Allan Brasier

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. pmc Expression of an IKKgamma splice variant determines IRF3 and canonical NF-kappaB pathway utilization in ssRNA virus infection
    Ping Liu
    Department of Medicine, University of Texas Medical Branch UTMB, Galveston, Texas, United States of America
    PLoS ONE 4:e8079. 2009
  2. pmc A probabilistic approach to learn chromatin architecture and accurate inference of the NF-κB/RelA regulatory network using ChIP-Seq
    Jun Yang
    Department of Internal Medicine, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1060, USA, Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1060, USA, Institute for Translational Sciences, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1060, USA, Institute of Informatics, University of Warsaw, Banacha 2, 02 097, Warsaw, Poland and Sealy Center for Molecular Medicine, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1060, USA
    Nucleic Acids Res 41:7240-59. 2013
  3. pmc Systems approaches to modeling chronic mucosal inflammation
    Mridul Kalita
    Sealy Center for Molecular Medicine, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA
    Biomed Res Int 2013:505864. 2013
  4. pmc Identification of innate immune response endotypes in asthma: implications for personalized medicine
    Allan R Brasier
    Institute for Translational Sciences, Department of Internal Medicine, Sealy Center for Molecular Medicine, 8 128 Medical Research Building, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555 1060, USA
    Curr Allergy Asthma Rep 13:462-8. 2013
  5. ncbi request reprint Analysis and predictive modeling of asthma phenotypes
    Allan R Brasier
    University of Texas Medical Branch, 8 128 Medical Research Building, 301 University Blvd, Galveston, TX, USA
    Adv Exp Med Biol 795:273-88. 2014
  6. ncbi request reprint Measurement of the innate immune response in the airway
    Allan R Brasier
    University of Texas Medical Branch, 8 128 Medical Research Building, 301 University Blvd, Galveston, TX, USA
    Adv Exp Med Biol 795:233-54. 2014
  7. pmc The dependence of expression of NF-κB-dependent genes: statistics and evolutionary conservation of control sequences in the promoter and in the 3' UTR
    Marta Iwanaszko
    Institute of Automatic Control, Silesian University of Technology, Akademicka 16, Gliwice, Poland
    BMC Genomics 13:182. 2012
  8. pmc Discovery proteomics and nonparametric modeling pipeline in the development of a candidate biomarker panel for dengue hemorrhagic fever
    Allan R Brasier
    Department of Internal Medicine, University of Texas Medical Branch UTMB, Galveston, Texas, USA
    Clin Transl Sci 5:8-20. 2012
  9. pmc A three-component biomarker panel for prediction of dengue hemorrhagic fever
    Allan R Brasier
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA
    Am J Trop Med Hyg 86:341-8. 2012
  10. pmc A TNF-induced gene expression program under oscillatory NF-kappaB control
    Bing Tian
    Department of Medicine, The University of Texas Medical Branch, Galveston, Texas 77555 1060, USA
    BMC Genomics 6:137. 2005

Detail Information

Publications73

  1. pmc Expression of an IKKgamma splice variant determines IRF3 and canonical NF-kappaB pathway utilization in ssRNA virus infection
    Ping Liu
    Department of Medicine, University of Texas Medical Branch UTMB, Galveston, Texas, United States of America
    PLoS ONE 4:e8079. 2009
    ..MAVS to activate divergent rate-limiting kinases downstream controlling the NF-kappaB and IRF3 pathways. Previously we discovered a ubiquitous IKKgamma splice-variant, IKKgammaDelta, that exhibits distinct signaling properties...
  2. pmc A probabilistic approach to learn chromatin architecture and accurate inference of the NF-κB/RelA regulatory network using ChIP-Seq
    Jun Yang
    Department of Internal Medicine, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1060, USA, Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1060, USA, Institute for Translational Sciences, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1060, USA, Institute of Informatics, University of Warsaw, Banacha 2, 02 097, Warsaw, Poland and Sealy Center for Molecular Medicine, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1060, USA
    Nucleic Acids Res 41:7240-59. 2013
    ..Our analysis provides new insights into how co-occurring TFBSs and local chromatin context orchestrate activation of NF-κB/RelA sub-pathways differing in biological function and temporal expression patterns. ..
  3. pmc Systems approaches to modeling chronic mucosal inflammation
    Mridul Kalita
    Sealy Center for Molecular Medicine, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA
    Biomed Res Int 2013:505864. 2013
    ..Further applications of systems approaches will provide understanding of this complex phenotype through deterministic modeling and multidimensional (genomic and proteomic) profiling. ..
  4. pmc Identification of innate immune response endotypes in asthma: implications for personalized medicine
    Allan R Brasier
    Institute for Translational Sciences, Department of Internal Medicine, Sealy Center for Molecular Medicine, 8 128 Medical Research Building, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555 1060, USA
    Curr Allergy Asthma Rep 13:462-8. 2013
    ..Potential applications to clinical research are proposed. Together, these developments open realistic prospects for how identification of the IIR endotype may inform asthma therapy in the future. ..
