D L Braff

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Lack of use in the literature from the last 20 years supports dropping traditional schizophrenia subtypes from DSM-5 and ICD-11
    David L Braff
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, San Diego, CA 92093 0804, USA
    Schizophr Bull 39:751-3. 2013
  2. pmc Neurophysiologic markers of abnormal brain activity in schizophrenia
    Anthony J Rissling
    Department of Psychiatry, University of California San Diego, La Jolla, 92093 0804, USA
    Curr Psychiatry Rep 12:572-8. 2010
  3. ncbi request reprint Prepulse inhibition of the startle reflex: a window on the brain in schizophrenia
    David L Braff
    Department of Psychiatry, University of California, San Diego UCSD, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Curr Top Behav Neurosci 4:349-71. 2010
  4. ncbi request reprint Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies
    D L Braff
    Department of Psychiatry, UCSD, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 156:234-58. 2001
  5. pmc The use of neurophysiological endophenotypes to understand the genetic basis of schizophrenia
    David L Braff
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, Mail Code 0804, La Jolla 92093, USA
    Dialogues Clin Neurosci 7:125-35. 2005
  6. ncbi request reprint Preattentional and attentional cognitive deficits as targets for treating schizophrenia
    David L Braff
    Department of Psychiatry, Medical Center, University of California, 200 West Arbor Drive, San Diego, CA 92103 8816, USA
    Psychopharmacology (Berl) 174:75-85. 2004
  7. ncbi request reprint Female schizophrenia patients have prepulse inhibition deficits
    David L Braff
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0804, USA
    Biol Psychiatry 57:817-20. 2005
  8. pmc Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder
    David L Braff
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, Mail Code 0804, La Jolla, CA 92093, USA
    Schizophr Bull 33:21-32. 2007
  9. doi request reprint Clinically responsible genetic testing in neuropsychiatric patients: a bridge too far and too soon
    David L Braff
    University of California, San Diego, School of Medicine, Department of Psychiatry, 9500 Gilman Drive, Mail Code 0804, La Jolla, CA 92093 0804, USA
    Am J Psychiatry 165:952-5. 2008
  10. ncbi request reprint Impact of prepulse characteristics on the detection of sensorimotor gating deficits in schizophrenia
    D L Braff
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Schizophr Res 49:171-8. 2001

Research Grants

  1. Gating and Inhibition in Schizophrenia
    David Braff; Fiscal Year: 2006
  2. The Genetics of Endophenotypes and Schizophrenia
    David Braff; Fiscal Year: 2007
  3. Gating and Inhibition in Schizophrenia
    David Braff; Fiscal Year: 2007
  4. 4/4-A Genomic Approach to Schizophrenia
    David L Braff; Fiscal Year: 2010
  5. SENSORY GATING & HABITUATION IN SCHIZOPHRENIA
    David Braff; Fiscal Year: 1992
  6. 1/6-The Genetics of Endophenotypes and Schizophrenia
    David L Braff; Fiscal Year: 2010

Detail Information

Publications82

  1. pmc Lack of use in the literature from the last 20 years supports dropping traditional schizophrenia subtypes from DSM-5 and ICD-11
    David L Braff
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, San Diego, CA 92093 0804, USA
    Schizophr Bull 39:751-3. 2013
    ....
  2. pmc Neurophysiologic markers of abnormal brain activity in schizophrenia
    Anthony J Rissling
    Department of Psychiatry, University of California San Diego, La Jolla, 92093 0804, USA
    Curr Psychiatry Rep 12:572-8. 2010
    ....
  3. ncbi request reprint Prepulse inhibition of the startle reflex: a window on the brain in schizophrenia
    David L Braff
    Department of Psychiatry, University of California, San Diego UCSD, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Curr Top Behav Neurosci 4:349-71. 2010
    ..PPI continues to hold promise as an exciting translational cross-species measure that can be used to understand the pathophysiology and treatment of the schizophrenias via pharmacological, anatomic, and genetic studies...
