M E Brecher

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Alternatives to albumin: starch replacement for plasma exchange
    M E Brecher
    Transfusion Medicine Service, University of North Carolina Hospitals, Chapel Hill 27514, USA
    J Clin Apher 12:146-53. 1997
  2. doi request reprint Is it HIV TTP or HIV-associated thrombotic microangiopathy?
    Mark E Brecher
    Department of Pathology and Laboratory Medicine, University of North Carolina Hospitals, Chapel Hill, North Carolina 27514, USA
    J Clin Apher 23:186-90. 2008
  3. ncbi request reprint Monitoring of apheresis platelet bacterial contamination with an automated liquid culture system: a university experience
    M E Brecher
    University of North Carolina, Chapel Hill, North Carolina 27514, USA
    Transfusion 43:974-8. 2003
  4. ncbi request reprint Validation of BacT/ALERT plastic culture bottles for use in testing of whole-blood-derived leukoreduced platelet-rich-plasma-derived platelets
    M E Brecher
    University of North Carolina, Chapel Hill, North Carolina 27514, USA
    Transfusion 44:1174-8. 2004
  5. ncbi request reprint Improving platelet safety: bacterial contamination of platelets
    Mark E Brecher
    University of North Carolina Hospitals, 101 Manning Drive, Chapel Hill, NC 27514, USA
    Curr Hematol Rep 3:121-7. 2004
  6. ncbi request reprint Evaluation of a new generation of plastic culture bottles with an automated microbial detection system for nine common contaminating organisms found in PLT components
    M E Brecher
    Transfusion Medicine Service, CB 7600, University of North Carolina Hospitals, 101 Manning Drive, Chapel Hill, NC 27514, USA
    Transfusion 44:359-63. 2004
  7. ncbi request reprint Evaluation of bacterial inactivation in prestorage pooled, leukoreduced, whole blood-derived platelet concentrates suspended in plasma prepared with photochemical treatment
    Mark E Brecher
    Department of Pathology and Laboratory Medicine, University of North Carolina, 101 Manning Drive, Chapel Hill, NC 27514, USA
    Transfusion 47:1896-901. 2007
  8. ncbi request reprint Transfusion medicine illustrated. Platelet swirling
    Mark E Brecher
    University of North Carolina, Chapel Hill, North Carolina, USA
    Transfusion 44:627. 2004
  9. ncbi request reprint Investigation of an isolate of Staphylococcus lugdunensis implicated in a platelet fatality: a possible advantage of the use of an anaerobic bottle
    Mark E Brecher
    Transfusion Medicine Service, University of North Carolina Hospitals, 101 Manning Drive, Chapel Hill, NC 27514, USA
    Transfusion 47:1390-4. 2007
  10. pmc Bacterial contamination of blood components
    Mark E Brecher
    Transfusion Medicine Service, CB 7600, University of North Carolina Hospitals, 101 Manning Dr, Chapel Hill, NC 27514, USA
    Clin Microbiol Rev 18:195-204. 2005

Research Grants

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Alternatives to albumin: starch replacement for plasma exchange
    M E Brecher
    Transfusion Medicine Service, University of North Carolina Hospitals, Chapel Hill 27514, USA
    J Clin Apher 12:146-53. 1997
    ..It is concluded that HES is well-tolerated and cost-effective as full or partial volume replacement with plasma exchange. It is anticipated that the use of HES will emerge as a standard of care in apheresis...
  2. doi request reprint Is it HIV TTP or HIV-associated thrombotic microangiopathy?
    Mark E Brecher
    Department of Pathology and Laboratory Medicine, University of North Carolina Hospitals, Chapel Hill, North Carolina 27514, USA
    J Clin Apher 23:186-90. 2008
    ..A sine que non for successful therapy of HIV-TMA appears to be the treatment of the underlying HIV infection...
  3. ncbi request reprint Monitoring of apheresis platelet bacterial contamination with an automated liquid culture system: a university experience
    M E Brecher
    University of North Carolina, Chapel Hill, North Carolina 27514, USA
    Transfusion 43:974-8. 2003
    ....
