Research Topics
Genomes and Genes
| David S BredtSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Endogenous nitric oxide synthesis: biological functions and pathophysiologyD S Bredt
Department of Physiology, University of California at San Francisco School of Medicine, 94143 0444, USA
Free Radic Res 31:577-96. 1999..Through these mechanisms, NO appears to play a major role in the pathophysiology of stroke, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis...- AMPA receptor trafficking at excitatory synapsesDavid S Bredt
Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
Neuron 40:361-79. 2003..Furthermore, neuronal activity controls synaptic AMPA receptor trafficking, and this dynamic process plays a key role in the synaptic plasticity that is thought to underlie aspects of learning and memory... 
Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complexOlav Olsen
Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
J Cell Biol 170:1127-34. 2005..These findings are consistent with a model whereby the MALS-CASK-liprin-alpha complex recruits components of the synaptic release machinery to adhesive proteins of the active zone...- Interaction with the unfolded protein response reveals a role for stargazin in biosynthetic AMPA receptor transportWim Vandenberghe
Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA
J Neurosci 25:1095-102. 2005..These findings uncover a role for stargazin in AMPA receptor trafficking through the early compartments of the biosynthetic pathway. Furthermore, they provide evidence for modulation of AMPA receptor trafficking by the UPR... - Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteinsGuillermo M Elias
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94143, USA
Neuron 52:307-20. 2006..These studies establish a PSD-MAGUK-specific regulation of AMPA-R synaptic expression that establishes and maintains glutamatergic synaptic transmission in the mammalian central nervous system... - TARP gamma-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticityNathalie Rouach
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143, USA
Nat Neurosci 8:1525-33. 2005.... - Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPsSusumu Tomita
Department of Physiology, University of California at San Francisco, San Francisco, CA 94143, USA
Neuron 45:269-77. 2005..These results establish stargazin as a critical substrate in the bidirectional control of synaptic strength, which is thought to underlie aspects of learning and memory... - Molecular constituents of neuronal AMPA receptorsYuko Fukata
Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
J Cell Biol 169:399-404. 2005..These studies establish TARPs as the auxiliary components of neuronal AMPARs... - TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gatingAaron D Milstein
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
Neuron 55:905-18. 2007.... - Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout miceOlav Olsen
Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
J Cell Biol 179:151-64. 2007..These studies demonstrate that defects in epithelial cell polarization can cause cystic and fibrotic renal disease... - Functional analysis of the nucleotide binding domain of membrane-associated guanylate kinasesOlav Olsen
Department of Physiology and Program in Neuroscience, University of California at San Francisco, San Francisco, California 94143 0444, USA
J Biol Chem 278:6873-8. 2003..These studies indicate that MAGUK proteins have lost affinity for GMP but may have retained the guanylate kinase structure to accommodate a related regulatory ligand... - AMPA receptors and stargazin-like transmembrane AMPA receptor-regulatory proteins mediate hippocampal kainate neurotoxicitySusumu Tomita
Department of Physiology, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 104:18784-8. 2007..This work decisively demonstrates that TARP-associated AMPA receptors mediate kainate neurotoxicity and identifies TARPs as targets for modulating neurotoxic properties of AMPA receptors... - TARP redundancy is critical for maintaining AMPA receptor functionKaren Menuz
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94143, USA
J Neurosci 28:8740-6. 2008..This study establishes a new role for TARPs in regulating AMPA receptor assembly and suggests that TARPs are necessary for proper AMPA receptor localization and function in most, if not all, neurons of the CNS... - Interaction of transmembrane AMPA receptor regulatory proteins with multiple membrane associated guanylate kinasesSrikanth Dakoji
Department of Physiology, UCSF School of Medicine, University of California at San Francisco, Genentech Hall 600 16th Street, N272-F, San Francisco, CA 94143-2140, USA
Neuropharmacology 45:849-56. 2003..This work identifies biochemical promiscuity for interaction of the TARP C-termini with PDZ domains in vitro, but also shows that only specific synaptic PDZ proteins associate with TARPs in brain... - Postsynaptic density-95 mimics and occludes hippocampal long-term potentiation and enhances long-term depressionValentin Stein
