Research Topics
Species | George BreeseSummaryAffiliation: University of North Carolina Country: USA Publications
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Publications
Prior multiple ethanol withdrawals enhance stress-induced anxiety-like behavior: inhibition by CRF1- and benzodiazepine-receptor antagonists and a 5-HT1a-receptor agonistGeorge R Breese
Bowles Center for Alcohol Studies, Department of Psychiatry, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7178, USA
Neuropsychopharmacology 30:1662-9. 2005....- Stress enhancement of craving during sobriety: a risk for relapseGeorge R Breese
Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
Alcohol Clin Exp Res 29:185-95. 2005..b>George Breese presented data demonstrating that stress could substitute for repeated withdrawals from chronic ethanol to .. - The neonate-6-hydroxydopamine-lesioned rat: a model for clinical neuroscience and neurobiological principlesGeorge R Breese
Department of Psychiatry, UNC School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7178, USA
Brain Res Brain Res Rev 48:57-73. 2005..Despite an extraordinary legacy from studies of the neurobiology of this treatment, a host of unknowns remain that will inspire future investigations... - Conceptual framework for the etiology of alcoholism: a "kindling"/stress hypothesisGeorge R Breese
Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina School of Medicine, 3007 Thurston Bowles Building CB 7178, Chapel Hill, NC 27599 7178, USA
Psychopharmacology (Berl) 178:367-80. 2005..The rationale for proposing the "kindling"/stress hypothesis is to provide a conceptual basis for the insidious development and maintenance of alcohol abuse... - Basis of the gabamimetic profile of ethanolG R Breese
Bowles Center for Alcohol Studies, UNC School of Medicine, Chapel Hill, North Carolina 27599, USA
Alcohol Clin Exp Res 30:731-44. 2006..Collectively, this series of reports support the GABAmimetic profile of acutely administered ethanol being dependent on several specific mechanisms distinct from a direct effect on the major synaptic isoforms of GABA(A) receptors... - Repeated lipopolysaccharide (LPS) or cytokine treatments sensitize ethanol withdrawal-induced anxiety-like behaviorGeorge R Breese
Department of Psychiatry, UNC School of Medicine, Chapel Hill, NC, USA
Neuropsychopharmacology 33:867-76. 2008..Together, these findings indicate that increased cytokine activity induces adaptive change that supports sensitization of ethanol withdrawal-induced anxiety that may be linked to GABA(A)-receptor function... - Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapseGeorge R Breese
Bowles Center for Alcohol Research and the UNC Neuroscience Center, UNC School of Medicine, Chapel Hill, NC 27599, USA
Pharmacol Ther 129:149-71. 2011.... - Integrative role for serotonergic and glutamatergic receptor mechanisms in the action of NMDA antagonists: potential relationships to antipsychotic drug actions on NMDA antagonist responsivenessGeorge R Breese
Department of Psychiatry, UNC School of Medicine, University of North Carolina, 3007 Thurston Bowles Bldg, Chapel Hill, NC 27599 7178, USA
Neurosci Biobehav Rev 26:441-55. 2002.... - Sustained extracellular signal-regulated kinase 1/2 phosphorylation in neonate 6-hydroxydopamine-lesioned rats after repeated D1-dopamine receptor agonist administration: implications for NMDA receptor involvementSophia T Papadeas
Neurobiology Curriculum, Department of Psychiatry and University of North Carolina Neuroscience Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7178, USA
J Neurosci 24:5863-76. 2004..Ultimately, long-lasting phosphorylation of ERK and CREB in MPC may play a pivotal role in any permanent adaptive change(s) in these animals... - Corticotropin-releasing factor (CRF) sensitization of ethanol withdrawal-induced anxiety-like behavior is brain site specific and mediated by CRF-1 receptors: relation to stress-induced sensitizationMae M Huang
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
J Pharmacol Exp Ther 332:298-307. 2010..These results indicate that CRF released by stress acts on CRF-1 receptors within specific brain regions to produce a cumulative adaptation that sensitizes anxiety-like behavior during withdrawal from chronic ethanol exposure... - Changes in the effect of isoflurane on N-methyl-D-aspartic acid-gated currents in cultured cerebral cortical neurons with time in culture: evidence for subunit specificityZhen Ming
Anesthesiology, Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, 27599, USA
