L Brass

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi Protease-activated G protein-coupled receptors on human platelets and endothelial cells
    L F Brass
    Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Thromb Haemost 78:234-41. 1997
  2. pmc Harnessing the platelet signaling network to produce an optimal hemostatic response
    Lawrence F Brass
    Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
    Hematol Oncol Clin North Am 27:381-409. 2013
  3. pmc Minding the gaps to promote thrombus growth and stability
    Lawrence F Brass
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 115:3385-92. 2005
  4. doi Understanding and evaluating platelet function
    Lawrence Brass
    Hematology Oncology Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19004, USA
    Hematology Am Soc Hematol Educ Program 2010:387-96. 2010
  5. doi Preventing and responding to complaints of sexual harassment in an academic health center: a 10-year review from the Medical University of South Carolina
    Connie L Best
    Office of Gender Equity, Medical University of South Carolina, Charleston, South Carolina, USA
    Acad Med 85:721-7. 2010
  6. doi Are MD-PhD programs meeting their goals? An analysis of career choices made by graduates of 24 MD-PhD programs
    Lawrence F Brass
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Acad Med 85:692-701. 2010
  7. ncbi ATVB in focus: Platelet signal transduction and interactions with vascular cells
    Lawrence F Brass
    University of Pennsylvania, Room 913, BRB II, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Arterioscler Thromb Vasc Biol 23:378. 2003
  8. ncbi Thrombin and platelet activation
    Lawrence F Brass
    Departments of Medicine and Pharmacology, and the Center for Experimental Therapeutics, University of Pennsylvania, PA 19104, USA
    Chest 124:18S-25S. 2003
  9. doi Novel therapeutic targets at the platelet vascular interface
    Lawrence F Brass
    University of Pennsylvania, Department of Medicine, Division of Hematology Oncology, Philadelphia, PA 19104, USA
    Arterioscler Thromb Vasc Biol 28:s43-50. 2008
  10. ncbi Boundary events: contact-dependent and contact-facilitated signaling between platelets
    Lawrence F Brass
    Center for Experimental Therapeutics at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Semin Thromb Hemost 30:399-410. 2004

Research Grants

  1. CHARACTERIZATION OF A NOVEL G PROTEIN IN PLATELETS
    Lawrence Brass; Fiscal Year: 2005
  2. FASEB Conf. Proteases in Hemostasis and Vascular Biology
    Lawrence Brass; Fiscal Year: 2005
  3. MEDICAL SCIENTIST TRAINING PROGRAM
    Lawrence Brass; Fiscal Year: 2007
  4. HEMATOLOGY CLINICAL RESEARCH TRAINING PROGRAM
    Lawrence Brass; Fiscal Year: 2007
  5. Blood Systems Biology
    Lawrence Brass; Fiscal Year: 2007
  6. Proteomic studies of normal and abnormal platelet function
    Lawrence Brass; Fiscal Year: 2007
  7. CHARACTERIZATION OF A NOVEL G PROTEIN IN HUMAN PLATELETS
    Lawrence Brass; Fiscal Year: 1993
  8. NOVEL G PROTEIN IN HUMAN PLATELETS
    Lawrence Brass; Fiscal Year: 2000
  9. Regulation of the early events of platelet activation
    Lawrence F Brass; Fiscal Year: 2010

