R A Bradshaw

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Receptor tyrosine kinase signaling mechanisms: Devolving TrkA responses with phosphoproteomics
    R A Bradshaw
    Dept Pharmaceutical Chemistry, University of California, San Francisco, CA, USA
    Adv Biol Regul 53:87-96. 2013
  2. ncbi request reprint Activation of the Stat3 signaling pathway is required for differentiation by interleukin-6 in PC12-E2 cells
    Y Y Wu
    Departments of Physiology and Biophysics, College of Medicine, University of California, Irvine, California 92697, USA
    J Biol Chem 275:2147-56. 2000
  3. ncbi request reprint Application of combined mass spectrometry and partial amino acid sequence to the identification of gel-separated proteins
    S D Patterson
    Amgen Inc, Thousand Oaks, CA, USA
    Electrophoresis 17:877-91. 1996
  4. ncbi request reprint O-sulfonation of serine and threonine: mass spectrometric detection and characterization of a new posttranslational modification in diverse proteins throughout the eukaryotes
    K F Medzihradszky
    Department of Pharmaceutical Chemistry and Mass Spectrometry Facility, University of California, San Francisco, CA 94143, USA
    Mol Cell Proteomics 3:429-40. 2004
  5. ncbi request reprint The role of tyrosine residues in fibroblast growth factor receptor 1 signaling in PC12 cells. Systematic site-directed mutagenesis in the endodomain
    E D Foehr
    Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, California 92697, USA
    J Biol Chem 276:37529-36. 2001

Collaborators

Detail Information

Publications5

  1. pmc Receptor tyrosine kinase signaling mechanisms: Devolving TrkA responses with phosphoproteomics
    R A Bradshaw
    Dept Pharmaceutical Chemistry, University of California, San Francisco, CA, USA
    Adv Biol Regul 53:87-96. 2013
    ..A comparison with a similar set of data for EGFR indicates a considerable degree of similarity in the downstream signaling profile between these two RTKs...
  2. ncbi request reprint Activation of the Stat3 signaling pathway is required for differentiation by interleukin-6 in PC12-E2 cells
    Y Y Wu
    Departments of Physiology and Biophysics, College of Medicine, University of California, Irvine, California 92697, USA
    J Biol Chem 275:2147-56. 2000
    ..Thus, activation of the Stat3 signaling pathway, but not RAS/ERK dependent pathways, is essential for differentiation of PC12-E2 cells by IL-6...
  3. ncbi request reprint Application of combined mass spectrometry and partial amino acid sequence to the identification of gel-separated proteins
    S D Patterson
    Amgen Inc, Thousand Oaks, CA, USA
    Electrophoresis 17:877-91. 1996
    ..In one case the identified protein clearly did not correspond to the radiolabeled band, but to a protein contaminant from the column. The advantages and pitfalls of the approach are discussed...
  4. ncbi request reprint O-sulfonation of serine and threonine: mass spectrometric detection and characterization of a new posttranslational modification in diverse proteins throughout the eukaryotes
    K F Medzihradszky
    Department of Pharmaceutical Chemistry and Mass Spectrometry Facility, University of California, San Francisco, CA 94143, USA
    Mol Cell Proteomics 3:429-40. 2004
    ..These findings suggest that sulfonation of serine and threonine may be involved in multiple functions including protein assembly and signal transduction...
  5. ncbi request reprint The role of tyrosine residues in fibroblast growth factor receptor 1 signaling in PC12 cells. Systematic site-directed mutagenesis in the endodomain
    E D Foehr
    Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, California 92697, USA
    J Biol Chem 276:37529-36. 2001
    ..However, it does require Tyr(677) and/or Tyr(701), which may function to stabilize the active conformation directly or indirectly...