  4. ncbi request reprint Validation of BacT/ALERT plastic culture bottles for use in testing of whole-blood-derived leukoreduced platelet-rich-plasma-derived platelets
    M E Brecher
    University of North Carolina, Chapel Hill, North Carolina 27514, USA
    Transfusion 44:1174-8. 2004
    ..This study validated the BacT/ALERT for use in testing pooled PRP-derived PLTs with nine contaminating organisms...
  5. ncbi request reprint Improving platelet safety: bacterial contamination of platelets
    Mark E Brecher
    University of North Carolina Hospitals, 101 Manning Drive, Chapel Hill, NC 27514, USA
    Curr Hematol Rep 3:121-7. 2004
    ..Implementation of bacterial detection methods would improve safety for patients, result in an extension of the shelf life of platelets, and reduce the outdating of platelets, thus being a cost-saving safety intervention...
  6. ncbi request reprint Evaluation of a new generation of plastic culture bottles with an automated microbial detection system for nine common contaminating organisms found in PLT components
    M E Brecher
    Transfusion Medicine Service, CB 7600, University of North Carolina Hospitals, 101 Manning Drive, Chapel Hill, NC 27514, USA
    Transfusion 44:359-63. 2004
    ..The recovery of nine organisms seeded into PLTs with new plastic culture bottles was studied in comparison to the current glass bottles. The use of plastic instead of glass would be expected to reduce the risk of injury...
  7. ncbi request reprint Evaluation of bacterial inactivation in prestorage pooled, leukoreduced, whole blood-derived platelet concentrates suspended in plasma prepared with photochemical treatment
    Mark E Brecher
    Department of Pathology and Laboratory Medicine, University of North Carolina, 101 Manning Drive, Chapel Hill, NC 27514, USA
    Transfusion 47:1896-901. 2007
    ..Because PLT additive solutions (ASs) are not used in the United States, this study evaluated the ability of the PCT process to inactivate low levels of bacteria in pooled whole blood-derived PLTs (RDP) suspended in 100 percent plasma...
  8. ncbi request reprint Transfusion medicine illustrated. Platelet swirling
    Mark E Brecher
    University of North Carolina, Chapel Hill, North Carolina, USA
    Transfusion 44:627. 2004
  9. ncbi request reprint Investigation of an isolate of Staphylococcus lugdunensis implicated in a platelet fatality: a possible advantage of the use of an anaerobic bottle
    Mark E Brecher
    Transfusion Medicine Service, University of North Carolina Hospitals, 101 Manning Drive, Chapel Hill, NC 27514, USA
    Transfusion 47:1390-4. 2007
    ..The utility of an anaerobic (BPN) bottle compared to a BPA bottle was investigated for the detection of S. lugdunensis...
  10. pmc Bacterial contamination of blood components
    Mark E Brecher
    Transfusion Medicine Service, CB 7600, University of North Carolina Hospitals, 101 Manning Dr, Chapel Hill, NC 27514, USA
    Clin Microbiol Rev 18:195-204. 2005
    ..This paper summarizes the current status of detection, prevention, and elimination of bacteria in blood products for transfusion...
  11. ncbi request reprint How I approach a thrombotic thrombocytopenia purpura patient
    Mark E Brecher
    Department of Pathology and Laboratory Medicine, University of North Carolina Hospitals, Chapel Hill, North Carolina 27514, USA
    Transfusion 46:687-9. 2006
    ..This article presents a summary of how our clinical service approaches TTP patients and manages commonly occurring problems...
  12. ncbi request reprint Evaluation of BacT/ALERT plastic culture bottles for use in testing pooled whole blood-derived leukoreduced platelet-rich plasma platelets with a single contaminated unit
    M E Brecher
    University of North Carolina Hospitals, 101 Manning Drive, Chapel Hill, NC 27514, USA
    Transfusion 45:1512-7. 2005
    ..10 colony-forming units [CFUs]/mL) once pooled (10/6 approx. 2 CFUs/mL). This study evaluated the BacT/ALERT (bioMérieux) for detection of bacteria in 1 unit of a 6-unit pool...