Collaborators

Detail Information

Publications53

  1. ncbi Protease-activated G protein-coupled receptors on human platelets and endothelial cells
    L F Brass
    Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Thromb Haemost 78:234-41. 1997
    ....
  2. pmc Harnessing the platelet signaling network to produce an optimal hemostatic response
    Lawrence F Brass
    Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
    Hematol Oncol Clin North Am 27:381-409. 2013
    ....
  3. pmc Minding the gaps to promote thrombus growth and stability
    Lawrence F Brass
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 115:3385-92. 2005
    ....
  4. doi Understanding and evaluating platelet function
    Lawrence Brass
    Hematology Oncology Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19004, USA
    Hematology Am Soc Hematol Educ Program 2010:387-96. 2010
    ..The second theme is a consideration of the strengths and weaknesses of the tools we have as hematologists to assess platelet function in the clinical setting, identify mechanisms, and evaluate the impact of antiplatelet agents...
  5. doi Preventing and responding to complaints of sexual harassment in an academic health center: a 10-year review from the Medical University of South Carolina
    Connie L Best
    Office of Gender Equity, Medical University of South Carolina, Charleston, South Carolina, USA
    Acad Med 85:721-7. 2010
    ..They describe their complaint process, components of their prevention training, and the outcomes of 115 complaints. Key elements of their policies are highlighted. The authors offer an approach that could serve as a model for other AHCs...
  6. doi Are MD-PhD programs meeting their goals? An analysis of career choices made by graduates of 24 MD-PhD programs
    Lawrence F Brass
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Acad Med 85:692-701. 2010
    ..The goal of this study was to characterize the career path taken by MD-PhD program alumni during the past 40 years and identify trends that affect their success...
  7. ncbi ATVB in focus: Platelet signal transduction and interactions with vascular cells
    Lawrence F Brass
    University of Pennsylvania, Room 913, BRB II, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Arterioscler Thromb Vasc Biol 23:378. 2003
  8. ncbi Thrombin and platelet activation
    Lawrence F Brass
    Departments of Medicine and Pharmacology, and the Center for Experimental Therapeutics, University of Pennsylvania, PA 19104, USA
    Chest 124:18S-25S. 2003
    ..How this is accomplished is the subject of this review...
  9. doi Novel therapeutic targets at the platelet vascular interface
    Lawrence F Brass
    University of Pennsylvania, Department of Medicine, Division of Hematology Oncology, Philadelphia, PA 19104, USA
    Arterioscler Thromb Vasc Biol 28:s43-50. 2008
    ..An understanding of how this balance is achieved helps to illuminate the events of platelet activation and, at the same time, provides potential targets for new classes of antiplatelet agents...
  10. ncbi Boundary events: contact-dependent and contact-facilitated signaling between platelets
    Lawrence F Brass
    Center for Experimental Therapeutics at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Semin Thromb Hemost 30:399-410. 2004
    ..The picture that emerges is one in which events after aggregation are nearly as complex as those that precede aggregation and the initiation of platelet plug formation...
  11. pmc Did dinosaurs have megakaryocytes? New ideas about platelets and their progenitors
    Lawrence F Brass
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 115:3329-31. 2005
    ..The underlying theme that connects the articles is the intense investigation of a complex system that keeps humans from bleeding to death, but at the same time exposes us to increased risk of thrombosis and vascular disease...
  12. ncbi Signaling through G proteins in platelets: to the integrins and beyond
    L F Brass
    Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Thromb Haemost 78:581-9. 1997
    ....
  13. ncbi Contact-dependent signaling during the late events of platelet activation
    N Prevost
    Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    J Thromb Haemost 1:1613-27. 2003
    ....
  14. ncbi Structure and function of the human platelet thrombin receptor. Studies using monoclonal antibodies directed against a defined domain within the receptor N terminus
    L F Brass
    Department of Medicine, University of Pennsylvania, Philadelphia 19104
    J Biol Chem 267:13795-8. 1992
    ....
  15. ncbi Changes in the structure and function of the human thrombin receptor during receptor activation, internalization, and recycling
    L F Brass
    Department of Medicine, University of Pennsylvania, Philadelphia 19104
    J Biol Chem 269:2943-52. 1994
    ....
  16. ncbi Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1
    P J O'Brien
    Departments of Medicine and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 275:13502-9. 2000
    ..Such transactivation may limit the effectiveness of PAR1 antagonists, which compete with the tethered ligand domain rather than preventing PAR1 cleavage...
  17. ncbi Reaction of mast cell proteases tryptase and chymase with protease activated receptors (PARs) on keratinocytes and fibroblasts
    N M Schechter
    Department of Dermatology, University of Pennsylvania, Philadelphia 19104 6142, USA
    J Cell Physiol 176:365-73. 1998
    ..These results suggest that the proteases tryptase and chymase secreted from mast cells in skin may affect the behavior of surrounding cells by the hydrolysis of PARs expressed by these cells...
  18. ncbi Pleckstrin inhibits phosphoinositide hydrolysis initiated by G-protein-coupled and growth factor receptors. A role for pleckstrin's PH domains
    C S Abrams
    Department of Medicine, University of Pennsylvania, Philadelphia, USA
    J Biol Chem 270:14485-92. 1995
    ..2+1..
  19. ncbi Interactions of mast cell tryptase with thrombin receptors and PAR-2
    M Molino
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 272:4043-9. 1997