Anesthesiology 97:856-67. 2002..This effect of isoflurane was subunit dependent with the NR2B-containing receptors more sensitive to isoflurane than the NR2A-containing receptors. A potent tachyphylaxis occurred after brief exposure to isoflurane... - Sensitization, duration, and pharmacological blockade of anxiety-like behavior following repeated ethanol withdrawal in adolescent and adult ratsTiffany A Wills
Neurobiology Curriculum, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27599, USA
Alcohol Clin Exp Res 33:455-63. 2009..Current experiments determined if adolescent rats exhibit sensitized anxiety-like behavior, the duration of this effect, if drug pretreatments blocked these effects, and if these effects differed from those seen in adults... - The alcohol deprivation effect in C57BL/6J mice is observed using operant self-administration procedures and is modulated by CRF-1 receptor signalingDennis R Sparta
Department of Psychology, University of North Carolina, Chapel Hill, NC 27599 3270, USA
Alcohol Clin Exp Res 33:31-42. 2009..Therefore, we determined whether the ADE can be observed in C57BL/6J mice using operant self-administration procedures and if expression of the ADE is modulated by the corticotropin releasing factor-1 (CRF-1) receptor... - Genetic essential tremor in gamma-aminobutyric acidA receptor alpha1 subunit knockout miceJason E Kralic
Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7178, USA
J Clin Invest 115:774-9. 2005..This genetic animal model elucidates a mechanism of GABAergic dysfunction in the major motor pathway and potential targets for pharmacotherapy of essential tremor... - The CRF-1 receptor antagonist, CP-154,526, attenuates stress-induced increases in ethanol consumption by BALB/cJ miceEmily G Lowery
Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599 3270, USA
Alcohol Clin Exp Res 32:240-8. 2008..The current experiment was conducted to further characterize the role of CRF1 receptor (CRF1R) signaling in stress-induced increases in ethanol consumption in BALB/cJ and C57BL/6N mice... - Differential dietary ethanol intake and blood ethanol levels in adolescent and adult rats: effects on anxiety-like behavior and seizure thresholdsTiffany A Wills
Neurobiology Curriculum, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Alcohol Clin Exp Res 32:1350-60. 2008..While adolescent rats have differential responses to both acute and chronic ethanol treatments, the potential differences in the effects of repeated withdrawals in this population have yet to be determined... - Comparison of basal neuropeptide Y and corticotropin releasing factor levels between the high ethanol drinking C57BL/6J and low ethanol drinking DBA/2J inbred mouse strainsDayna M Hayes
Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599-3270, USA
Alcohol Clin Exp Res 29:721-9. 2005.... - Systemic LPS causes chronic neuroinflammation and progressive neurodegenerationLiya Qin
Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Glia 55:453-62. 2007..These findings provide valuable insight into the potential pathogenesis and self-propelling nature of Parkinson's disease... - Predictors of high ethanol consumption in RIIbeta knock-out mice: assessment of anxiety and ethanol-induced sedationJon R Fee
Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599-3270, USA
Alcohol Clin Exp Res 28:1459-68. 2004.... - Effect of acute and chronic olanzapine treatment on phencyclidine-induced behavioral sensitization in rats with neonatal dopamine lossSheryl S Moy
Department of Psychiatry, University of North Carolina, Chapel Hill 27599-7178, USA
Pharmacol Biochem Behav 78:47-56. 2004.... - Phencyclidine supersensitivity in rats with neonatal dopamine lossSheryl S Moy
Neurodevelopmental Disorders Research Center and Skipper Bowles Center for Alcohol Studies, Department of Psychiatry, CB 7178, University of North Carolina, Chapel Hill 27599, USA
Psychopharmacology (Berl) 161:255-62. 2002.... - Calcium release from presynaptic internal stores is required for ethanol to increase spontaneous gamma-aminobutyric acid release onto cerebellum Purkinje neuronsM Katherine Kelm
Bowles Center for Alcohol Studies, CB 7178, Thurston Bowles Building, Chapel Hill, NC 27599 7178, USA
J Pharmacol Exp Ther 323:356-64. 2007..Overall, these data suggest that calcium release from presynaptic internal stores plays a vital role in the mechanism of ethanol-enhanced spontaneous GABA release at the interneuron-Purkinje cell synapse... - The amygdala regulates the antianxiety sensitization effect of flumazenil during repeated chronic ethanol or repeated stressDarin J Knapp
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7158, USA