  4. ncbi request reprint Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies
    D L Braff
    Department of Psychiatry, UCSD, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 156:234-58. 2001
    ..In humans, PPI occurs in a robust, predictable manner when the prepulse and startling stimuli occur in either the same or different modalities (acoustic, visual, or cutaneous)...
  5. pmc The use of neurophysiological endophenotypes to understand the genetic basis of schizophrenia
    David L Braff
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, Mail Code 0804, La Jolla 92093, USA
    Dialogues Clin Neurosci 7:125-35. 2005
    ..The power and utility of utilizing endophenotypes to understand the genetics of schizophrenia is discussed in detail in this article...
  6. ncbi request reprint Preattentional and attentional cognitive deficits as targets for treating schizophrenia
    David L Braff
    Department of Psychiatry, Medical Center, University of California, 200 West Arbor Drive, San Diego, CA 92103 8816, USA
    Psychopharmacology (Berl) 174:75-85. 2004
    ..These neurophysiological measures cover a spectrum from automatic preattentional to attention-dependent processes...
  7. ncbi request reprint Female schizophrenia patients have prepulse inhibition deficits
    David L Braff
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0804, USA
    Biol Psychiatry 57:817-20. 2005
    ..This study was designed to determine whether female schizophrenia patients have lower levels of PPI than normal females...
  8. pmc Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder
    David L Braff
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, Mail Code 0804, La Jolla, CA 92093, USA
    Schizophr Bull 33:21-32. 2007
    ..The endophenotype strategy offers powerful and exciting opportunities to understand the genetically conferred neurobiological vulnerabilities and possible new strong inference and molecularly based treatments for schizophrenia...
  9. doi request reprint Clinically responsible genetic testing in neuropsychiatric patients: a bridge too far and too soon
    David L Braff
    University of California, San Diego, School of Medicine, Department of Psychiatry, 9500 Gilman Drive, Mail Code 0804, La Jolla, CA 92093 0804, USA
    Am J Psychiatry 165:952-5. 2008
  10. ncbi request reprint Impact of prepulse characteristics on the detection of sensorimotor gating deficits in schizophrenia
    D L Braff
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Schizophr Res 49:171-8. 2001
    ....
  11. ncbi request reprint Prepulse inhibition and P50 suppression are both deficient but not correlated in schizophrenia patients
    David L Braff
    Department of Psychiatry, School of Medicine, University of California, San Diego, California 92093 0804, USA
    Biol Psychiatry 61:1204-7. 2007
    ..The relationship between PPI and P50 suppression in schizophrenia patients has remained unclear...
  12. ncbi request reprint Symptom correlates of prepulse inhibition deficits in male schizophrenic patients
    D L Braff
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Am J Psychiatry 156:596-602. 1999
    ..Prepulse inhibition deficits in schizophrenic patients correlate with core cognitive symptoms, such as thought disorder and distractibility, but their relationship to positive and negative symptoms of schizophrenia is less clear...
  13. ncbi request reprint Sensory gating deficits assessed by the P50 event-related potential in subjects with schizotypal personality disorder
    K S Cadenhead
    Department of Psychiatry, University of California, San Diego 92093 0804, USA
    Am J Psychiatry 157:55-9. 2000
    ..Although schizotypal subjects have been shown to have deficits in sensorimotor gating as measured by prepulse inhibition, to the authors' knowledge P50 sensory gating in schizotypal personality disorder has yet to be reported...
  14. ncbi request reprint Sensorimotor gating and thought disturbance measured in close temporal proximity in schizophrenic patients
    W Perry
    Department of Psychiatry, University of California, San Diego, USA
    Arch Gen Psychiatry 56:277-81. 1999
    ..To address this issue, sensorimotor gating and thought disturbance were measured in close temporal proximity, thus strengthening the evidence for the association of these 2 abnormalities in schizophrenic patients...
  15. ncbi request reprint Measuring P50 suppression and prepulse inhibition in a single recording session
    G A Light
    Department of Psychiatry, University of California, San Diego, CA 92093-0804, USA
    Am J Psychiatry 158:2066-8. 2001
    ....