    ..Tryptase is the first protease other than trypsin that has been shown to activate human PAR-2. Its presence within mast cell granules places it in tissues where PAR-2 is expressed but trypsin is unlikely to reach...
  20. ncbi A site of interaction between pleckstrin's PH domains and G beta gamma
    C S Abrams
    Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Biochim Biophys Acta 1314:233-8. 1996
    ..We propose that pleckstrin may interact with G beta gamma, and that one potential site for this interaction involves the first 30 residues of pleckstrin's C-terminal PH domain...
  21. pmc Pleckstrin associates with plasma membranes and induces the formation of membrane projections: requirements for phosphorylation and the NH2-terminal PH domain
    A D Ma
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Cell Biol 136:1071-9. 1997
    ....
  22. ncbi Phosphorylation of Gz in human platelets. Selectivity and site of modification
    K M Lounsbury
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104
    J Biol Chem 266:22051-6. 1991
    ..Results obtained with 6354 also suggest that phorbol ester-promoted phosphorylation of Gz alpha approaches 1 mol of phosphate per mol of subunit in permeabilized platelets...
  23. ncbi Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation
    M Molino
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 272:6011-7. 1997
    ..This difference underlies the ability of endothelial cells to recover responsiveness to thrombin rapidly while platelets do not, despite the presence on both of the same receptor for thrombin...
  24. ncbi Protease activated receptors: theme and variations
    M Molino
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Oncogene 20:1570-81. 2001
    ....
  25. ncbi Stromal cell-derived factor-1 and macrophage-derived chemokine: 2 chemokines that activate platelets
    M A Kowalska
    Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Blood 96:50-7. 2000
    ..In summary, SDF-1 and MDC are platelet agonists that activate distinct intracellular pathways. Their importance in the development of thrombosis at sites of inflammation needs to be further evaluated...
  26. ncbi Protein kinase C regulates pleckstrin by phosphorylation of sites adjacent to the N-terminal pleckstrin homology domain
    C S Abrams
    Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    J Biol Chem 270:23317-21. 1995
    ..This may have an allosteric effect on the N-terminal PH domain, regulating its interaction with other molecules necessary for the inhibition of phosphoinositide hydrolysis...
  27. pmc Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs
    J Yang
    Departments of Medicine, Pediatrics, Psychiatry, and Pharmacology, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 97:9984-9. 2000
    ..Therefore, these results provide insights into receptor selectivity among G proteins and a model for understanding platelet function and the effects of psychoactive drugs...
  28. ncbi Identification of Gz alpha as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes
    A W Gagnon
    Department of Medicine, University of Pennsylvania, Philadelphia 19104
    Blood 78:1247-53. 1991
    ....
  29. ncbi Evaluation of the substrate specificity of human mast cell tryptase beta I and demonstration of its importance in bacterial infections of the lung
    C Huang
    Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:26276-84. 2001
    ..Because neutrophils are required to combat bacterial infections, human tryptase beta I plays a critical role in the antibacterial host defenses of the lung by recruiting neutrophils in a manner that does not alter airway reactivity...
  30. ncbi The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins
    X Fan
    Departments of Pharmacology, Medicine and Pathology, and Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 275:32129-34. 2000
    ..We show here a novel functional regulation of a co-activator directly by G protein subunits...
  31. ncbi Inhibition of thrombin-induced platelet activation by leupeptin. Implications for the participation of calpain in the initiation of platelet activation
    L F Brass
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104
    J Biol Chem 263:5210-6. 1988
    ..Therefore, our observations suggest that the inhibition of platelet activation by leupeptin is due to a direct interaction with thrombin and need not reflect a role for calpain in the initiation of platelet activation...
  32. ncbi Interactions in platelets between G proteins and the agonists that stimulate phospholipase C and inhibit adenylyl cyclase
    L F Brass
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 4283
    J Biol Chem 263:5348-55. 1988
    ....
  33. ncbi Analysis of Gz alpha by site-directed mutagenesis. Sites and specificity of protein kinase C-dependent phosphorylation
    K M Lounsbury
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia
    J Biol Chem 268:3494-8. 1993
    ..Moreover, Gi alpha, Gz alpha, and Gq alpha were not phosphorylated in response to analogues of cAMP or cGMP. Thus, only Gz alpha is phosphorylated in platelets and only in response to activation of protein kinase C...
  34. doi Microfluidic focal thrombosis model for measuring murine platelet deposition and stability: PAR4 signaling enhances shear-resistance of platelet aggregates
    K B Neeves
    Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Thromb Haemost 6:2193-201. 2008
    ..Flow chambers allow the ex vivo study of platelet response to defined surfaces at controlled wall shear stresses. However, most assays require 1-10 mL of blood and are poorly suited for murine whole blood experiments...
  35. doi Endothelial cell specific adhesion molecule (ESAM) localizes to platelet-platelet contacts and regulates thrombus formation in vivo
    T J Stalker
    Department of Medicine, The Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Thromb Haemost 7:1886-96. 2009
    ..In resting platelets, endothelial cell specific adhesion molecule (ESAM) is located in alpha granules, increasing its cell surface expression following platelet activation. However, the function of ESAM on platelets is unknown...
  36. ncbi Inhibition of T cell antigen receptor-dependent phosphorylation of CD4 in human immunodeficiency virus type 1 infected cells
    G N Gaulton