  5. ncbi request reprint Analysis and predictive modeling of asthma phenotypes
    Allan R Brasier
    University of Texas Medical Branch, 8 128 Medical Research Building, 301 University Blvd, Galveston, TX, USA
    Adv Exp Med Biol 795:273-88. 2014
    ..The application of validated predictive models for outcome prediction will significantly impact the clinical management of asthma. ..
  6. ncbi request reprint Measurement of the innate immune response in the airway
    Allan R Brasier
    University of Texas Medical Branch, 8 128 Medical Research Building, 301 University Blvd, Galveston, TX, USA
    Adv Exp Med Biol 795:233-54. 2014
    ..Application of these methods for quantitation of the IIR will further our understanding of the role of the IIR in asthma and its contribution to disease heterogeneity. ..
  7. pmc The dependence of expression of NF-κB-dependent genes: statistics and evolutionary conservation of control sequences in the promoter and in the 3' UTR
    Marta Iwanaszko
    Institute of Automatic Control, Silesian University of Technology, Akademicka 16, Gliwice, Poland
    BMC Genomics 13:182. 2012
    ..It is not obvious what mechanism is responsible for segregation of the genes' timing of transcriptional response...
  8. pmc Discovery proteomics and nonparametric modeling pipeline in the development of a candidate biomarker panel for dengue hemorrhagic fever
    Allan R Brasier
    Department of Internal Medicine, University of Texas Medical Branch UTMB, Galveston, Texas, USA
    Clin Transl Sci 5:8-20. 2012
    ..Although this DHF risk model will need validation in a larger cohort, we conclude that approaches to develop predictive biomarker models for disease outcome will need to incorporate nonparametric modeling approaches...
  9. pmc A three-component biomarker panel for prediction of dengue hemorrhagic fever
    Allan R Brasier
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA
    Am J Trop Med Hyg 86:341-8. 2012
    ....
  10. pmc A TNF-induced gene expression program under oscillatory NF-kappaB control
    Bing Tian
    Department of Medicine, The University of Texas Medical Branch, Galveston, Texas 77555 1060, USA
    BMC Genomics 6:137. 2005
    ..Characterization of temporal expression patterns for the NF-kappaB network and determination of those genes under monophasic- or oscillatory control has not been experimentally addressed...
  11. pmc Single TNFalpha trimers mediating NF-kappaB activation: stochastic robustness of NF-kappaB signaling
    Tomasz Lipniacki
    Institute of Fundamental Technological Research, Swietokrzyska 21, 00 049 Warsaw, Poland
    BMC Bioinformatics 8:376. 2007
    ..The NF-kappaB regulatory network controls innate immune response by transducing variety of pathogen-derived and cytokine stimuli into well defined single-cell gene regulatory events...
  12. pmc The nuclear factor-kappaB-interleukin-6 signalling pathway mediating vascular inflammation
    Allan R Brasier
    Division of Endocrinology, Department of Internal Medicine, Sealy Center for Molecular Medicine and Institute for Translational Sciences, University of Texas Medical Branch, MRB 8 122, 301 University Blvd, Galveston, TX 77555 1060, USA
    Cardiovasc Res 86:211-8. 2010
    ..These new discoveries further our understanding for the important role of the NF-kappaB-IL-6 signalling pathway in the process of vascular inflammation...
  13. pmc Nuclear heat shock response and novel nuclear domain 10 reorganization in respiratory syncytial virus-infected a549 cells identified by high-resolution two-dimensional gel electrophoresis
    Allan R Brasier
    Division of Endocrinology, MRB 8 138, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1060, USA
    J Virol 78:11461-76. 2004
    ..Thus, a high-resolution proteomics approach, combined with immunofluorescence localization and coupled with genomic response data, yielded unexpected novel insights into compensatory nuclear responses to RSV infection...
  14. ncbi request reprint A promoter recruitment mechanism for tumor necrosis factor-alpha-induced interleukin-8 transcription in type II pulmonary epithelial cells. Dependence on nuclear abundance of Rel A, NF-kappaB1, and c-Rel transcription factors
    A R Brasier
    Department of Medicine and Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston, Texas 77555 1060, USA
    J Biol Chem 273:3551-61. 1998
    ....
  15. pmc Expanding role of cyclin dependent kinases in cytokine inducible gene expression
    Allan R Brasier
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 1060, USA
    Cell Cycle 7:2661-6. 2008
    ..The potential of inhibiting P-TEFb as an anti-inflammatory therapy in innate immunity and systemic inflammation will be discussed...