  16. ncbi request reprint Poor P50 suppression among schizophrenia patients and their first-degree biological relatives
    B A Clementz
    Department of Psychology, University of California, San Diego, La Jolla 92093 0109, USA
    Am J Psychiatry 155:1691-4. 1998
    ..This study's goal was to replicate the finding that family members of schizophrenia patients show poor P50 suppression during a paired-click auditory evoked response paradigm...
  17. ncbi request reprint Latent inhibition in schizophrenia
    N R Swerdlow
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Schizophr Res 20:91-103. 1996
    ....
  18. ncbi request reprint A multimethod approach to assessing perseverations in schizophrenia patients
    W Perry
    University of California, San Diego, Department of Psychiatry, La Jolla 92093 8620, USA
    Schizophr Res 33:69-77. 1998
    ..These data provide evidence that perseverative behavior is widely observed in schizophrenia patients using a variety of instruments. The authors discuss the benefit of using multiple measures of perseveration in schizophrenia research...
  19. ncbi request reprint Sex differences in sensorimotor gating of the human startle reflex: all smoke?
    N R Swerdlow
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 146:228-32. 1999
    ..A recent report described sex differences in the effects of nicotine use and withdrawal on prepulse inhibition of acoustic startle (PPI), but no sex differences in PPI in non-smokers...
  20. ncbi request reprint Modulation of the startle response and startle laterality in relatives of schizophrenic patients and in subjects with schizotypal personality disorder: evidence of inhibitory deficits
    K S Cadenhead
    Department of Psychiatry, University of California, San Diego, La Jolla, 92093 0804, USA
    Am J Psychiatry 157:1660-8. 2000
    ..The authors hypothesized that nonschizophrenic relatives of patients with schizophrenia would also have prepulse inhibition deficits, thereby reflecting a genetically transmitted susceptibility to sensorimotor gating deficits...
  21. ncbi request reprint Animal models of deficient sensorimotor gating: what we know, what we think we know, and what we hope to know soon
    N R Swerdlow
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Behav Pharmacol 11:185-204. 2000
    ..Some of these issues--ranging from the cross-species methods for quantifying specific variables to the relevance of genetic drift to animal and human studies of PPI--and their implications for future studies are the focus of this review...
  22. pmc Reduced multisensory integration in patients with schizophrenia on a target detection task
    Lisa E Williams
    Department of Psychology, University of California, San Diego, CA, United States
    Neuropsychologia 48:3128-36. 2010
    ....
  23. pmc Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of Schizophrenia
    Ann Olincy
    Department of Psychiatry, Veterans Affairs Denver Medical Center VISN 19 MIRECC, CO 80045, USA
    Schizophr Res 119:175-82. 2010
    ....
  24. ncbi request reprint Cross-species studies of sensorimotor gating of the startle reflex
    N R Swerdlow
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Ann N Y Acad Sci 877:202-16. 1999
    ..In this manner, PPI can be used to probe the sensitivity of DAergic systems, and perhaps other CSPP elements, across normal and neuropsychiatric-disordered populations...
  25. ncbi request reprint Multiple site evaluation of P50 suppression among schizophrenia and normal comparison subjects
    B A Clementz
    Department of Psychology, University of California, La Jolla, San Diego 92093 0109, USA
    Schizophr Res 30:71-80. 1998
    ..Further work investigating the neuropathological correlates of poor P50 suppression among schizophrenia patients by recording from multiple electrode locations, however, could be helpful...
  26. ncbi request reprint Sensorimotor gating deficits in bipolar disorder patients with acute psychotic mania
    W Perry
    Department of Psychiatry, University of California at San Diego, 200 West Arbor Drive, Mail Code 8218, La Jolla, CA 92093-8620, USA
    Biol Psychiatry 50:418-24. 2001
    ....
  27. pmc Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probands
    Bruce I Turetsky
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 64:1051-9. 2008
    ..We report initial results from the COGS dataset of auditory N100 amplitude and gating as candidate endophenotypes...
  28. pmc Effects of olanzapine, risperidone and haloperidol on prepulse inhibition in schizophrenia patients: a double-blind, randomized controlled trial
    Jonathan K Wynn
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
    Schizophr Res 95:134-42. 2007
    ..The results are discussed in terms of animal models, neural substrates, and treatment implications...