    Department of Pathology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104
    J Biol Chem 267:4102-9. 1992
    ..These studies indicate that infection with HIV-1 inhibits the activation of protein kinase associated with the T cell receptor-CD3 complex by a mechanism which is independent of viral env protein components...
  37. pmc Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation
    Yanfeng Wang
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:14064-9. 2008
    ..These results also demonstrate that after stimulation of a G protein-coupled receptor, IP(3) is completely derived from a rapidly synthesized discrete pool of PIP(2) synthesized by PIP5KIalpha and PIP5KIbeta...
  38. pmc Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury
    Li Zhu
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 104:1621-6. 2007
    ..As thrombus formation continues, sema4D is shed from the platelet surface and becomes available to interact with receptors on endothelial cells and monocytes, as well as continuing to interact with platelets...
  39. ncbi Contact-dependent signaling events that promote thrombus formation
    Lawrence F Brass
    Department of Medicine, University of Pennsylvania, Room 915 BRB II, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Blood Cells Mol Dis 36:157-61. 2006
    ..Collectively, these molecules promote the continued growth and stability of the hemostatic plug...
  40. pmc Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo
    Natalie A Bezman
    Leonard and Madlyn Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Exp Med 205:1775-88. 2008
    ..Using genetic complementation, we further demonstrate that all three phosphorylatable tyrosines are required within the same SLP76 molecule to support platelet activation by GPVI...
  41. pmc Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred
    Nicolas Prevost
    Department of Medicine and Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 99:9219-24. 2002
    ....
  42. pmc Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2
    Donna Woulfe
    Department of Medicine, University of Pennsylvania, Philadelphia, USA
    J Clin Invest 113:441-50. 2004
    ..The contribution of Akt1 is less evident except in the setting in which Akt2 is absent...
  43. ncbi Signaling by ephrinB1 and Eph kinases in platelets promotes Rap1 activation, platelet adhesion, and aggregation via effector pathways that do not require phosphorylation of ephrinB1
    Nicolas Prevost
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 103:1348-55. 2004
    ....
  44. pmc Eph kinases and ephrins support thrombus growth and stability by regulating integrin outside-in signaling in platelets
    Nicolas Prevost
    Department of Medicine, and Center for Experimental Therapeutics, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 102:9820-5. 2005
    ....
  45. ncbi Activation of Rap1B by G(i) family members in platelets
    Donna Woulfe
    Department of Medicine, Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:23382-90. 2002
    ..In summary, activation of Rap1 can be stimulated by G(alpha)(i)- and PI3K-dependent mechanisms in platelets and by G(q)- and Ca(2+)-dependent mechanisms, both of which may play a role in promoting platelet activation...
  46. pmc Thrombin receptors and protease-activated receptor-2 in human placentation: receptor activation mediates extravillous trophoblast invasion in vitro
    Peter J O'Brien
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Pathol 163:1245-54. 2003
    ..Together these results support a role for PAR1, and potentially PAR2 and PAR3 in the invasive phase of human placentation...
  47. ncbi Signaling through Gi family members in platelets. Redundancy and specificity in the regulation of adenylyl cyclase and other effectors
    Jing Yang
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:46035-42. 2002
    ..Finally, the failure of ADP and epinephrine to inhibit basal, as opposed to PGI(2)-stimulated, cAMP formation highlights the need during platelet activation for G(i) signaling pathways that involve effectors other than adenylyl cyclase...
  48. ncbi Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis
    Xiaoli Shi
    Cancer Biology Division, La Jolla Institute for Molecular Medicine, 4570 Executive Drive, San Diego, CA 92121, USA
    Mol Cancer Res 2:395-402. 2004
    ..Together, these data confirm a role for PAR1 in migration and metastasis and demonstrate an unexpected role for PAR2 in thrombin-dependent tumor cell migration and in metastasis...
  49. ncbi Signaling receptors on platelets and megakaryocytes
    Donna Woulfe
    Hematology Oncology Division, University of Pennsylvania, Philadelphia, USA
    Methods Mol Biol 273:3-32. 2004
  50. pmc Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin
    Reto A Schuepbach
    Department of Immunology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Blood 111:2667-73. 2008
    ..The data suggest that different trafficking of activated PAR1 might explain how PAR1 signaling by APC can be relevant when thrombin is present...
  51. pmc Hematopoietic lineage cell specific protein 1 (HS1) is a functionally important signaling molecule in platelet activation
    Bryan N Kahner
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Blood 110:2449-56. 2007
    ..These results demonstrate that phosphorylation of the HS1 protein occurs downstream of GPVI stimulation and that HS1 plays a significant functional role in platelet activation downstream of GPVI and PARs...
  52. ncbi Spontaneous fetal loss caused by placental thrombosis in estrogen sulfotransferase-deficient mice
    Ming Han Tong
    Institute for Translational Medicine and Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nat Med 11:153-9. 2005
    ..These findings may have implications for understanding and treating human pregnancy failure and intrauterine growth retardation...
  53. ncbi Extracellular signal-regulated kinases and g protein-coupled receptors in megakaryocytic human erythroleukemia cells: selective activation, differential regulation, and dissociation from mitogenesis
    Hung Wu
    Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan, Taiwan
    J Pharmacol Exp Ther 300:339-45. 2002
    ....