  16. pmc Molecular phenotyping of severe asthma using pattern recognition of bronchoalveolar lavage-derived cytokines
    Allan R Brasier
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555 1060, USA
    J Allergy Clin Immunol 121:30-37.e6. 2008
    ..Asthma is a heterogeneous clinical disorder. Methods for objective identification of disease subtypes will focus on clinical interventions and help identify causative pathways. Few studies have explored phenotypes at a molecular level...
  17. pmc Predicting intermediate phenotypes in asthma using bronchoalveolar lavage-derived cytokines
    Allan R Brasier
    Sealy Center for Molecular Medicine, University of Texas Medical Branch, Galveston, USA
    Clin Transl Sci 3:147-57. 2010
    ..These robust classification methods will aid future translational studies in asthma targeted at specific intermediate phenotypes...
  18. ncbi request reprint The NF-kappaB regulatory network
    Allan R Brasier
    Department of Internal Medicine and Sealy Center for Molecular Sciences, University of Texas Medical Branch, Galveston, TX 77555 1060, USA
    Cardiovasc Toxicol 6:111-30. 2006
    ..In this way, a single family of transcription factors can respond to diverse stimuli to regulate cardiovascular homeostasis...
  19. ncbi request reprint NF-kappa B-inducible BCL-3 expression is an autoregulatory loop controlling nuclear p50/NF-kappa B1 residence
    A R Brasier
    Department of Internal Medicine, The University of Texas Medical Branch, Galveston, Texas 77555 1060, USA
    J Biol Chem 276:32080-93. 2001
    ....
  20. pmc RelA Ser276 phosphorylation-coupled Lys310 acetylation controls transcriptional elongation of inflammatory cytokines in respiratory syncytial virus infection
    Allan R Brasier
    MRB 8 126, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1060, USA
    J Virol 85:11752-69. 2011
    ..We conclude that RelA Ser276 phosphorylation mediates RelA acetylation, Brd4/CDK9 association, and activation of downstream inflammatory genes by transcriptional elongation in RSV infection...
  21. ncbi request reprint Retriever and CompareTable, two informatics tools for data analysis of high-density oligonucleotide arrays
    Allan R Brasier
    Division of Endocrinology, The University of Texas Medical Branch, Galveston 77555 1060, USA
    Biotechniques 32:100-2, 104, 106, 108-9. 2002
    ..The output files generated by these two programs can be opened and manipulated by any software application recognizing tab-delimited text files (e.g., Microsoft NotePad or Excel)...
  22. ncbi request reprint Vascular inflammation and the renin-angiotensin system
    Allan R Brasier
    Department of Medicine, The University of Texas Medical Branch, Galveston, 77555 1060, USA
    Arterioscler Thromb Vasc Biol 22:1257-66. 2002
    ..Moreover, antagonizing the vascular nuclear factor-kappaB and/or hepatic JAK/STAT pathways may modulate the atherosclerotic process...
  23. ncbi request reprint Identification of direct genomic targets downstream of the nuclear factor-kappaB transcription factor mediating tumor necrosis factor signaling
    Bing Tian
    Department of Medicine, The University of Texas Medical Branch, Galveston, Texas 77555 1060, USA
    J Biol Chem 280:17435-48. 2005
    ..Together, these studies systematically identify the direct NF-kappaB-dependent gene network downstream of TNF signaling, extending our knowledge of biological processes regulated by this pathway...
  24. ncbi request reprint The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression
    Tieying Hou
    Department of Biochemistry, and Sealy Center for Molecular Medicine, University of Texas Medical Branch, Galveston, Texas 77555 1060, USA
    J Biol Chem 282:37091-102. 2007
    ..Therefore, disruption of IL-6 signaling by CDK9 inhibitors could be a potential therapeutic strategy for inflammatory disease...
  25. pmc The STAT3 NH2-terminal domain stabilizes enhanceosome assembly by interacting with the p300 bromodomain
    Tieying Hou
    Department of Biochemistry, University of Texas Medical Branch, Galveston, Texas 77555 1060, USA
    J Biol Chem 283:30725-34. 2008
    ..Taken together, our data suggest that the STAT3 NH(2)-terminal domain plays an important role in the interleukin-6 signaling pathway by interacting with the p300 bromodomain, thereby stabilizing enhanceosome assembly...
  26. pmc An alternative splice product of IkappaB kinase (IKKgamma), IKKgamma-delta, differentially mediates cytokine and human T-cell leukemia virus type 1 tax-induced NF-kappaB activation
    Tao Hai
    Department of Internal Medicine, The University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555 1060, USA
    J Virol 80:4227-41. 2006
    ..Differing levels of IKKgamma-delta expression, therefore, may affect signal transduction cascades coupling to IKK...
  27. ncbi request reprint STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen
    Sutapa Ray
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 8709, USA
    Gastroenterology 129:1616-32. 2005
    ..The mechanisms of how STAT3 activates target genes are unknown. Here we analyzed the biochemistry of STAT3 activation by interleukin (IL)-6 in hepatocellular carcinoma HepG2 and Balb/C mice...
