Affiliation: University of Miami
Brambilla R, Persaud T, Hu X, Karmally S, Shestopalov V, Dvoriantchikova G, et al
. Transgenic inhibition of astroglial NF-kappa B improves functional outcome in experimental autoimmune encephalomyelitis by suppressing chronic central nervous system inflammation. J Immunol. 2009;182:2628-40 pubmed publisher
..Our data indicate that inhibiting NF-kappaB in astrocytes results in neuroprotective effects following experimental autoimmune encephalomyelitis, directly implicating astrocytes in the pathophysiology of this disease. ..
Gao H, Danzi M, Choi C, Taherian M, Dalby Hansen C, Ellman D, et al
. Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis. Cell Rep. 2017;18:198-212 pubmed publisher
..This must be taken into account when targeting TNFR2 for therapeutic purposes in neuroinflammatory diseases. ..
Madsen P, Sloley S, Vitores A, Carballosa Gautam M, Brambilla R, Hentall I. Prolonged stimulation of a brainstem raphe region attenuates experimental autoimmune encephalomyelitis. Neuroscience. 2017;346:395-402 pubmed publisher
..Studies of restorative treatments for MS might profitably consider ways to stimulate the raphe magnus, directly or via its inputs, or to emulate its serotonergic and peptidergic output. ..
Madsen P, Pinto M, Patel S, McCarthy S, Gao H, Taherian M, et al
. Mitochondrial DNA Double-Strand Breaks in Oligodendrocytes Cause Demyelination, Axonal Injury, and CNS Inflammation. J Neurosci. 2017;37:10185-10199 pubmed publisher
..Hence, PLP:mtPstI mice represent a unique tool to study the pathological consequences of mitochondrial dysfunction in oligodendrocytes, as well as an ideal platform to test remyelinating and neuroprotective agents. ..
Brambilla R, Hurtado A, Persaud T, Esham K, Pearse D, Oudega M, et al
. Transgenic inhibition of astroglial NF-kappa B leads to increased axonal sparing and sprouting following spinal cord injury. J Neurochem. 2009;110:765-78 pubmed publisher
Brambilla R, Ashbaugh J, Magliozzi R, Dellarole A, Karmally S, Szymkowski D, et al
. Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination. Brain. 2011;134:2736-54 pubmed publisher
Madsen P, Motti D, Karmally S, Szymkowski D, Lambertsen K, Bethea J, et al
. Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination. J Neurosci. 2016;36:5128-43 pubmed publisher
..This identifies TNFR2 as a new molecular target for the development of therapeutic agents in multiple sclerosis. ..