BENJAMIN BRAUN

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Targeting Ras in myeloid leukemias
    Benjamin S Braun
    Department of Pediatrics, University of California, San Francisco, CA 94143, USA
    Clin Cancer Res 14:2249-52. 2008
  2. ncbi Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder
    Benjamin S Braun
    Department of Pediatrics, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 101:597-602. 2004
  3. ncbi Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder
    Doan T Le
    Department of Pediatrics, University of California, San Francisco, 513 Parnassus Ave, HSE 302, San Francisco, CA 94143, USA
    Blood 103:4243-50. 2004
  4. ncbi Inherited predispositions and hyperactive Ras in myeloid leukemogenesis
    Jennifer O Lauchle
    Department of Pediatrics and Comprehensive Cancer Center, University of California, San Francisco, California 94143, USA
    Pediatr Blood Cancer 46:579-85. 2006
  5. ncbi Congenital leukemia cutis with subsequent development of leukemia
    Inga Hofmann Zhang
    Department of Pediatrics, University of California-San Francisco, California 94143-0519, USA
    J Am Acad Dermatol 54:S22-7. 2006
  6. ncbi Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo
    Benjamin S Braun
    Department of Pediatrics, HSE 302, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Blood 108:2041-4. 2006
  7. ncbi The sum is greater than the FGFR1 partner
    Benjamin S Braun
    Department of Pediatrics and Comprehensive Cancer Center, University of California San Fransisco, San Francisco, CA 94143 USA
    Cancer Cell 5:203-4. 2004

Research Grants

  1. In Vivo Analysis of Oncogenic Kras in Leukemogenesis
    BENJAMIN BRAUN; Fiscal Year: 2007

Collaborators

  • K Shannon
  • M L Loh
  • Jennifer O Lauchle
  • Inga Hofmann Zhang
  • Doan T Le
  • John Maize
  • Seymour Zoger
  • Lee T Zane
  • Luis Parada
  • Scott C Kogan
  • Namie Kong
  • Abigail Aiyigari
  • Endi Wang
  • Yuan Zhu
  • Michelle M Le Beau

Detail Information

Publications7

  1. ncbi Targeting Ras in myeloid leukemias
    Benjamin S Braun
    Department of Pediatrics, University of California, San Francisco, CA 94143, USA
    Clin Cancer Res 14:2249-52. 2008
    ..Here, we discuss general strategies for targeting hyperactive Ras signaling in cancer cells with specific reference to myeloid malignancies...
  2. ncbi Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder
    Benjamin S Braun
    Department of Pediatrics, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 101:597-602. 2004
    ..Oncogenic RAS is sufficient to initiate myeloid leukemogenesis in mice, and this provides an in vivo system for biologic and preclinical studies...
  3. ncbi Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder
    Doan T Le
    Department of Pediatrics, University of California, San Francisco, 513 Parnassus Ave, HSE 302, San Francisco, CA 94143, USA
    Blood 103:4243-50. 2004
    ..These Mx1-Cre, Nf1(flox/flox) mice establish a tractable experimental model for testing therapeutics and for identifying mutations that cooperate with hyperactive Ras in myeloid leukemogenesis...
  4. ncbi Inherited predispositions and hyperactive Ras in myeloid leukemogenesis
    Jennifer O Lauchle
    Department of Pediatrics and Comprehensive Cancer Center, University of California, San Francisco, California 94143, USA
    Pediatr Blood Cancer 46:579-85. 2006
    ..These strains model human disease features and provide an opportunity to investigate novel therapeutic strategies that may ultimately cure JMML and other myeloid malignancies characterized by hyperactive Ras...
  5. ncbi Congenital leukemia cutis with subsequent development of leukemia
    Inga Hofmann Zhang
    Department of Pediatrics, University of California-San Francisco, California 94143-0519, USA
    J Am Acad Dermatol 54:S22-7. 2006
    ..The patient died of refractory leukemia and secondary fungal disease. This case report supports the observation that leukemia cutis with an 11q23 rearrangement should be treated aggressively...
  6. ncbi Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo
    Benjamin S Braun
    Department of Pediatrics, HSE 302, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Blood 108:2041-4. 2006
    ....
  7. ncbi The sum is greater than the FGFR1 partner
    Benjamin S Braun
    Department of Pediatrics and Comprehensive Cancer Center, University of California San Fransisco, San Francisco, CA 94143 USA
    Cancer Cell 5:203-4. 2004
    ..Their results show that these chromosomal rearrangements play a central role in pathogenesis, underscore the role of partner genes in modulating disease phenotypes, and uncover potential therapeutic targets...

Research Grants2

  1. In Vivo Analysis of Oncogenic Kras in Leukemogenesis
    BENJAMIN BRAUN; Fiscal Year: 2007
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