  28. ncbi request reprint MAPK activation is involved in posttranscriptional regulation of RSV-induced RANTES gene expression
    Konrad Pazdrak
    Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Am J Physiol Lung Cell Mol Physiol 283:L364-72. 2002
    ..These results indicate that the MAPK signaling cascade regulates RANTES production in alveolar epithelial cells through a posttranscriptional mechanism...
  29. ncbi request reprint Two-step cross-linking method for identification of NF-kappaB gene network by chromatin immunoprecipitation
    David E Nowak
    The University of Texas Medical Branch, Galveston 77555 1060, USA
    Biotechniques 39:715-25. 2005
    ..Our method represents a significant improvement in the efficiency of ChIP analysis in the study of endogenous targets for rare transcription factors...
  30. ncbi request reprint Ikkepsilon regulates viral-induced interferon regulatory factor-3 activation via a redox-sensitive pathway
    Hemalatha Indukuri
    Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555 0366, USA
    Virology 353:155-65. 2006
    ....
  31. pmc RelA Ser276 phosphorylation is required for activation of a subset of NF-kappaB-dependent genes by recruiting cyclin-dependent kinase 9/cyclin T1 complexes
    David E Nowak
    Department of Medicine, The University of Texas Medical Branch, Galveston, TX 77555 1060, USA
    Mol Cell Biol 28:3623-38. 2008
    ....
  32. pmc Respiratory syncytial virus infection induces a reactive oxygen species-MSK1-phospho-Ser-276 RelA pathway required for cytokine expression
    Mohammad Jamaluddin
    Institute for Translational Sciences, University of Texas Medical Branch UTMB, Galveston, TX 77555 1060, USA
    J Virol 83:10605-15. 2009
    ....
  33. pmc Identification of NF-kappaB-dependent gene networks in respiratory syncytial virus-infected cells
    Bing Tian
    Department of Medicine, Sealy Center for Structural Biology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1060, USA
    J Virol 76:6800-14. 2002
    ..These data suggest that NF-kappaB action induces global cellular responses after viral infection...
  34. pmc An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice
    Brian C Tieu
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA
    J Clin Invest 119:3637-51. 2009
    ....
  35. ncbi request reprint Role of interferon-stimulated responsive element-like element in interleukin-8 promoter in Helicobacter pylori infection
    Yoshio Yamaoka
    Department of Medicine, Veterans Affairs Medicial Center and Baylor College of Medicine, Houston, TX 77030, USA
    Gastroenterology 126:1030-43. 2004
    ..Gastric mucosal interleukin (IL)-8 levels are related to the presence of both the cag pathogenicity island (PAI) and OipA. We investigated the regions of the IL-8 promoter and the upstream signaling involved in IL-8 gene transcription...
  36. pmc Strategies for molecular classification of asthma using bipartite network analysis of cytokine expression
    Regina R Pillai
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Texas Medical Branch, 5 140 John Sealy Annex, 301 University Blvd, Galveston, TX 77555 0561, USA
    Curr Allergy Asthma Rep 12:388-95. 2012
    ..Innovative techniques such as bipartite network analysis and visual analytics introduce a new dimension of data analysis to identify underlying mechanistic pathways...
  37. pmc IKKε modulates RSV-induced NF-κB-dependent gene transcription
    Xiaoyong Bao
    Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, USA
    Virology 408:224-31. 2010
    ..This study identifies a novel mechanism by which IKKε regulates viral-induced cellular signaling...
  38. pmc Respiratory syncytial virus influences NF-kappaB-dependent gene expression through a novel pathway involving MAP3K14/NIK expression and nuclear complex formation with NF-kappaB2
    Sanjeev Choudhary
    Department of Medicine, The University of Texas Medical Branch, Galveston, TX 77555 1060, USA
    J Virol 79:8948-59. 2005
    ..This appears to be through a novel mechanism involving induction of NIK kinase activity, expression, and nuclear translocation of a ternary complex with IKKalpha and processed NF-kappaB2...
  39. ncbi request reprint RhoA mediates angiotensin II-induced phospho-Ser536 nuclear factor kappaB/RelA subunit exchange on the interleukin-6 promoter in VSMCs
    Ruwen Cui
    Department of Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA
    Circ Res 99:723-30. 2006
    ..Together, these data indicate a novel mechanism for Ang II-induced NF-kappaB activation in VSMCs, mediated by RhoA-induced phospho-Ser536 RelA formation, IL-6 expression, and vascular inflammation...
  40. pmc Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter
    Mohammad Jamaluddin
    Division of Endocrinology, MRB 8 138, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1060, USA
    J Virol 79:15302-13. 2005
    ....