Research Grants24

  1. CHARACTERIZATION OF A NOVEL G PROTEIN IN PLATELETS
    Lawrence Brass; Fiscal Year: 2005
    ..All four of these aims will combine biochemical and pharmacologic approaches with studies on genetically engineered mice lacking selected receptors and G proteins, allowing us to better understand platelet activation in vivo. ..
  2. FASEB Conf. Proteases in Hemostasis and Vascular Biology
    Lawrence Brass; Fiscal Year: 2005
    ..Tissue factor, platelets and coagulation; 8. Regulators of hemostasis; 9. Protease receptors. The keynote lecture will be on gene therapy for disorders of hemostasis delivered by Dr. Katherine High. ..
  3. MEDICAL SCIENTIST TRAINING PROGRAM
    Lawrence Brass; Fiscal Year: 2007
    ....
  4. HEMATOLOGY CLINICAL RESEARCH TRAINING PROGRAM
    Lawrence Brass; Fiscal Year: 2007
    ..abstract_text> ..
  5. Blood Systems Biology
    Lawrence Brass; Fiscal Year: 2007
    ....
  6. Proteomic studies of normal and abnormal platelet function
    Lawrence Brass; Fiscal Year: 2007
    ..This includes novel methods that permit quantitation of individual molecules so that changes in levels of expression can be measured. ..
  7. CHARACTERIZATION OF A NOVEL G PROTEIN IN HUMAN PLATELETS
    Lawrence Brass; Fiscal Year: 1993
    ....
  8. NOVEL G PROTEIN IN HUMAN PLATELETS
    Lawrence Brass; Fiscal Year: 2000
    ..It is suggested that these aims will help to define the role of Gz in platelet activation and understand factors responsible for megakaryocyte-selective gene regulation. ..
  9. Regulation of the early events of platelet activation
    Lawrence F Brass; Fiscal Year: 2010
    ..A better understanding of this critical, but under-explored aspect of platelet biology is key to understanding and preventing what goes wrong when people have heart and strokes. ..