  13. ncbi request reprint Plasma exchange: why we do what we do
    Mark E Brecher
    Department of Pathology and Laboratory Medicine, Transfusion Medicine Service, University of North Carolina at Chapel Hill, NC 27514, USA
    J Clin Apher 17:207-11. 2002
  14. ncbi request reprint Evaluation of an automated culture system for detecting bacterial contamination of platelets: an analysis with 15 contaminating organisms
    M E Brecher
    University of North Carolina Hospitals, Chapel Hill, North Carolina 27514, USA
    Transfusion 41:477-82. 2001
    ..Approximately 1 in 2000 platelet components are bacterially contaminated. The time to detection of 15 seeded organisms in platelets recovered from an automated culture system was studied...
  15. ncbi request reprint Number of RBC units and rate of transfusionto anemic HIV-positive patients assigned to receiveWBC-reduced or non-WBC-reduced RBCs: the viral activation transfusion study experience
    M E Brecher
    Transfusion Medicine Service, University of North Carolina, Chapel Hill, North Carolina 27514, USA
    Transfusion 41:794-8. 2001
    ..It is not known if the use of such WBC-reduced RBCs results in an increased need for RBC units or in the transfusion of more units per year to patients with anemia...
  16. ncbi request reprint Evaluation of a new generation of culture bottle using an automated bacterial culture system for detecting nine common contaminating organisms found in platelet components
    M E Brecher
    Transfusion Medicine Service, Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27514, USA
    Transfusion 42:774-9. 2002
    ..The recovery of bacteria in platelets using a new generation of culture bottles that do not require venting and that use a liquid emulsion sensor was studied...
  17. ncbi request reprint Transfusion medicine illustrated. Pseudohemolysis with iron dextran therapy
    Mark E Brecher
    Transfusion Medicine Service, UNC Hospitals, Chapel Hill, North Carolina, USA
    Transfusion 42:135. 2002
  18. ncbi request reprint Growth of bacteria in inoculated platelets: implications for bacteria detection and the extension of platelet storage
    M E Brecher
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, USA
    Transfusion 40:1308-12. 2000
    ....
  19. ncbi request reprint Methods to minimize transfusion related bacterial sepsis
    M E Brecher
    Transfusion Medicine Service, University of North Carolina Hospitals, University of North Carolina at Chapel Hill, 27514, USA
    Dev Biol (Basel) 108:69-84. 2002
  20. ncbi request reprint Bacterial contamination of blood products: factors, options, and insights
    N D Depcik-Smith
    University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA
    J Clin Apher 16:192-201. 2001
    ..There is no one existing strategy that can completely eliminate the risk of bacterial contamination. It is inevitable that partial solutions or combinations of methods will be implemented in the near future...
  21. ncbi request reprint In vivo and in vitro characteristics of double units of RBCs collected by apheresis with a single in-line WBC-reduction filter
    N Bandarenko
    University of North Carolina, Chapel Hill, USA
    Transfusion 41:1373-7. 2001
    ..The objective of this study was to evaluate the filtration performance in connection with different prefiltration RBC storage conditions and with the in vitro and in vivo storage quality of the filtered units...
  22. ncbi request reprint Incidence of allergic reactions with fresh frozen plasma or cryo-supernatant plasma in the treatment of thrombotic thrombocytopenic purpura
    J C Reutter
    Department of Pathology and Lab Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    J Clin Apher 16:134-8. 2001
    ..Because of the large volume, the number of donor exposures, and prolonged duration of therapy, allergic reactions to plasma are common (65.8%) in the treatment of TTP...
  23. ncbi request reprint Antibiotic-labeled probes and microvolume fluorimetry for the rapid detection of bacterial contamination in platelet components: a preliminary report
    M E Brecher
    University of North Carolina Hospitals, Chapel Hill, NC 27514, USA
    Transfusion 40:411-3. 2000
    ..or Bacillus sp.). A novel approach to the rapid diagnosis of gram positive contamination by the use of a fluorescence-labeled antibiotic probe with affinity for the gram positive cell was investigated...
  24. ncbi request reprint Differentiating thrombotic microangiopathies induced by severe hypertension from anemia and thrombocytopenia seen in thrombotic thrombocytopenia purpura
    J A Egan
    Department of Pathology and Laboratory Medicine, University of North Carolina Hospitals, Chapel Hill 27514, USA
    J Clin Apher 19:125-9. 2004
    ..In cases of severe HTN (with or without papilledema), the diagnosis of TTP should be held in abeyance until the effect of HTN control can be assessed...