  41. pmc IkappaB kinase is a critical regulator of chemokine expression and lung inflammation in respiratory syncytial virus infection
    Helene A Haeberle
    Department of Pediatrics, Sealy Center for Vaccine Development, The University of Texas Medical Branch, Galveston, Texas 77555 0369, USA
    J Virol 78:2232-41. 2004
    ..These findings suggest that IKKbeta may be a potential target for the treatment of acute or chronic inflammatory diseases of the lung...
  42. ncbi request reprint Angiotensinogen gene expression is dependent on signal transducer and activator of transcription 3-mediated p300/cAMP response element binding protein-binding protein coactivator recruitment and histone acetyltransferase activity
    Sutapa Ray
    Department of Internal Medicine and Sealy Center for Molecular Sciences, The University of Texas Medical Branch, Galveston, Texas 77555 1060, USA
    Mol Endocrinol 16:824-36. 2002
    ....
  43. pmc Ribavirin treatment up-regulates antiviral gene expression via the interferon-stimulated response element in respiratory syncytial virus-infected epithelial cells
    Yuhong Zhang
    Department of Medicine, The University of Texas Medical Branch, Galveston, Texas 77555 1060, USA
    J Virol 77:5933-47. 2003
    ..We conclude that ribavirin potentiates virus-induced ISRE signaling to enhance the expression of antiviral ISGs, suggesting a mechanism for the efficacy of combined treatment with ribavirin and IFN in other chronic viral diseases...
  44. pmc Regulation of signal transducer and activator of transcription 3 enhanceosome formation by apurinic/apyrimidinic endonuclease 1 in hepatic acute phase response
    Sutapa Ray
    Department of Internal Medicine and the Sealy Center for Molecular Medicine, University of Texas Medical Branch, Galveston, Texas 77555 1060, USA
    Mol Endocrinol 24:391-401. 2010
    ..Taken together, our study indicates that IL-6 induces a novel STAT3-APE1 complex, whose interaction is required for stable chromatin association in the IL-6-induced hepatic acute phase response...
  45. pmc Respiratory syncytial virus induces RelA release from cytoplasmic 100-kDa NF-kappa B2 complexes via a novel retinoic acid-inducible gene-I{middle dot}NF- kappa B-inducing kinase signaling pathway
    Ping Liu
    Department of Medicine, University of Texas Medical Branch, Galveston, TX 77555 1060, USA
    J Biol Chem 283:23169-78. 2008
    ..IKKalpha complex downstream of RIG-I.MAVS. This pathway may be a potential target for RSV treatment...
  46. ncbi request reprint Liver gene expression associated with diet and lesion development in atherosclerosis-prone mice: induction of components of alternative complement pathway
    Adrian Recinos
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 1060, USA
    Physiol Genomics 19:131-42. 2004
    ..These findings suggest that induction of the alternative complement pathway may be an additional mechanism by which a high-fat/Western diet accelerates atherosclerosis...
  47. pmc Role of peroxiredoxin 1 and peroxiredoxin 4 in protection of respiratory syncytial virus-induced cysteinyl oxidation of nuclear cytoskeletal proteins
    Mohammad Jamaluddin
    Institute for Translational Sciences, MRB 8 126, RT 1060, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1060, USA
    J Virol 84:9533-45. 2010
    ..Our results suggest that Prdx-1 and Prdx-4 are essential for preventing RSV-induced oxidative damage in a subset of nuclear intermediate filament and actin binding proteins in epithelial cells...
  48. ncbi request reprint Interleukin-8 gene regulation in intestinal epithelial cells infected with rotavirus: role of viral-induced IkappaB kinase activation
    Antonella Casola
    Department of Pediatrics, University of Texas Medical Branch, Galveston 77555 0366, USA
    Virology 298:8-19. 2002
    ....
  49. ncbi request reprint Regulation of RANTES promoter activation in alveolar epithelial cells after cytokine stimulation
    Antonella Casola
    Departments of Pediatrics, Microbiology and Immunology, and Internal Medicine and Sealy Center for Molecular Sciences, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Am J Physiol Lung Cell Mol Physiol 283:L1280-90. 2002
    ..Identification of molecular mechanisms involved in RANTES gene expression is fundamental for developing strategies to modulate lung inflammatory responses...
  50. ncbi request reprint Diabetes-induced changes in the renal cortical proteome assessed with two-dimensional gel electrophoresis and mass spectrometry
    Ronald G Tilton
    Department of Internal Medicine, The University of Texas Medical Branch, Galveston, TX 77555, USA
    Proteomics 7:1729-42. 2007
    ..These differentially regulated proteins create a foundation for a systems biology exploration of molecular mechanisms underlying the pathophysiology of diabetic nephropathy...
