S Bradesi

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Current insights into the pathophysiology of irritable bowel syndrome
    Ines Schwetz
    Center of Neurovisceral Sciences and Women s Health, CURE Digestive Diseases Research Center, David Geffen School of Medicine at UCLA, VAGLAHS, Bldg 115, Room 223, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Curr Gastroenterol Rep 5:331-6. 2003
  2. ncbi request reprint Alosetron and irritable bowel syndrome
    Emeran A Mayer
    Center for Neurovisceral Sciences and Women s Health, VAGLAHS, Bldg 115 CURE 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Expert Opin Pharmacother 4:2089-98. 2003
  3. pmc Visceral analgesics: drugs with a great potential in functional disorders?
    Sylvie Bradesi
    Center for Neurobiology of Stress, Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    Curr Opin Pharmacol 8:697-703. 2008
  4. pmc Role of astrocytes and altered regulation of spinal glutamatergic neurotransmission in stress-induced visceral hyperalgesia in rats
    Sylvie Bradesi
    Center for Neurobiology of Stress, University of California, Los Angeles David Geffen School of Medicine, Digestive Diseases Division, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 301:G580-9. 2011
  5. doi request reprint Involvement of vasopressin 3 receptors in chronic psychological stress-induced visceral hyperalgesia in rats
    Sylvie Bradesi
    University of California Los Angeles Center for Neurobiology of Stress, Departments of Medicine, Physiology, and Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073
    Am J Physiol Gastrointest Liver Physiol 296:G302-9. 2009
  6. pmc Role of spinal microglia in visceral hyperalgesia and NK1R up-regulation in a rat model of chronic stress
    Sylvie Bradesi
    Center for Neurobiology of Stress, Department of Medicine, University of California, Los Angeles, Los Angeles, California 90073, USA
    Gastroenterology 136:1339-48, e1-2. 2009
  7. pmc PAR4: a new role in the modulation of visceral nociception
    S Bradesi
    Center for Neurobiology of Stress, University of California Los Angeles, Division of Digestive Diseases, Los Angeles, CA 90073, USA
    Neurogastroenterol Motil 21:1129-32. 2009
  8. doi request reprint Experimental models of stress and pain: do they help to develop new therapies?
    Sylvie Bradesi
    UCLA Center for Neurobiology of Stress, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    Dig Dis 27:55-67. 2009
  9. pmc Role of spinal cord glia in the central processing of peripheral pain perception
    S Bradesi
    Center for Neurobiology of Stress, Department of Medicine, David Geffen School of Medicine at UCLA, VAGLA HC, Los Angeles, CA, USA
    Neurogastroenterol Motil 22:499-511. 2010
  10. doi request reprint Corticotropin-releasing factor type 1 receptors mediate the visceral hyperalgesia induced by repeated psychological stress in rats
    Muriel Larauche
    Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1033-40. 2008

