David S Bredt

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Endogenous nitric oxide synthesis: biological functions and pathophysiology
    D S Bredt
    Department of Physiology, University of California at San Francisco School of Medicine, 94143 0444, USA
    Free Radic Res 31:577-96. 1999
  2. pmc Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins
    Susumu Tomita
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 161:805-16. 2003
  3. pmc Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex
    Olav Olsen
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 170:1127-34. 2005
  4. pmc Molecular constituents of neuronal AMPA receptors
    Yuko Fukata
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 169:399-404. 2005
  5. pmc Dual palmitoylation of PSD-95 mediates its vesiculotubular sorting, postsynaptic targeting, and ion channel clustering
    A E El-Husseini
    Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA
    J Cell Biol 148:159-72. 2000
  6. ncbi request reprint AMPA receptor trafficking at excitatory synapses
    David S Bredt
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 40:361-79. 2003
  7. ncbi request reprint Interaction with the unfolded protein response reveals a role for stargazin in biosynthetic AMPA receptor transport
    Wim Vandenberghe
    Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 25:1095-102. 2005
  8. ncbi request reprint Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins
    Guillermo M Elias
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94143, USA
    Neuron 52:307-20. 2006
  9. ncbi request reprint TARP gamma-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity
    Nathalie Rouach
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143, USA
    Nat Neurosci 8:1525-33. 2005
  10. pmc Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice
    Olav Olsen
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 179:151-64. 2007

Collaborators

Detail Information

Publications83

  1. ncbi request reprint Endogenous nitric oxide synthesis: biological functions and pathophysiology
    D S Bredt
    Department of Physiology, University of California at San Francisco School of Medicine, 94143 0444, USA
    Free Radic Res 31:577-96. 1999
    ..Through these mechanisms, NO appears to play a major role in the pathophysiology of stroke, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis...
  2. pmc Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins
    Susumu Tomita
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 161:805-16. 2003
    ..These studies indicate a general role for TARPs in controlling synaptic AMPA receptors throughout the central nervous system...
  3. pmc Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex
    Olav Olsen
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 170:1127-34. 2005
    ..These findings are consistent with a model whereby the MALS-CASK-liprin-alpha complex recruits components of the synaptic release machinery to adhesive proteins of the active zone...
  4. pmc Molecular constituents of neuronal AMPA receptors
    Yuko Fukata
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 169:399-404. 2005
    ..These studies establish TARPs as the auxiliary components of neuronal AMPARs...
  5. pmc Dual palmitoylation of PSD-95 mediates its vesiculotubular sorting, postsynaptic targeting, and ion channel clustering
    A E El-Husseini
    Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA
    J Cell Biol 148:159-72. 2000
    ..These data imply that PSD-95 is an itinerant vesicular protein; initial targeting of PSD-95 to an intracellular membrane compartment may participate in postsynaptic ion channel clustering by PSD-95...
  6. ncbi request reprint AMPA receptor trafficking at excitatory synapses
    David S Bredt
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 40:361-79. 2003
    ..Furthermore, neuronal activity controls synaptic AMPA receptor trafficking, and this dynamic process plays a key role in the synaptic plasticity that is thought to underlie aspects of learning and memory...
  7. ncbi request reprint Interaction with the unfolded protein response reveals a role for stargazin in biosynthetic AMPA receptor transport
    Wim Vandenberghe
    Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 25:1095-102. 2005
    ..These findings uncover a role for stargazin in AMPA receptor trafficking through the early compartments of the biosynthetic pathway. Furthermore, they provide evidence for modulation of AMPA receptor trafficking by the UPR...
  8. ncbi request reprint Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins
    Guillermo M Elias
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94143, USA
    Neuron 52:307-20. 2006
    ..These studies establish a PSD-MAGUK-specific regulation of AMPA-R synaptic expression that establishes and maintains glutamatergic synaptic transmission in the mammalian central nervous system...
  9. ncbi request reprint TARP gamma-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity
    Nathalie Rouach
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143, USA
    Nat Neurosci 8:1525-33. 2005
    ....
  10. pmc Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice
    Olav Olsen
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 179:151-64. 2007
    ..These studies demonstrate that defects in epithelial cell polarization can cause cystic and fibrotic renal disease...