Alcohol Clin Exp Res 31:1872-82. 2007..This investigation explored the potential role of several brain regions (amygdala, raphe, inferior colliculus, nucleus accumbens, and paraventricular hypothalamus) for these actions of flumazenil... - Modulation of multiple ethanol withdrawal-induced anxiety-like behavior by CRF and CRF1 receptorsDavid H Overstreet
Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina, 3009 Thurston Bowles Building, CB 7178, Chapel Hill, NC 27599 7178, USA
Pharmacol Biochem Behav 77:405-13. 2004..These findings indicate that the CRF system and CRF(1) receptors play key roles in the adaptive change responsible for the anxiety-like behavior induced by repeated withdrawals from chronic ethanol... - Brain regional differences in the effect of ethanol on GABA release from presynaptic terminalsHugh E Criswell
Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC 27599, USA
J Pharmacol Exp Ther 326:596-603. 2008..This regional difference is consistent with earlier in vivo studies in which ethanol affected neural activity and sensitivity to GABA in some, but not all, brain sites... - Stress sensitization of ethanol withdrawal-induced reduction in social interaction: inhibition by CRF-1 and benzodiazepine receptor antagonists and a 5-HT1A-receptor agonistGeorge R Breese
Department of Psychiatry, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
Neuropsychopharmacology 29:470-82. 2004.... - Comparison of effect of ethanol on N-methyl-D-aspartate- and GABA-gated currents from acutely dissociated neurons: absence of regional differences in sensitivity to ethanolHugh E Criswell
Bowles Center for Alcohol Studies, Chapel Hill, North Carolina 27599 7178, USA
J Pharmacol Exp Ther 304:192-9. 2003..These data suggest that the regional differences in the effect of ethanol observed in vivo are not due to a differential action of ethanol at the postsynaptic NMDA or GABAA receptor subtypes... - The role of protein kinase A in the ethanol-induced increase in spontaneous GABA release onto cerebellar Purkinje neuronsM Katherine Kelm
Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
J Neurophysiol 100:3417-28. 2008..Overall, these results suggest that PKA activation is necessary for ethanol to increase spontaneous GABA release... - A 5-HT1A agonist and a 5-HT2c antagonist reduce social interaction deficit induced by multiple ethanol withdrawals in ratsDavid H Overstreet
Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, CB 7178, Chapel Hill, NC 27599 7178, USA
Psychopharmacology (Berl) 167:344-52. 2003..The deficits in social interaction behavior following withdrawal from continuous ethanol exposure can be reduced following acute treatments with 5-HT(2C) antagonists or 5-HT(1A) agonists... - A selective ALDH-2 inhibitor reduces anxiety in ratsDavid H Overstreet
Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, United States
Pharmacol Biochem Behav 94:255-61. 2009..Thus, a non-addictive selective inhibitor of ALDH-2 has both anxiolytic and antidipsotropic properties, which may be dependent, in part on the involvement of the GABA-benzodiazepine system... - Accentuated decrease in social interaction in rats subjected to repeated ethanol withdrawalsDavid H Overstreet
Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
Alcohol Clin Exp Res 26:1259-68. 2002..In this article, the effects of a three-cycle model of ethanol exposure and withdrawal on the social interaction test of anxiety are summarized... - The PLC/IP 3 R/PKC pathway is required for ethanol-enhanced GABA releaseM Katherine Kelm
Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7365, USA
Neuropharmacology 58:1179-86. 2010..Overall, these results suggest that activation of the PLC/IP(3)R/PKC pathway is necessary for ethanol to increase spontaneous GABA release from presynaptic terminals onto Purkinje cells... - Drug challenges reveal differences in mediation of stress facilitation of voluntary alcohol drinking and withdrawal-induced anxiety in alcohol-preferring P ratsDavid H Overstreet
Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
Alcohol Clin Exp Res 31:1473-81. 2007..Because anxiety is often regarded as a precipitating factor in relapsing alcoholics, we decided to examine the consequences of stressing alcohol-preferring P rats on both voluntary alcohol drinking and withdrawal-induced anxiety... - Baclofen blocks expression and sensitization of anxiety-like behavior in an animal model of repeated stress and ethanol withdrawalDarin J Knapp
Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
