Chad A Brautigam

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Structural analysis of Xanthomonas XopD provides insights into substrate specificity of ubiquitin-like protein proteases
    Renee Chosed
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    J Biol Chem 282:6773-82. 2007
  2. pmc Purification, crystallization and preliminary X-ray analysis of TP0435 (Tp17) from the syphilis spirochete Treponema pallidum
    Chad A Brautigam
    Department of Biophysics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 69:453-5. 2013
  3. pmc Structural insight into interactions between dihydrolipoamide dehydrogenase (E3) and E3 binding protein of human pyruvate dehydrogenase complex
    Chad A Brautigam
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Structure 14:611-21. 2006
  4. pmc Subunit and catalytic component stoichiometries of an in vitro reconstituted human pyruvate dehydrogenase complex
    Chad A Brautigam
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Biol Chem 284:13086-98. 2009
  5. pmc Using Lamm-Equation modeling of sedimentation velocity data to determine the kinetic and thermodynamic properties of macromolecular interactions
    Chad A Brautigam
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 8816, USA
    Methods 54:4-15. 2011
  6. pmc Structural and thermodynamic basis for weak interactions between dihydrolipoamide dehydrogenase and subunit-binding domain of the branched-chain alpha-ketoacid dehydrogenase complex
    Chad A Brautigam
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 286:23476-88. 2011
  7. ncbi request reprint Crystal structure of human dihydrolipoamide dehydrogenase: NAD+/NADH binding and the structural basis of disease-causing mutations
    Chad A Brautigam
    Department of Biochemistry, The University of Texas, Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    J Mol Biol 350:543-52. 2005
  8. ncbi request reprint The PnrA (Tp0319; TmpC) lipoprotein represents a new family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC)-like operon in Treponema pallidum
    Ranjit K Deka
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 281:8072-81. 2006
  9. pmc Biophysical and bioinformatic analyses implicate the Treponema pallidum Tp34 lipoprotein (Tp0971) in transition metal homeostasis
    Chad A Brautigam
    Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Bacteriol 194:6771-81. 2012
  10. pmc Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domain
    Phi Luong
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 285:20155-63. 2010

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Structural analysis of Xanthomonas XopD provides insights into substrate specificity of ubiquitin-like protein proteases
    Renee Chosed
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    J Biol Chem 282:6773-82. 2007
    ..By incorporating structural information with sequence alignments and enzyme assays, we were able to elucidate determinants of the rigid SUMO specificity exhibited by the Xanthomonas virulence factor XopD...
  2. pmc Purification, crystallization and preliminary X-ray analysis of TP0435 (Tp17) from the syphilis spirochete Treponema pallidum
    Chad A Brautigam
    Department of Biophysics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 69:453-5. 2013
    ..The protein crystals obtained from this preparation diffracted to 2.4 Å resolution and had the symmetry of space group R3. In the hexagonal setting, the unit-cell parameters were a = b = 85.7, c = 85.4 Å...
  3. pmc Structural insight into interactions between dihydrolipoamide dehydrogenase (E3) and E3 binding protein of human pyruvate dehydrogenase complex
    Chad A Brautigam
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Structure 14:611-21. 2006
    ..A cluster of disease-causing E3 mutations located near the center of the E3BD/E3 interface prevents the efficient recruitment of these E3 variants by E3BP into the PDC, leading to the dysfunction of the PDC catalytic machine...
  4. pmc Subunit and catalytic component stoichiometries of an in vitro reconstituted human pyruvate dehydrogenase complex
    Chad A Brautigam
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Biol Chem 284:13086-98. 2009
    ..Prior, A. E., Brown, A. E., Cooper, A., Byron, O., and Lindsay, J. G. (2006) J. Biol. Chem. 281, 19772-19780)...