  11. ncbi request reprint Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPs
    Susumu Tomita
    Department of Physiology, University of California at San Francisco, San Francisco, CA 94143, USA
    Neuron 45:269-77. 2005
    ..These results establish stargazin as a critical substrate in the bidirectional control of synaptic strength, which is thought to underlie aspects of learning and memory...
  12. pmc TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating
    Aaron D Milstein
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 55:905-18. 2007
    ....
  13. ncbi request reprint Functional analysis of the nucleotide binding domain of membrane-associated guanylate kinases
    Olav Olsen
    Department of Physiology and Program in Neuroscience, University of California at San Francisco, San Francisco, California 94143 0444, USA
    J Biol Chem 278:6873-8. 2003
    ..These studies indicate that MAGUK proteins have lost affinity for GMP but may have retained the guanylate kinase structure to accommodate a related regulatory ligand...
  14. ncbi request reprint Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms
    Dane M Chetkovich
    Department of Physiology, University of California, San Francisco, San Francisco, California 94143 0444, USA
    J Neurosci 22:6415-25. 2002
    ..These studies identify molecular and functional heterogeneity in synaptic PSD95 complexes and reveal critical roles for L27 domain interactions and Hrs regulated vesicular trafficking in postsynaptic protein clustering...
  15. ncbi request reprint Synaptic glutamate receptor clustering in mice lacking the SH3 and GK domains of SAP97
    Nikolaj Klocker
    Department of Physiology, University of California, San Francisco, CA 94143, USA
    Eur J Neurosci 16:1517-22. 2002
    ....
  16. ncbi request reprint Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses
    Susumu Tomita
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94143 2140, USA
    Science 303:1508-11. 2004
    ..This did not require ion flux or intracellular second messengers. This allosteric mechanism for AMPA receptor dissociation from TARPs may participate in glutamate-mediated internalization of receptors in synaptic plasticity...
  17. pmc Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number
    Eric Schnell
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143
    Proc Natl Acad Sci U S A 99:13902-7. 2002
    ..Finally, we make compensatory mutations to both PSD-95 and stargazin to demonstrate the central role of direct interactions between them in determining the number of synaptic AMPARs...
  18. ncbi request reprint Interaction of transmembrane AMPA receptor regulatory proteins with multiple membrane associated guanylate kinases
    Srikanth Dakoji
    Department of Physiology, UCSF School of Medicine, University of California at San Francisco, Genentech Hall 600 16th Street, N272 F, San Francisco, CA 94143 2140, USA
    Neuropharmacology 45:849-56. 2003
    ..This work identifies biochemical promiscuity for interaction of the TARP C-termini with PDZ domains in vitro, but also shows that only specific synaptic PDZ proteins associate with TARPs in brain...
  19. pmc TARP redundancy is critical for maintaining AMPA receptor function
    Karen Menuz
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 28:8740-6. 2008
    ..This study establishes a new role for TARPs in regulating AMPA receptor assembly and suggests that TARPs are necessary for proper AMPA receptor localization and function in most, if not all, neurons of the CNS...
  20. pmc AMPA receptors and stargazin-like transmembrane AMPA receptor-regulatory proteins mediate hippocampal kainate neurotoxicity
    Susumu Tomita
    Department of Physiology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 104:18784-8. 2007
    ..This work decisively demonstrates that TARP-associated AMPA receptors mediate kainate neurotoxicity and identifies TARPs as targets for modulating neurotoxic properties of AMPA receptors...
  21. ncbi request reprint Phosphorylation of the postsynaptic density-95 (PSD-95)/discs large/zona occludens-1 binding site of stargazin regulates binding to PSD-95 and synaptic targeting of AMPA receptors
    Dane M Chetkovich
    Department of Neurology, University of California at San Francisco, San Francisco, California 94143 0444, USA
    J Neurosci 22:5791-6. 2002
    ..These data suggest that phosphorylation of the stargazin PDZ ligand can disrupt stargazin interaction with PSD-95 and thereby regulate synaptic AMPAR function...
  22. ncbi request reprint Postsynaptic density-95 mimics and occludes hippocampal long-term potentiation and enhances long-term depression
    Valentin Stein
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143, USA
    J Neurosci 23:5503-6. 2003
    ..In addition, LTP is completely occluded in cells expressing PSD-95, whereas LTD is greatly enhanced. These results suggest that common mechanisms are involved in controlling synaptic AMPA receptors by PSD-95 and synaptic plasticity...
