ..The current experiment was conducted to further characterize the role of CRF1 receptor (CRF1R) signaling in stress-induced increases in ethanol consumption in BALB/cJ and C57BL/6N mice...
  16. pmc Differential dietary ethanol intake and blood ethanol levels in adolescent and adult rats: effects on anxiety-like behavior and seizure thresholds
    Tiffany A Wills
    Neurobiology Curriculum, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 32:1350-60. 2008
    ..While adolescent rats have differential responses to both acute and chronic ethanol treatments, the potential differences in the effects of repeated withdrawals in this population have yet to be determined...
  17. pmc Comparison of basal neuropeptide Y and corticotropin releasing factor levels between the high ethanol drinking C57BL/6J and low ethanol drinking DBA/2J inbred mouse strains
    Dayna M Hayes
    Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599 3270, USA
    Alcohol Clin Exp Res 29:721-9. 2005
    ..Therefore, we used immunohistochemical techniques to determine if basal NPY and/or CRF levels differed in predicted directions between C57BL/6J and DBA/2J mice...
  18. pmc Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
    Liya Qin
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Glia 55:453-62. 2007
    ..These findings provide valuable insight into the potential pathogenesis and self-propelling nature of Parkinson's disease...
  19. pmc Predictors of high ethanol consumption in RIIbeta knock-out mice: assessment of anxiety and ethanol-induced sedation
    Jon R Fee
    Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599 3270, USA
    Alcohol Clin Exp Res 28:1459-68. 2004
    ..We determined whether high ethanol intake by the RIIbeta(-/-) mice on alternate genetic backgrounds is reliably predicted by high basal levels of anxiety or resistance to the sedative effects of ethanol...
  20. ncbi request reprint Effect of acute and chronic olanzapine treatment on phencyclidine-induced behavioral sensitization in rats with neonatal dopamine loss
    Sheryl S Moy
    Department of Psychiatry, University of North Carolina, Chapel Hill 27599 7178, USA
    Pharmacol Biochem Behav 78:47-56. 2004
    ....
  21. ncbi request reprint Phencyclidine supersensitivity in rats with neonatal dopamine loss
    Sheryl S Moy
    Neurodevelopmental Disorders Research Center and Skipper Bowles Center for Alcohol Studies, Department of Psychiatry, CB 7178, University of North Carolina, Chapel Hill 27599, USA
    Psychopharmacology (Berl) 161:255-62. 2002
    ....
  22. pmc Calcium release from presynaptic internal stores is required for ethanol to increase spontaneous gamma-aminobutyric acid release onto cerebellum Purkinje neurons
    M Katherine Kelm
    Bowles Center for Alcohol Studies, CB 7178, Thurston Bowles Building, Chapel Hill, NC 27599 7178, USA
    J Pharmacol Exp Ther 323:356-64. 2007
    ..Overall, these data suggest that calcium release from presynaptic internal stores plays a vital role in the mechanism of ethanol-enhanced spontaneous GABA release at the interneuron-Purkinje cell synapse...
  23. pmc The amygdala regulates the antianxiety sensitization effect of flumazenil during repeated chronic ethanol or repeated stress
    Darin J Knapp
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7158, USA
    Alcohol Clin Exp Res 31:1872-82. 2007
    ..This investigation explored the potential role of several brain regions (amygdala, raphe, inferior colliculus, nucleus accumbens, and paraventricular hypothalamus) for these actions of flumazenil...
  24. pmc Modulation of multiple ethanol withdrawal-induced anxiety-like behavior by CRF and CRF1 receptors
    David H Overstreet
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina, 3009 Thurston Bowles Building, CB 7178, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 77:405-13. 2004
    ..These findings indicate that the CRF system and CRF(1) receptors play key roles in the adaptive change responsible for the anxiety-like behavior induced by repeated withdrawals from chronic ethanol...
  25. pmc Brain regional differences in the effect of ethanol on GABA release from presynaptic terminals
    Hugh E Criswell
    Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC 27599, USA
    J Pharmacol Exp Ther 326:596-603. 2008
    ..This regional difference is consistent with earlier in vivo studies in which ethanol affected neural activity and sensitivity to GABA in some, but not all, brain sites...
