RALPH BRADSHAW

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Reporting protein identification data: the next generation of guidelines
    Ralph A Bradshaw
    Mol Cell Proteomics 5:787-8. 2006
  2. ncbi Methionine aminopeptidases and angiogenesis
    Ralph A Bradshaw
    Department of Physiology and Biophysics, College of Medicine, University of California, Irvine, CA 92697, USA
    Essays Biochem 38:65-78. 2002
  3. ncbi PC12 cell activation by epidermal growth factor receptor: role of autophosphorylation sites
    Darren R Tyson
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697 4560, USA
    Int J Dev Neurosci 21:63-74. 2003
  4. ncbi How I became a biochemist
    Ralph A Bradshaw
    Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA
    IUBMB Life 58:495-8. 2006
  5. ncbi From proteins to proteomics
    Ralph A Bradshaw
    Department of Biochemistry, University of Cambridge, Cambridge, UK
    IUBMB Life 57:267-72. 2005
  6. ncbi Sustained ERK1/2 but not STAT1 or 3 activation is required for thanatophoric dysplasia phenotypes in PC12 cells
    Nakisa Nowroozi
    Department of Psychiatry and Human Behavior, 2121 Gillespie, University of California at Irvine, Irvine, CA 92697, USA
    Hum Mol Genet 14:1529-38. 2005
  7. ncbi Human embryonic kidney cells (HEK-293 cells): characterization and dose-response relationship for modulated release of nerve growth factor for nerve regeneration
    Juan Carlos Jimenez
    Division of Plastic Surgery, University of California, Irvine, USA
    Plast Reconstr Surg 113:605-10. 2004
  8. ncbi Characterization of symmetric complexes of nerve growth factor and the ectodomain of the pan-neurotrophin receptor, p75NTR
    Jukka P Aurikko
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom
    J Biol Chem 280:33453-60. 2005
  9. ncbi Nerve growth factor expression response to induction agent booster dosing in transfected human embryonic kidney cells
    Michael P McConnell
    Aesthetic and Plastic Surgery Institute, University of California, Irvine, Orange, Calif 92868-3298, USA
    Plast Reconstr Surg 115:506-14. 2005
  10. ncbi Revised draft guidelines for proteomic data publication
    Ralph A Bradshaw
    Mol Cell Proteomics 4:1223-5. 2005

Research Grants

  1. CO-TRANSLATIONAL PROCESSING AND PROTEIN TURNOVER
    RALPH BRADSHAW; Fiscal Year: 1993
  2. STRUCTURE AND INTRACELLULAR LOCALIZATION OF PROTEINS
    RALPH BRADSHAW; Fiscal Year: 1990
  3. CO-TRANSLATIONAL PROCESSING AND PROTEIN TURNOVER
    RALPH BRADSHAW; Fiscal Year: 1991
  4. COTRANSLATIONAL PROCESSING AND PROTEIN TURNOVER
    RALPH BRADSHAW; Fiscal Year: 2001

Collaborators

  • G R Evans
  • Carol V Robinson
  • Martin C Moncrieffe
  • John J M Bergeron
  • KENNETH NEET
  • Ruedi H Aebersold
  • Darren R Tyson
  • Nakisa Nowroozi
  • Jukka P Aurikko
  • Michael P McConnell
  • Sanjay Dhar
  • Thang Nguyen
  • Juan Carlos Jimenez
  • Yousuke Hamai
  • Shivanand P Lad
  • Elaine Stephens
  • Leslie Michels Thompson
  • Brandon T Ruotolo
  • Veli Matti Leppänen
  • J Gunter Grossmann
  • Simona Raffioni
  • Tracy Wang
  • Tom L Blundell
  • Sanjay Naran
  • Barbara L Apostol
  • Mart Saarma
  • Jay W Calvert
  • Michael J Sundine
  • Selena Larkin
  • Daniel A Peterson