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Current insights into the pathophysiology of irritable bowel syndrome
    Ines Schwetz
    Center of Neurovisceral Sciences and Women s Health, CURE Digestive Diseases Research Center, David Geffen School of Medicine at UCLA, VAGLAHS, Bldg 115, Room 223, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Curr Gastroenterol Rep 5:331-6. 2003
    ....
  2. ncbi request reprint Alosetron and irritable bowel syndrome
    Emeran A Mayer
    Center for Neurovisceral Sciences and Women s Health, VAGLAHS, Bldg 115 CURE 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Expert Opin Pharmacother 4:2089-98. 2003
    ..The impact of alosetron on QOL in IBS patients and the safety of treatment with alosetron, will also be covered...
  3. pmc Visceral analgesics: drugs with a great potential in functional disorders?
    Sylvie Bradesi
    Center for Neurobiology of Stress, Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    Curr Opin Pharmacol 8:697-703. 2008
    ....
  4. pmc Role of astrocytes and altered regulation of spinal glutamatergic neurotransmission in stress-induced visceral hyperalgesia in rats
    Sylvie Bradesi
    Center for Neurobiology of Stress, University of California, Los Angeles David Geffen School of Medicine, Digestive Diseases Division, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 301:G580-9. 2011
    ..The findings reported in this study demonstrate a unique pattern of stress-induced changes in spinal Glu signaling and metabolism associated with enhanced responses to visceral distension...
  5. doi request reprint Involvement of vasopressin 3 receptors in chronic psychological stress-induced visceral hyperalgesia in rats
    Sylvie Bradesi
    University of California Los Angeles Center for Neurobiology of Stress, Departments of Medicine, Physiology, and Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073
    Am J Physiol Gastrointest Liver Physiol 296:G302-9. 2009
    ....
  6. pmc Role of spinal microglia in visceral hyperalgesia and NK1R up-regulation in a rat model of chronic stress
    Sylvie Bradesi
    Center for Neurobiology of Stress, Department of Medicine, University of California, Los Angeles, Los Angeles, California 90073, USA
    Gastroenterology 136:1339-48, e1-2. 2009
    ..Chronic psychological stress is associated with visceral hyperalgesia and increased expression of spinal NK1 receptors (NK1Rs). We aimed to identify the role of spinal microglia in this process...
  7. pmc PAR4: a new role in the modulation of visceral nociception
    S Bradesi
    Center for Neurobiology of Stress, University of California Los Angeles, Division of Digestive Diseases, Los Angeles, CA 90073, USA
    Neurogastroenterol Motil 21:1129-32. 2009
    ....
  8. doi request reprint Experimental models of stress and pain: do they help to develop new therapies?
    Sylvie Bradesi
    UCLA Center for Neurobiology of Stress, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    Dig Dis 27:55-67. 2009
    ..Continuation of the current approach focusing on complex clinical phenotypes is likely to be ineffective for the development of novel and effect treatments...
  9. pmc Role of spinal cord glia in the central processing of peripheral pain perception
    S Bradesi
    Center for Neurobiology of Stress, Department of Medicine, David Geffen School of Medicine at UCLA, VAGLA HC, Los Angeles, CA, USA
    Neurogastroenterol Motil 22:499-511. 2010
    ..In addition, spinal glial activation is also involved in some forms of visceral hyperalgesia...
  10. doi request reprint Corticotropin-releasing factor type 1 receptors mediate the visceral hyperalgesia induced by repeated psychological stress in rats
    Muriel Larauche
    Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1033-40. 2008
    ..These data support a major role for CRF(1) in both the development and maintenance of visceral hyperalgesia induced by repeated stress and indicate a possible role of peripheral CRF receptors in such mechanisms...
  11. ncbi request reprint Dual role of 5-HT3 receptors in a rat model of delayed stress-induced visceral hyperalgesia
    Sylvie Bradesi
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, VAGLAHS CURE Building 115, Room 223, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Pain 130:56-65. 2007
    ..In addition, we showed that stress-induced sensitization of visceral nociception is independent of 5-HT3R activation on vagal afferents...
  12. ncbi request reprint Functional GI disorders: from animal models to drug development
    E A Mayer
    UCLA Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    Gut 57:384-404. 2008
    ....
  13. ncbi request reprint Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia
    Sylvie Bradesi
    Department of Medicine, Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at University of California, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, California 90073, USA
    Am J Physiol Gastrointest Liver Physiol 289:G42-53. 2005
    ....
  14. ncbi request reprint Delayed stress-induced colonic hypersensitivity in male Wistar rats: role of neurokinin-1 and corticotropin-releasing factor-1 receptors
    Ines Schwetz
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Gaffen School of Medicine ar University of California, Los Angeles 90024, USA
    Am J Physiol Gastrointest Liver Physiol 286:G683-91. 2004
    ..Chemical sympathectomy did not affect delayed SICH. Our results indicate that in male Wistar rats, both NK(1)R and CRF(1)R activation, but not sympathetic nervous system activation, play a role in the development of SICH...
  15. ncbi request reprint Review article: modulation of the brain-gut axis as a therapeutic approach in gastrointestinal disease
    E A Mayer
    Department of Medicine, Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    Aliment Pharmacol Ther 24:919-33. 2006
    ..Numerous current and emerging therapies aimed at normalizing brain-gut interactions are a focus of interest, particularly for irritable bowel syndrome and functional dyspepsia...
  16. ncbi request reprint The pathophysiology of irritable bowel syndrome
    I Schwetz
    Center of Neurovisceral Sciences and Women s Health CNS, Division of Digestive Diseases and Brain Research Institute, Department of Medicine, Los Angeles, CA, USA
    Minerva Med 95:419-26. 2004
    ....
  17. ncbi request reprint The role of neurokinin 1 receptors in the maintenance of visceral hyperalgesia induced by repeated stress in rats
    Sylvie Bradesi
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Gastroenterology 130:1729-42. 2006
    ..Here we examined the participation of NK(1)Rs in sustained visceral hyperalgesia observed in rats exposed to chronic psychological stress...
  18. ncbi request reprint Corticotropin-releasing factor receptor 1 mediates acute and delayed stress-induced visceral hyperalgesia in maternally separated Long-Evans rats
    Ines Schwetz
    Center for Neurovisceral Sciences and Women s Health, University of California Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 289:G704-12. 2005
    ..Both acute and delayed stress-induced visceral hypersensitivity in MS rats are mediated by the CRF/CRF(1)R system...
  19. pmc Sex differences in functional brain activation during noxious visceral stimulation in rats
    Zhuo Wang
    Center for Neurobiology of Stress, UCLA, Los Angeles, CA, USA
    Pain 145:120-8. 2009
    ..These findings show remarkable similarities to reported sex differences in brain responses to visceral stimuli in humans...
  20. pmc Regional brain activation in conscious, nonrestrained rats in response to noxious visceral stimulation
    Zhuo Wang
    Center for the Neurobiology of Stress, Brain Research Institute, UCLA, Los Angeles, CA, USA
    Pain 138:233-43. 2008
    ..This suggests that functional brain imaging captures more extensive responses of the central nervous system to noxious visceral distension than those identified by traditional measures...
  21. ncbi request reprint Emerging drugs for irritable bowel syndrome
    Sylvie Bradesi
    Center for Neurovisceral Sciences and Women s Health, CURE Digestive Diseases Research Center, UCLA Division of Digestive Diseases, GLA VA HC Bldg, 115 CURE, 11301 Wilshire Blvd, Los Angeles, California 90073, USA
    Expert Opin Emerg Drugs 11:293-313. 2006
    ..Advances in clinical trial design will help to evaluate these compounds in different IBS patient populations...
  22. pmc Novel therapeutic approaches in IBS
    Sylvie Bradesi
    UCLA Center for Neurovisceral Sciences and Women s Health, and Departments of Medicine, David Geffen School of Medicine at UCLA, University of California Los Angeles, CA 90024, USA
    Curr Opin Pharmacol 7:598-604. 2007
    ..Recent new evidence for a possible role of altered microflora and altered host microbial interactions may provide new treatment targets in the future...

Research Grants3

  1. Spinal glia activation in chronic stress-induced visceral hyperalgesia
    Sylvie Bradesi; Fiscal Year: 2010
    ....
  2. Regulation of spinal NK1R expression by chronic stress
    Sylvie Bradesi; Fiscal Year: 2006
    ..This proposal is expected to provide new insights into the mechanisms by which stress affects the processing of visceral nociception. ..