Research Topics
Species | S BradesiSummaryAffiliation: University of California Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Current insights into the pathophysiology of irritable bowel syndromeInes Schwetz
Center of Neurovisceral Sciences and Women s Health, CURE Digestive Diseases Research Center, David Geffen School of Medicine at UCLA, VAGLAHS, Bldg 115, Room 223, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
Curr Gastroenterol Rep 5:331-6. 2003....- Alosetron and irritable bowel syndromeEmeran A Mayer
Center for Neurovisceral Sciences and Women s Health, VAGLAHS, Bldg 115 CURE 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
Expert Opin Pharmacother 4:2089-98. 2003..The impact of alosetron on QOL in IBS patients and the safety of treatment with alosetron, will also be covered... 
Visceral analgesics: drugs with a great potential in functional disorders?Sylvie Bradesi
Center for Neurobiology of Stress, Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
Curr Opin Pharmacol 8:697-703. 2008....- Role of astrocytes and altered regulation of spinal glutamatergic neurotransmission in stress-induced visceral hyperalgesia in ratsSylvie Bradesi
Center for Neurobiology of Stress, University of California, Los Angeles David Geffen School of Medicine, Digestive Diseases Division, CA 90073, USA
Am J Physiol Gastrointest Liver Physiol 301:G580-9. 2011..The findings reported in this study demonstrate a unique pattern of stress-induced changes in spinal Glu signaling and metabolism associated with enhanced responses to visceral distension... 
Involvement of vasopressin 3 receptors in chronic psychological stress-induced visceral hyperalgesia in ratsSylvie Bradesi
University of California Los Angeles Center for Neurobiology of Stress, Departments of Medicine, Physiology, and Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073
Am J Physiol Gastrointest Liver Physiol 296:G302-9. 2009....- Role of spinal microglia in visceral hyperalgesia and NK1R up-regulation in a rat model of chronic stressSylvie Bradesi
Center for Neurobiology of Stress, Department of Medicine, University of California, Los Angeles, Los Angeles, California 90073, USA
Gastroenterology 136:1339-48, e1-2. 2009..Chronic psychological stress is associated with visceral hyperalgesia and increased expression of spinal NK1 receptors (NK1Rs). We aimed to identify the role of spinal microglia in this process... - PAR4: a new role in the modulation of visceral nociceptionS Bradesi
Center for Neurobiology of Stress, University of California Los Angeles, Division of Digestive Diseases, Los Angeles, CA 90073, USA
Neurogastroenterol Motil 21:1129-32. 2009.... - Experimental models of stress and pain: do they help to develop new therapies?Sylvie Bradesi
UCLA Center for Neurobiology of Stress, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
Dig Dis 27:55-67. 2009..Continuation of the current approach focusing on complex clinical phenotypes is likely to be ineffective for the development of novel and effect treatments... - Role of spinal cord glia in the central processing of peripheral pain perceptionS Bradesi
Center for Neurobiology of Stress, Department of Medicine, David Geffen School of Medicine at UCLA, VAGLA HC, Los Angeles, CA, USA
Neurogastroenterol Motil 22:499-511. 2010.... - Corticotropin-releasing factor type 1 receptors mediate the visceral hyperalgesia induced by repeated psychological stress in ratsMuriel Larauche
Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
Am J Physiol Gastrointest Liver Physiol 294:G1033-40. 2008..These data support a major role for CRF(1) in both the development and maintenance of visceral hyperalgesia induced by repeated stress and indicate a possible role of peripheral CRF receptors in such mechanisms... - Dual role of 5-HT3 receptors in a rat model of delayed stress-induced visceral hyperalgesiaSylvie Bradesi
Center for Neurovisceral Sciences and Women s Health, Department of Medicine, VAGLAHS CURE Building 115, Room 223, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
Pain 130:56-65. 2007..In addition, we showed that stress-induced sensitization of visceral nociception is independent of 5-HT3R activation on vagal afferents... - Functional GI disorders: from animal models to drug developmentE A Mayer