  29. ncbi request reprint Endophenotyping schizotypy: a prelude to genetic studies within the schizophrenia spectrum
    Kristin S Cadenhead
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Schizophr Res 54:47-57. 2002
    ..Composite phenotypes can also be developed, which increase the probability of identifying the complex genetic architecture of schizophrenia spectrum disorders, which interact with nongenetic protective and exacerbating factors...
  30. ncbi request reprint Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review
    M A Geyer
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Psychopharmacology (Berl) 156:117-54. 2001
    ..In addition, some developmental manipulations, such as isolation rearing, have provided non-pharmacological animal models of the PPI deficits seen in schizophrenia...
  31. ncbi request reprint Schizophrenic-like sensorimotor gating abnormalities in rats following dopamine infusion into the nucleus accumbens
    N R Swerdlow
    Department of Psychiatry, University of California, San Diego, La Jolla 92093
    Psychopharmacology (Berl) 101:414-20. 1990
    ....
  32. ncbi request reprint Toward understanding the biology of a complex phenotype: rat strain and substrain differences in the sensorimotor gating-disruptive effects of dopamine agonists
    N R Swerdlow
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0804, USA
    J Neurosci 20:4325-36. 2000
    ..These findings demonstrate robust, innate, neurochemically specific, and apparently heritable phenotypic differences in an animal model of sensorimotor gating deficits in human neuropsychiatric disorders...
  33. ncbi request reprint Schizophrenia patients demonstrate a dissociation on declarative and non-declarative memory tests
    W Perry
    University of California, Department of Psychiatry, 9500 Gilman Drive, La Yolla, San Diego, CA 92093 8620, USA
    Schizophr Res 46:167-74. 2000
    ..The schizophrenia patients' dissociation on declarative vs. non-declarative memory tests is discussed in terms of possible underlying structural impairment...
  34. ncbi request reprint Cognitive functions in schizotypal personality disorder
    K S Cadenhead
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Schizophr Res 37:123-32. 1999
    ..Schizotypal personality disordered (SPD) subjects do not have many of the confounds seen in schizophrenic patients, but may have the same pattern of cognitive deficits in attention and executive functioning...
  35. ncbi request reprint The relationship of age to prepulse inhibition and habituation of the acoustic startle response
    Joel Ellwanger
    Department of Psychiatry, University of California, San Diego, USA
    Biol Psychol 62:175-95. 2003
    ..The results do not support the theory that aging is associated with a general decline in inhibitory function and contrast with previous studies that have compared only extreme age groups and have found no effects of age on PPI...
  36. ncbi request reprint Working memory in schizophrenia: transient "online" storage versus executive functioning
    W Perry
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 8620, USA
    Schizophr Bull 27:157-76. 2001
    ..The importance of clearly identifying which distinct aspects of working memory are assessed is discussed...
  37. ncbi request reprint Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges
    N R Swerdlow
    Department of Psychiatry, UCSD Schools of Medicine, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 156:194-215. 2001
    ..Prepulse inhibition (PPI), a measure of sensorimotor gating, is reduced in patients with some neuropsychiatric disorders, and in rats after manipulations of limbic cortex, striatum, pallidum or pontine tegmentum ("CSPP" circuitry)...
  38. ncbi request reprint Self-monitoring enhances Wisconsin Card Sorting Test performance in patients with schizophrenia: performance is improved by simply asking patients to verbalize their sorting strategy
    W Perry
    University of California, San Diego, Department of Psychiatry, USA
    J Int Neuropsychol Soc 7:344-52. 2001
    ..Cumulatively, these data suggest that a simple instruction may enhance executive function and impact WCST performance in patients with schizophrenia...
  39. ncbi request reprint Information processing deficits of schizophrenia patients: relationship to clinical ratings, gender and medication status
    K S Cadenhead
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Schizophr Res 28:51-62. 1997
    ..It is possible that VBM and RT share overlapping or interacting neural substrates...