  26. pmc Stress sensitization of ethanol withdrawal-induced reduction in social interaction: inhibition by CRF-1 and benzodiazepine receptor antagonists and a 5-HT1A-receptor agonist
    George R Breese
    Department of Psychiatry, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Neuropsychopharmacology 29:470-82. 2004
    ....
  27. ncbi request reprint Comparison of effect of ethanol on N-methyl-D-aspartate- and GABA-gated currents from acutely dissociated neurons: absence of regional differences in sensitivity to ethanol
    Hugh E Criswell
    Bowles Center for Alcohol Studies, Chapel Hill, North Carolina 27599 7178, USA
    J Pharmacol Exp Ther 304:192-9. 2003
    ..These data suggest that the regional differences in the effect of ethanol observed in vivo are not due to a differential action of ethanol at the postsynaptic NMDA or GABAA receptor subtypes...
  28. pmc The role of protein kinase A in the ethanol-induced increase in spontaneous GABA release onto cerebellar Purkinje neurons
    M Katherine Kelm
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    J Neurophysiol 100:3417-28. 2008
    ..Overall, these results suggest that PKA activation is necessary for ethanol to increase spontaneous GABA release...
  29. pmc A 5-HT1A agonist and a 5-HT2c antagonist reduce social interaction deficit induced by multiple ethanol withdrawals in rats
    David H Overstreet
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, CB 7178, Chapel Hill, NC 27599 7178, USA
    Psychopharmacology (Berl) 167:344-52. 2003
    ..The deficits in social interaction behavior following withdrawal from continuous ethanol exposure can be reduced following acute treatments with 5-HT(2C) antagonists or 5-HT(1A) agonists...
  30. pmc A selective ALDH-2 inhibitor reduces anxiety in rats
    David H Overstreet
    Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, United States
    Pharmacol Biochem Behav 94:255-61. 2009
    ..Thus, a non-addictive selective inhibitor of ALDH-2 has both anxiolytic and antidipsotropic properties, which may be dependent, in part on the involvement of the GABA-benzodiazepine system...
  31. pmc Accentuated decrease in social interaction in rats subjected to repeated ethanol withdrawals
    David H Overstreet
    Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Alcohol Clin Exp Res 26:1259-68. 2002
    ..In this article, the effects of a three-cycle model of ethanol exposure and withdrawal on the social interaction test of anxiety are summarized...
  32. pmc The PLC/IP 3 R/PKC pathway is required for ethanol-enhanced GABA release
    M Katherine Kelm
    Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7365, USA
    Neuropharmacology 58:1179-86. 2010
    ..Overall, these results suggest that activation of the PLC/IP(3)R/PKC pathway is necessary for ethanol to increase spontaneous GABA release from presynaptic terminals onto Purkinje cells...
  33. pmc Drug challenges reveal differences in mediation of stress facilitation of voluntary alcohol drinking and withdrawal-induced anxiety in alcohol-preferring P rats
    David H Overstreet
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 31:1473-81. 2007
    ..Because anxiety is often regarded as a precipitating factor in relapsing alcoholics, we decided to examine the consequences of stressing alcohol-preferring P rats on both voluntary alcohol drinking and withdrawal-induced anxiety...
  34. pmc Baclofen blocks expression and sensitization of anxiety-like behavior in an animal model of repeated stress and ethanol withdrawal
    Darin J Knapp
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 31:582-95. 2007
    ..The present investigation assessed whether pretreatment of rats with agents targeting receptor systems thought to be important in treating relapse in alcoholic patients would prevent sensitization of anxiety-like behavior...
  35. pmc Increased consumption but not operant self-administration of ethanol in mice lacking the RIIbeta subunit of protein kinase A
    Frank M Ferraro
    Department of Psychology, University of North Carolina, Chapel Hill 27599 3270, USA
    Alcohol Clin Exp Res 30:825-35. 2006
    ..Therefore, we determined whether the high ethanol consumption characteristic of RIIbeta(-/-) mice would be complemented by increased appetitive ethanol-seeking behavior in an operant paradigm...