  5. pmc Using Lamm-Equation modeling of sedimentation velocity data to determine the kinetic and thermodynamic properties of macromolecular interactions
    Chad A Brautigam
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 8816, USA
    Methods 54:4-15. 2011
    ..Detailed analyses of SV data using these strategies are presented. Finally, a few highlights of recent literature reports that feature this type of SV data analysis are surveyed...
  6. pmc Structural and thermodynamic basis for weak interactions between dihydrolipoamide dehydrogenase and subunit-binding domain of the branched-chain alpha-ketoacid dehydrogenase complex
    Chad A Brautigam
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 286:23476-88. 2011
    ..Taken together, our results represent a starting point for explaining the long standing enigma that the E2b core of the BCKDC binds E3 far more weakly relative to other α-ketoacid dehydrogenase complexes...
  7. ncbi request reprint Crystal structure of human dihydrolipoamide dehydrogenase: NAD+/NADH binding and the structural basis of disease-causing mutations
    Chad A Brautigam
    Department of Biochemistry, The University of Texas, Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    J Mol Biol 350:543-52. 2005
    ..The mechanisms by which these mutations impede the function of hE3 are discussed...
  8. ncbi request reprint The PnrA (Tp0319; TmpC) lipoprotein represents a new family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC)-like operon in Treponema pallidum
    Ranjit K Deka
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 281:8072-81. 2006
    ..PnrA has been grouped with a functionally uncharacterized protein family (HBG016869), thereby implying that other members of the family may have similar nucleoside-binding function(s)...
  9. pmc Biophysical and bioinformatic analyses implicate the Treponema pallidum Tp34 lipoprotein (Tp0971) in transition metal homeostasis
    Chad A Brautigam
    Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Bacteriol 194:6771-81. 2012
    ..The findings presented herein, coupled with bioinformatic analyses of related proteins, point to Tp34's likely role in metal ion homeostasis in T. pallidum...
  10. pmc Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domain
    Phi Luong
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 285:20155-63. 2010
    ..Discovery of a ternary reaction mechanism along with structural insight provides critical groundwork for future studies for the family of AMPylators that modify hydroxyl-containing residues with AMP...
  11. ncbi request reprint Structural evidence that the 32-kilodalton lipoprotein (Tp32) of Treponema pallidum is an L-methionine-binding protein
    Ranjit K Deka
    Department of Microbiology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Biol Chem 279:55644-50. 2004
    ..Sequence comparison shows strong similarity to other hypothetical methionine-binding proteins. Together, the data support the notion that rTp32 is a component of a periplasmic methionine uptake transporter system in T. pallidum...
  12. pmc The TP0796 lipoprotein of Treponema pallidum is a bimetal-dependent FAD pyrophosphatase with a potential role in flavin homeostasis
    Ranjit K Deka
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 288:11106-21. 2013
    ..TP0796 is the first structurally and biochemically characterized FAD pyrophosphate enzyme in bacteria. This new paradigm for a bacterial flavin utilization pathway may prove to be useful for future inhibitor design...
  13. pmc Structural and thermodynamic characterization of the interaction between two periplasmic Treponema pallidum lipoproteins that are components of a TPR-protein-associated TRAP transporter (TPAT)
    Chad A Brautigam
    Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Mol Biol 420:70-86. 2012
    ..These observations confirm that the observed crystallographic interface is recapitulated in solution. These results prompt a hypothesis of the molecular mechanism(s) of hydrophobic ligand transport by the TPATs...
  14. pmc Structural, bioinformatic, and in vivo analyses of two Treponema pallidum lipoproteins reveal a unique TRAP transporter
    Ranjit K Deka
    Department of Microbiology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Mol Biol 416:678-96. 2012
    ....
  15. ncbi request reprint Crystal structure of the Tp34 (TP0971) lipoprotein of treponema pallidum: implications of its metal-bound state and affinity for human lactoferrin
    Ranjit K Deka
    Departments of Microbiology and Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 282:5944-58. 2007
    ..pallidum but, rather, is periplasmic. How propensity of Tp34 to bind zinc and the iron-sequestering lactoferrin may relate overall to the biology of T. pallidum infection in humans is discussed...