  25. ncbi request reprint Cardiogenic shock complicates successful treatment of refractory thrombotic thrombocytopenia purpura with rituximab
    P M Millward
    Department of Pathology and Laboratory Medicine, Division of Cardiology, University of North Carolina Hospitals, 101 Manning Drive, Chapel Hill, NC 27514, USA
    Transfusion 45:1481-6. 2005
    ..Because of severe and fatal infusion reactions including heart failure, rituximab carries a boxed warning...
  26. ncbi request reprint Update on multi-center clinical trials in the United States
    Araba Afenyi-Annan
    University of North Carolina Hospitals, 101 Manning Drive, 1021 East Wing, Blood Bank, CB 7525, Chapel Hill, NC 27514, USA
    Transfus Apher Sci 36:5-12. 2007
    ....
  27. ncbi request reprint An expanded phase I/II trial of cyclophosphamide, etoposide, and carboplatin plus total body irradiation with autologous marrow or stem cell support for patients with hematologic malignancies
    Thomas C Shea
    Division of Medical Oncology, Campus Box 7305, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Biol Blood Marrow Transplant 9:443-52. 2003
    ..This regimen is intensive and causes considerable mucositis but is otherwise well tolerated and has demonstrated activity in a number of hematologic malignancies, especially AML...
  28. doi request reprint ADAMTS13 activity levels in patients with human immunodeficiency virus-associated thrombotic microangiopathy and profound CD4 deficiency
    Yara A Park
    Department of Pathology and Laboratory Medicine, University of North Carolina Hospitals, Chapel Hill, North Carolina, USA
    J Clin Apher 24:32-6. 2009
    ..Patients with human immunodeficiency virus (HIV) infection can have a TTP-like illness; however, it appears to have a different etiology...
  29. ncbi request reprint Transfusion-related bacterial sepsis
    F C Reading
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Curr Opin Hematol 8:380-6. 2001
    ....
  30. ncbi request reprint Patterns of platelet response in idiopathic TTP/HUS: frequency of declining platelet counts with plasma exchange and the recognition and significance of a pseudo refractory state
    Shauna N Hay
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27514, USA
    Ther Apher Dial 10:237-41. 2006
    ..Recognition of this pseudo-refractory state can minimize the risks of prolonged TPE and the risks of adjunct interventions...
  31. ncbi request reprint Severe hemolytic anemia due to auto anti-N
    C C Immel
    Transfusion Medicine Service, UNC Hospitals, 1021 East Wing, 101 Manning Drive, Chapel Hill, NC 27514, USA
    Immunohematology 21:63-5. 2005
    ..As in three other case reports, the autoimmune hemolytic anemia resolved, with disappearance of the auto anti-N, after corticosteroid therapy...
  32. ncbi request reprint Frequency and significance of schistocytes in TTP/HUS patients at the discontinuation of plasma exchange therapy
    Jennifer A Egan
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA
    J Clin Apher 19:165-7. 2004
    ..We evaluated the frequency and significance of residual schistocytosis in TTP/HUS patients when the patients' platelet counts returned to normal levels (e.g., 100-150 x 10(9)/L)...
  33. ncbi request reprint Comparison of granulocyte colony-stimulating factor (G-CSF)--mobilized peripheral blood progenitor cells and G-CSF--stimulated bone marrow as a source of stem cells in HLA-matched sibling transplantation
    J S Serody
    Department of Medicine, University of North Carolina at Chapel Hill, The Lineberger Comprehensive Cancer Center, USA
    Biol Blood Marrow Transplant 6:434-40. 2000
    ..Overall survival was not different between the 2 groups. Thus, G-CSF--stimulated bone marrow offers a source of stem cells that allows for early neutrophil engraftment with a decreased risk of GVHD...
  34. ncbi request reprint Dendritic cells can be rapidly expanded ex vivo and safely administered in patients with metastatic breast cancer
    E Claire Dees
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Campus Box 7295, Chapel Hill, NC 27599 7295, USA
    Cancer Immunol Immunother 53:777-85. 2004
    ..DCs can be generated ex vivo from monocytes or CD34+ precursors. The ability to expand and safely administer CD34-derived DCs in patients with MBC that have received prior cytotoxic chemotherapy has not been evaluated...