  23. ncbi request reprint Auxiliary subunits assist AMPA-type glutamate receptors
    Roger A Nicoll
    Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, CA 94143, USA
    Science 311:1253-6. 2006
    ..TARPs provide the first example of auxiliary subunits of ionotropic receptors. Here we review the pivotal role that TARPs play in the life cycle of AMPA receptors...
  24. pmc Activity-dependent NMDA receptor degradation mediated by retrotranslocation and ubiquitination
    Akihiko Kato
    Department of Physiology, University of California San Francisco, 600 16th Street, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 102:5600-5. 2005
    ..These results suggest that homeostatic control of synaptic NR1 involves receptor retrotranslocation and degradation by the ubiquitin-proteasome pathway...
  25. ncbi request reprint Synaptic strength regulated by palmitate cycling on PSD-95
    Alaa El Din El-Husseini
    Department of Physiology, University of California, San Francisco, CA 94143, USA
    Cell 108:849-63. 2002
    ..These studies suggest that palmitate cycling on PSD-95 can regulate synaptic strength and regulates aspects of activity-dependent plasticity...
  26. ncbi request reprint Calcium channel function regulated by the SH3-GK module in beta subunits
    Aaron W McGee
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 42:89-99. 2004
    ..In MAGUKs, the SH3-GK module controls protein scaffolding. In beta subunits, this module regulates the inactivation of VGCCs and provides an additional mechanism for tuning calcium responsiveness...
  27. ncbi request reprint Identification of PSD-95 palmitoylating enzymes
    Masaki Fukata
    Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA
    Neuron 44:987-96. 2004
    ..This study suggests that P-PATs regulate synaptic function through PSD-95 palmitoylation...
  28. ncbi request reprint Stargazin interacts functionally with the AMPA receptor glutamate-binding module
    Susumu Tomita
    Department of Physiology, University of California at San Francisco, San Francisco, CA 94143, USA
    Neuropharmacology 52:87-91. 2007
    ..These studies identify a functional interaction of stargazin with the extracellular glutamate-binding domain of AMPA receptors...
  29. ncbi request reprint The guanylate kinase domain of the MAGUK PSD-95 binds dynamically to a conserved motif in MAP1a
    Michael L Reese
    Graduate Group in Biophysics, University of California, San Francisco, California 94143, USA
    Nat Struct Mol Biol 14:155-63. 2007
    ..Furthermore, we show that PSD-95 GK has adopted the conformational flexibility of the ancestral enzyme to bind its varied ligands, which suggests a mechanism of regulation...
  30. ncbi request reprint Stargazin differentially controls the trafficking of alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate and kainate receptors
    Lu Chen
    Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, CA 94143, USA
    Mol Pharmacol 64:703-6. 2003
    ..These results suggest that stargazin action is highly selective for AMPA receptors...
  31. ncbi request reprint Membrane-associated guanylate kinases regulate adhesion and plasticity at cell junctions
    Lars Funke
    Department of Physiology, University of California at San Francisco, California 94143, USA
    Annu Rev Biochem 74:219-45. 2005
    ..These diverse roles are explained by recent biochemical and structural analyses of MAGUKs, which demonstrate their capacity to assemble well--efined--yet adaptable--protein complexes at cellular junctions...
  32. pmc Stargazin is an AMPA receptor auxiliary subunit
    Wim Vandenberghe
    Department of Physiology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 102:485-90. 2005
    ..1N, do not show significant association with AMPA receptor complexes on native gels. These data identify stargazin as an auxiliary subunit for a neurotransmitter-gated ion channel...
  33. pmc Stargazin controls the pharmacology of AMPA receptor potentiators
    Susumu Tomita
    Department of Physiology, University of California San Francisco, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 103:10064-7. 2006
    ..This work demonstrates that stargazin controls AMPAR potentiator pharmacology, which has important implications for development of AMPAR potentiators as therapeutic agents...
  34. ncbi request reprint Synaptic transmission regulated by a presynaptic MALS/Liprin-alpha protein complex
    Olav Olsen
    Departments of Physiology and Cellular and Molecular Pharmacology, University of California San Francisco, 600 16th Street, San Francisco, CA, USA
    Curr Opin Cell Biol 18:223-7. 2006
    ....