  40. pmc Statistical genetics concepts and approaches in schizophrenia and related neuropsychiatric research
    Nicholas J Schork
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    Schizophr Bull 33:95-104. 2007
    ..We also provide a discussion of the most pressing contemporary problems that demand further research if progress is to be made in the identification of genes and genetic variations that predispose to complex neuropsychiatric diseases...
  41. pmc The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaboration
    Monica E Calkins
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
    Schizophr Bull 33:33-48. 2007
    ..The purpose of this article is to provide a description of the COGS structure and methods, including participant recruitment and assessment...
  42. ncbi request reprint Stability of mismatch negativity deficits and their relationship to functional impairments in chronic schizophrenia
    Gregory A Light
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0804, USA
    Am J Psychiatry 162:1741-3. 2005
    ....
  43. ncbi request reprint Startle gating deficits in a large cohort of patients with schizophrenia: relationship to medications, symptoms, neurocognition, and level of function
    Neal R Swerdlow
    Departments of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Arch Gen Psychiatry 63:1325-35. 2006
    ..Patients with schizophrenia exhibit deficits in automatic, preattentive sensorimotor gating (prepulse inhibition [PPI]) of the startle reflex...
  44. pmc Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of Schizophrenia
    Neal R Swerdlow
    Department of Psychiatry, University of California San Diego, San Diego, California, USA
    Schizophr Res 92:237-51. 2007
    ..Genetic studies now often employ multiple, geographically dispersed test sites to accommodate the need for large and complex study samples. Here, we assessed the feasibility of using PPI in multi-site studies...
  45. ncbi request reprint Electrophysiological insights into conceptual disorganization in schizophrenia
    Michael Kiang
    Department of Cognitive Science, University of California San Diego, 9500 Gilman Dr, Mail Code 0515, La Jolla, CA 92093 0515, USA
    Schizophr Res 92:225-36. 2007
    ....
  46. ncbi request reprint Cognitive, neurophysiological, and functional correlates of proverb interpretation abnormalities in schizophrenia
    Michael Kiang
    Department of Cognitive Science, University of California San Diego, La Jolla, California 92093, USA
    J Int Neuropsychol Soc 13:653-63. 2007
    ..These results offer no support for disorganized associations in abnormal proverb interpretation in schizophrenia, but implicate WM deficits, perhaps as a part of a syndrome related to generalized frontal cortical dysfunction...
  47. ncbi request reprint An event-related brain potential study of direct and indirect semantic priming in schizophrenia
    Michael Kiang
    University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0515, USA
    Am J Psychiatry 165:74-81. 2008
    ..The authors tested these hypotheses using the N400 event-related brain potential as a probe of activation of concepts in semantic memory...
  48. pmc Preattentive sensory processing as indexed by the MMN and P3a brain responses is associated with cognitive and psychosocial functioning in healthy adults
    Gregory A Light
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0804, USA
    J Cogn Neurosci 19:1624-32. 2007
    ....
  49. ncbi request reprint Proceedings and data from The Schizophrenia Summit: a critical appraisal to improve the management of Schizophrenia
    Henry A Nasrallah
    Department of Psychiatry, University of Cincinnati College of Medicine, 260 Stetson St, Suite 3224, Cincinnati, OH 45267 0559, USA
    J Clin Psychiatry 70:4-46. 2009
    ..Summit faculty member opinion is compared with field survey results, and recommendations are made for future research...
  50. pmc Realistic expectations of prepulse inhibition in translational models for schizophrenia research
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, La Jolla, CA, 92093 0804, USA
    Psychopharmacology (Berl) 199:331-88. 2008
    ..This rapid expansion and broad application of PPI as a tool for understanding schizophrenia has, at times, outpaced critical thinking and falsifiable hypotheses about the relative strengths vs. limitations of this measure...
  51. pmc Electroencephalography (EEG) and event-related potentials (ERPs) with human participants
    Gregory A Light
    Department of Psychiatry, University of California, San Diego, La Jolla, California, USA
    Curr Protoc Neurosci . 2010
    ..These paradigms can be used to assess the integrity of early sensory processing in normal individuals and clinical populations, such as individuals with schizophrenia...
