Research Topics
| M E BrecherSummaryAffiliation: University of North Carolina Country: USA Publications
Research Grants
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Detail Information
Publications
Alternatives to albumin: starch replacement for plasma exchangeM E Brecher
Transfusion Medicine Service, University of North Carolina Hospitals, Chapel Hill 27514, USA
J Clin Apher 12:146-53. 1997..It is concluded that HES is well-tolerated and cost-effective as full or partial volume replacement with plasma exchange. It is anticipated that the use of HES will emerge as a standard of care in apheresis...
Is it HIV TTP or HIV-associated thrombotic microangiopathy?Mark E Brecher
Department of Pathology and Laboratory Medicine, University of North Carolina Hospitals, Chapel Hill, North Carolina 27514, USA
J Clin Apher 23:186-90. 2008..A sine que non for successful therapy of HIV-TMA appears to be the treatment of the underlying HIV infection...- Monitoring of apheresis platelet bacterial contamination with an automated liquid culture system: a university experienceM E Brecher
University of North Carolina, Chapel Hill, North Carolina 27514, USA
Transfusion 43:974-8. 2003.... - Validation of BacT/ALERT plastic culture bottles for use in testing of whole-blood-derived leukoreduced platelet-rich-plasma-derived plateletsM E Brecher
University of North Carolina, Chapel Hill, North Carolina 27514, USA
Transfusion 44:1174-8. 2004..This study validated the BacT/ALERT for use in testing pooled PRP-derived PLTs with nine contaminating organisms... - Improving platelet safety: bacterial contamination of plateletsMark E Brecher
University of North Carolina Hospitals, 101 Manning Drive, Chapel Hill, NC 27514, USA
Curr Hematol Rep 3:121-7. 2004..Implementation of bacterial detection methods would improve safety for patients, result in an extension of the shelf life of platelets, and reduce the outdating of platelets, thus being a cost-saving safety intervention... - Evaluation of a new generation of plastic culture bottles with an automated microbial detection system for nine common contaminating organisms found in PLT componentsM E Brecher
Transfusion Medicine Service, CB 7600, University of North Carolina Hospitals, 101 Manning Drive, Chapel Hill, NC 27514, USA
Transfusion 44:359-63. 2004..The recovery of nine organisms seeded into PLTs with new plastic culture bottles was studied in comparison to the current glass bottles. The use of plastic instead of glass would be expected to reduce the risk of injury... - Evaluation of bacterial inactivation in prestorage pooled, leukoreduced, whole blood-derived platelet concentrates suspended in plasma prepared with photochemical treatmentMark E Brecher
Department of Pathology and Laboratory Medicine, University of North Carolina, 101 Manning Drive, Chapel Hill, NC 27514, USA
Transfusion 47:1896-901. 2007..Because PLT additive solutions (ASs) are not used in the United States, this study evaluated the ability of the PCT process to inactivate low levels of bacteria in pooled whole blood-derived PLTs (RDP) suspended in 100 percent plasma... - Transfusion medicine illustrated. Platelet swirlingMark E Brecher
University of North Carolina, Chapel Hill, North Carolina, USA
Transfusion 44:627. 2004 - Investigation of an isolate of Staphylococcus lugdunensis implicated in a platelet fatality: a possible advantage of the use of an anaerobic bottleMark E Brecher
Transfusion Medicine Service, University of North Carolina Hospitals, 101 Manning Drive, Chapel Hill, NC 27514, USA
Transfusion 47:1390-4. 2007..The utility of an anaerobic (BPN) bottle compared to a BPA bottle was investigated for the detection of S. lugdunensis... 