Alcohol Clin Exp Res 31:582-95. 2007..The present investigation assessed whether pretreatment of rats with agents targeting receptor systems thought to be important in treating relapse in alcoholic patients would prevent sensitization of anxiety-like behavior... - Increased consumption but not operant self-administration of ethanol in mice lacking the RIIbeta subunit of protein kinase AFrank M Ferraro
Department of Psychology, University of North Carolina, Chapel Hill 27599 3270, USA
Alcohol Clin Exp Res 30:825-35. 2006..Therefore, we determined whether the high ethanol consumption characteristic of RIIbeta(-/-) mice would be complemented by increased appetitive ethanol-seeking behavior in an operant paradigm... - A conceptualization of integrated actions of ethanol contributing to its GABAmimetic profile: a commentaryHugh E Criswell
Center for Alcohol Studies, UNC Neuroscience Center, Department of Psychiatry, University of North Carolina, School of Medicine, Chapel Hill, NC 27599 7178, USA
Neuropsychopharmacology 30:1407-25. 2005..Thus, an integration of these consequences induced by ethanol is proposed to provide a logical basis for its in vivo GABAmimetic profile... - Factors mediating alcohol craving and relapse: stress, compulsivity, and geneticsZachary A Rodd
Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, 46202-4887, USA
Alcohol Clin Exp Res 29:1325-33. 2005 - Reduction in repeated ethanol-withdrawal-induced anxiety-like behavior by site-selective injections of 5-HT1A and 5-HT2C ligandsDavid H Overstreet
Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina School of Medicine, CB 7178, Chapel Hill, NC 27599 7178, USA
Psychopharmacology (Berl) 187:1-12. 2006..Anxiety-like behavior resulting from repeated withdrawals from chronic ethanol diets is counteracted by systemic administration of a 5-HT2C receptor antagonist or a 5-HT1A receptor partial agonist... - Competing presynaptic and postsynaptic effects of ethanol on cerebellar purkinje neuronsZhen Ming
Department of Psychiatry, Center for Alcohol Studies, UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7178, USA
Alcohol Clin Exp Res 30:1400-7. 2006..Specifically, ethanol acts presynaptically to increase inhibition by release of GABA, while simultaneously acting postsynaptically to increase intrinsic excitatory drive... - Macrokinetic analysis of blockade of NMDA-gated currents by substituted alcohols, alkanes and ethersHugh E Criswell
Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
Brain Res 1015:107-13. 2004..These data indicate that a wide variety of volatile hydrocarbon based CNS depressants produce a similar inhibition of NMDA-gated currents and that the kinetics for these agents are inconsistent with an open channel block... - Nifedipine suppresses self-injurious behaviors in animalsBonita L Blake
Department of Psychiatry, University of North Carolina, Chapel Hill, USA
Dev Neurosci 29:241-50. 2007..These results suggest that nifedipine may target a common biological mechanism in the expression of self-injurious behavior, and they suggest it should be considered in the treatment of self-injury in humans... - Modulation of ethanol withdrawal-induced anxiety-like behavior during later withdrawals by treatment of early withdrawals with benzodiazepine/gamma-aminobutyric acid ligandsDarin J Knapp
Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Alcohol Clin Exp Res 29:553-63. 2005..The studies reported herein examined the effects of gamma-aminobutyric acid-modulating drugs on social interaction behavior-an established model of anxiety-in rats exposed to repeated cycles of ethanol treatment and withdrawal... - Pharmacological modulation of repeated ethanol withdrawal-induced anxiety-like behavior differs in alcohol-preferring P and Sprague-Dawley ratsDavid H Overstreet
Bowles Center for Alcohol Studies, Department of Psychiatry, 3009 Thurston Bowles Bldg, CB 7178, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
Pharmacol Biochem Behav 81:122-30. 2005.... - SB242084, flumazenil, and CRA1000 block ethanol withdrawal-induced anxiety in ratsDarin J Knapp
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Alcohol 32:101-11. 2004..Because anxiety may be a complicating factor in alcohol withdrawal and relapse, future studies of this type are needed to provide focus for the effort to define selective and novel antianxiety agents for these disorders... - Ethanol-enhanced GABA release: a focus on G protein-coupled receptorsM Katherine Kelm
Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7178, USA
Brain Res Rev 65:113-23. 2011.... - Nerve growth factor (NGF) has novel antidepressant-like properties in ratsDavid H Overstreet
Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7178, Chapel Hill, NC 27599 7178, USA
Pharmacol Biochem Behav 94:553-60. 2010..Thus, NGF has antidepressant-like effects but does not appear to have biochemical actions typical of other antidepressants... - Effects of melanocortin receptor activation and blockade on ethanol intake: a possible role for the melanocortin-4 receptorMontserrat Navarro
Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Alcohol Clin Exp Res 29:949-57. 2005..These findings strengthen the argument that MCR signaling controls ethanol consumption and that compounds directed at MCR may represent promising targets for treating alcohol abuse disorders in addition to obesity... - Decreased immunoreactivity of the melanocortin neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) after chronic ethanol exposure in Sprague-Dawley ratsMontserrat Navarro
Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599 3270, USA
Alcohol Clin Exp Res 32:266-76. 2008..We also determined if ethanol exposure would alter the immunoreactivity of agouti-related protein (AgRP), an endogenous MCR antagonist... - Similar anxiety-like responses in male and female rats exposed to repeated withdrawals from ethanolDavid H Overstreet
Department of Psychiatry, Skipper Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Thurston-Bowles Building 3009, CB #7178, Chapel Hill, NC 27599-7178, USA
Pharmacol Biochem Behav 78:459-64. 2004..Thus, there are no sex differences in the three-cycle multiple-withdrawal paradigm, but there may be differences after briefer exposures... - Changes in apical dendritic structure correlate with sustained ERK1/2 phosphorylation in medial prefrontal cortex of a rat model of dopamine D1 receptor agonist sensitizationSophia T Papadeas
Graduate Program in Neurobiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
J Comp Neurol 511:271-85. 2008..Furthermore, sustained elevation of ERK activity in mPFC pyramidal neurons may play a role in guiding these morphological changes in vivo... - Elevated anxiety-like behavior following ethanol exposure in mutant mice lacking neuropeptide Y (NPY)Dennis R Sparta
Department of Psychology, University of North Carolina, Chapel Hill, NC 27599 3270, USA
Drug Alcohol Depend 90:297-300. 2007..5% ethanol... - The role of dopamine receptors in the neurobehavioral syndrome provoked by activation of L-type calcium channels in rodentsSuhail Kasim
Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
Dev Neurosci 28:505-17. 2006..Instead, the behaviors appear to result from a postsynaptic activation of the drug, which does not require but can be modified by D(3) or D(1/5) receptors... - Oxidative stress and dopamine deficiency in a genetic mouse model of Lesch-Nyhan diseaseJasper E Visser
Department of Neurology, Meyer 6 181, Johns Hopkins Hospital, Baltimore, MD 21287, USA
Brain Res Dev Brain Res 133:127-39. 2002..Overall, these data provide evidence for increased oxidative stress, but the failure to protect the knockout mice by over-expressing SOD1 argues that oxidative stress is not the sole process responsible for the loss of striatal dopamine...
Research Grants
- GABAA R-subunit changes in adolescents by a cytokine/ethanol withdrawal protocolGeorge Breese; Fiscal Year: 2009..Since cytokines contribute to stress responses, this proposal examines adaptive changes in adolescent rats that result from an interaction of cytokines and ethanol. ..
- Stress Sensitization of CRF-Induced Withdrawal BehaviorsGeorge Breese; Fiscal Year: 2009..New treatment strategies could emerge from such knowledge ..
- Flumazenil on Multiple Stress and Withdrawal AnxietyGeorge Breese; Fiscal Year: 2007....
- NEUROSTEROIDS IN THE ACTION OF ETHANOL ON GABAGeorge Breese; Fiscal Year: 2004..Completion of the Aims will allow critical new information to emerge concerning the molecular basis of neurosteroid action on GABAA receptor function that allows ethanol to enhance GABA function in vitro. ..
- MOLECULAR BIOLOGY OF ETHANOL ACTION ON RECEPTORSGeorge Breese; Fiscal Year: 2002..Further, based upon structural analysis of ethanol's action on protein-protein inter-actions for the receptors, results may ultimately allow us to predict other protein-protein interactions influenced by ethanol. ..
- GABAA R-subunit changes in adolescents by a cytokine/ethanol withdrawal protocolGeorge R Breese; Fiscal Year: 2010..Since cytokines contribute to stress responses, this proposal examines adaptive changes in adolescent rats that result from an interaction of cytokines and ethanol. ..