UCLA Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
Gut 57:384-404. 2008.... - Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesiaSylvie Bradesi
Department of Medicine, Center for Neurovisceral Sciences and Women's Health, David Geffen School of Medicine at University of California, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, California 90073, USA
Am J Physiol Gastrointest Liver Physiol 289:G42-53. 2005.... - Delayed stress-induced colonic hypersensitivity in male Wistar rats: role of neurokinin-1 and corticotropin-releasing factor-1 receptorsInes Schwetz
Center for Neurovisceral Sciences and Women's Health, Department of Medicine, David Gaffen School of Medicine ar University of California, Los Angeles 90024, USA
Am J Physiol Gastrointest Liver Physiol 286:G683-91. 2004..Chemical sympathectomy did not affect delayed SICH. Our results indicate that in male Wistar rats, both NK(1)R and CRF(1)R activation, but not sympathetic nervous system activation, play a role in the development of SICH... - Review article: modulation of the brain-gut axis as a therapeutic approach in gastrointestinal diseaseE A Mayer
Department of Medicine, Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
Aliment Pharmacol Ther 24:919-33. 2006..Numerous current and emerging therapies aimed at normalizing brain-gut interactions are a focus of interest, particularly for irritable bowel syndrome and functional dyspepsia... - The pathophysiology of irritable bowel syndromeI Schwetz
Center of Neurovisceral Sciences and Women's Health (CNS, Division of Digestive Diseases and Brain Research Institute, Department of Medicine, Los Angeles, CA, USA
Minerva Med 95:419-26. 2004.... - The role of neurokinin 1 receptors in the maintenance of visceral hyperalgesia induced by repeated stress in ratsSylvie Bradesi
Center for Neurovisceral Sciences and Women's Health, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
Gastroenterology 130:1729-42. 2006.... - Corticotropin-releasing factor receptor 1 mediates acute and delayed stress-induced visceral hyperalgesia in maternally separated Long-Evans ratsInes Schwetz
Center for Neurovisceral Sciences and Women's Health, University of California Los Angeles, CA 90073, USA
Am J Physiol Gastrointest Liver Physiol 289:G704-12. 2005..Both acute and delayed stress-induced visceral hypersensitivity in MS rats are mediated by the CRF/CRF(1)R system... - Sex differences in functional brain activation during noxious visceral stimulation in ratsZhuo Wang
Center for Neurobiology of Stress, UCLA, Los Angeles, CA, USA
Pain 145:120-8. 2009..These findings show remarkable similarities to reported sex differences in brain responses to visceral stimuli in humans... - Regional brain activation in conscious, nonrestrained rats in response to noxious visceral stimulationZhuo Wang
Center for the Neurobiology of Stress, Brain Research Institute, UCLA, Los Angeles, CA, USA
Pain 138:233-43. 2008..This suggests that functional brain imaging captures more extensive responses of the central nervous system to noxious visceral distension than those identified by traditional measures... - Emerging drugs for irritable bowel syndromeSylvie Bradesi
Center for Neurovisceral Sciences and Women's Health, CURE: Digestive Diseases Research Center, UCLA Division of Digestive Diseases, GLA VA HC Bldg, 115/CURE, 11301 Wilshire Blvd, Los Angeles, California 90073, USA
Expert Opin Emerg Drugs 11:293-313. 2006..Advances in clinical trial design will help to evaluate these compounds in different IBS patient populations... - Novel therapeutic approaches in IBSSylvie Bradesi
UCLA Center for Neurovisceral Sciences and Women s Health, and Departments of Medicine, David Geffen School of Medicine at UCLA, University of California Los Angeles, CA 90024, USA
Curr Opin Pharmacol 7:598-604. 2007..Recent new evidence for a possible role of altered microflora and altered host microbial interactions may provide new treatment targets in the future...
Research Grants
- Spinal glia activation in chronic stress-induced visceral hyperalgesiaSylvie Bradesi; Fiscal Year: 2010....
- Regulation of spinal NK1R expression by chronic stressSylvie Bradesi; Fiscal Year: 2006..This proposal is expected to provide new insights into the mechanisms by which stress affects the processing of visceral nociception. ..