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143, USA
J Neurosci 23:5503-6. 2003..In addition, LTP is completely occluded in cells expressing PSD-95, whereas LTD is greatly enhanced. These results suggest that common mechanisms are involved in controlling synaptic AMPA receptors by PSD-95 and synaptic plasticity... - Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor numberEric Schnell
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143
Proc Natl Acad Sci U S A 99:13902-7. 2002..Finally, we make compensatory mutations to both PSD-95 and stargazin to demonstrate the central role of direct interactions between them in determining the number of synaptic AMPARs... - Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapsesSusumu Tomita
Department of Physiology, University of California, San Francisco, San Francisco, CA 94143 2140, USA
Science 303:1508-11. 2004..This did not require ion flux or intracellular second messengers. This allosteric mechanism for AMPA receptor dissociation from TARPs may participate in glutamate-mediated internalization of receptors in synaptic plasticity... - Synaptic glutamate receptor clustering in mice lacking the SH3 and GK domains of SAP97Nikolaj Klocker
Department of Physiology, University of California, San Francisco, CA 94143, USA
Eur J Neurosci 16:1517-22. 2002.... - Auxiliary subunits assist AMPA-type glutamate receptorsRoger A Nicoll
Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, CA 94143, USA
Science 311:1253-6. 2006..TARPs provide the first example of auxiliary subunits of ionotropic receptors. Here we review the pivotal role that TARPs play in the life cycle of AMPA receptors... - Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteinsSusumu Tomita
Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
J Cell Biol 161:805-16. 2003..These studies indicate a general role for TARPs in controlling synaptic AMPA receptors throughout the central nervous system... - Activity-dependent NMDA receptor degradation mediated by retrotranslocation and ubiquitinationAkihiko Kato
Department of Physiology, University of California San Francisco, 600 16th Street, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 102:5600-5. 2005..These results suggest that homeostatic control of synaptic NR1 involves receptor retrotranslocation and degradation by the ubiquitin-proteasome pathway... - Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanismsDane M Chetkovich
Department of Physiology, University of California, San Francisco, San Francisco, California 94143 0444, USA
J Neurosci 22:6415-25. 2002..These studies identify molecular and functional heterogeneity in synaptic PSD95 complexes and reveal critical roles for L27 domain interactions and Hrs regulated vesicular trafficking in postsynaptic protein clustering... - Phosphorylation of the postsynaptic density-95 (PSD-95)/discs large/zona occludens-1 binding site of stargazin regulates binding to PSD-95 and synaptic targeting of AMPA receptorsDane M Chetkovich
Department of Neurology, University of California at San Francisco, San Francisco, California 94143-0444, USA
J Neurosci 22:5791-6. 2002..These data suggest that phosphorylation of the stargazin PDZ ligand can disrupt stargazin interaction with PSD-95 and thereby regulate synaptic AMPAR function... - Stargazin interacts functionally with the AMPA receptor glutamate-binding moduleSusumu Tomita
Department of Physiology, University of California at San Francisco, San Francisco, CA 94143, USA
Neuropharmacology 52:87-91. 2007..These studies identify a functional interaction of stargazin with the extracellular glutamate-binding domain of AMPA receptors... - Calcium channel function regulated by the SH3-GK module in beta subunitsAaron W McGee
Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
Neuron 42:89-99. 2004..In MAGUKs, the SH3-GK module controls protein scaffolding. In beta subunits, this module regulates the inactivation of VGCCs and provides an additional mechanism for tuning calcium responsiveness... - The guanylate kinase domain of the MAGUK PSD-95 binds dynamically to a conserved motif in MAP1aMichael L Reese
Graduate Group in Biophysics, University of California, San Francisco, California 94143, USA
Nat Struct Mol Biol 14:155-63. 2007..Furthermore, we show that PSD-95 GK has adopted the conformational flexibility of the ancestral enzyme to bind its varied ligands, which suggests a mechanism of regulation... - Stargazin controls the pharmacology of AMPA receptor potentiatorsSusumu Tomita
Department of Physiology, University of California-San Francisco, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 103:10064-7. 2006..This work demonstrates that stargazin controls AMPAR potentiator pharmacology, which has important implications for development of AMPAR potentiators as therapeutic agents... - Stargazin is an AMPA receptor auxiliary subunitWim Vandenberghe
