- Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapyPauline Chugh
Department of Microbiology and Immunology, School of Medicine, University of Rochester Medical Center 601 Elmwood Avenue Box 672 Rochester, New York 14742 USA
Retrovirology 5:11. 2008..Unlike CD4+ T cells, HIV-1 infected macrophages exhibit extended life span even upon stress, consistent with their in vivo role as long-lived HIV-1 reservoirs...
- The human H5N1 influenza A virus polymerase complex is active in vitro over a broad range of temperatures, in contrast to the WSN complex, and this property can be attributed to the PB2 subunitBirgit G Bradel-Tretheway
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
J Gen Virol 89:2923-32. 2008..These results show that PB2 plays an important role in regulating the temperature optimum for IAV RNA polymerase activity, possibly due to effects on the functional stability of the 3P complex...