Detail Information

Publications14

  1. ncbi Reporting protein identification data: the next generation of guidelines
    Ralph A Bradshaw
    Mol Cell Proteomics 5:787-8. 2006
  2. ncbi Methionine aminopeptidases and angiogenesis
    Ralph A Bradshaw
    Department of Physiology and Biophysics, College of Medicine, University of California, Irvine, CA 92697, USA
    Essays Biochem 38:65-78. 2002
    ..The resulting covalent modification inhibits the protease activity of MetAP2 and blocks cell-cycle function in endothelial and some cancer cells. The role of MetAP2 in the mitogenic activity of these cells is unknown...
  3. ncbi PC12 cell activation by epidermal growth factor receptor: role of autophosphorylation sites
    Darren R Tyson
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697 4560, USA
    Int J Dev Neurosci 21:63-74. 2003
    ..Our results show that the five autophosphorylation sites in the extra-kinase C-terminal domain of EGFR are not required for the ability of EGFR to induce morphological differentiation of PC12 cells...
  4. ncbi How I became a biochemist
    Ralph A Bradshaw
    Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA
    IUBMB Life 58:495-8. 2006
  5. ncbi From proteins to proteomics
    Ralph A Bradshaw
    Department of Biochemistry, University of Cambridge, Cambridge, UK
    IUBMB Life 57:267-72. 2005
    ..These hold great promise for the identification of disease markers and drug targets, but are not without their challenges and pitfalls...
  6. ncbi Sustained ERK1/2 but not STAT1 or 3 activation is required for thanatophoric dysplasia phenotypes in PC12 cells
    Nakisa Nowroozi
    Department of Psychiatry and Human Behavior, 2121 Gillespie, University of California at Irvine, Irvine, CA 92697, USA
    Hum Mol Genet 14:1529-38. 2005
    ..These results support a model in which sustained activation of ERK1/2 is a key regulator of the increased transition to hypertrophic differentiation of the growth plate, whereas activation of STATs 1 and 3 is not required...
  7. ncbi Human embryonic kidney cells (HEK-293 cells): characterization and dose-response relationship for modulated release of nerve growth factor for nerve regeneration
    Juan Carlos Jimenez
    Division of Plastic Surgery, University of California, Irvine, USA
    Plast Reconstr Surg 113:605-10. 2004
    ..It was demonstrated that this regulated delivery system could secrete bioactive NGF for up to 9 days and might be useful for in vivo applications. This regulated delivery system should be useful for tissue-engineered nerve constructs...
  8. ncbi Characterization of symmetric complexes of nerve growth factor and the ectodomain of the pan-neurotrophin receptor, p75NTR
    Jukka P Aurikko
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom
    J Biol Chem 280:33453-60. 2005
    ..Molecular models of the 2:2 p75(NTR) x NGF complex based on these data are not consistent with the further assembly of either symmetric (2:2:2) or asymmetric (2:2:1) ternary p75(NTR) x NGF x TrkA complexes...
  9. ncbi Nerve growth factor expression response to induction agent booster dosing in transfected human embryonic kidney cells
    Michael P McConnell
    Aesthetic and Plastic Surgery Institute, University of California, Irvine, Orange, Calif 92868-3298, USA
    Plast Reconstr Surg 115:506-14. 2005
    ..Furthermore, repeated bioactive NGF expression peaks beyond that previously demonstrated can be achieved using induction agent booster dosing, indicating the ability to regulate the system over an extended period...
  10. ncbi Revised draft guidelines for proteomic data publication
    Ralph A Bradshaw
    Mol Cell Proteomics 4:1223-5. 2005
  11. ncbi Protein identification: the good, the bad, and the ugly
    Ralph A Bradshaw
    Mol Cell Proteomics 4:1221-2. 2005
  12. ncbi Proteomics - boom or bust?
    Ralph A Bradshaw
    Mol Cell Proteomics 1:177-8. 2002
  13. ncbi Individual and combined effects of TrkA and p75NTR nerve growth factor receptors. A role for the high affinity receptor site
    Shivanand P Lad
    Department of Biochemistry and Molecular Biology, University of Health Sciences/The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Biol Chem 278:24808-17. 2003
    ..In addition, a new interaction in the TrkA/p75NTR heteromeric receptor signal transduction network was revealed, namely that NGF-induced activation of the MAPK pathway appears to inhibit the parallel NGF-induced Akt pathway...
  14. ncbi What has proteomics accomplished?
    John J M Bergeron
    McGill University, Montreal, H3A 282, Canada
    Mol Cell Proteomics 6:1824-6. 2007

Research Grants17

  1. CO-TRANSLATIONAL PROCESSING AND PROTEIN TURNOVER
    RALPH BRADSHAW; Fiscal Year: 1993
    ..Two proteins (asparagine synthetase and hypoxanthine phosphoribosyl transferase) will be used as the principal substrates in these studies. Appropriate nucleic acid and immunological reagents are either in-hand or will be generated...
  2. STRUCTURE AND INTRACELLULAR LOCALIZATION OF PROTEINS
    RALPH BRADSHAW; Fiscal Year: 1990
    ..We will also continue to sequence chicken phosphoglycerate mutase, C. vinosum hemoprotein and spinach chloroplast fructose-P2-aldolase...
  3. CO-TRANSLATIONAL PROCESSING AND PROTEIN TURNOVER
    RALPH BRADSHAW; Fiscal Year: 1991
    ..Appropriate nucleic acid and immunological reagents are either in-hand or will be generated...
  4. COTRANSLATIONAL PROCESSING AND PROTEIN TURNOVER
    RALPH BRADSHAW; Fiscal Year: 2001
    ....