  35. pmc A combination of three distinct trafficking signals mediates axonal targeting and presynaptic clustering of GAD65
    Jamil Kanaani
    Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 158:1229-38. 2002
    ..The palmitoylated NH(2)-terminal region of GAD65 is the first identified protein region that can target other proteins to presynaptic clusters...
  36. ncbi request reprint Early events in glutamate receptor trafficking
    Wim Vandenberghe
    Department of Physiology, University of California at San Francisco, Genentech Hall N274, 600 16 th Street, San Francisco, CA 94143, USA
    Curr Opin Cell Biol 16:134-9. 2004
    ..Recent work shows that receptor exit from the endoplasmic reticulum represents a critical regulatory step in glutamate receptor trafficking to the neuronal cell surface...
  37. ncbi request reprint Identification of a monogenic locus (jams1) causing juvenile audiogenic seizures in mice
    Hidemi Misawa
    Department of Physiology, University of California at San Francisco, School of Medicine, San Francisco, California 94143 0444, USA
    J Neurosci 22:10088-93. 2002
    ..3 implicated in a familial form of juvenile febrile convulsions. Cloning the gene for audiogenic seizures in these mice may provide important insight into the fundamental mechanisms for developmentally regulated human epilepsy syndromes...
  38. ncbi request reprint New transmembrane AMPA receptor regulatory protein isoform, gamma-7, differentially regulates AMPA receptors
    Akihiko S Kato
    Neuroscience Discovery, Lilly Research Laboratories, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:4969-77. 2007
    ..These studies define gamma-7 as a new member of the TARP family that can differentially influence AMPA receptors in cerebellar neurons...
  39. ncbi request reprint nNOS at a glance: implications for brain and brawn
    Imran N Mungrue
    Department of Physiology, University of California at San Francisco School of Medicine, 513 Parnassus Avenue, San Francisco, CA 94143 0444, USA
    J Cell Sci 117:2627-9. 2004
  40. ncbi request reprint Lipid- and protein-mediated multimerization of PSD-95: implications for receptor clustering and assembly of synaptic protein networks
    Karen S Christopherson
    Department of Physiology University of California at San Francisco, San Francisco, CA 94143 2140, USA
    J Cell Sci 116:3213-9. 2003
    ..Finally, disrupting palmitoylation with 2-bromopalmitate disperses PSD-95/K+-channel clusters. These data suggest new models for K+ channel clustering by PSD-95 - a reversible process regulated by protein palmitoylation...
  41. ncbi request reprint Assembly and plasticity of the glutamatergic postsynaptic specialization
    Aaron W McGee
    University of California at San Francisco School of Medicine, 513 Parnassus Avenue, San Francisco, California 94143 0444, USA
    Curr Opin Neurobiol 13:111-8. 2003
    ..Recent studies demonstrate that these 'scaffolding' proteins within the postsynaptic specialization have the capacity to promote synaptic maturation, influence synapse size, and modulate glutamate receptor function...
  42. ncbi request reprint Interaction of neuronal nitric-oxide synthase and phosphofructokinase-M
    B L Firestein
    Department of Physiology, UCSF, San Francisco, California 94143 0444, USA
    J Biol Chem 274:10545-50. 1999
    ..As fructose-1, 6-bisphosphate, the product of PFK activity, is neuroprotective, the interaction of nNOS and PFK may contribute to neuroprotection of nNOS positive cells...
  43. ncbi request reprint Nitric oxide signaling specificity--the heart of the problem
    David S Bredt
    Department of Physiology, University of California at San Francisco School of Medicine, 513 Parnassus Avenue, San Francisco, CA 94143 0444, USA
    J Cell Sci 116:9-15. 2003
    ..Understanding these cellular pathways that control NOS will help us to elucidate the functional roles of NO and provide novel strategies to treat diseases associated with NO abnormalities...
  44. ncbi request reprint Differential localization of mammalian Lin-7 (MALS/Veli) PDZ proteins in the kidney
    Olav Olsen
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Physiol Renal Physiol 288:F345-52. 2005
    ..The TAL and distal segments appear to have the most significant capacity for a basolateral membrane-targeting mechanism involving different MALS/Veli isoforms...
  45. ncbi request reprint Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy
    J E Brenman
    Department of Physiology, University of California, San Francisco School of Medicine 94143 0444, USA
    Cell 82:743-52. 1995
    ..Aberrant regulation of nNOS may contribute to preferential degeneration of fast-twitch muscle fibers in DMD...