  36. ncbi request reprint A conceptualization of integrated actions of ethanol contributing to its GABAmimetic profile: a commentary
    Hugh E Criswell
    Center for Alcohol Studies, UNC Neuroscience Center, Department of Psychiatry, University of North Carolina, School of Medicine, Chapel Hill, NC 27599 7178, USA
    Neuropsychopharmacology 30:1407-25. 2005
    ..Thus, an integration of these consequences induced by ethanol is proposed to provide a logical basis for its in vivo GABAmimetic profile...
  37. pmc Factors mediating alcohol craving and relapse: stress, compulsivity, and genetics
    Zachary A Rodd
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, 46202 4887, USA
    Alcohol Clin Exp Res 29:1325-33. 2005
  38. pmc Reduction in repeated ethanol-withdrawal-induced anxiety-like behavior by site-selective injections of 5-HT1A and 5-HT2C ligands
    David H Overstreet
    Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina School of Medicine, CB 7178, Chapel Hill, NC 27599 7178, USA
    Psychopharmacology (Berl) 187:1-12. 2006
    ..Anxiety-like behavior resulting from repeated withdrawals from chronic ethanol diets is counteracted by systemic administration of a 5-HT2C receptor antagonist or a 5-HT1A receptor partial agonist...
  39. pmc Competing presynaptic and postsynaptic effects of ethanol on cerebellar purkinje neurons
    Zhen Ming
    Department of Psychiatry, Center for Alcohol Studies, UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 30:1400-7. 2006
    ..The present study examines the interplay of presynaptic and postsynaptic mechanisms to determine the net effect of ethanol on the neuronal firing rate of cerebellar Purkinje neurons...
  40. ncbi request reprint Macrokinetic analysis of blockade of NMDA-gated currents by substituted alcohols, alkanes and ethers
    Hugh E Criswell
    Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Brain Res 1015:107-13. 2004
    ..These data indicate that a wide variety of volatile hydrocarbon based CNS depressants produce a similar inhibition of NMDA-gated currents and that the kinetics for these agents are inconsistent with an open channel block...
  41. pmc Nifedipine suppresses self-injurious behaviors in animals
    Bonita L Blake
    Department of Psychiatry, University of North Carolina, Chapel Hill, USA
    Dev Neurosci 29:241-50. 2007
    ..These results suggest that nifedipine may target a common biological mechanism in the expression of self-injurious behavior, and they suggest it should be considered in the treatment of self-injury in humans...
  42. pmc Modulation of ethanol withdrawal-induced anxiety-like behavior during later withdrawals by treatment of early withdrawals with benzodiazepine/gamma-aminobutyric acid ligands
    Darin J Knapp
    Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 29:553-63. 2005
    ..The studies reported herein examined the effects of gamma-aminobutyric acid-modulating drugs on social interaction behavior-an established model of anxiety-in rats exposed to repeated cycles of ethanol treatment and withdrawal...
  43. pmc Pharmacological modulation of repeated ethanol withdrawal-induced anxiety-like behavior differs in alcohol-preferring P and Sprague-Dawley rats
    David H Overstreet
    Bowles Center for Alcohol Studies, Department of Psychiatry, 3009 Thurston Bowles Bldg, CB 7178, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 81:122-30. 2005
    ....
  44. pmc SB242084, flumazenil, and CRA1000 block ethanol withdrawal-induced anxiety in rats
    Darin J Knapp
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Alcohol 32:101-11. 2004
    ..Because anxiety may be a complicating factor in alcohol withdrawal and relapse, future studies of this type are needed to provide focus for the effort to define selective and novel antianxiety agents for these disorders...
  45. pmc Ethanol-enhanced GABA release: a focus on G protein-coupled receptors
    M Katherine Kelm
    Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7178, USA
    Brain Res Rev 65:113-23. 2011
    ....
  46. pmc Nerve growth factor (NGF) has novel antidepressant-like properties in rats
    David H Overstreet
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7178, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 94:553-60. 2010
    ..Thus, NGF has antidepressant-like effects but does not appear to have biochemical actions typical of other antidepressants...