Department of Physiology, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 102:485-90. 2005..1N, do not show significant association with AMPA receptor complexes on native gels. These data identify stargazin as an auxiliary subunit for a neurotransmitter-gated ion channel... - Synaptic transmission regulated by a presynaptic MALS/Liprin-alpha protein complexOlav Olsen
Departments of Physiology and Cellular and Molecular Pharmacology, University of California-San Francisco, 600 16th Street, San Francisco, CA, USA
Curr Opin Cell Biol 18:223-7. 2006.... - Stargazin differentially controls the trafficking of alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate and kainate receptorsLu Chen
Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, CA 94143, USA
Mol Pharmacol 64:703-6. 2003..These results suggest that stargazin action is highly selective for AMPA receptors... - Early events in glutamate receptor traffickingWim Vandenberghe
Department of Physiology, University of California at San Francisco, Genentech Hall N274, 600 16 th Street, San Francisco, CA 94143, USA
Curr Opin Cell Biol 16:134-9. 2004..Recent work shows that receptor exit from the endoplasmic reticulum represents a critical regulatory step in glutamate receptor trafficking to the neuronal cell surface... - Identification of PSD-95 palmitoylating enzymesMasaki Fukata
Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA
Neuron 44:987-96. 2004..This study suggests that P-PATs regulate synaptic function through PSD-95 palmitoylation... - Membrane-associated guanylate kinases regulate adhesion and plasticity at cell junctionsLars Funke
Department of Physiology, University of California at San Francisco, California 94143, USA
Annu Rev Biochem 74:219-45. 2005..These diverse roles are explained by recent biochemical and structural analyses of MAGUKs, which demonstrate their capacity to assemble well--efined--yet adaptable--protein complexes at cellular junctions... - nNOS at a glance: implications for brain and brawnImran N Mungrue
Department of Physiology, University of California at San Francisco School of Medicine, 513 Parnassus Avenue, San Francisco, CA 94143-0444, USA
J Cell Sci 117:2627-9. 2004 - New transmembrane AMPA receptor regulatory protein isoform, gamma-7, differentially regulates AMPA receptorsAkihiko S Kato
Neuroscience Discovery, Lilly Research Laboratories, University of California, San Francisco, San Francisco, California 94143, USA
J Neurosci 27:4969-77. 2007..These studies define gamma-7 as a new member of the TARP family that can differentially influence AMPA receptors in cerebellar neurons... - Lipid- and protein-mediated multimerization of PSD-95: implications for receptor clustering and assembly of synaptic protein networksKaren S Christopherson
Department of Physiology University of California at San Francisco, San Francisco, CA 94143-2140, USA
J Cell Sci 116:3213-9. 2003..Finally, disrupting palmitoylation with 2-bromopalmitate disperses PSD-95/K+-channel clusters. These data suggest new models for K+ channel clustering by PSD-95 - a reversible process regulated by protein palmitoylation... - A combination of three distinct trafficking signals mediates axonal targeting and presynaptic clustering of GAD65Jamil Kanaani
Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
J Cell Biol 158:1229-38. 2002..The palmitoylated NH(2)-terminal region of GAD65 is the first identified protein region that can target other proteins to presynaptic clusters... - Synaptic strength regulated by palmitate cycling on PSD-95Alaa El-Din El-Husseini
Department of Physiology, University of California, San Francisco, CA 94143, USA
Cell 108:849-63. 2002..These studies suggest that palmitate cycling on PSD-95 can regulate synaptic strength and regulates aspects of activity-dependent plasticity... - Assembly and plasticity of the glutamatergic postsynaptic specializationAaron W McGee
University of California at San Francisco School of Medicine, 513 Parnassus Avenue, San Francisco, California 94143-0444, USA
Curr Opin Neurobiol 13:111-8. 2003..Recent studies demonstrate that these 'scaffolding' proteins within the postsynaptic specialization have the capacity to promote synaptic maturation, influence synapse size, and modulate glutamate receptor function... - Interaction of neuronal nitric-oxide synthase and phosphofructokinase-MB L Firestein
Department of Physiology, UCSF, San Francisco, California 94143 0444, USA
J Biol Chem 274:10545-50. 1999..As fructose-1, 6-bisphosphate, the product of PFK activity, is neuroprotective, the interaction of nNOS and PFK may contribute to neuroprotection of nNOS positive cells... - Differential localization of mammalian Lin-7 (MALS/Veli) PDZ proteins in the kidneyOlav Olsen
Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Am J Physiol Renal Physiol 288:F345-52. 2005..The TAL and distal segments appear to have the most significant capacity for a basolateral membrane-targeting mechanism involving different MALS/Veli isoforms... - Nitric oxide signaling specificity--the heart of the problemDavid S Bredt
Department of Physiology, University of California at San Francisco School of Medicine, 513 Parnassus Avenue, San Francisco, CA 94143 0444, USA
J Cell Sci 116:9-15. 2003..Understanding these cellular pathways that control NOS will help us to elucidate the functional roles of NO and provide novel strategies to treat diseases associated with NO abnormalities... - Regulation of neuronal nitric oxide synthase through alternative transcriptsJ E Brenman
Department of Physiology, University of California at San Francisco School of Medicine 94143 0444, USA
Dev Neurosci 19:224-31. 1997..Finally, we also find a 2.5-kb testis-specific nNOS mRNA corresponding to the C-terminal reductase domain of nNOS whose function is unclear... - Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domainsJ E Brenman
Department of Physiology, School of Medicine, University of California at San Fancisco, California 94143, USA
Cell 84:757-67. 1996..Interaction of PDZ-containing domains therefore mediates synaptic association of nNOS and may play a more general role in formation of macromolecular signaling complexes... - Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophyJ E Brenman
Department of Physiology, University of California, San Francisco School of Medicine 94143 0444, USA
Cell 82:743-52. 1995..Aberrant regulation of nNOS may contribute to preferential degeneration of fast-twitch muscle fibers in DMD... - Cloning and characterization of postsynaptic density 93, a nitric oxide synthase interacting proteinJ E Brenman
Department of Physiology, University of California at San Francisco School of Medicine, 94143 0444, USA
J Neurosci 16:7407-15. 1996.... - Neuronal nitric-oxide synthase-mu, an alternatively spliced isoform expressed in differentiated skeletal muscleF Silvagno
Department of Physiology, University of California, San Francisco School of Medicine 94143 0444, USA
J Biol Chem 271:11204-8. 1996..This study identifies alternative splicing as a means for tissue-specific regulation of nNOS and reports the first additional protein sequence for a mammalian NOS since the original cloning of the gene family... - Muscular dystrophy in mdx mice despite lack of neuronal nitric oxide synthaseD S Chao
Department of Physiology, University of California at San Francisco, USA
J Neurochem 71:784-9. 1998..Thus, histological analyses of nNOS-dystrophin double mutants show pathological changes similar to the dystrophin mutation alone. Taken together, nNOS defects alone do not produce muscular dystrophy in the mdx model... - Identification of a monogenic locus (jams1) causing juvenile audiogenic seizures in miceHidemi Misawa
Department of Physiology, University of California at San Francisco, School of Medicine, San Francisco, California 94143 0444, USA
J Neurosci 22:10088-93. 2002..3 implicated in a familial form of juvenile febrile convulsions. Cloning the gene for audiogenic seizures in these mice may provide important insight into the fundamental mechanisms for developmentally regulated human epilepsy syndromes... - Nitric oxide signaling in brain: potentiating the gain with YC-1David S Bredt
Department of Physiology, School of Medicine, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA, USA
Mol Pharmacol 63:1206-8. 2003 - Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanismsL Chen
Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143, USA
Nature 408:936-43. 2000.... - Actinin-associated LIM protein-deficient mice maintain normal development and structure of skeletal muscleK Jo
Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA
Mol Cell Biol 21:1682-7. 2001..These data suggest that ALP does not participate in muscle development or that an alternative PDZ-LIM protein can compensate for the lack of ALP... - Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complexB J Hillier
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
Science 284:812-5. 1999..This structure explains how PDZ domains can participate in diverse interaction modes to assemble protein networks... - PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domainK S Christopherson
Department of Physiology, and Program in Biomedical Sciences, University of California, San Francisco, California 94143 0444, USA
J Biol Chem 274:27467-73. 1999..Accordingly, we find that the nNOS PDZ domain can bind PSD-95 PDZ2 and a COOH-terminal peptide simultaneously. This bivalent nature of the nNOS PDZ domain further expands the scope for assembly of protein networks by PDZ domains... - Cypin: a cytosolic regulator of PSD-95 postsynaptic targetingB L Firestein