  46. ncbi request reprint Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains
    J E Brenman
    Department of Physiology, School of Medicine, University of California at San Fancisco, California 94143, USA
    Cell 84:757-67. 1996
    ..Interaction of PDZ-containing domains therefore mediates synaptic association of nNOS and may play a more general role in formation of macromolecular signaling complexes...
  47. ncbi request reprint Regulation of neuronal nitric oxide synthase through alternative transcripts
    J E Brenman
    Department of Physiology, University of California at San Francisco School of Medicine 94143 0444, USA
    Dev Neurosci 19:224-31. 1997
    ..Finally, we also find a 2.5-kb testis-specific nNOS mRNA corresponding to the C-terminal reductase domain of nNOS whose function is unclear...
  48. ncbi request reprint Cloning and characterization of postsynaptic density 93, a nitric oxide synthase interacting protein
    J E Brenman
    Department of Physiology, University of California at San Francisco School of Medicine, 94143 0444, USA
    J Neurosci 16:7407-15. 1996
    ....
  49. ncbi request reprint Muscular dystrophy in mdx mice despite lack of neuronal nitric oxide synthase
    D S Chao
    Department of Physiology, University of California at San Francisco, USA
    J Neurochem 71:784-9. 1998
    ..Thus, histological analyses of nNOS-dystrophin double mutants show pathological changes similar to the dystrophin mutation alone. Taken together, nNOS defects alone do not produce muscular dystrophy in the mdx model...
  50. ncbi request reprint Neuronal nitric-oxide synthase-mu, an alternatively spliced isoform expressed in differentiated skeletal muscle
    F Silvagno
    Department of Physiology, University of California, San Francisco School of Medicine 94143 0444, USA
    J Biol Chem 271:11204-8. 1996
    ..This study identifies alternative splicing as a means for tissue-specific regulation of nNOS and reports the first additional protein sequence for a mammalian NOS since the original cloning of the gene family...
  51. ncbi request reprint Nitric oxide signaling in brain: potentiating the gain with YC-1
    David S Bredt
    Department of Physiology, School of Medicine, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA, USA
    Mol Pharmacol 63:1206-8. 2003
  52. ncbi request reprint Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex
    B J Hillier
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
    Science 284:812-5. 1999
    ..This structure explains how PDZ domains can participate in diverse interaction modes to assemble protein networks...
  53. ncbi request reprint Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
    L Chen
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143, USA
    Nature 408:936-43. 2000
    ....
  54. pmc Actinin-associated LIM protein-deficient mice maintain normal development and structure of skeletal muscle
    K Jo
    Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA
    Mol Cell Biol 21:1682-7. 2001
    ..These data suggest that ALP does not participate in muscle development or that an alternative PDZ-LIM protein can compensate for the lack of ALP...
  55. ncbi request reprint PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain
    K S Christopherson
    Department of Physiology, and Program in Biomedical Sciences, University of California, San Francisco, California 94143 0444, USA
    J Biol Chem 274:27467-73. 1999
    ..Accordingly, we find that the nNOS PDZ domain can bind PSD-95 PDZ2 and a COOH-terminal peptide simultaneously. This bivalent nature of the nNOS PDZ domain further expands the scope for assembly of protein networks by PDZ domains...
  56. ncbi request reprint Structure of the SH3-guanylate kinase module from PSD-95 suggests a mechanism for regulated assembly of MAGUK scaffolding proteins
    A W McGee
    Department of Physiology, University of California-San Francisco, San Francisco, CA 94143, USA
    Mol Cell 8:1291-301. 2001
    ..We propose a model for MAGUK oligomerization in which complementary SH3 subdomains associate by 3D domain swapping. This model provides a possible mechanism for ligand regulation of oligomerization...
  57. ncbi request reprint Polarized targeting of peripheral membrane proteins in neurons
    A el-D El-Husseini
    Department of Physiology and Program in Neuroscience, University of California at San Francisco School of Medicine, San Francisco, California 94143, USA
    J Biol Chem 276:44984-92. 2001
    ....
  58. ncbi request reprint PSD-93 knock-out mice reveal that neuronal MAGUKs are not required for development or function of parallel fiber synapses in cerebellum
    A W McGee
    Department of Physiology and Programs in Biomedical Sciences and Neuroscience, University of California at San Francisco School of Medicine, San Francisco, California 94143 0444, USA
    J Neurosci 21:3085-91. 2001
    ..Our data demonstrate that MAGUK proteins of the PSD-93/95 family are not essential for development of certain central synapses but may instead participate in specialized aspects of synaptic signaling and plasticity...