  52. ncbi request reprint Gamma band oscillations reveal neural network cortical coherence dysfunction in schizophrenia patients
    Gregory A Light
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0804, USA
    Biol Psychiatry 60:1231-40. 2006
    ....
  53. ncbi request reprint Prepulse-elicited motor reactions do not differ between schizophrenia patients and control subjects
    Neal R Swerdlow
    Department of PsychiatryUniversity of California, San Diego School of Medicine, La Jolla, CA 92093 0804, USA
    Behav Neurosci 120:224-7. 2006
    ..Thus, differential sensitivity to the motor-activating effects of prepulses should not contribute to reduced prepulse inhibition in schizophrenia patients versus control subjects...
  54. ncbi request reprint Neurobiological measures of schizotypal personality disorder: defining an inhibitory endophenotype?
    Kristin S Cadenhead
    Department of Psychiatry, University of California, San Diego, La Jolla, 92093 0810, USA
    Am J Psychiatry 159:869-71. 2002
    ....
  55. ncbi request reprint Schizophrenia subjects show intact success-related neural activation but impaired uncertainty processing during decision-making
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California at San Diego, La Jolla, CA, USA
    Neuropsychopharmacology 28:795-806. 2003
    ..In contrast, task-related activation in SZS was not modulated by the degree of uncertainty. Thus, SZS failed to utilize the parietal cortex to process decision-making situations with highly uncertain outcomes...
  56. ncbi request reprint Mismatch negativity deficits are associated with poor functioning in schizophrenia patients
    Gregory A Light
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Arch Gen Psychiatry 62:127-36. 2005
    ..While many studies have reported MMN deficits in schizophrenia patients, little is known about the functional significance of MMN deficits in schizophrenia patients...
  57. ncbi request reprint Information processing deficits in acutely psychotic schizophrenia patients medicated and unmedicated at the time of admission
    William Perry
    Neuropsychiatry and Behavioral Medicine Service, Department of Psychiatry, University of California San Diego, La Jolla 92093 8620, USA
    Am J Psychiatry 159:1375-81. 2002
    ..The present study investigated the effects of antipsychotics on prepulse inhibition and startle habituation in acutely hospitalized patients with schizophrenia...
  58. ncbi request reprint Startle modulation in Caucasian-Americans and Asian-Americans: a prelude to genetic/endophenotypic studies across the 'Pacific Rim'
    Neal R Swerdlow
    Department of Psychiatry, UCSD, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Psychiatr Genet 15:61-5. 2005
    ....
  59. ncbi request reprint Prepulse inhibition of perceived stimulus intensity: paradigm assessment
    Neal R Swerdlow
    Department of Psychiatry, University of California, 9500 Gilman Dr La Jolla, San Diego, CA 92039 0804, USA
    Biol Psychol 69:133-47. 2005
    ..PPIPSI is a robust, stable, parametrically sensitive and "low tech" measure of sensory gating that is relatively unaffected by a number of biological variables in normal individuals...
  60. ncbi request reprint P50 suppression in individuals at risk for schizophrenia: the convergence of clinical, familial, and vulnerability marker risk assessment
    Kristin S Cadenhead
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0810, USA
    Biol Psychiatry 57:1504-9. 2005
    ..The aim of the present study was to determine whether individuals "at risk" for schizophrenia have deficits in P50 suppression, a preattentive measure of sensory gating...
  61. pmc Convergence and divergence in the neurochemical regulation of prepulse inhibition of startle and N40 suppression in rats
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, La Jolla, CA 92093 0804, USA
    Neuropsychopharmacology 31:506-15. 2006
    ..Despite similarities in drug sensitivity, these results suggest that distinct neurobiological mechanisms underlie drug-induced deficits in PPI and N40 gating...
  62. ncbi request reprint Behavioral and functional neuroimaging evidence for prefrontal dysfunction in methamphetamine-dependent subjects
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California San Diego, San Diego, CA 92093 0603, USA
    Neuropsychopharmacology 26:53-63. 2002
    ..These results support the basic hypothesis that stimulant-dependent subjects exhibit fundamental cognitive deficits during decision-making that are consistent with both orbitofrontal and dorsolateral prefrontal dysfunction...
