Anatol Bragin

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Analysis of seizure onset on the basis of wideband EEG recordings
    Anatol Bragin
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095, USA
    Epilepsia 46:59-63. 2005
  2. doi request reprint Functional connectivity in the brain estimated by analysis of gamma events
    Anatol Bragin
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
    PLoS ONE 9:e85900. 2014
  3. pmc Patterns of the UP-Down state in normal and epileptic mice
    A Bragin
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Neuroscience 225:76-87. 2012
  4. ncbi request reprint High-frequency oscillations after status epilepticus: epileptogenesis and seizure genesis
    Anatol Bragin
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095, USA
    Epilepsia 45:1017-23. 2004
  5. ncbi request reprint Analysis of chronic seizure onsets after intrahippocampal kainic acid injection in freely moving rats
    Anatol Bragin
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Epilepsia 46:1592-8. 2005
  6. ncbi request reprint Analysis of initial slow waves (ISWs) at the seizure onset in patients with drug resistant temporal lobe epilepsy
    Anatol Bragin
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Epilepsia 48:1883-94. 2007
  7. ncbi request reprint Voltage depth profiles of high-frequency oscillations after kainic acid-induced status epilepticus
    Anatol Bragin
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Epilepsia 48:35-40. 2007
  8. pmc The cause of the imbalance in the neuronal network leading to seizure activity can be predicted by the electrographic pattern of the seizure onset
    Anatol Bragin
    Departments of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 29:3660-71. 2009
  9. pmc Further evidence that pathologic high-frequency oscillations are bursts of population spikes derived from recordings of identified cells in dentate gyrus
    Anatol Bragin
    Department of Neurology The Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Epilepsia 52:45-52. 2011
  10. ncbi request reprint Large-scale microarray gene expression analysis in discrete electrophysiologically identified neuronal clusters
    Anatol Bragin
    Department of Neurology, Seizure Disorder Center, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    J Neurosci Methods 133:49-55. 2004

Detail Information

Publications39

  1. ncbi request reprint Analysis of seizure onset on the basis of wideband EEG recordings
    Anatol Bragin
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095, USA
    Epilepsia 46:59-63. 2005
    ..The absence of phase reversal of the initial slow wave in white matter or at the border of deep temporal areas indicates a possible nonneuronal mechanism of generation...
  2. doi request reprint Functional connectivity in the brain estimated by analysis of gamma events
    Anatol Bragin
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
    PLoS ONE 9:e85900. 2014
    ..This approach presents opportunities for merging electrographic and fMRI data on brain functional connectivity in normal and pathological conditions. ..
  3. pmc Patterns of the UP-Down state in normal and epileptic mice
    A Bragin
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Neuroscience 225:76-87. 2012
    ..Unraveling the neuronal substrates of UP-spikes may further improve our understanding of the mechanisms of epilepsy...
  4. ncbi request reprint High-frequency oscillations after status epilepticus: epileptogenesis and seizure genesis
    Anatol Bragin
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095, USA
    Epilepsia 45:1017-23. 2004
    ..To investigate the temporal relation between high-frequency oscillations (HFOs) in the dentate gyrus and recurrent spontaneous seizures after intrahippocampal kainite-induced status epilepticus...
  5. ncbi request reprint Analysis of chronic seizure onsets after intrahippocampal kainic acid injection in freely moving rats
    Anatol Bragin
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Epilepsia 46:1592-8. 2005
    ..The goal of this study was to analyze the transition period between interictal and ictal activity in freely moving rats with recurrent spontaneous seizures after unilateral intrahippocampal kainic acid (KA) injection...
  6. ncbi request reprint Analysis of initial slow waves (ISWs) at the seizure onset in patients with drug resistant temporal lobe epilepsy
    Anatol Bragin
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Epilepsia 48:1883-94. 2007
    ..ISWs are a specific type of ictal EEG pattern characterized by a slow wave at the seizure onset followed by low voltage fast activity...
  7. ncbi request reprint Voltage depth profiles of high-frequency oscillations after kainic acid-induced status epilepticus
    Anatol Bragin
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Epilepsia 48:35-40. 2007
    ..In areas outside of the generator of the BPS, this activity looks more like pathological high-frequency oscillations (pHFO), which were observed in earlier experiments...
  8. pmc The cause of the imbalance in the neuronal network leading to seizure activity can be predicted by the electrographic pattern of the seizure onset
    Anatol Bragin
    Departments of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 29:3660-71. 2009
    ..The knowledge of the network mechanisms underlying these two distinct electrographic patterns might be helpful in designing differential strategies for preventing seizure occurrence...
  9. pmc Further evidence that pathologic high-frequency oscillations are bursts of population spikes derived from recordings of identified cells in dentate gyrus
    Anatol Bragin
    Department of Neurology The Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Epilepsia 52:45-52. 2011
    ..To analyze activity of identified dentate gyrus granular cells and interneurons during pathologic high-frequency oscillations (pHFOs)...