  35. ncbi request reprint The introduction of 7-day platelets: a university hospital experience
    Shauna N Hay
    The Transfusion Medicine Service, University of North Carolina, Chapel Hill, North Carolina, USA
    J Clin Apher 22:283-6. 2007
    ..As one of the first hospitals to implement a 7-day protocol, we reviewed our hospital experience with 7-day Gambro apheresis platelets to determine the impact on inventory...
  36. doi request reprint Is it quinine TTP/HUS or quinine TMA? ADAMTS13 levels and implications for therapy
    Yara A Park
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    J Clin Apher 24:115-9. 2009
    ..The use of plasma exchange in quinine-TMA is called into question...
  37. ncbi request reprint Life, death, and the risk of transfusion: a university hospital experience
    Shauna N Hay
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina 27514, USA
    Transfusion 46:1491-3. 2006
    ..It would be expected that patients dying in a tertiary-care, Level 1 trauma center university hospital would have one of the highest transfusion rates...
  38. ncbi request reprint Validation of pH and glucose determination for bacteria detection screening in platelet concentrates stored in the Terumo Teruflex XT612 platelet container
    Shauna N Hay
    Transfusion 44:1395. 2004
  39. ncbi request reprint Summary of the AABB Interorganizational Task Force on Bacterial Contamination of Platelets: Fall 2004 impact survey
    Marianne A Silva
    UCLA Medical Center, Los Angeles, California, USA
    Transfusion 46:636-41. 2006
    ..This article summarizes a survey conducted by the Task Force to assess the impact of bacterial detection...
  40. ncbi request reprint Platelet senescent cultures and the predictive value of an early culture
    Mark E Brecher
    Transfusion 46:311-2. 2006
  41. ncbi request reprint Protecting the blood supply from emerging pathogens: the role of pathogen inactivation
    Jean Pierre Allain
    Department of Hematology, University of Cambridge, Cambridge Blood Centre, UK
    Transfus Med Rev 19:110-26. 2005
    ..However, widespread use of a pathogen inactivation technology can only be realized when proven safe and efficacious and not cost-prohibitive...
  42. doi request reprint Fatal streptococcal infection despite routine bacterial culture screening
    Mark E Brecher
    Transfusion 48:2269-70. 2008
  43. doi request reprint Modeling of bacterial contamination
    Mark E Brecher
    Transfusion 48:569-70; author reply 570. 2008
  44. ncbi request reprint Transfusion medicine: looking to the future
    Lawrence T Goodnough
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Lancet 361:161-9. 2003
    ..Finally, serious difficulties in blood safety and availability for poor, developing countries require innovative strategies and commitment of resources...
  45. ncbi request reprint Transfusion medicine illustrated. Visualizing the hemolytic transfusion reaction
    Kathryn Elliott
    Southwest Washigton Medical Center, Vancouver, Washington 98683 0000, USA
    Transfusion 43:297. 2003
  46. ncbi request reprint Pre-transfusion phenotype matching for sickle cell disease patients
    Araba Afenyi-Annan
    Transfusion 44:619-20. 2004
  47. ncbi request reprint The platelet prophylactic transfusion trigger: when expectations meet reality
    Mark E Brecher
    Transfusion 47:188-91. 2007
  48. ncbi request reprint pH and glucose testing of single-donor apheresis platelets should be discontinued in favor of a more sensitive detection method
    Roslyn Yomtovian
    Transfusion 45:646-8. 2005
  49. ncbi request reprint Transfusion medicine illustrated. G-CSF-associated rash in an allogeneic PBPC donor
    Marla C Brumit
    University of North Carolina Hospitals, Transfusion Medicine Services, Chapel Hill, North Carolina 27514 4216, USA
    Transfusion 43:1343. 2003

Research Grants1

  1. Transfusion Medicine/Hemostasis Clinical Trials Network
    Mark Brecher; Fiscal Year: 2007
    ..Two TMH CTN protocols are ongoing at UNC, and it is the intention of the investigators at this site to support new network protocols in the future. UNIVERSITY OF NORTH CAROLINA CHAPEL HILL CRITIQUES ..