Bacterial contamination of blood componentsMark E Brecher
Transfusion Medicine Service, CB 7600, University of North Carolina Hospitals, 101 Manning Dr, Chapel Hill, NC 27514, USA
Clin Microbiol Rev 18:195-204. 2005..This paper summarizes the current status of detection, prevention, and elimination of bacteria in blood products for transfusion...- How I approach a thrombotic thrombocytopenia purpura patientMark E Brecher
Department of Pathology and Laboratory Medicine, University of North Carolina Hospitals, Chapel Hill, North Carolina 27514, USA
Transfusion 46:687-9. 2006..This article presents a summary of how our clinical service approaches TTP patients and manages commonly occurring problems... - Evaluation of BacT/ALERT plastic culture bottles for use in testing pooled whole blood-derived leukoreduced platelet-rich plasma platelets with a single contaminated unitM E Brecher
University of North Carolina Hospitals, 101 Manning Drive, Chapel Hill, NC 27514, USA
Transfusion 45:1512-7. 2005..10 colony-forming units [CFUs]/mL) once pooled (10/6 approx. 2 CFUs/mL). This study evaluated the BacT/ALERT (bioMérieux) for detection of bacteria in 1 unit of a 6-unit pool... - Plasma exchange: why we do what we doMark E Brecher
Department of Pathology and Laboratory Medicine, Transfusion Medicine Service, University of North Carolina at Chapel Hill, NC 27514, USA
J Clin Apher 17:207-11. 2002 - Evaluation of an automated culture system for detecting bacterial contamination of platelets: an analysis with 15 contaminating organismsM E Brecher
University of North Carolina Hospitals, Chapel Hill, North Carolina 27514, USA
Transfusion 41:477-82. 2001..Approximately 1 in 2000 platelet components are bacterially contaminated. The time to detection of 15 seeded organisms in platelets recovered from an automated culture system was studied... - Number of RBC units and rate of transfusionto anemic HIV-positive patients assigned to receiveWBC-reduced or non-WBC-reduced RBCs: the viral activation transfusion study experienceM E Brecher
Transfusion Medicine Service, University of North Carolina, Chapel Hill, North Carolina 27514, USA
Transfusion 41:794-8. 2001..It is not known if the use of such WBC-reduced RBCs results in an increased need for RBC units or in the transfusion of more units per year to patients with anemia... - Evaluation of a new generation of culture bottle using an automated bacterial culture system for detecting nine common contaminating organisms found in platelet componentsM E Brecher
Transfusion Medicine Service, Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27514, USA
Transfusion 42:774-9. 2002..The recovery of bacteria in platelets using a new generation of culture bottles that do not require venting and that use a liquid emulsion sensor was studied... - Transfusion medicine illustrated. Pseudohemolysis with iron dextran therapyMark E Brecher
Transfusion Medicine Service, UNC Hospitals, Chapel Hill, North Carolina, USA
Transfusion 42:135. 2002 - Growth of bacteria in inoculated platelets: implications for bacteria detection and the extension of platelet storageM E Brecher
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, USA
Transfusion 40:1308-12. 2000.... - Methods to minimize transfusion related bacterial sepsisM E Brecher
Transfusion Medicine Service, University of North Carolina Hospitals, University of North Carolina at Chapel Hill, 27514, USA
Dev Biol (Basel) 108:69-84. 2002 - Bacterial contamination of blood products: factors, options, and insightsN D Depcik-Smith
University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA
J Clin Apher 16:192-201. 2001..There is no one existing strategy that can completely eliminate the risk of bacterial contamination. It is inevitable that partial solutions or combinations of methods will be implemented in the near future... - In vivo and in vitro characteristics of double units of RBCs collected by apheresis with a single in-line WBC-reduction filterN Bandarenko
University of North Carolina, Chapel Hill, USA
Transfusion 41:1373-7. 2001..The objective of this study was to evaluate the filtration performance in connection with different prefiltration RBC storage conditions and with the in vitro and in vivo storage quality of the filtered units... - Incidence of allergic reactions with fresh frozen plasma or cryo-supernatant plasma in the treatment of thrombotic thrombocytopenic purpuraJ C Reutter
Department of Pathology and Lab Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