  47. pmc Effects of melanocortin receptor activation and blockade on ethanol intake: a possible role for the melanocortin-4 receptor
    Montserrat Navarro
    Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 29:949-57. 2005
    ..Here we assessed the possibility that MC receptor (MCR) agonists modulate ethanol intake via the MC3 receptor (MC3R) and/or the MC4 receptor (MC4R) and whether the MCR antagonist AgRP-(83-132) controls ethanol consumption...
  48. pmc Decreased immunoreactivity of the melanocortin neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) after chronic ethanol exposure in Sprague-Dawley rats
    Montserrat Navarro
    Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599 3270, USA
    Alcohol Clin Exp Res 32:266-76. 2008
    ..We also determined if ethanol exposure would alter the immunoreactivity of agouti-related protein (AgRP), an endogenous MCR antagonist...
  49. pmc Similar anxiety-like responses in male and female rats exposed to repeated withdrawals from ethanol
    David H Overstreet
    Department of Psychiatry, Skipper Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Thurston Bowles Building 3009, CB 7178, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 78:459-64. 2004
    ..Thus, there are no sex differences in the three-cycle multiple-withdrawal paradigm, but there may be differences after briefer exposures...
  50. pmc Changes in apical dendritic structure correlate with sustained ERK1/2 phosphorylation in medial prefrontal cortex of a rat model of dopamine D1 receptor agonist sensitization
    Sophia T Papadeas
    Graduate Program in Neurobiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Comp Neurol 511:271-85. 2008
    ..Furthermore, sustained elevation of ERK activity in mPFC pyramidal neurons may play a role in guiding these morphological changes in vivo...
  51. pmc Elevated anxiety-like behavior following ethanol exposure in mutant mice lacking neuropeptide Y (NPY)
    Dennis R Sparta
    Department of Psychology, University of North Carolina, Chapel Hill, NC 27599 3270, USA
    Drug Alcohol Depend 90:297-300. 2007
    ..5% ethanol...
  52. pmc The role of dopamine receptors in the neurobehavioral syndrome provoked by activation of L-type calcium channels in rodents
    Suhail Kasim
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
    Dev Neurosci 28:505-17. 2006
    ..Instead, the behaviors appear to result from a postsynaptic activation of the drug, which does not require but can be modified by D(3) or D(1/5) receptors...
  53. ncbi request reprint Oxidative stress and dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease
    Jasper E Visser
    Department of Neurology, Meyer 6 181, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Brain Res Dev Brain Res 133:127-39. 2002
    ..Overall, these data provide evidence for increased oxidative stress, but the failure to protect the knockout mice by over-expressing SOD1 argues that oxidative stress is not the sole process responsible for the loss of striatal dopamine...

Research Grants17

  1. GABAA R-subunit changes in adolescents by a cytokine/ethanol withdrawal protocol
    George Breese; Fiscal Year: 2009
    ..Since cytokines contribute to stress responses, this proposal examines adaptive changes in adolescent rats that result from an interaction of cytokines and ethanol. ..
  2. Stress Sensitization of CRF-Induced Withdrawal Behaviors
    George Breese; Fiscal Year: 2009
    ..New treatment strategies could emerge from such knowledge ..
  3. Flumazenil on Multiple Stress and Withdrawal Anxiety
    George Breese; Fiscal Year: 2007
    ....
  4. NEUROSTEROIDS IN THE ACTION OF ETHANOL ON GABA
    George Breese; Fiscal Year: 2004
    ..Completion of the Aims will allow critical new information to emerge concerning the molecular basis of neurosteroid action on GABAA receptor function that allows ethanol to enhance GABA function in vitro. ..
  5. MOLECULAR BIOLOGY OF ETHANOL ACTION ON RECEPTORS
    George Breese; Fiscal Year: 2002
    ..Further, based upon structural analysis of ethanol's action on protein-protein inter-actions for the receptors, results may ultimately allow us to predict other protein-protein interactions influenced by ethanol. ..
  6. GABAA R-subunit changes in adolescents by a cytokine/ethanol withdrawal protocol
    George R Breese; Fiscal Year: 2010
    ..Since cytokines contribute to stress responses, this proposal examines adaptive changes in adolescent rats that result from an interaction of cytokines and ethanol. ..