  51. ncbi request reprint TNF-alpha-induced NF-kappaB/RelA Ser(276) phosphorylation and enhanceosome formation is mediated by an ROS-dependent PKAc pathway
    Mohammad Jamaluddin
    Department of Medicine, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1060, USA
    Cell Signal 19:1419-33. 2007
    ..These studies provide insight into a novel antioxidant-sensitive pathway that can be targeted to inhibit NF-kappaB-mediated inflammation...
  52. pmc Angiotensin II induces IL-6 expression and the Jak-STAT3 pathway in aortic adventitia of LDL receptor-deficient mice
    Adrian Recinos
    Department of Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA
    Atherosclerosis 194:125-33. 2007
    ..These findings define cytokine profiles in the A-II infusion model and demonstrate that IL-6, produced by activated macrophages and fibroblasts in the adventitia, induces the Jak-STAT3 pathway during early A-II-induced atherosclerosis...
  53. pmc Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution
    Sutapa Ray
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555 1060, USA
    Nucleic Acids Res 36:4510-20. 2008
    ..Together, our study reveals the novel functional consequences of IL-6-induced STAT3-HDAC1 interaction on nucleocytoplasmic distribution of STAT3...
  54. ncbi request reprint Identification of a nuclear factor kappa B-dependent gene network
    Bing Tian
    Department of Medicine, Sealy Center for Molecular Sciences, The University of Texas Medical Branch, Galveston, Texas 77555 1060, USA
    Recent Prog Horm Res 58:95-130. 2003
    ..These data reveal complexity in the genetic response to NF-kappaB and serve as a foundation for further informatics analysis to identify genetic features common to up- and downregulated NF-kappaB-dependent promoters...
  55. ncbi request reprint Reactive oxygen species mediate virus-induced STAT activation: role of tyrosine phosphatases
    Tianshuang Liu
    Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas 77555 0366, USA
    J Biol Chem 279:2461-9. 2004
    ....
  56. ncbi request reprint Functional analysis of the nuclear proteome of human A549 alveolar epithelial cells by HPLC-high resolution 2-D gel electrophoresis
    Jeffery Forbus
    Department of Medicine, The University of Texas Medical Branch, Galveston, TX 77555 1060, USA
    Proteomics 6:2656-72. 2006
    ..This database represents the most comprehensive data set of mammalian nuclear proteins and will serve as a foundation for further discovery...
  57. ncbi request reprint Diabetes-induced activation of canonical and noncanonical nuclear factor-kappaB pathways in renal cortex
    Jonathan M Starkey
    Division of Endocrinology, Department of Internal Medicine, Stark Diabetes Center, 8 138 Medical Research Building, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1060, USA
    Diabetes 55:1252-9. 2006
    ..These results provide evidence for chronic NF-kappaB activation in the renal cortex of db/db mice and suggest a novel, diabetes-linked mechanism involving both canonical and noncanonical NF-kappaB pathway proteins...
  58. ncbi request reprint Involvement of a novel Rac/RhoA guanosine triphosphatase-nuclear factor-kappaB inducing kinase signaling pathway mediating angiotensin II-induced RelA transactivation
    Sanjeev Choudhary
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 1060, USA
    Mol Endocrinol 21:2203-17. 2007
    ..RelA complex formation and inducible Ser(536) RelA phosphorylation...
  59. pmc Systemic cytokine response profiles associated with respiratory virus-induced acute otitis media
    Janak A Patel
    Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555 0371, USA
    Pediatr Infect Dis J 28:407-11. 2009
    ..Cytokines play a major role in the pathogenesis of AOM, but there are few studies on the systemic cytokine response during AOM...
  60. pmc Alternaria-induced release of IL-18 from damaged airway epithelial cells: an NF-κB dependent mechanism of Th2 differentiation?
    Hiroki Murai
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 7:e30280. 2012
    ..We hypothesized that exposure of the airway epithelium to Alternaria releasing cytokines that can induce Th2 differentiation...
  61. pmc Junín virus pathogenesis and virus replication
    Ashley Grant
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Viruses 4:2317-39. 2012
    ..We will also summarize current knowledge on Junín virus pathogenesis focusing on the recent development of vaccines and potential therapeutics...
  62. ncbi request reprint Respiratory syncytial virus-induced activation of nuclear factor-kappaB in the lung involves alveolar macrophages and toll-like receptor 4-dependent pathways
    Helene A Haeberle
    Department of Pediatrics, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Infect Dis 186:1199-206. 2002
    ..NF-kappaB may be considered a central activator of not only inflammatory but also innate immune responses to RSV...
  63. ncbi request reprint Genomic mechanisms of p210BCR-ABL signaling: induction of heat shock protein 70 through the GATA response element confers resistance to paclitaxel-induced apoptosis
    Sutapa Ray
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 1060, USA
    J Biol Chem 279:35604-15. 2004
    ..We suggest that down-regulation of the GATA-Hsp70 pathway may be useful in the treatment of chemotherapy-resistant CML...