Department of Physiology, University of California, San Francisco 94143, USA
Neuron 24:659-72. 1999..In fact, PSD-95 can induce postsynaptic clustering of an otherwise diffusely localized K+ channel, Kv1.4. By regulating postsynaptic protein sorting, cypin may influence synaptic development and plasticity... - Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifsS E Craven
Department of Physiology and Program in Neuroscience, University of California, San Francisco 94143 0444, USA
Neuron 22:497-509. 1999..The requirements for PDZ domains and a C-terminal domain of PSD-95 indicate that protein-protein interactions cooperate with lipid interactions in synaptic targeting... - PSD-93 knock-out mice reveal that neuronal MAGUKs are not required for development or function of parallel fiber synapses in cerebellumA W McGee
Department of Physiology and Programs in Biomedical Sciences and Neuroscience, University of California at San Francisco School of Medicine, San Francisco, California 94143 0444, USA
J Neurosci 21:3085-91. 2001..Our data demonstrate that MAGUK proteins of the PSD-93/95 family are not essential for development of certain central synapses but may instead participate in specialized aspects of synaptic signaling and plasticity... - Polarized targeting of peripheral membrane proteins in neuronsA el-D El-Husseini
Department of Physiology and Program in Neuroscience, University of California at San Francisco School of Medicine, San Francisco, California 94143, USA
J Biol Chem 276:44984-92. 2001.... - Actinin-associated LIM protein: identification of a domain interaction between PDZ and spectrin-like repeat motifsH Xia
Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA
J Cell Biol 139:507-15. 1997..Fine genetic mapping studies demonstrate that ALP occurs on chromosome 4q35, near the heterochromatic locus that is mutated in fascioscapulohumeral muscular dystrophy... - Structure of the SH3-guanylate kinase module from PSD-95 suggests a mechanism for regulated assembly of MAGUK scaffolding proteinsA W McGee
Department of Physiology, University of California-San Francisco, San Francisco, CA 94143, USA
Mol Cell 8:1291-301. 2001..We propose a model for MAGUK oligomerization in which complementary SH3 subdomains associate by 3D domain swapping. This model provides a possible mechanism for ligand regulation of oligomerization... - Identification of an intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95A W McGee
Department of Physiology and Program in Neuroscience, University of California at San Francisco, San Francisco, California 94143 0444, USA
J Biol Chem 274:17431-6. 1999..Many previously identified genetic mutations of MAGUKs in invertebrates occur in the SH3 or GK domains, and all of these mutations disrupt intramolecular SH3/GK binding... - Postsynaptic targeting of MAGUKs mediated by distinct N-terminal domainsB L Firestein
Department of Physiology, University of California at San Francisco, 94143 0444, USA
Neuroreport 11:3479-84. 2000..These results suggest that MAGUKs contain diverse signals within their N-termini for postsynaptic targeting... 
AMPA receptor subunit-specific regulation by a distinct family of type II TARPsAkihiko S Kato
Department of Neuroscience, Eli Lilly and Company, Indianapolis, IN 46285, USA
Neuron 59:986-96. 2008..We also find that gamma-7 regulation of GluR2 is dictated by mRNA editing. These data establish gamma-5 and gamma-7 as a separate family of "type II TARPs" that impart distinct physiological features to specific AMPA receptors...- MALS-3 regulates polarity and early neurogenesis in the developing cerebral cortexKarpagam Srinivasan
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Development 135:1781-90. 2008..Our results suggest that MALS-3 plays a role in maintaining apicobasal polarity and is required for normal neurogenesis in the developing cortex... - Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2Yasuhiro Ogawa
Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 28:5731-9. 2008..In contrast, Caspr2, which mediates Kv1 channel clustering at the juxtaparanode, is not required for localization of Kv1 channels at the AIS. These results show PSD-93 mediates AIS accumulation of Kv1 channels independently of Caspr2... - Fibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesisEvgeni Ponimaskin
Abteilung Neuro und Sinnesphysiologie, Physiologisches Institut, Universitat Gottingen, 37073 Gottingen, Germany
J Neurosci 28:8897-907. 2008..Thus, our study uncovers a molecular mechanism by which a growth factor regulates neuronal morphogenesis via activation of palmitoylation, which in turn modifies subcellular location and thus signaling via an adhesion molecule... - Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmissionYuko Fukata
Laboratory of Genomics and Proteomics, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Aichi 474 8522, Japan