  16. pmc Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments
    Shae B Padrick
    Department of Biochemistry, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Anal Biochem 407:89-103. 2010
    ..The overall method is described in detail in this work, as are experimental examples and caveats...
  17. pmc Identification of a bacteriocin and its cognate immunity factor expressed by Moraxella catarrhalis
    Ahmed S Attia
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    BMC Microbiol 9:207. 2009
    ..Bacteriocins are antimicrobial proteins and peptides ribosomally synthesized by some bacteria which can effect both intraspecies and interspecies killing...
  18. ncbi request reprint A versatile conformational switch regulates reactivity in human branched-chain alpha-ketoacid dehydrogenase
    Mischa Machius
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Structure 14:287-98. 2006
    ..Our results illustrate the versatility of the tyrosine switch in coordinating the catalytic events in E1b by modulating the reactivity of reaction intermediates...
  19. pmc A synchronized substrate-gating mechanism revealed by cubic-core structure of the bovine branched-chain alpha-ketoacid dehydrogenase complex
    Masato Kato
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    EMBO J 25:5983-94. 2006
    ..We suggest that this gating mechanism synchronizes the binding of the two substrates to the active-site channel, which serves as a feed-forward switch to coordinate the E2b-catalyzed acyltransfer reaction...
  20. pmc Structural and biochemical basis for polyamine binding to the Tp0655 lipoprotein of Treponema pallidum: putative role for Tp0655 (TpPotD) as a polyamine receptor
    Mischa Machius
    Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Mol Biol 373:681-94. 2007
    ..pallidum. We thus rename Tp0655 as TpPotD. The ramifications of TpPotD as a polyamine-binding protein to the parasitic strategy of T. pallidum are discussed...
  21. pmc Arp2/3 complex is bound and activated by two WASP proteins
    Shae B Padrick
    Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 108:E472-9. 2011
    ..The VCAs at these sites have distinct roles in activation. Our findings reconcile apparently conflicting literature on VCA activation of Arp2/3 complex and lead to a new model for this process...
  22. pmc Evidence for an ABC-type riboflavin transporter system in pathogenic spirochetes
    Ranjit K Deka
    Department of Microbiology, University of Texas, Southwestern Medical Center, Dallas, Texas, USA
    MBio 4:e00615-12. 2013
    ..Taken together, it appears that pathogenic spirochetes have evolved an ABC-type transport system (RfuABCD) for survival in their host environments, particularly that of the human host...
  23. pmc Mechanism of actin filament nucleation by the bacterial effector VopL
    Bingke Yu
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Struct Mol Biol 18:1068-74. 2011
    ..Stabilization of lateral contacts may be a common feature of actin filament nucleation by WH2-based factors...
  24. pmc Moraxella catarrhalis expresses an unusual Hfq protein
    Ahmed S Attia
    Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9048, USA
    Infect Immun 76:2520-30. 2008
    ..coli mutant to methyl viologen. The use of an electrophoretic mobility shift assay showed that this M. catarrhalis Hfq protein could bind RNA derived from a gene whose expression was altered in the M. catarrhalis hfq mutant...
  25. pmc Trypanosoma brucei S-adenosylmethionine decarboxylase N terminus is essential for allosteric activation by the regulatory subunit prozyme
    NAHIR VELEZ
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
    J Biol Chem 288:5232-40. 2013
    ..Our findings provide the first insight into the mechanisms that influence catalytic regulation of AdoMetDC and may have potential implications for the development of new inhibitors against this enzyme...