  64. pmc Retinoic acid-inducible gene I mediates early antiviral response and Toll-like receptor 3 expression in respiratory syncytial virus-infected airway epithelial cells
    Ping Liu
    Departments of Medicine, University of Texas Medical Branch, Galveston, Texas 77555 1060, USA
    J Virol 81:1401-11. 2007
    ..Together these findings indicate distinct temporal roles of RIG-I and TLR3 in mediating RSV-induced innate immune responses, which are coupled to distinct pathways controlling NF-kappaB activation...
  65. ncbi request reprint Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter
    W Clay Gustafson
    Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    J Biol Chem 279:9400-8. 2004
    ..Our results indicate that Bcr-Abl-mediated transformation involves transcriptional activation of the PKCiota gene, which in turn is required for Bcr-Abl-mediated chemoresistance...
  66. pmc Stochastic regulation in early immune response
    Tomasz Lipniacki
    Institute of Fundamental Technological Research, Warsaw, Poland
    Biophys J 90:725-42. 2006
    ..Our theoretical predictions of single cell kinetics are supported by recent experimental studies of oscillations in NF-kappaB signaling made on single cells...
  67. ncbi request reprint Regulation of human airway epithelial cell IL-8 expression by MAP kinases
    Jing Li
    Am J Physiol Lung Cell Mol Physiol 283:L690-9. 2002
    ..We conclude that, in human airway epithelial cells, MAP kinases may regulate IL-8 promoter activity by NF-kappaB-dependent (in the case of JNK) and -independent (ERK) processes, as well as by posttranscriptional mechanisms (p38)...
  68. pmc Identification of an NF-kappaB-dependent gene network in cells infected by mammalian reovirus
    Sean M O'Donnell
    Lamb Center for Pediatric Research, D7235 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Virol 80:1077-86. 2006
    ..Together, these results suggest a genetic program for reovirus-induced apoptosis involving NF-kappaB-directed expression of cellular genes that activate death signaling pathways in infected cells...
  69. ncbi request reprint Transcriptional stochasticity in gene expression
    Tomasz Lipniacki
    Institute of Fundamental Technological Research, Swietokrzyska 21, 00 049 Warsaw, Poland
    J Theor Biol 238:348-67. 2006
    ..The resulting PDEs are approximated by a system of many ordinary equations, which are then numerically solved...
  70. ncbi request reprint Stochastic effects of multiple regulators on expression profiles in eukaryotes
    Pawel Paszek
    Department of Statistics, Rice University, 6100 Main Street, MS 138, Houston, TX 77005, USA
    J Theor Biol 233:423-33. 2005
    ..Comparison between these two modes of description reveals that single cells behave qualitatively different from the cell population. This analysis provides insights useful for understanding of microarray experiments...
  71. ncbi request reprint Regulation of airway epithelial cell NF-kappa B-dependent gene expression by protein kinase C delta
    Kristen Page
    Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA
    J Immunol 170:5681-9. 2003
    ..Finally, PKC delta-CAT induced transcription from the GM-CSF, RANTES, and ICAM-1 promoters. Together these data suggest that PKC delta plays a key role in the regulation of airway epithelial cell NF-kappa B-dependent gene expression...
  72. ncbi request reprint Interleukin (IL)-1 beta in tracheal aspirates from premature infants induces airway epithelial cell IL-8 expression via an NF-kappa B dependent pathway
    Thomas K Shimotake
    Department of Pediatrics, University of Chicago, Illinois 60637, USA
    Pediatr Res 56:907-13. 2004
    ....
  73. pmc MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II
    Hariyadarshi Pannu
    Department of Internal Medicine and Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Hum Mol Genet 16:2453-62. 2007
    ..These data suggest that MYH11 mutations are likely to be specific to the phenotype of TAAD/PDA and result in a distinct aortic and occlusive vascular pathology potentially driven by IGF-1 and Ang II...

Research Grants29

  1. Mechanisms for Hormone-Dependent NF-kB Activation
    Allan Brasier; Fiscal Year: 2004
    ..These studies will identify new therapeutic targets that can disrupt the vicious cycle of inflammation and atherosclerosis. ..
  2. VASCULAR INFLAMMATION, IL-6 & RENIN ANGIOTENSIN SYSTEM
    Allan Brasier; Fiscal Year: 2004
    ..These studies will determine new targets for anti-inflammatory therapy in high-risk patients for AS. ..
  3. Mechanisms for Hormone-Dependent NF-kB Activation
    Allan Brasier; Fiscal Year: 2005
    ..These studies will identify new therapeutic targets that can disrupt the vicious cycle of inflammation and atherosclerosis. ..
  4. REGULATION OF CYTOKINE GENES IN MUCOSAL VIRAL INFECTION
    Allan Brasier; Fiscal Year: 2005
    ..Expression of dominant-negative NF-KB and CBP/p300 coactivators will be used to determine their effect on coactivator recruitment. These studies will identify signaling mechanisms and protein interactions in viral-induced inflammation. ..