  10. ncbi request reprint Large-scale microarray gene expression analysis in discrete electrophysiologically identified neuronal clusters
    Anatol Bragin
    Department of Neurology, Seizure Disorder Center, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    J Neurosci Methods 133:49-55. 2004
    ....
  11. ncbi request reprint Multiple site silicon-based probes for chronic recordings in freely moving rats: implantation, recording and histological verification
    A Bragin
    Department of Neurology, UCLA School of Medicine, 2147 RNRC, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    J Neurosci Methods 98:77-82. 2000
    ..Successful recordings of single and multiunit activity with parallel depth profiles of spontaneous and evoked field potentials are shown. The procedure for histological verification of the position of the silicon probe is described...
  12. ncbi request reprint Chronic epileptogenesis requires development of a network of pathologically interconnected neuron clusters: a hypothesis
    A Bragin
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
    Epilepsia 41:S144-52. 2000
    ....
  13. ncbi request reprint Increased afterdischarge threshold during kindling in epileptic rats
    Anatol Bragin
    Department of Neurology, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Exp Brain Res 144:30-7. 2002
    ....
  14. ncbi request reprint Local generation of fast ripples in epileptic brain
    Anatol Bragin
    Department of Neurology, University of California at Los Angeles School of Medicine, Los Angeles, California 90095 1769, USA
    J Neurosci 22:2012-21. 2002
    ..Our data illustrate that hypothesized clusters of highly interconnected neurons are capable of overcoming interneuron feedback inhibition, resulting in generation of epileptiform bursts, eventually leading to seizure activity...
  15. ncbi request reprint Interictal high-frequency oscillations (80-500 Hz) in the human epileptic brain: entorhinal cortex
    Anatol Bragin
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Ann Neurol 52:407-15. 2002
    ....
  16. ncbi request reprint Rate of interictal events and spontaneous seizures in epileptic rats after electrical stimulation of hippocampus and its afferents
    Anatol Bragin
    Department of Neurology, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Epilepsia 43:81-5. 2002
    ....
  17. ncbi request reprint Increased fast ripple to ripple ratios correlate with reduced hippocampal volumes and neuron loss in temporal lobe epilepsy patients
    Richard J Staba
    Department of Neurology, David Geffen School of Medicine at UCLA, University of California Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Epilepsia 48:2130-8. 2007
    ..To determine whether hippocampal sclerosis might form an anatomical substrate for pathological high-frequency oscillations in patients with temporal lobe epilepsy (TLE)...
  18. pmc Three-dimensional surface maps link local atrophy and fast ripples in human epileptic hippocampus
    Jennifer A Ogren
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7169, USA
    Ann Neurol 66:783-91. 2009
    ..It is hypothesized that morphological changes associated with hippocampal atrophy (HA) contribute to the generation of FR, yet there is limited evidence that hippocampal FR-generating sites correspond with local areas of atrophy...
  19. ncbi request reprint Epileptogenesis after self-sustaining status epilepticus
    Andrey Mazarati
    Department of Neurology, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Epilepsia 43:74-80. 2002
    ..To describe the natural history of chronic epilepsy after experimental self-sustaining status epilepticus (SSSE) and to correlate patterns of SSSE with ictal, interictal, and plastic changes that characterize chronic epilepsy...
  20. ncbi request reprint Sleep states differentiate single neuron activity recorded from human epileptic hippocampus, entorhinal cortex, and subiculum
    Richard J Staba
    Department of Neurobiology, David Greffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 22:5694-704. 2002
    ....
  21. ncbi request reprint High-frequency oscillations recorded in human medial temporal lobe during sleep
    Richard J Staba
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Ann Neurol 56:108-15. 2004
    ....
  22. pmc Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy
    Andrey M Mazarati
    Department of Pediatrics, Neurology Division, David Geffen School of Medicine, University of California Los Angeles, Box 951752, 22 474 MDCC, Los Angeles, CA 90095 1752, USA
    Neurobiol Dis 34:457-61. 2009
    ..We suggest that the observed hyperactivity of the HPA axis may underlie co-morbidity between epilepsy and depression...
  23. doi request reprint Imaging brain neuronal activity using functionalized magnetonanoparticles and MRI
    Massoud Akhtari
    Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Brain Topogr 25:374-88. 2012
    ....
  24. ncbi request reprint Quantitative analysis of high-frequency oscillations (80-500 Hz) recorded in human epileptic hippocampus and entorhinal cortex
    Richard J Staba
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Neurophysiol 88:1743-52. 2002
    ..The strong association between FR and regions of seizure initiation supports the view that FR reflects pathological hypersynchronous events crucially associated with seizure genesis...