  59. ncbi request reprint Postsynaptic targeting of MAGUKs mediated by distinct N-terminal domains
    B L Firestein
    Department of Physiology, University of California at San Francisco, 94143 0444, USA
    Neuroreport 11:3479-84. 2000
    ..These results suggest that MAGUKs contain diverse signals within their N-termini for postsynaptic targeting...
  60. ncbi request reprint Identification of an intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95
    A W McGee
    Department of Physiology and Program in Neuroscience, University of California at San Francisco, San Francisco, California 94143 0444, USA
    J Biol Chem 274:17431-6. 1999
    ..Many previously identified genetic mutations of MAGUKs in invertebrates occur in the SH3 or GK domains, and all of these mutations disrupt intramolecular SH3/GK binding...
  61. ncbi request reprint Cypin: a cytosolic regulator of PSD-95 postsynaptic targeting
    B L Firestein
    Department of Physiology, University of California, San Francisco 94143, USA
    Neuron 24:659-72. 1999
    ..In fact, PSD-95 can induce postsynaptic clustering of an otherwise diffusely localized K+ channel, Kv1.4. By regulating postsynaptic protein sorting, cypin may influence synaptic development and plasticity...
  62. ncbi request reprint Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifs
    S E Craven
    Department of Physiology and Program in Neuroscience, University of California, San Francisco 94143 0444, USA
    Neuron 22:497-509. 1999
    ..The requirements for PDZ domains and a C-terminal domain of PSD-95 indicate that protein-protein interactions cooperate with lipid interactions in synaptic targeting...
  63. pmc Actinin-associated LIM protein: identification of a domain interaction between PDZ and spectrin-like repeat motifs
    H Xia
    Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA
    J Cell Biol 139:507-15. 1997
    ..Fine genetic mapping studies demonstrate that ALP occurs on chromosome 4q35, near the heterochromatic locus that is mutated in fascioscapulohumeral muscular dystrophy...
  64. pmc MALS-3 regulates polarity and early neurogenesis in the developing cerebral cortex
    Karpagam Srinivasan
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Development 135:1781-90. 2008
    ..Our results suggest that MALS-3 plays a role in maintaining apicobasal polarity and is required for normal neurogenesis in the developing cortex...
  65. pmc Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2
    Yasuhiro Ogawa
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 28:5731-9. 2008
    ..In contrast, Caspr2, which mediates Kv1 channel clustering at the juxtaparanode, is not required for localization of Kv1 channels at the AIS. These results show PSD-93 mediates AIS accumulation of Kv1 channels independently of Caspr2...
  66. doi request reprint AMPA receptor subunit-specific regulation by a distinct family of type II TARPs
    Akihiko S Kato
    Department of Neuroscience, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Neuron 59:986-96. 2008
    ..We also find that gamma-7 regulation of GluR2 is dictated by mRNA editing. These data establish gamma-5 and gamma-7 as a separate family of "type II TARPs" that impart distinct physiological features to specific AMPA receptors...
  67. doi request reprint Fibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis
    Evgeni Ponimaskin
    Abteilung Neuro und Sinnesphysiologie, Physiologisches Institut, Universitat Gottingen, 37073 Gottingen, Germany
    J Neurosci 28:8897-907. 2008
    ..Thus, our study uncovers a molecular mechanism by which a growth factor regulates neuronal morphogenesis via activation of palmitoylation, which in turn modifies subcellular location and thus signaling via an adhesion molecule...
  68. ncbi request reprint AMPA receptor synaptic targeting regulated by stargazin interactions with the Golgi-resident PDZ protein nPIST
    Adolfo E Cuadra
    Davee Department of Neurology and Clinical Neurosciences, Northwestern University Medical School, Chicago, Illinois 60611 3008, USA
    J Neurosci 24:7491-502. 2004
    ..These studies identify a novel stargazin domain necessary for synaptic clustering of AMPARs and suggest that nPIST and stargazin interactions play a critical role in AMPAR trafficking to the synapse...