  26. pmc Structural and biochemical characterization of human mitochondrial branched-chain α-ketoacid dehydrogenase phosphatase
    R Max Wynn
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9038, USA
    J Biol Chem 287:9178-92. 2012
    ..Alteration of the nearby Arg-104 increases the K(m) for p-E1b peptide by 60-fold, suggesting that this residue is critical for the recognition of the native p-E1b protein...
  27. pmc Bifunctional NMN adenylyltransferase/ADP-ribose pyrophosphatase: structure and function in bacterial NAD metabolism
    Nian Huang
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Structure 16:196-209. 2008
    ..The latter observation provided new insights into the ligand binding mode of ADPR-gated Ca2+ channel TRPM2...
  28. doi request reprint Changes at the KinA PAS-A dimerization interface influence histidine kinase function
    James Lee
    Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 8816, USA
    Biochemistry 47:4051-64. 2008
    ..These results support the importance of PAS domains within KinA and other histidine kinases and suggest possible routes for natural or artificial regulation of kinase activity...
  29. pmc Characterization of the CpxRA regulon in Haemophilus ducreyi
    Maria Labandeira-Rey
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9048, USA
    Infect Immun 78:4779-91. 2010
    ..Taken together, these data suggest that the CpxRA system in H. ducreyi, in contrast to that in E. coli, may be involved primarily in controlling expression of genes not involved in the cell envelope stress response...
  30. pmc Multi-signal sedimentation velocity analysis with mass conservation for determining the stoichiometry of protein complexes
    Chad A Brautigam
    Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 8:e62694. 2013
    ..This should broaden the applicability of MSSV to the analysis of the composition of reversible macromolecular complexes...
  31. pmc Structure of the human cohesin inhibitor Wapl
    Zhuqing Ouyang
    Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 110:11355-60. 2013
    ..Thus, Wapl-N forms extensive interactions with Pds5 and Scc1-SA2. Wapl-C interacts with other cohesin subunits and possibly unknown effectors to trigger cohesin release from chromatin. ..
  32. ncbi request reprint Structural basis of histone demethylation by LSD1 revealed by suicide inactivation
    Maojun Yang
    Department of Pharmacology, The University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390, USA
    Nat Struct Mol Biol 14:535-9. 2007
    ..The unusual backbone conformation of LSD1-bound H3 suggests a strategy for designing potent LSD1 inhibitors with therapeutic potential...
  33. pmc Moraxella catarrhalis synthesizes an autotransporter that is an acid phosphatase
    Todd C Hoopman
    Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9048, USA
    J Bacteriol 190:1459-72. 2008
    ..This is the first description of an autotransporter protein that expresses acid phosphatase activity...
  34. pmc Evaluating the stoichiometry of macromolecular complexes using multisignal sedimentation velocity
    Shae B Padrick
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 8816, USA
    Methods 54:39-55. 2011
    ..A detailed example of the analysis of MSSV experiments is offered, and the possibility of deriving equilibrium association constants from MSSV analyses is explored. Finally, successful implementations of MSSV are reviewed...
  35. pmc Identification of gene products involved in the oxidative stress response of Moraxella catarrhalis
    Todd C Hoopman
    Department of Internal Medicine, Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Infect Immun 79:745-55. 2011
    ..catarrhalis strain ETSU-4 showed that the growth of a ETSU-4 katA mutant was markedly inhibited by the addition of 50 mM H₂O₂ but that this mutant could still form a biofilm equivalent to that produced by its wild-type parent strain...
  36. pmc Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana
    Chad A Brautigam
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9050, USA
    Proc Natl Acad Sci U S A 101:12142-7. 2004
    ..ATP, and we observe a single molecule of an ATP analog bound in the aforementioned surface cavity, near the bound FAD cofactor. The structure has implications for the signaling mechanism of CRY blue-light photoreceptors...
  37. pmc Hierarchical regulation of WASP/WAVE proteins
    Shae B Padrick
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Cell 32:426-38. 2008
    ..Allostery and dimerization act in hierarchical fashion, enabling WASP/WAVE proteins to integrate different classes of inputs to produce a wide range of cellular actin responses...