  5. VASCULAR INFLAMMATION, IL-6 & RENIN ANGIOTENSIN SYSTEM
    Allan Brasier; Fiscal Year: 2005
    ..These studies will determine new targets for anti-inflammatory therapy in high-risk patients for AS. ..
  6. Mechanisms for Hormone-Dependent NF-kB Activation
    Allan Brasier; Fiscal Year: 2006
    ..These studies will identify new therapeutic targets that can disrupt the vicious cycle of inflammation and atherosclerosis. ..
  7. REGULATION OF CYTOKINE GENES IN MUCOSAL VIRAL INFECTION
    Allan Brasier; Fiscal Year: 2006
    ..Expression of dominant-negative NF-KB and CBP/p300 coactivators will be used to determine their effect on coactivator recruitment. These studies will identify signaling mechanisms and protein interactions in viral-induced inflammation. ..
  8. Mechanisms for Hormone-Dependent NF-kB Activation
    Allan Brasier; Fiscal Year: 2007
    ..These studies will identify new therapeutic targets that can disrupt the vicious cycle of inflammation and atherosclerosis. ..
  9. Vascular Inflammation, IL-6 and the Renin-Angiotensin System
    Allan Brasier; Fiscal Year: 2009
    ..This project seeks to understand the role(s) of IL-6 plays in inflammation. This work will point to key regulatory steps that can be suppressed as a treatment for atherosclerosis and heart disease. ..
  10. REGULATION OF CYTOKINE GENES IN MUCOSAL VIRAL INFECTION
    Allan Brasier; Fiscal Year: 2004
    ..Expression of dominant-negative NF-KB and CBP/p300 coactivators will be used to determine their effect on coactivator recruitment. These studies will identify signaling mechanisms and protein interactions in viral-induced inflammation. ..
  11. REGULATION OF CYTOKINE GENES IN MUCOSAL VIRAL INFECTION
    Allan Brasier; Fiscal Year: 2003
    ..Expression of dominant-negative NF-KB and CBP/p300 coactivators will be used to determine their effect on coactivator recruitment. These studies will identify signaling mechanisms and protein interactions in viral-induced inflammation. ..
  12. VASCULAR INFLAMMATION, IL-6 & RENIN ANGIOTENSIN SYSTEM
    Allan Brasier; Fiscal Year: 2003
    ..These studies will determine new targets for anti-inflammatory therapy in high-risk patients for AS. ..
  13. REGULATION OF CYTOKINE GENES IN MUCOSAL VIRAL INFECTION
    Allan Brasier; Fiscal Year: 1999
    ..This project will define RSV-inducible mechanisms for transcription factor activation, and so should identify new cellular targets that can be therapeutically blocked to inhibit pro-inflammatory cytokine production. ..
  14. HORMONE DEPENDENT NUCLEAR FACTOR KAPPA BETA ACTIVATION
    Allan Brasier; Fiscal Year: 1999
    ..abstract_text> ..
  15. REGULATION OF CYTOKINE GENES IN MUCOSAL VIRAL INFECTION
    Allan Brasier; Fiscal Year: 2000
    ..This project will define RSV-inducible mechanisms for transcription factor activation, and so should identify new cellular targets that can be therapeutically blocked to inhibit pro-inflammatory cytokine production. ..
  16. HORMONE DEPENDENT NUCLEAR FACTOR KAPPA BETA ACTIVATION
    Allan Brasier; Fiscal Year: 2000
    ..abstract_text> ..
  17. HORMONE DEPENDENT NUCLEAR FACTOR KAPPA BETA ACTIVATION
    Allan Brasier; Fiscal Year: 2001
    ..abstract_text> ..
  18. REGULATION OF CYTOKINE GENES IN MUCOSAL VIRAL INFECTION
    Allan Brasier; Fiscal Year: 2002
    ..Expression of dominant-negative NF-KB and CBP/p300 coactivators will be used to determine their effect on coactivator recruitment. These studies will identify signaling mechanisms and protein interactions in viral-induced inflammation. ..
  19. HORMONE DEPENDENT NUCLEAR FACTOR KAPPA BETA ACTIVATION
    Allan Brasier; Fiscal Year: 2002
    ..abstract_text> ..
  20. VASCULAR INFLAMMATION, IL-6 & RENIN ANGIOTENSIN SYSTEM
    Allan Brasier; Fiscal Year: 2002
    ..These studies will determine new targets for anti-inflammatory therapy in high-risk patients for AS. ..
  21. Vascular Inflammation, IL-6 and the Renin-Angiotensin System
    Allan R Brasier; Fiscal Year: 2010
    ..This project seeks to understand the role(s) of IL-6 plays in inflammation. This work will point to key regulatory steps that can be suppressed as a treatment for atherosclerosis and heart disease. ..