  69. ncbi request reprint Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission
    Yuko Fukata
    Laboratory of Genomics and Proteomics, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Aichi 474 8522, Japan
    Science 313:1792-5. 2006
    ..The mutated form of LGI1 fails to bind to ADAM22. ADAM22 is anchored to the postsynaptic density by cytoskeletal scaffolds containing stargazin. These studies in rat brain indicate possible avenues for understanding human epilepsy...
  70. pmc Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs
    Catherine Gauthier-Campbell
    Department of Psychiatry and the Brain Research Centre, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Mol Biol Cell 15:2205-17. 2004
    ..These results demonstrate that select dually lipidated protein motifs trigger changes in the development and growth of neuronal processes...
  71. ncbi request reprint Stargazin modulates AMPA receptor gating and trafficking by distinct domains
    Susumu Tomita
    Department of Physiology
    Nature 435:1052-8. 2005
    ....
  72. ncbi request reprint Targeted disruption of PSD-93 gene reduces platelet-activating factor-induced neurotoxicity in cultured cortical neurons
    Yun Xu
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Exp Neurol 189:16-24. 2004
    ....
  73. ncbi request reprint PSD93 regulates synaptic stability at neuronal cholinergic synapses
    Michael J Parker
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 24:378-88. 2004
    ..In addition, these results suggest that the mechanism of postsynaptic scaffolding is conserved between neuronal cholinergic and glutamatergic synapses...
  74. ncbi request reprint Effect of knock down of spinal cord PSD-93/chapsin-110 on persistent pain induced by complete Freund's adjuvant and peripheral nerve injury
    Bosheng Zhang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 355 Ross, 720 Rutland Ave, Baltimore, MD 21205, USA
    Pain 106:187-96. 2003
    ..This suggests that spinal cord PSD-93/chapsin-110 might be involved in the central mechanism of chronic pain. Our work might provide a new target for the therapy of chronic pain...
  75. ncbi request reprint Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein
    Yuan Xiang Tao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci 23:6703-12. 2003
    ..PSD-93 appears to be important for NMDAR synaptic targeting and function and to be a potential biochemical target for the treatment of persistent pain...
  76. ncbi request reprint Organization of postsynaptic density proteins and glutamate receptors in axodendritic and dendrodendritic synapses of the rat olfactory bulb
    Marco Sassoè-Pognetto
    Department of Anatomy, Pharmacology, and Forensic Medicine, University of Turin, I 10126 Torino, Italy
    J Comp Neurol 463:237-48. 2003
    ..The latter molecules appear to be expressed in an all-or-none fashion and may form a standard lattice common to different types of glutamatergic synapse...
  77. pmc Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase
    Carlos Fernandez-Hernando
    Department of Pharmacology and Program in Vascular Cell Signaling and Therapeutics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
    J Cell Biol 174:369-77. 2006
    ..Collectively, our data describe five new Golgi-targeted DHHC enzymes in human endothelial cells and suggest a regulatory role of DHHC-21 in governing eNOS localization and function...
  78. ncbi request reprint Protein palmitoylation: a regulator of neuronal development and function
    Alaa El Din El-Husseini
    Kinsmen Laboratory, Department of Psychiatry and the Brain Research Centre, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Nat Rev Neurosci 3:791-802. 2002
  79. ncbi request reprint Palmitoylation controls trafficking of GAD65 from Golgi membranes to axon-specific endosomes and a Rab5a-dependent pathway to presynaptic clusters
    Jamil Kanaani
    Departments of Medicine, Microbiology Immunology, and Diabetes Center, University of California San Francisco, CA 94143 0534, USA
    J Cell Sci 117:2001-13. 2004
    ....
  80. pmc AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase
    Yan Qun Chen
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    J Biol Chem 283:10048-57. 2008
    ..Our data indicate that AGPAT6 is a microsomal GPAT, and we propose renaming this enzyme GPAT4...
  81. doi request reprint Identification and characterization of a major liver lysophosphatidylcholine acyltransferase
    Yang Zhao
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    J Biol Chem 283:8258-65. 2008
    ....
  82. ncbi request reprint Pharmacological regulation of ion channels by auxiliary subunits
    Akihiko S Kato
    Neuroscience Discovery, Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, IN 46285, USA
    Curr Opin Drug Discov Devel 10:565-72. 2007
    ..The recent molecular characterization of neuronal glutamate receptor ion channel complexes identified auxiliary subunits and associated proteins that may provide new targets for treating psychiatric and neurodegenerative diseases...