Science 313:1792-5. 2006..The mutated form of LGI1 fails to bind to ADAM22. ADAM22 is anchored to the postsynaptic density by cytoskeletal scaffolds containing stargazin. These studies in rat brain indicate possible avenues for understanding human epilepsy... - Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthaseCarlos Fernandez-Hernando
Department of Pharmacology and Program in Vascular Cell Signaling and Therapeutics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
J Cell Biol 174:369-77. 2006..Collectively, our data describe five new Golgi-targeted DHHC enzymes in human endothelial cells and suggest a regulatory role of DHHC-21 in governing eNOS localization and function... - Organization of postsynaptic density proteins and glutamate receptors in axodendritic and dendrodendritic synapses of the rat olfactory bulbMarco Sassoè-Pognetto
Department of Anatomy, Pharmacology, and Forensic Medicine, University of Turin, I 10126 Torino, Italy
J Comp Neurol 463:237-48. 2003..The latter molecules appear to be expressed in an all-or-none fashion and may form a standard lattice common to different types of glutamatergic synapse... - Palmitoylation controls trafficking of GAD65 from Golgi membranes to axon-specific endosomes and a Rab5a-dependent pathway to presynaptic clustersJamil Kanaani
Departments of Medicine, Microbiology Immunology, and Diabetes Center, University of California San Francisco, CA 94143 0534, USA
J Cell Sci 117:2001-13. 2004.... - PSD93 regulates synaptic stability at neuronal cholinergic synapsesMichael J Parker
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 24:378-88. 2004..In addition, these results suggest that the mechanism of postsynaptic scaffolding is conserved between neuronal cholinergic and glutamatergic synapses... - Targeted disruption of PSD-93 gene reduces platelet-activating factor-induced neurotoxicity in cultured cortical neuronsYun Xu
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Exp Neurol 189:16-24. 2004.... - AMPA receptor synaptic targeting regulated by stargazin interactions with the Golgi-resident PDZ protein nPISTAdolfo E Cuadra
Davee Department of Neurology and Clinical Neurosciences, Northwestern University Medical School, Chicago, Illinois 60611 3008, USA
J Neurosci 24:7491-502. 2004..These studies identify a novel stargazin domain necessary for synaptic clustering of AMPARs and suggest that nPIST and stargazin interactions play a critical role in AMPAR trafficking to the synapse... - Effect of knock down of spinal cord PSD-93/chapsin-110 on persistent pain induced by complete Freund's adjuvant and peripheral nerve injuryBosheng Zhang
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 355 Ross, 720 Rutland Ave, Baltimore, MD 21205, USA
Pain 106:187-96. 2003..This suggests that spinal cord PSD-93/chapsin-110 might be involved in the central mechanism of chronic pain. Our work might provide a new target for the therapy of chronic pain... - Protein palmitoylation: a regulator of neuronal development and functionAlaa El-Din El-Husseini
Kinsmen Laboratory, Department of Psychiatry and the Brain Research Centre, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
Nat Rev Neurosci 3:791-802. 2002 - Stargazin modulates AMPA receptor gating and trafficking by distinct domainsSusumu Tomita
Department of Physiology
Nature 435:1052-8. 2005.... - Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifsCatherine Gauthier-Campbell
Department of Psychiatry and the Brain Research Centre, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
Mol Biol Cell 15:2205-17. 2004..These results demonstrate that select dually lipidated protein motifs trigger changes in the development and growth of neuronal processes... - Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 proteinYuan Xiang Tao
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Neurosci 23:6703-12. 2003..PSD-93 appears to be important for NMDAR synaptic targeting and function and to be a potential biochemical target for the treatment of persistent pain... - AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferaseYan Qun Chen
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
J Biol Chem 283:10048-57. 2008..Our data indicate that AGPAT6 is a microsomal GPAT, and we propose renaming this enzyme GPAT4... - Identification and characterization of a major liver lysophosphatidylcholine acyltransferaseYang Zhao
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
J Biol Chem 283:8258-65. 2008.... - Pharmacological regulation of ion channels by auxiliary subunitsAkihiko S Kato
Neuroscience Discovery, Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, IN 46285, USA
Curr Opin Drug Discov Devel 10:565-72. 2007..The recent molecular characterization of neuronal glutamate receptor ion channel complexes identified auxiliary subunits and associated proteins that may provide new targets for treating psychiatric and neurodegenerative diseases...