- Interlinked fast and slow positive feedback loops drive reliable cell decisionsOnn Brandman
Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA, 94305, USA
Science 310:496-8. 2005..Mathematical simulations revealed that linking fast and slow positive feedback loops creates a "dual-time" switch that is both rapidly inducible and resistant to noise in the upstream signaling system...
- Feedback loops shape cellular signals in space and timeOnn Brandman
Department of Cellular and Molecular Pharmacology, University of California San Francisco and Howard Hughes Medical Institute, San Francisco, CA 94158, USA
Science 322:390-5. 2008..We discuss core feedback motifs that have distinct roles in shaping signaling responses in space and time. We also discuss approaches to experimentally investigate feedback loops in signaling systems...
- STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levelsOnn Brandman
Department of Chemical and Systems Biology, Bio X Clark Center W200, Stanford University, Stanford, CA 94305, USA
Cell 131:1327-39. 2007..STIM2, like STIM1, caused Ca2+ influx via activation of the plasma membrane Ca2+ channel Orai1. Our study places STIM2 at the center of a feedback module that keeps basal cytosolic and ER Ca2+ concentrations within tight limits...