  38. pmc Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response
    Xiaomo Jiang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Immunity 36:959-73. 2012
    ..These results suggest a unified mechanism of RIG-I and MDA5 activation and reveal a unique mechanism by which ubiquitin regulates cell signaling and immune response...
  39. doi request reprint Methods for analysis of ligand-induced RNA conformational changes
    Chad A Brautigam
    The University of Texas Southwestern Medical Center, Department of Biochemistry, Dallas, TX 75390 9038, USA
    Methods Mol Biol 540:77-95. 2009
    ..Several hydrodynamic methods, including analytical ultracentrifugation, size-exclusion chromatography, and nondenaturing gel electrophoresis, are briefly discussed herein...
  40. doi request reprint Sequence, biophysical, and structural analyses of the PstS lipoprotein (BB0215) from Borrelia burgdorferi reveal a likely binding component of an ABC-type phosphate transporter
    Chad A Brautigam
    Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390
    Protein Sci 23:200-12. 2014
    ..Taken together, the gene products of bb0215-0218 function as a phosphate transporter for B. burgdorferi. ..
  41. doi request reprint The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop
    Xu Zhang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA Electronic address
    Cell Rep 6:421-30. 2014
    ..Functional analyses of cGAS mutants demonstrate that both the protein-protein interface and the two DNA binding surfaces are critical for cGAS activation. These results provide insights into the mechanism of DNA sensing by cGAS. ..
  42. pmc Multivalent di-nucleosome recognition enables the Rpd3S histone deacetylase complex to tolerate decreased H3K36 methylation levels
    Jae Wan Huh
    Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX 75390 9148, USA
    EMBO J 31:3564-74. 2012
    ..Our data suggest that chromatin regulators utilize an intrinsic di-nucleosome-recognition mechanism to prevent compromised function when their primary recognition modifications are diluted...
  43. pmc Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5
    Lisheng Ni
    Department of Pharmacology, The University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA
    Structure 21:1757-68. 2013
    ..We propose that these temporally sensitive functions of RASSFs enable the Hippo pathway to respond to and integrate diverse cellular signals...
  44. pmc A TOG:αβ-tubulin complex structure reveals conformation-based mechanisms for a microtubule polymerase
    Pelin Ayaz
    Department of Biophysics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Science 337:857-60. 2012
    ..Conformation-selective interactions with αβ-tubulin explain how TOG-containing polymerases discriminate between unpolymerized and polymerized forms of αβ-tubulin and how they selectively recognize the growing end of the microtubule...
  45. pmc Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5)
    Joel W Thompson
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 287:7357-65. 2012
    ..Detailed molecular and structural characterization of the ligand-responsive hemerythrin domain provides insights into the mechanisms by which FBXL5 serves as a unique mammalian metabolic sensor...
  46. pmc Requirements for efficient correction of ΔF508 CFTR revealed by analyses of evolved sequences
    Juan L Mendoza
    Molecular Biophysics Program, and Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9040, USA
    Cell 148:164-74. 2012
    ..These results provide a mechanistic rationale for the limited efficacy of extant corrector compounds and suggest approaches for identifying compounds that correct both defective steps...
  47. ncbi request reprint Tetramerization and ATP binding by a protein comprising the A, B, and C domains of rat synapsin I
    Chad A Brautigam
    Howard Hughes Medical Institute and the Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9050, USA
    J Biol Chem 279:11948-56. 2004
    ..The evidence supports a view of synapsin I as an ATP-utilizing, tetrameric protein made up of monomers that have a flexible, extended N terminus...
  48. pmc Side chain and backbone contributions of Phe508 to CFTR folding
    Patrick H Thibodeau
    Department of Physiology, The University of Texas Southwestern Medical Center at Dallas, 75390 USA
    Nat Struct Mol Biol 12:10-6. 2005
    ....