  63. ncbi request reprint Prepulse inhibition and habituation of the startle response are stable neurobiological measures in a normal male population
    K S Cadenhead
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Biol Psychiatry 45:360-4. 1999
    ..These data support the hypothesis that PPI and habituation are relatively stable neurobiological markers...
  64. ncbi request reprint Translating the basic and clinical cognitive neuroscience of schizophrenia to drug development and clinical trials of antipsychotic medications
    M F Green
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles California, USA
    Biol Psychiatry 49:374-84. 2001
    ..Thus, there is an informed translation and cross-fertilization between basic and clinical research focused on the development and assessment of putative new antipsychotic compounds...
  65. ncbi request reprint Parietal dysfunction is associated with increased outcome-related decision-making in schizophrenia patients
    Martin P Paulus
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0603, USA
    Biol Psychiatry 51:995-1004. 2002
    ..This study tested the hypothesis that schizophrenia patients show less decision-making-related activation in the prefrontal and parietal cortex...
  66. ncbi request reprint Visual masking as a probe for abnormal gamma range activity in schizophrenia
    Michael Foster Green
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90024 1759, USA
    Biol Psychiatry 53:1113-9. 2003
    ..We conducted two experiments to determine whether visual masking procedures can reveal underlying abnormalities in gamma range oscillations in schizophrenia...
  67. ncbi request reprint Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California San Diego, La Jolla, USA
    Arch Gen Psychiatry 64:1242-50. 2007
    ..Exploration of the genetic architecture of specific endophenotypes may be a powerful strategy for understanding the genetic basis of schizophrenia...
  68. ncbi request reprint Neural correlates of refixation saccades and antisaccades in normal and schizophrenia subjects
    Jennifer E McDowell
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0804, USA
    Biol Psychiatry 51:216-23. 2002
    ..The current study tests hypotheses about the neural substrates of normal and abnormal saccadic performance among subjects with schizophrenia...
  69. ncbi request reprint The relationship of information-processing deficits and clinical symptoms in schizotypal personality disorder
    K S Cadenhead
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Biol Psychiatry 40:853-8. 1996
    ..These findings suggest an important relationship between symptoms of SPD and neurophysiologic deficits...
  70. ncbi request reprint Chaos and schizophrenia: does the method fit the madness?
    Martin P Paulus
    Department of Psychiatry, University of California, and Veterans Affairs San Diego Health Care System, San Diego, California, USA
    Biol Psychiatry 53:3-11. 2003
    ....
  71. pmc Superior size-weight illusion performance in patients with schizophrenia: evidence for deficits in forward models
    Lisa E Williams
    Department of Psychology, University of California San Diego, 9500 Gilman Drive 0109, La Jolla, CA 92093 0109, USA
    Schizophr Res 121:101-6. 2010
    ..The current findings are consistent with a dysfunctional forward model mechanism in this population. Future studies to elucidate the locus of this impairment using variations on the current study are also proposed...
  72. ncbi request reprint Prefrontal, parietal, and temporal cortex networks underlie decision-making in the presence of uncertainty
    M P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California San Diego, 92093-0603, USA
    Neuroimage 13:91-100. 2001
    ..These results support the hypothesis that subjects use a frontoparietal neural system to establish a contingency based decision-making strategy even in the presence of random reinforcement...
  73. ncbi request reprint On the waveform of the acoustic startle blink in the paradigm of prepulse inhibition - methodological and physiological aspects
    Ulrich Meincke
    Department of Psychiatry, University of California San Diego, La Jolla, USA
    Neuropsychobiology 52:24-7. 2005
    ..These findings support the view that both components of the acoustically evoked OOM response exhibit similar plasticity in the paradigm of prepulse inhibition...
  74. ncbi request reprint The neural correlates of habituation of response to startling tactile stimuli presented in a functional magnetic resonance imaging environment
    Jennifer E McDowell
    Department of Psychology, University of Georgia, Athens, GA 30602, USA
    Psychiatry Res 148:1-10. 2006
    ..Thus, startling tactile stimuli initially induce widespread cortical and thalamic activity, perhaps mediated by the reticular activating system. The activity then habituates in a graded fashion with repeated presentations of the stimuli...