J Clin Apher 16:134-8. 2001..Because of the large volume, the number of donor exposures, and prolonged duration of therapy, allergic reactions to plasma are common (65.8%) in the treatment of TTP... - Antibiotic-labeled probes and microvolume fluorimetry for the rapid detection of bacterial contamination in platelet components: a preliminary reportM E Brecher
University of North Carolina Hospitals, Chapel Hill, NC 27514, USA
Transfusion 40:411-3. 2000..or Bacillus sp.). A novel approach to the rapid diagnosis of gram positive contamination by the use of a fluorescence-labeled antibiotic probe with affinity for the gram positive cell was investigated... - Differentiating thrombotic microangiopathies induced by severe hypertension from anemia and thrombocytopenia seen in thrombotic thrombocytopenia purpuraJ A Egan
Department of Pathology and Laboratory Medicine, University of North Carolina Hospitals, Chapel Hill 27514, USA
J Clin Apher 19:125-9. 2004..In cases of severe HTN (with or without papilledema), the diagnosis of TTP should be held in abeyance until the effect of HTN control can be assessed... - Cardiogenic shock complicates successful treatment of refractory thrombotic thrombocytopenia purpura with rituximabP M Millward
Department of Pathology and Laboratory Medicine, Division of Cardiology, University of North Carolina Hospitals, 101 Manning Drive, Chapel Hill, NC 27514, USA
Transfusion 45:1481-6. 2005..Interventions, however, can also carry significant risk as illustrated by the cardiogenic shock in our patient. Use of rituximab for refractory TTP should follow a careful assessment of benefits... - Update on multi-center clinical trials in the United StatesAraba Afenyi-Annan
University of North Carolina Hospitals, 101 Manning Drive, 1021 East Wing, Blood Bank, CB 7525, Chapel Hill, NC 27514, USA
Transfus Apher Sci 36:5-12. 2007.... - An expanded phase I/II trial of cyclophosphamide, etoposide, and carboplatin plus total body irradiation with autologous marrow or stem cell support for patients with hematologic malignanciesThomas C Shea
Division of Medical Oncology, Campus Box 7305, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Biol Blood Marrow Transplant 9:443-52. 2003..This regimen is intensive and causes considerable mucositis but is otherwise well tolerated and has demonstrated activity in a number of hematologic malignancies, especially AML... - ADAMTS13 activity levels in patients with human immunodeficiency virus-associated thrombotic microangiopathy and profound CD4 deficiencyYara A Park
Department of Pathology and Laboratory Medicine, University of North Carolina Hospitals, Chapel Hill, North Carolina, USA
J Clin Apher 24:32-6. 2009..Patients with human immunodeficiency virus (HIV) infection can have a TTP-like illness; however, it appears to have a different etiology... - Transfusion-related bacterial sepsisF C Reading
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Curr Opin Hematol 8:380-6. 2001.... - Patterns of platelet response in idiopathic TTP/HUS: frequency of declining platelet counts with plasma exchange and the recognition and significance of a pseudo refractory stateShauna N Hay
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27514, USA
Ther Apher Dial 10:237-41. 2006..Recognition of this pseudo-refractory state can minimize the risks of prolonged TPE and the risks of adjunct interventions... - Severe hemolytic anemia due to auto anti-NC C Immel
Transfusion Medicine Service, UNC Hospitals, 1021 East Wing, 101 Manning Drive, Chapel Hill, NC 27514, USA
Immunohematology 21:63-5. 2005..As in three other case reports, the autoimmune hemolytic anemia resolved, with disappearance of the auto anti-N, after corticosteroid therapy... - Frequency and significance of schistocytes in TTP/HUS patients at the discontinuation of plasma exchange therapyJennifer A Egan
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA
J Clin Apher 19:165-7. 2004..00, Fisher's Exact test, 2 sided). CONCLUSIONS: In this study, we found that the presence of residual schistocytosis is common (35.6%). The presence of residual schistocytosis, however, was not predictive of relapse... - Comparison of granulocyte colony-stimulating factor (G-CSF)--mobilized peripheral blood progenitor cells and G-CSF--stimulated bone marrow as a source of stem cells in HLA-matched sibling transplantationJ S Serody
Department of Medicine, University of North Carolina at Chapel Hill, The Lineberger Comprehensive Cancer Center, USA