  25. doi request reprint Connectomics and epilepsy
    Jerome Engel
    Department of Neurology, The Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Curr Opin Neurol 26:186-94. 2013
    ..Epilepsy is such a disease, and our understanding of the mechanisms underlying the development of epilepsy and the generation of epileptic seizures will undoubtedly benefit from research utilizing these connectomic approaches...
  26. pmc Three-dimensional hippocampal atrophy maps distinguish two common temporal lobe seizure-onset patterns
    Jennifer A Ogren
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 7169, USA
    Epilepsia 50:1361-70. 2009
    ..We used three-dimensional (3D) hippocampal mapping to quantify HA and determine whether each onset group exhibited a unique distribution of atrophy consistent with the functional differences that distinguish the two onset morphologies...
  27. doi request reprint High-frequency oscillations: what is normal and what is not?
    Jerome Engel
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1769, USA
    Epilepsia 50:598-604. 2009
    ..The potential for pHFOs to act as biomarkers for epileptogenesis and epileptogenicity is also discussed...
  28. pmc A systems level, functional genomics analysis of chronic epilepsy
    Kellen D Winden
    Interdepartmental Program for Neuroscience, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 6:e20763. 2011
    ....
  29. pmc Non-linear classification of heart rate parameters as a biomarker for epileptogenesis
    Farshad Kheiri
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States
    Epilepsy Res 100:59-66. 2012
    ..To characterize a biomarker for epileptogenesis based on cardiac interbeat interval characteristics...
  30. ncbi request reprint Spatial stability over time of brain areas generating fast ripples in the epileptic rat
    Anatol Bragin
    Neurology Neurobiology Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Epilepsia 44:1233-7. 2003
    ..To evaluate the spatial stability of FR-generating brain areas over long periods, we monitored interictal FR oscillations in rats with chronic recurrent spontaneous seizures...
  31. pmc Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits
    Olga Penagarikano
    Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Cell 147:235-46. 2011
    ..These data demonstrate a functional role for CNTNAP2 in brain development and provide a new tool for mechanistic and therapeutic research in ASD...
  32. pmc Functional connectivity between brain areas estimated by analysis of gamma waves
    Farshad Kheiri
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Neurosci Methods 214:184-91. 2013
    ..The specificity in the connectivity pattern from one subject to another can be explained by the existence of unique functional networks for each subject...
  33. doi request reprint High-frequency oscillations in epileptic brain
    Anatol Bragin
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Curr Opin Neurol 23:151-6. 2010
    ..This review summarizes progress in research on mechanisms of their generation and potential clinical applications over that period...
  34. ncbi request reprint Advances in understanding the process of epileptogenesis based on patient material: what can the patient tell us?
    Jerome Engel
    Departments of Neurology and Neurobiology, David Geffen School of Medicine at UCLA, University of California Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095 1769, U S A
    Epilepsia 44:60-71. 2003
    ..Further research is needed to determine if these observations are relevant to other types of epilepsies...
  35. pmc High-frequency oscillations and other electrophysiological biomarkers of epilepsy: underlying mechanisms
    Richard J Staba
    Department of Neurology, 710 Westwood Plaza, Reed Neurological Research Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Biomark Med 5:545-56. 2011
    ..This article focuses on the properties and neuronal mechanisms supporting the generation of high-frequency oscillations and interictal spikes, and introduces a new phenomenon called Up-spikes...
  36. pmc Novel Cell and Tissue Acquisition System (CTAS): microdissection of live and frozen brain tissues
    Lili C Kudo
    NeuroInDx, Inc, Signal Hill, California, United States of America
    PLoS ONE 7:e41564. 2012
    ....
  37. pmc Functionalized magnetonanoparticles for MRI diagnosis and localization in epilepsy
    Massoud Akhtari
    Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Epilepsia 49:1419-30. 2008
    ....
  38. ncbi request reprint Analysis of dynamic brain oscillations: methodological advances
    Michel Le Van Quyen
    LENA CNRS UPR640, Universite Pierre et Marie Curie, Hopital de la Salpetriere, 75651 Paris Cedex 13, France
    Trends Neurosci 30:365-73. 2007
    ..This review is part of the INMED and TINS special issue, Physiogenic and pathogenic oscillations: the beauty and the beast, derived from presentations at the annual INMED and TINS symposium (http://inmednet.com)...
  39. pmc Cell type-specific firing during ripple oscillations in the hippocampal formation of humans
    Michel Le Van Quyen
    Centre National de la Recherche Scientifique, Cognitive Neuroscience and Brain Imaging Laboratory, Unité Propre de Recherche 640, Hopital de la Pitie Salpetriere, 75651 Paris, France
    J Neurosci 28:6104-10. 2008
    ..These relationships between human ripples and unit activity are qualitatively similar to that observed in vivo in the rodents, suggesting that their underlying mechanisms are similar...