  75. ncbi request reprint Effects of background and prepulse characteristics on prepulse inhibition and facilitation: implications for neuropsychiatric research
    Ming H Hsieh
    Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan
    Biol Psychiatry 59:555-9. 2006
    ..We assessed the effects of different parameters on PPI and PPF in normal subjects...
  76. ncbi request reprint Social cognition in schizophrenia: relationships with neurocognition and negative symptoms
    Mark J Sergi
    Department of Psychology, California State University at Northridge, Northridge, CA 91330 8255, USA
    Schizophr Res 90:316-24. 2007
    ..The current findings start to provide insights into the structure of social cognition, neurocognition, and negative symptoms in schizophrenia...
  77. ncbi request reprint Successful multi-site measurement of antisaccade performance deficits in schizophrenia
    Allen D Radant
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States
    Schizophr Res 89:320-9. 2007
    ..These results confirm previous findings of antisaccade deficits in schizophrenia subjects and support the use of the antisaccade task as a potential schizophrenia endophenotype in multi-site genetic studies...
  78. ncbi request reprint Social cognition [corrected] and neurocognition: effects of risperidone, olanzapine, and haloperidol
    Mark J Sergi
    Department of Psychology, California State University, 18111 Nordhoff St, Northridge, CA 91330 8255, USA
    Am J Psychiatry 164:1585-92. 2007
    ..This study examined the short-term effects of first- and second-generation antipsychotic medications on social cognition and basic cognition...
  79. ncbi request reprint Sensitization and habituation of the acoustic startle reflex in patients with schizophrenia
    Ulrich Meincke
    Department of Psychiatry and Psychotherapy, Technical University of Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    Psychiatry Res 126:51-61. 2004
    ..In addition, the present data have important implications for designing startle studies to assess sensitization, habituation and prepulse inhibition in one session...
  80. pmc Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of Schizophrenia
    William P Horan
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 6968, USA
    Schizophr Res 103:218-28. 2008
    ....
  81. ncbi request reprint The value of referring to recently introduced antipsychotics as "second generation"
    James B Lohr
    Am J Psychiatry 160:1371-2. 2003
  82. ncbi request reprint Some possible genetic parallels across alcoholism, bipolar disorder and schizophrenia
    Marc A Schuckit
    J Stud Alcohol 64:157-9. 2003

Research Grants20

  1. Gating and Inhibition in Schizophrenia
    David Braff; Fiscal Year: 2006
    ..g. applying these measures to understand the neural substrates of schizophrenia using lesion, pharmacological, and genetic manipulations) by using the interactive human and animal experiments. ..
  2. The Genetics of Endophenotypes and Schizophrenia
    David Braff; Fiscal Year: 2007
    ..Findings of heritable deficits in specific measures will be used to guide the next generation of studies of the genetics of schizophrenia. ..
  3. Gating and Inhibition in Schizophrenia
    David Braff; Fiscal Year: 2007
    ..g. applying these measures to understand the neural substrates of schizophrenia using lesion, pharmacological, and genetic manipulations) by using the interactive human and animal experiments. ..
  4. 4/4-A Genomic Approach to Schizophrenia
    David L Braff; Fiscal Year: 2010
    ..Our goal is to use state-of-the-art genomic tools to detect these mutations anywhere in the genome, and to identify genes that are more often impacted by structural mutations in persons with schizophrenia compared to healthy controls. ..
  5. SENSORY GATING & HABITUATION IN SCHIZOPHRENIA
    David Braff; Fiscal Year: 1992
    ..We intend to further our understanding of how DA overactivity and its underlying neuroanatomic correlates may relate to the specific cognitive dysfunction, symptoms, and outcome of the schizophrenic disorders...
  6. 1/6-The Genetics of Endophenotypes and Schizophrenia
    David L Braff; Fiscal Year: 2010
    ..Once we understand the genetic architecture of these abnormalities, new medications that aim to improve the functioning and quality of life of schizophrenia patients can be developed. ..