Biol Blood Marrow Transplant 6:434-40. 2000..Overall survival was not different between the 2 groups. Thus, G-CSF--stimulated bone marrow offers a source of stem cells that allows for early neutrophil engraftment with a decreased risk of GVHD... - Dendritic cells can be rapidly expanded ex vivo and safely administered in patients with metastatic breast cancerE Claire Dees
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Campus Box #7295, Chapel Hill, NC 27599-7295, USA
Cancer Immunol Immunother 53:777-85. 2004..CONCLUSIONS: This approach is safe and effective in generating a significant quantity of DCs from CD34-precursors... - The introduction of 7-day platelets: a university hospital experienceShauna N Hay
The Transfusion Medicine Service, University of North Carolina, Chapel Hill, North Carolina, USA
J Clin Apher 22:283-6. 2007..As one of the first hospitals to implement a 7-day protocol, we reviewed our hospital experience with 7-day Gambro apheresis platelets to determine the impact on inventory... - Is it quinine TTP/HUS or quinine TMA? ADAMTS13 levels and implications for therapyYara A Park
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
J Clin Apher 24:115-9. 2009..The use of plasma exchange in quinine-TMA is called into question... - Life, death, and the risk of transfusion: a university hospital experienceShauna N Hay
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina 27514, USA
Transfusion 46:1491-3. 2006..001, Fisher's exact test, two-sided). CONCLUSIONS: The majority of patients who expire at our institution have a history of transfusion (67.9%-71.0%). Patients who die before the age of 31 have the highest rate of transfusion... - Validation of pH and glucose determination for bacteria detection screening in platelet concentrates stored in the Terumo Teruflex XT612 platelet containerShauna N Hay
Transfusion 44:1395. 2004 - Summary of the AABB Interorganizational Task Force on Bacterial Contamination of Platelets: Fall 2004 impact surveyMarianne A Silva
UCLA Medical Center, Los Angeles, California, USA
Transfusion 46:636-41. 2006..Some facilities were greatly impacted. Based on the data gathered, it is impossible to conclude whether such shortages resulted from production or distribution problems or were due to decreased shelf life and increased outdates... - Platelet senescent cultures and the predictive value of an early cultureMark E Brecher
Transfusion 46:311-2. 2006 - Protecting the blood supply from emerging pathogens: the role of pathogen inactivationJean Pierre Allain
Department of Hematology, University of Cambridge, Cambridge Blood Centre, UK
Transfus Med Rev 19:110-26. 2005..However, widespread use of a pathogen inactivation technology can only be realized when proven safe and efficacious and not cost-prohibitive... - Fatal streptococcal infection despite routine bacterial culture screeningMark E Brecher
Transfusion 48:2269-70. 2008 - Modeling of bacterial contaminationMark E Brecher
Transfusion 48:569-70; author reply 570. 2008 - Transfusion medicine: looking to the futureLawrence T Goodnough
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Lancet 361:161-9. 2003..Finally, serious difficulties in blood safety and availability for poor, developing countries require innovative strategies and commitment of resources... - Transfusion medicine illustrated. Visualizing the hemolytic transfusion reactionKathryn Elliott
Southwest Washigton Medical Center, Vancouver, Washington 98683-0000, USA
Transfusion 43:297. 2003 - Pre-transfusion phenotype matching for sickle cell disease patientsAraba Afenyi-Annan
Transfusion 44:619-20. 2004 - The platelet prophylactic transfusion trigger: when expectations meet realityMark E Brecher
Transfusion 47:188-91. 2007 - pH and glucose testing of single-donor apheresis platelets should be discontinued in favor of a more sensitive detection methodRoslyn Yomtovian
Transfusion 45:646-8. 2005 - Transfusion medicine illustrated. G-CSF-associated rash in an allogeneic PBPC donorMarla C Brumit
University of North Carolina Hospitals, Transfusion Medicine Services, Chapel Hill, North Carolina 27514-4216, USA
Transfusion 43:1343. 2003
Research Grants
- Transfusion Medicine/Hemostasis Clinical Trials NetworkMark Brecher; Fiscal Year: 2007..Two TMH CTN protocols are ongoing at UNC, and it is the intention of the investigators at this site to support new network protocols in the future. UNIVERSITY OF NORTH CAROLINA CHAPEL HILL CRITIQUES ..